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中国介入影像与治疗学 2005年第1期2卷 1-5页

作者： Kuniaki HAYASHI Ichiro SAKAMOTO Naofumi MATSUNAGA kazuto ashizawa Masataka UETANI NagasakiRosai Hospital SaseboNagasaki 857-0134Japan Department of Radiology Nagasaki University School of MedicineSakamotoNagasaki 852-8501Japan Department of Radiology Yamaguchi University School of MedicineUbeYamaguchi 755-8505Japan

This is a review article describing some new and interesting aspects in the diagnosis and treatment in systemic vasculitis and demonstrating several cases that we have *** emphasis will be put on Takayasu arteritis(also known as aortitis syndrome)most commonly observed in Japan and other oriental *** and MRI better demonstrate the vessel wall abnormality of Takayasu arteritis than *** of plain chest radiograph should also be kept in mind;it could provide a clue in the diagnosis of Takayasu arteritis in its early stage.

关键词： Systemic vasculitis Takayasu arteritis Aortitis syndrome Imaging diagnosis

Imaging diagnosis and interventional radiology in systemic vasculitis with particular emphasis on Takayasu arteritis: Part 2

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中国介入影像与治疗学 2005年第2期2卷 79-84页

作者： Ichiro SAKAMOTO Kuniaki HAYASHI Naofumi MATSUNAGA kazuto ashizawa Yohjiro MATSUOKA Masataka UETANI Department of Radiology Nagasaki University School of MedicineSakamotoNagasaki 852-8501Japan Nagasaki Rosai Hospital SaseboNagasaki 857-0134Japan Department of Radiology Yamaguchi University School of MedicineUbeYamaguchi 755-8505Japan Department of Radiology National Nagasaki Medical CenterKubaraOmura 856-8562Japan

In part 1 of this article,clinical features and imaging findings of Takayasu arteritis(also known as aortitis syndrome)were described in *** part 2,treatment of Takayasu arteritis will be first described and *** will be followed by description of clinical features and imaging findings of other systemic *** on interventional radiology for systemic vasculitis will also be made.

关键词： Systemic vasculitis Takayasu arteritis Aortitis syndrome Temporal arteritis Polyarteritis nodosa Kawasaki disease Wegener granulomatosis Behcet disease

Recent advances in the management of pruritus in chronic liver diseases

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World Journal of Gastroenterology 2017年第19期23卷 3418-3426页

作者： kazuto Tajiri Yukihiro Shimizu Department of Gastroenterology Toyama University Hospital Gastroenterology Center Nanto Municipal Hospital

Pruritus is a symptom found in patients with chronic liver diseases,especially cholestatic liver diseases such as primary biliary *** symptom impairs patient quality of life by disturbing sleep and may lead to consideration of liver *** implicated in pruritus have been associated with the peripheral and central nervous systems,leading to the development of various therapeutic *** evidence for the efficacy of most of these treatments is currently available,indicating a need for further investigations.

关键词： Pruritus Cholestasis Autotaxin Opioid receptor antagonist

Cooling Curve's Effect on Hardening Behavior of Steel

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材料热处理学报 2004年第5期25卷 462-464页

作者： kazuto Fukuhara Shigeru Asada Yoshihiro Tomita Syusaku Maeda Nippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka Japan

Quenching Oils are comprised mostly of mineral oil as major component, but mineral oil alone result in lower cooling performance. Therefore, various additives are formulated as required for each particular case. Cooling curves of mineral oil as determined by JIS method can be divided into three stages, vapor film stage, boiling stage and convection stage. And there are many types of additives used for quenching oil, one effective to shorten vapor film stage and another to shift boiling stage toward lower temperature side. As rapid quenching required temperature range for particular steel varies pending on its shape of CCT curve"1, it is possible to provide higher quench hardening performance using quenching oil formulated of adequate additives.

关键词：淬火油冷却效果硬化性能钢

Systemic abnormalities in liver disease

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World Journal of Gastroenterology 2009年第24期15卷 2960-2974页

作者： Masami Minemura kazuto Tajiri Yukihiro Shimizu Department of Gastroenterology and Hematology Graduate School of Medicine and Pharmaceutical Sciences University of Toyama Department of Internal Medicine Nanto Municipal Hospital

Systemic abnormalities often occur in patients with liver disease. In particular, cardiopulmonary or renal diseases accompanied by advanced liver disease can be serious and may determine the quality of life and prognosis of patients. Therefore, both hepatologists and non-hepatologists should pay attention to such abnormalities in the management of patients with liver diseases.

关键词： Systemic abnormality Risk of surgery Drug dosage Liver disease

Influence of oxygen flow rate and compost addition on reduction of organic matter in aerated waste layer containing mainly incineration residue

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Journal of Environmental Sciences 2013年第1期25卷 53-58页

作者： Hiroshi Asakura Kei Nakagawa kazuto Endo Masato Yamada Yusaku Ono Yoshiro Ono Nagasaki University 1-14 Bunkyo-machi Nagasaki 852-8521Japan National Institute for Environmental Studies Onogawa 16-2TsukubaIbaraki 305-8506Japan Nippon Institute of Technology 4-1 GakuendaiMiyashiro-machiMinamisaitama-gunSaitama 345-8501Japan Kyoto Institute of Technology MatsugasakiSakyo-kuKyoto 606-8585Japan

Landfilling municipal solid waste incineration （MSWI） residue alkalizes the waste layer, causing a subsequent decrease in microbial activity and a delay in the decomposition of organic matter. In this study, efficiencies of neutralization of the leachate and organic matter decomposition in the waste layer in a column filled with MSWI residue using aeration and compost addition were evaluated. Total organic carbon （TOC） reduction in the waste layer is large at high oxygen flow rate （OFR）. To effectively accelerate TOC reduction in the waste layer to which compost was added, a high OFR exceeding that by natural ventilation was required. At day 65, the pH of the leachate when OFR was above 102 mol-O2/（day.m3） was lower than that when OFR was below 101 mol-Oz/（day.m3）. At the same OFR, the pH of waste sample was lower than that of waste sample with compost. Although leachate neutralization could be affected by compost addition, TOC reduction in the waste layer became rather small. It is possible that humic substances in compost prevent the decomposition of TOC in MSWI residue.

关键词： waste landfill aeration neutralization acceleration of stabilization

Efficacy and Safety of the Atrial Septal Defect Closure for Patients with Absent or Malaligned Aortic Rim Using a Figulla Flex II Device Flared and Straddling Behind the Aorta

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Congenital Heart Disease 2021年第3期16卷 269-283页

作者： Masataka Kitano kazuto Fujimoto Atsuko Kato Ken-ichi Kurosaki Isao Shiraishi Department of Pediatric Cardiology National Cerebral and Cardiovascular CenterOsakaJapan Department of Pediatric Cardiology Okinawa Prefectural Nanbu Medical Center&Children’s Medical CenterOkinawa PrefectureJapan

Background:Although transcatheter closure of atrial septal defect(ASD)is safe and effective for patients with sufficient rim,ASD patients with absent and/or malaligned aortic and/or superior rim have higher risks of device embolization and cardiac *** have treated such high-risk patients using a Figulla Flex II(FFII)device shaped flared and straddling behind the aorta because this method would avoid such serious ***,its long-term efficacy and safety remain ***,the midterm efficacy and safety of this method were ***:We retrospectively evaluated the outcome of 47 consecutive patients with such rim(age 6–73 years,weight 17–75 kg,31 females)treated with this method at our hospital between February 2016 and September *** make the flared and straddling shape,we selected a FFII 4–6 mm larger than the balloon sizing diameter by stop-flow *** also studied the device shape,the disc pressure to the Valsalva wall and their changes over 6 months by transesophageal ***:All procedures were successful,and leakage disappeared within 1 *** a mean follow up of 37±12 months,complications included a transient sinus node dysfunction and one I°atrioventricular block within 3 *** device shape changed from bulky to thin:the device waist and thickness significantly decreased by around 1.5 mm and 3.5 mm,respectively(p<0.05),but the two discs remained flared and straddling behind the aorta over 6 months;therefore,the disc edges seldom pressed the Valsalva wall perpendicularly,even though the inner plane of either disc often slightly pressed the ***:ASD closure using a FFII shaped flared and straddling behind the aorta is probably effective and safe for patients with absent and/or malaligned aortic and/or superior rim although requiring care for conduction disorders.

关键词： Atrial septal defect catheter intervention device embolization cardiac erosion conduction disorder

Secretory carcinoma——impact of translocation and gene fusions on salivary gland tumor

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Chinese Journal of Cancer Research 2017年第5期29卷 379-384页

作者： Ryoko Inaki Masanobu Abe Liang Zong Takahiro Abe Aya Shinozaki-Ushiku Tetsuo Ushiku kazuto Hoshi Department of Oral & Maxillofacial Surgery University of Tokyo Hospital Division for Health Service Promotion University of Tokyo Graduate School of Medicine University of Tokyo Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Department of Gastrointestinal Surgery Peking University Cancer Hospital & Institute Department of Pathology Graduate School of Medicine University of Tokyo

Secretory carcinoma（SC）, previously described as mammary analogue secretory carcinoma（MASC）, is a recently described salivary gland tumor which morphologically resembles mammary secretory carcinoma. The first description of SC/MASC, reported by Skálová et al. in 2010, was as a rare salivary carcinoma imitating secretory carcinoma of the breast. SC/MASC is a unique salivary gland tumor with morphological overlap with acinic cell carcinoma（Aci CC）, mucoepidermoid carcinoma（MEC）, and adenocarcinoma not otherwise specified（ADCNOS）. SC/MASC shares similar clinicopathological features with Aci CC. As a critical difference between SC/MASC and Aci CC, SC/MASC characteristically has the chromosomal translocation t（12;15）（p13;q25） which leads to a fusion gene between the ETV6 gene on chromosome 12 and the NTRK3 gene on chromosome 15. This genetic background is an important differential diagnostic finding for excluding other salivary gland tumors and may be a critical factor determining the prognosis for patients with SC/MASC. Research in recent years has provided a large body of new data on SC/MASC and suggests the possibility that the ETV6-NTRK3 translocation could be a therapeutic target. Here, we review the morphological and clinicopathological features of SC/MASC and discuss new directions for therapy.

关键词： Secretory carcinoma mammary analogue secretory carcinoma MASC ETV6-NTRK3 fusion gene salivary gland tumor

Practical guidelines for diagnosis and early management of drug-induced liver injury

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World Journal of Gastroenterology 2008年第44期14卷 6774-6785页

作者： kazuto Tajiri Yukihiro Shimizu Department of Gastroenterology and Hematology Graduate School of Medical and Pharmaceutical SciencesUniversity of ToyamaSugitani 2630ToyamaJapan Center for Gastroenterology and Hepatology Kyoto Katsura Hospital17 Yamada-HiraoNishikyoKyoto 615-8256Japan

The spectrum of drug-induced liver injury （DILI） is both diverse and complex. The first step in diagnosis is a suspicion of DILl based on careful consideration of recent comprehensive reports on the disease. There are some situations in which the suspicion of DILI is particularly strong. Exclusion of other possible etiologies according to the pattern of liver injury is essential for the diagnosis. In patients with suspected DILl, diagnostic scales, such as the Councils for International Organizations of Medical Sciences/ Roussel Uclaf Causality Assessment Method （CIOMS/RUCAM） scale, may be helpful for the final diagnosis. Early management of DILl involves prompt withdrawal of the drug suspected of being responsible, according to serum levels of alanine aminotransferase （ALT）, alkaline phosphatase （ALP）, and total bilirubin （T-Bil）. However, as DILI patients may show resolution of liver injury without discontinuation of the drug, it should be carefully evaluated whether the suspected drug should be discontinued immediately with adequate consideration of the importance of the medication.

关键词： Diagnosis Drug-induced liver injury Guidelines Management

Intraarterial and intravenous contrast enhanced CT and MR imaging of multi-step hepatocarcinogenesis defining the early stage of hepatocellular carcinoma development

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Hepatoma Research 2020年第6期6卷 107-120页

作者： Satoshi Kobayashi kazuto Kozaka Toshifumi Gabata Osamu Matsui Tetsuya Minami Department of Quantum Medical Technology Kanazawa University Graduate School of Medical SciencesKanazawa 920-0942Japan Department of Radiology Kanazawa University Graduate School of Medical SciencesKanazawa 920-8641Japan Department of Radiology Kanazawa Medical UniversityUchinada 920-0293Japan

Liver cancer is the second leading cause of cancer deaths in men worldwide,and the 6th and 7th cause of cancer deaths in men and women in developed countries.70%-90%of primary liver cancer is hepatocellular *** B or C viruses and chronic inflammation due to alcohol intake are the main risk factors for hepatocellular *** of the key approaches for the early detection of hepatocellular carcinoma is to understand the specific imaging findings of liver nodules in the multi-step hepatocrcinogenesis *** this article,we review the imaging findings of multistep hepatocarcinogenesis,with a focus on the early detection of malignant,cirrhotic nodules with CT and MRI.

关键词： Hepatocellular carcinoma multistep hepatocarcinogenesis early hepatocellular carcinoma dysplastic nodule CT MRI