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A visible light-driven plasmonic photocatalyst

Light(Science & Applications) 2014年第1期3卷 349-354页

作者： Francesca Pincella Katsuhiro Isozaki kazushi miki Polymer Materials Unit National Institute for Materials ScienceIbaraki 305-0044Japan Department of Pure and Applied Sciences University of TsukubaIbaraki 305-8571Japan Current address:International Research Center for Elements Science Institute for Chemical ResearchKyoto UniversityKyoto 611-0011Japan

We demonstrate a bottom-up approach to fabricating a visible light-driven titania photocatalyst device bearing an embeddedtwo-dimensional (2D) array of gold nanoparticles (AuNPs) as a near-field light-generating layer. The device is a layered structureprepared by depositing a 2D array of AuNPs on a transparent conductive substrate (10 nm indium tin oxide (ITO) layer on quartz),coating the 2D array of AuNPs with a monolayer of trimethoxyoctylsilane (TMOS), and depositing titania nanocrystals on the anchoringmolecule (TMOS) layer. The visible light activity of the device was tested using photocatalytic degradation of methylene blue (MB) byilluminating the device with visible light (700 nm light) and ultraviolet (UV) light (250–380 nm). The localized surface plasmonresonance peak of the 36 nm AuNP 2D array is around 700 nm with a full-width at half-maximum of 350 nm. In comparison with othercontrol samples, the device showed the highest photocatalytic activity with visible irradiation, which was 1.7 times higher than that oftitania with UV irradiation. The origin of the visible light activity was confirmed by both quadratic incident light power dependency andaction spectrum to be plasmon-induced (near-field enhancement by AuNPs) two-photon absorption.

关键词： gold nanoparticles near-field light plasmonics two-photon absorption visible photocatalysis

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TTYH2,a human homologue of the Drosophila melanogaster gene tweety,is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation

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World Journal of Gastroenterology 2007年第19期13卷 2717-2721页

作者： Yuji Toiyama Akira Mizoguchi kazushi Kimura Junichirou Hiro Yasuhiro Inoue Tomonari Tutumi Chikao miki Masato Kusunoki Department of Gastrointestinal and Pediatric Surgery Division of Reparative Medicine Institute of Life Sciences Mie University Graduate School of Medicine Japan Department of Anatomy Faculty of Medicine Mie University 2-174 EdobashiTsu Mie 514-8507 Japan

AIM: To investigate the expression patterns of TTYH2 in the human colon cancer and colon cancer cell lines and to evaluate the inhibitory effect of small interfering RNA (siRNA) on the expression of TTYH2 in colon cancer cell ***: We investigated the expression patterns of TTYH2 in colon cancer, adjacent non-tumorous colon mucosa, and cancer cell lines (DLD-1, caco-2, and Lovo) by RT-PCR. Furthermore, a siRNA plasmid expression vector against TTYH2 was constructed and transfected into DLD-1 and Caco-2 with LipofectamineTM 2000. The down regulation of TTYH2 expression was detected by RT-PCR and the role of siRNA in inducing cell proliferation and cell aggregation was evaluated by MTT and aggregation ***: TTYH2 gene expression in colon cancer tissue was significantly up-regulated compared with normal colonic mucosa (1.23 ± 0.404 vs 0.655 ± 0.373, P = 0.0103). Colon cancer derived cell lines including DLD-1, Caco-2, and Lovo also expressed high levels of TTYH2. In contrast, transfection with siRNA-TTYH2 signifi cantly inhibited both proliferation and scattering of these cancer cell ***: The present work demonstrates, for the fi rst time, that the TTYH2 gene expression is signifi cantly up-regulated in colon cancer. The TTYH2 gene may play an important role in regulating both proliferating andmetastatic potentials of colorectal cancer.

关键词： TTYH2 Colorectal carcinoma Cell proliferation Cell aggregation

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Persistence of gene expression changes in noninflamed and inflamed colonic mucosa in ulcerative colitis and their presence in colonic carcinoma

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World Journal of Gastroenterology 2005年第33期11卷 5151-5155页

作者： Yuji Toiyama Akira Mizoguchi kazushi Kimura Toshimitsu Araki Shigeyuki Yoshiyama Kouhei Sakaguchi Chikao miki Masato Kusunoki The Second Department of Surgery Mie University School of Medicine 2-174 EdobashiTsuMie 514-8507Japan the Department of Anatomy Faculty of Medicine Mie UniversityEdobashiTsu Mie 514-8507 Japan The Second Department of Surgery Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507Japan the Department of Anatomy Faculty of Medicine Mie University Edobashi Tsu Mie 514-8507 Japan The Second Department of Surgery Mie University School of Medicine 2-174 Edobashi Tsu Mie 514-8507 Japan

AIM： A few studies have applied genomic-wide gene expression analysis in inflamed colon tissue sample in ulcerative colitis （UC）. We reported the first study of non-inflamed mucosal gene expression in UC and explored its clinical implication. METHODS： Non-inflamed mucosa was obtained from 6 UC patients who received total colectomy. The gene expression of UC in noninflamed mucosa was monitored with a microarray. For a selected gene, RT-PCR was performed to verify array results and to further examine expression pattern in inflamed mucosa of UC, colorectal cancer tissue and normal mucosa using additional matched pairs. RESULTS： Two genes showing 2.5-fold decreased expression with significance set at in UC samples were borneo box a4 （HOXa4） and mads box transcription enhancer factor 2, polypeptide B （MEF2b）. RT-PCR showed that MEF2b expression in non-inflamed mucosa was significantly downregulated, whereas the expression of MEF2b increased in accordance with the severity of mucosal inflammation. HOXa4 expression both in inflamed and non-inflamed mucosa in UC was consistently downregulated, and the downregulation of HOXa4 was also found in colorectal carcinoma. CONCLUSION： It is suggested that the MEF2b expression in UC which increase in accordance with inflammation may be induced by the inflammatory mediator. In contrast the downregulation of HOXa4 may be partly involved in the pathogenesis of disease including UC and UC-related carcinogenesis.

关键词： Ulcerative colitis OligonucleoUde array Geneexpression

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