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Broccoli sprout extract induces detoxification-related gene expression and attenuates acute liver injury

World Journal of Gastroenterology 2015年第35期21卷 10091-10103页

作者： kazutaka yoshida Yusuke Ushida Tomoko Ishijima Hiroyuki Suganuma Takahiro Inakuma Nobuhiro Yajima Keiko Abe Yuji Nakai Research and Development Division Kagome Co.Ltd. Department of Applied Biological Chemistry Graduate School of Agricultural and Life ScienceThe University of Tokyo Faculty of Contemporary Human Life Science Department of Food and NutritionTezukayama University Institute for Food Science Hirosaki University

AIM: To investigate the effects of broccoli sprout extract(BSEx) on liver gene expression and acute liver injury in the rat.METHODS: First, the effects of BSEx on liver gene expression were examined. Male rats were divided into two groups. The Control group was fed the AIN-76 diet, and the BSEx group was fed the AIN-76 diet containing BSEx. After a 10-d feeding period, rats were sacrificed and their livers were used for DNA microarray and realtime reverse transcription-polymerase chain reaction(RT-PCR) analyses. Next, the effects of BSEx on acute liver injury were examined. In experiments using acute liver injury models, 1000 mg/kg acetaminophen(APAP) or 350 mg/kg D-galactosamine(D-Gal N) was used to induce injury. These male rats were divided into four groups: Control, BSEx, Inducer(APAP or D-Gal N), and Inducer+BSEx. The feeding regimens were identical for the two analyses. Twenty-four hours following APAP administration via p.o. or D-Gal N administration via i.p., rats were sacrificed to determine serum aspartate transaminase(AST) and alanine transaminase(ALT) levels, hepatic glutathione(GSH) and thiobarbituric acid-reactive substances accumulation and glutathioneS-transferase(GST) activity. RESULTS: Microarray and real-time RT-PCR analyses revealed that BSEx upregulated the expression of genes related to detoxification and glutathione synthesis in normal rat liver. The levels of AST(70.91 ± 15.74 IU/m L vs 5614.41 ± 1997.83 IU/m L, P < 0.05) and ALT(11.78 ± 2.08 IU/m L vs 1297.71 ± 447.33 IU/m L, P < 0.05) were significantly suppressed in the APAP + BSEx group compared with the APAP group. The level of GSH(2.61 ± 0.75 nmol/g tissue vs 1.66 ± 0.59 nmol/g tissue, P < 0.05) and liver GST activity(93.19 ± 16.55 U/g tissue vs 51.90 ± 16.85 U/g tissue, P < 0.05) were significantly increased in the APAP + BSEx group compared with the APAP group. AST(4820.05 ± 3094.93 IU/m L vs 12465.63 ± 3223.97 IU/m L, P < 0.05) and ALT(1808.95 ± 1014.04 IU/m L vs 3936.46 ± 777.52 IU/m L, P < 0.05) levels were significantly suppres

关键词： Broccoli sprout Galactosamine Acute liver injury G

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Daily Intake of a Commercially Available Vegetable Juice Has Beneficial Effects on Metabolic Syndrome-Related Biomarkers in Young, Healthy Japanese Adults

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Food and Nutrition Sciences 2016年第10期7卷 844-854页

作者： kazutaka yoshida Mari Mori Tatsuya Miyashita Shuko Murakami Takahiro Inakuma Satoshi Sunabori Hiroyuki Suganuma Yukio Yamori Innovation Division KAGOME Co. Ltd. Tochigi Japan Institution for World Health Development Mukogawa Women’s University Hyogo Japan Hyogo Prefecture Health Promotion Association Hyogo Japan Faculty of Contemporary Human Life Science Department of Food and Nutrition Tezukayama University Nara Japan

Adequate vegetable intake is important in reducing the risk of lifestyle-related diseases;however, intake amongst young Japanese adults is poor. This study aimed to assess the effect of daily intake of a commercially available vegetable juice on nutritional status and metabolic syndrome-related markers in healthy young adults. Fifty-one healthy adults (14 men, 37 women), age 20 - 22 years were recruited, and their food and nutritional intake was surveyed using an FFQ based on Food Groups. Subjects were divided into either a control group, who were not administered vegetable juice, or an intervention group, who consumed 200 mL vegetable juice daily for 2 months. Anthropometric data, serum carotenoid concentrations, blood and urinary parameters were measured at baseline and at 2 months. The average intake of vegetables in all subjects at baseline was approximately 140 g/day, less than half the dose recommended by the Japanese government. Total serum carotenoid concentration in the intervention group doubled from baseline after 2 months. In particular, serum concentrations of α-carotene, β-carotene, and lycopene were increased. In the intervention group, 24-hour urinary potassium excretion increased significantly, and 24-hour urinary sodium to potassium ratio decreased significantly. Waist circumference and systolic blood pressure also decreased significantly. Daily intake of a commercial vegetable juice for 2 months improved nutritional status in young adults with inadequate vegetable intake, shown by improved serum carotenoid and urine potassium levels. In addition, intake of vegetable juice may be beneficial in reducing the risk of metabolic syndrome.

关键词： Vegetable Juice Carotenoid Potassium Metabolic Syndrome Urinary Sodium to Potassium Ratio

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Prior or Concomitant Drinking of Vegetable Juice with a Meal Attenuates Postprandial Blood Glucose Elevation in Healthy Young Adults

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Food and Nutrition Sciences 2016年第9期7卷 797-806页

作者： Noriaki Kasuya Megumi Okuyama kazutaka yoshida Satoshi Sunabori Hiroyuki Suganuma Isamu Murata Yutaka Inoue Ikuo Kanamoto Laboratory of Drug Safety Management Faculty of Pharmaceutical Sciences Josai University Saitama Japan Innovation Division KAGOME CO. LTD. Tochigi Japan

Controlling postprandial blood glucose levels can prevent and improve lifestyle-related diseases. We aimed to evaluate the effects of a commercially available vegetable juice, which is a convenient alternative to vegetables, on postprandial glucose elevation. In test 1, we confirmed the appropriate timing to consume the vegetable juice (200 mL), and demonstrated that postprandial glucose elevation was attenuated by drinking the vegetable juice with or before the experimental meal. The change in maximum concentration (ΔCmax) of blood glucose was the lowest when the vegetable juice was consumed at 30 min before the meal. In test 2, we confirmed the necessary ingestion volumes of vegetable juice (range: 68.5 - 274 mL) for attenuating the response to 50 g of carbohydrates. After drinking 200 mL of vegetable juice, the ΔCmax and incremental area under the curve values for blood glucose were significantly lower than those for after drinking the same volume of water (p < 0.05). However, a greater volume of vegetable juice did not provide an additive effect. Our results suggest that approximately 200 mL of vegetable juice at 30 min before meals is the most effective method for using vegetable juice to suppress postprandial blood glucose elevation. Stimulation of insulin secretion due to the pre-meal vegetable juice intake may contribute to this effect, although further studies are needed to identify the detailed mechanism for the attenuation.

关键词： Pre-Meal Vegetable Juice Carbohydrate Postprandial Blood Glucose Insulin

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Variation in Texture and Lankford Value of 1070 Aluminum Sheet Rolled by Cone-shaped Roll

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Journal of Materials Science & Technology 2013年第2期29卷 175-179页

作者： Yasumasa Chino Xinsheng Huang kazutaka Suzuki Mamoru Mabuchi Materials Research Institute for Sustainable Development National Institute of Advanced Industrial Science and Technology 2266-98 AnagahoraShimo-shidami Moriyama-ku Nagoya 463-8560 Japan Department of Energy Science and Technology Graduate School of Energy Science Kyoto University Yoshida-honmachi Sakyo-ku Kyoto 606-8501 Japan

A rolling with cone-shaped roll, the diameter of which continuously varies along the axial direction, has been proposed as a new shear rolling for controlling the texture of an aluminum alloy sheet. In this study, variations in the texture and Lankford value of a 1070 aluminum sheet rolled by the cone-shaped roll were investigated. Rolling with the cone-shaped roll was found to impose intense shear strain at the edges of the specimen, specifically near the surface. The shear directions in the left and right portions of the specimen were opposite to each other. The surface and middle layer of the specimen rolled by the cone-shaped roll and the reference specimen were characterized by a shear texture and typical recrystallization texture components, respectively. Notably, the specimen rolled by the cone-shaped roll exhibited smaller texture intensity than the reference specimen, especially at the surface, and the shear texture-components were observed at relatively deeper positions. As a result of Lankford value measurements, the specimen rolled with the cone-shape roll exhibited a smaller planar anisotropy than the reference specimen and an average Lankford value close to unity, which are likely due to the texture modifications introduced during rolling with the cone-shaped roll.

关键词： Aluminum Mechanical properties Texture Rolling Shear deformation

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Comparison between combination therapy of percutaneous ethanol injection and radiofrequency ablation and radiofrequency ablation alone for patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2005年第10期11卷 1426-1432页

作者： kazutaka Kurokohchi Seishiro Watanabe Tsutomu Masaki Naoki Hosomi Yoshiaki Miyauchi Takashi Himoto Yasuhiko Kimura Seiji Nakai Akihiro Deguchi Hirohito Yoneyama Shuhei yoshida Shigeki Kuriyama Third Department of Internal Medicine

AIM: In the present study, the characteristics of PEI-RFA treatment were further elucidated by analyzing the relationship between the volume of coagulated necrosis and the energy requirement for ablation or the amount of ethanol injected into HCC.METHODS: The volume of coagulated necrosis, total energy requirement and energy requirement for coagulation of per unit volume were examined in the groups of PEI-RFA and RFA alone using the Cool-tip RF system.RESULTS: The results showed that the volume of coagulated necrosis induced was significantly larger in PEI-RFA group than in routine RFA group, when the total energy administered was comparable in both groups.In PEI-RFA, enlargement of coagulated necrosis was admitted in 3 dimensions and the amount of energy requirement per unit volume of coagulated necrosis was negatively correlated with the amount of ethanol injected into HCC.CONCLUSION: These results suggest that, compared to RFA alone, PEI-RFA enables to induce comparable coagulated necrosis with smaller energy requirement, and that PEI-RFA is likely to be less invasive than RFA alone irrespective of inducing enhanced coagulated necrosis.Thus, simple prior injection of ethanol may make RFA treatment more effective and less invasive for the treatment of patients with HCC.

关键词：综合治疗经皮乙醇注射射频消融肝细胞癌

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温度对液态水结构的影响:中子及X射线散射研究

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化学通报 2020年第5期83卷 434-441页

作者：周永全山口敏男池田一贵房春晖吉田亨次张文倩朱发岩刘红艳王广国中国科学院青海盐湖研究所西宁810008 福冈大学理学院化学系日本福冈814-0180 日本高能加速器研究设施(KEK) 日本筑波305-0801 青海省盐湖资源化学重点实验室西宁810008

采用中子散射和X射线散射研究了液态水在298~373 K温度范围内的结构,通过偏径向分布函数(PDF)、配位数分布(CN)、角分布(ADF)及空间密度分布(SDF)等讨论了温度对液态水结构的影响。整体来看,液态水具有"不规则四面体"氢键网络的短程有... 详细信息

采用中子散射和X射线散射研究了液态水在298~373 K温度范围内的结构,通过偏径向分布函数(PDF)、配位数分布(CN)、角分布(ADF)及空间密度分布(SDF)等讨论了温度对液态水结构的影响。整体来看,液态水具有"不规则四面体"氢键网络的短程有序结构,该有序度可延续到第三水合层。液态水分子的第一水合层中,围绕中心水分子约有4.8个水分子,然而其中仅有约3.3个水分子与中心水分子通过氢键相键合,约1/3进入到第一水合层的水分子并未与中心水分子直接键合,也正是这些间隙水分子的存在加剧了液态水结构的复杂性。温度对液态水的有序度存在一定的影响,在298~373 K的有限温度变化范围内,温度对液态水中氢键的键长、键角分布及第一水合层SDF的影响不大。从298K升温到373K,O(W)-O(W)距离仅增加0.03?,氢键数目也仅有微小减少,温度对第二和第三水合层的影响则要显著很多。

关键词：水结构中子散射 X射线散射径向分布函数经验势结构参数精修

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