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Journal of Integrative Plant Biology 2019年第7期61卷 836-852页

作者： kazusato oikawa Makoto Hayashi Yasuko Hayashi Mikio Nishimura Biomacromolecules Research Team RIKEN Center for Sustainable Resource Science2-1 HirosawaWakoSaitama 351-0198Japan Department of Bioscience Nagahama Institute of Bio-Scie nee and Technology1266 Tamura-ChoNagahama 526-0829Japan Department of Biology Faculty of scienceNiigata UniversityNiigata 950-2181Japan Department of Cell Biology National Institute for Basic BiologyOkazaki 444-8585Japan

The dynamic behavior of organelles is essential for plant survival under various environmental conditions. Plant organelles, with various functions,migrate along actin filaments and contact other types of organelles, leading to physical interactions at a specific site called the membrane contact site. Recent studies have revealed the importance of physical interactions in maintaining efficient metabolite flow between organelles.In this review, we first summarize peroxisome function under different environmental conditions and growth stages to understand organelle interactions. We then discuss current knowledge regarding the interactions between peroxisome and other organelles, i.e., the oil bodies, chloroplast, and mitochondria from the perspective of metabolic and physiological regulation, with reference to various organelle interactions and techniques for estimating organelle interactions occurring in plant cells.

关键词： physical interaction plant peroxisomes live-cell

Synergy of Prediction Rule and Total Synthesis in Solving the Stereochemical Puzzle of Valactamides

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Precision Chemistry

Precision Chemistry 2024年第3期2卷 120-126页

作者： Tao Zhang Jiaxuan Feng Hideaki oikawa Yian Guo Tao Ye State Key Laboratory of Chemical Oncogenomics Peking University Shenzhen Graduate SchoolShenzhen 518055China Innovation Center of Marine Biotechnology and Pharmaceuticals School of Biotechnology and Health SciencesWuyi UniversityJiangmen 529020China QianYan(Shenzhen)Pharmatech.Ltd. Shenzhen 518172China

Natural products with diverse functional groups and stereo-genic centers have inspired therapeutics and underpin the modern drug discovery process.Their three-dimensional molecular structures need to be unambiguously determined in order to be realized as clinical candidates or to achieve further activity-guided structural optimization.Although recent advances in spectroscopic methods have made it possible for researchers to determine the structures of microgram samples of complex natural products,there is no universally accepted method for determining the relative and absolute configuration of a naturally occurring compound.We report the determination of the full stereostructure of valactamide A,an eight-stereogenic-center-containing fungal metabolite by the synergy of prediction rule-guided analysis and chemical synthesis.The expedient total synthesis resulted in unambiguous verification of the predicted stereochemistry for valactamide A.

关键词： stereochemistry configuration prediction total synthesis valactamide A

Bibliographical Review on Rehabilitation of Executive Functions in Patients With Developmental Coordination Disorder(DCD)

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Psychology Research 2024年第2期14卷 45-56页

作者： Keiko da Costa oikawa Fabrício Bruno Cardoso Filipe M.Bonone Samuel Pereira de Souza Vitor da Silva Loureiro Alfred Sholl-Franco Faculdade Censupeg JoinvilleBrazil Faculdade Censupeg JoinvilleBrazil Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

The present study aims to establish a literature review on intervention programs for executive functions(EFs)through the use of fundamental motor skills,from a neuropsychopedagogical perspective in subjects with Developmental Coordination Disorder(DCD).An exploratory study was carried out through an integrative literature review.The research was carried out in the Scientific databases Electronic Library Online(SciELO),Latin American and Caribbean Literature in Health Sciences(LILACS),Virtual Health Library-Psychology Brazil(BVSPSI),Electronic Journals of Psychology(PePSIC),in the periodicals available in the Brazilian Digital Library of Theses and Dissertations(BDTD)and on the website of the Coordination for the Improvement of Higher Education Personnel(CAPES).The covering publications took place from 2018 to 2023,14 articles were selected for analysis.This literature review made it possible to create strategies for stimulating EF and Visuomotor Functions so that educators and other professionals can better deal with students with DCD.It was perceived the need to carry out and develop more empirical research regarding the intervention of EFs and Visuomotor Functions by educators and professionals,with a greater sampling amplitude,to increase the number of studies that enable interventions both in children and in teenagers with DCD.

关键词： developmental coordination disorder executive functions school neuropsychology stimulation of executive functions

Targeting fructose metabolism by glucose transporter 5 regulation in human cholangiocarcinoma

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Genes & Diseases 2022年第6期9卷 1727-1741页

作者： Nattawan Suwannakul Napat Armartmuntree Raynoo Thanan Kaoru Midorikawa Tetsuo Kon Shinji oikawa Hatasu Kobayashi Ning Ma Shosuke Kawanishi Mariko Murata Department of Environmental and Molecular Medicine Mie University Graduate School of MedicineTsuMie 514-8507Japan Department of Biochemistry Faculty of MedicineKhon Kaen UniversityKhon Kaen 40002Thailand Laboratory of Functional Genomics Graduate School of BioscienceNagahama Institute of Bioscience and TechnologyNagahamaShiga 526-0829Japan Graduate School of Health Science Suzuka University of Medical ScienceSuzukaMie 513-8670Japan Faculty of Pharmaceutical Sciences Suzuka University of Medical ScienceSuzukaMie 513-8670Japan

Alterations in cellular metabolism may contribute to tumor proliferation and survival.Upregulation of the facilitative glucose transporter(GLUT)plays a key role in promoting cancer.GLUT5 mediates modulation of fructose utilization,and its overexpression has been associated with poor prognosis in several cancers.However,its metabolic regulation remains poorly understood.Here,we demonstrated elevated GLUT5 expression in human cholangiocarcinoma(CCA),using RNA sequencing data from samples of human tissues and cell lines,as compared to normal liver tissues or a cholangiocyte cell line.Cells exhibiting highexpression of GLUT5 showed increased rates of cell proliferation and ATP production,particularly in a fructose-supplemented medium.In contrast,GLUT5 silencing attenuated cell proliferation,ATP production,cell migration/invasion,and improved epithelialemesenchymal transition(EMT)balance.Correspondingly,fructose consumption increased tumor growth in a nude mouse xenograft model,and GLUT5 silencing suppressed growth,supporting the tumor-inhibitory effect of GLUT5 downregulation.Furthermore,in the metabolic pathways of fructolysis-Warburg effect,the expression levels of relative downstream genes,including ketohexokinase(KHK),aldolase B(ALDOB),lactate dehydrogenase A(LDHA),and monocarboxylate transporter 4(MCT4),as well as hypoxia-inducible factor 1 alpha(HIF1A),were altered in a GLUT5 expression-dependent manner.Taken together,these findings indicate that GLUT5 could be a potential target for CCA therapeutic approach via metabolic regulation.

关键词： Cholangiocarcinoma Fructose Glucose transporter 5 Metabolic regulation Warburg effect

New Realization of Disaster Risk Reduction Education in the Context of a Global Pandemic: Lessons from Japan

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International Journal of Disaster Risk Science 2021年第4期12卷 568-580页

作者： Rajib Shaw Aiko Sakurai Yukihiko oikawa Graduate School of Media and Governance Keio UniversityFujisawa252-0882Japan Department of Social Sciences Toyo Eiwa UniversityYokohama226-0015Japan International Research Institute of Disaster Science Tohoku UniversitySendai980-0845Japan Center for Ocean Literacy and Education University of TokyoTokyo113-0032Japan

The global COVID-19 pandemic has challenged different development sectors,including education.In this article,two main analyses are provided:one on the biological hazards of the pandemic in the context of the Sendai Framework for Disaster Risk Reduction 2015−2030,which analyzes the overall impacts on the education sector.Then we discuss the overall impact on education sectors,with specific focus on disaster risk reduction(DRR)education and education for sustainable development(ESD).Disaster risk reduction education and ESD are analyzed from the perspective of school-community-family linkages.Specific case analysis of COVID-19 response in the education sector is presented from Omuta City,Japan,which is considered as a champion city for ESD.Four phases of response in Omuta City are characterized with three specific foci:(1)mitigating covid impacts on educational program and participants;(2)preventing exacerbation of covid transmission within and outside schools;and(3)maintaining educational program integrity despite covid.Key lessons are summarized in the concluding section,which explore the importance of(1)educational governance(on critical decision making)during the pandemic as well as with cascading risks;(2)enhancement of school-community-family linkages as pandemic response commonalities between ESD and DRR education;(3)risk communication and citizen behavior;and(4)use of technology.We argue that integration of health and DRR education is important,that resilience needs to be redefined in terms of sustainable development goals(SDGs),and that education plays a vital role in achieving these ends.

关键词： Citizen behavior Disaster risk reduction education Education for sustainable development Global COVID-19 pandemic Japan School-community-family linkage

Non-invasive determination of hepatic steatosis by acoustic structure quantification from ultrasound echo amplitude

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World Journal of Gastroenterology 2012年第29期18卷 3889-3895页

作者： Hidekatsu Kuroda Keisuke Kakisaka Naohisa Kamiyama Takayoshi oikawa Mio Onodera Kei Sawara Kanta oikawa Ryujin Endo Yasuhiro Takikawa Kazuyuki Suzuki Division of Gastroenterology and Hepatology Department of Internal MedicineIwate Medical UniversityIwate 020-8505Japan Ultrasound Systems Division Toshiba Medical Systems CorporationTochigi 324-8550Japan

AIM:To use leptin-deficient(ob/ob) mice with demonstrated differences in steatosis levels to test a new diagnostic method using the acoustical structure quantification(ASQ) mode and the associated analytical parameter,"focal disturbance ratio"(FD-ratio).METHODS:Nine ob/ob mice,at 5,8,and 12 wk of age(n = 3 in each age group),were used as models for hepatic steatosis.Echo signals obtained from ultrasonography in the mice were analyzed by ASQ,which uses a statistical analysis of echo amplitude to estimate inhomogeneity in the diagnostic region.FD-ratio,as calculated from this analysis,was the focus of the present study.FD-ratio and fat droplet areas and sizes were compared between age groups.RESULTS:No fibrosis or inflammation was observed in any of the groups.The fat droplet area significantly(P < 0.01) increased with age from 1.25% ± 0.28% at 5 wk to 31.07% ± 0.48% at 8 wk to 51.69% ± 3.19% at 12 wk.The median fat droplet size also significantly(P < 0.01) increased with age,from 1.33(0.55-10.52) m at 5 wk,2.82(0.61-44.13) m at 8 wk and 6.34(0.66-81.83) m at 12 wk.The mean FD-ratio was 0.42 ± 0.11 at 5 wk,0.11 ± 0.05 at 8 wk,and 0.03 ± 0.02 at 12 wk.The FD-ratio was significantly lower at 12 wk than at 5 wk and 8 wk(P < 0.01).A significant negative correlation was observed between the FD-ratio and either the fat droplet area(r =-0.7211,P = 0.0017) or fat droplet size(r =-0.9811,P = 0.0052).CONCLUSION:This tool for statistical analysis of signals from ultrasonography using the FD-ratio can be used to accurately quantify fat in vivo in an animal model of hepatic steatosis,and may serve as a quantitative biomarker of hepatic steatosis.

关键词：超声信号脂肪肝回波幅度声学结构量化侵入性测定诊断方法

Valproic acid as a micro RNA modulator to promote neurite outgrowth

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Neural Regeneration Research 2016年第10期11卷 1564-1565页

作者： Hirotaka oikawa Judy C.G.Sng Neuroepigenetics Laboratory Singapore Institute for Clinical Sciences Agency for Science and Technology (A*STAR) Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore

Valproic acid （VPA） has been a first-choice drug for clinical treatment of epilepsy and manic disorder. For decades, its phar- macological action was believed to act on inhibition of gam- ma-aminobutyric acid （GABA） transaminase, in turn, increas- ing GABA in inhibitory synapses. However, in recent years, VPA has been investigated on other therapeutic actions. Those investigations demonstrate that VPA shows neuroprotective ef- fects by promoting neurogenesis, neuronal differentiation, and neuroregeneration （Foti et al., 2013）.

关键词： VPA RNA Valproic acid as a micro RNA modulator to promote neurite outgrowth acid

High-throughput analysis of anthocyanins in horticultural crops using probe electrospray ionization tandem mass spectrometry (PESI/MS/MS)

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Horticulture Research 2023年第4期10卷 249-258页

作者： Misaki Ishibashi Kei Zaitsu Ikue Yoshikawa Shungo Otagaki Shogo Matsumoto Akira oikawa Katsuhiro Shiratake Graduate School of Bioagricultural Sciences Nagoya UniversityChikusaNagoyaAichi 464-8601Japan Graduate School of Agriculture Kyoto UniversitySakyoKyoto 606-8502Japan Faculty of Biology-Oriented Science and Technology Kindai UniversityNishimitaniKinokawaWakayama 649-6493Japan Faculty of Agriculture Meijo UniversityTenpakuNagoyaAichi 468-8502Japan

Plant secondary metabolites exhibit various horticultural traits.Simple and rapid analysis methods for evaluating these metabolites are in demand in breeding and consumer markets dealing with horticultural crops.We applied probe electrospray ionization(PESI)to evaluate secondary metabolite levels in horticultural crops.PESI does not require pre-treatment and separation of samples,which makes it suitable for high-throughput analysis.In this study,we targeted anthocyanins,one of the primary pigments in horticultural crops.Eighty-one anthocyanins were detected in approximately 3 minutes in the selected reaction-monitoring mode.Tandem mass spectrometry(MS/MS)could adequately distinguish between the fragments of anthocyanins and flavonols.Probe sampling,an intuitive method of sticking a probe directly to the sample,could detect anthocyanins qualitatively on a micro-area scale,such as achenes and receptacles in strawberry fruit.Our results suggest that PESI/MS/MS can be a powerful tool to characterize the profile of anthocyanins and compare their content among cultivars.

关键词： MS/MS ionization dealing

Contribution of Root Respiration to Total Soil Respiration in a Leymus chinensis （Trin.） Tzvel, Grassland of Northeast China

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Journal of Integrative Plant Biology 2006年第4期48卷 409-414页

作者： Wei Wang Ji-Xun Guo Jiang Feng Takehisa oikawa Department of Ecology College of Environmental Sciences Peking University Beijing 100871 China Key Laboratory for Vegetation Ecology of the Ministry of Education Northeast Normal University Changchun 130024 China Institutes of Biological Sciences University of Tsukuba Tsukuba Ibaraki 305-8572 Japan

The loss of carbon through root respiration Is an Important component of grassland carbon budgets. However, few data are available concerning the contribution of root respiration to total soil respiration in grasslands in China. We Investigated seasonal variations of soil respiration rate, root blomaaa, microbial blomaaa C and organic C content of the soil In a semi-arid Leymus chinensis （Trin.） Tzvel. grassland of northeast China during the 2002 growing season （from May to September）. The linear regression relationship between soil respiration rate and root blomaaa was used to determine the contribution of root respiration to total soil respiration. Soil respiration rate ranged from 2.5 to 11.9 g C/m^2 per d with the maximum in late June and minimum In September. The microbial blomaaa C and organic C content of the soil ranged from 0.3 to 1.5 g C/m^2 and from 29 to 34 g C/kg respectively. Root blomaaa had two peaks, In early June （1.80 kg/m^2） and mid-August （1.73 kg/m^2）. Root respiration rate peaked In mid-August （6.26 g C/m^2 per d）, whereas microbial respiration rate peaked In late June （7.43 g C/m^2 per d）. We estimated that the contribution of root respiration to total soil respiration during the growing season ranged from 38% to 76%.

关键词： meadow steppe root biomass root respiration soil organic carbon soil respiration.

Martensitic and magnetic transformation of Co_(41)Ni_(32)Al_(24)Sb_3 and Co_(41)Ni_(32)Al_(27) alloys

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中国有色金属学会会刊：英文版 2006年第4期16卷 776-782页

作者：徐国富尹志民罗丰华牟申周 K.oikawa School of Materials Science and Engineering Central South University Changsha 410083 China State Key Laboratory of Powder Metallurgy Central South University Changsha 410083 China Department of Materials Science Graduate School of E ngineering Tohoku University Sendai 980-8579 Japan

The martensitic transformation and magnetic property of Co41Ni32Al27 and Co41Ni32Al24Sb3 alloys were investigated by optical microscopy(OM), scanning electric microscopy(SEM), energy dispersive X-ray spectroscopy(EDS), X-ray diffractometry (XRD), differential scanning calorimeter analysis(DSC) and vibration sample magnetometer(VSM) methods. The results show that martensitic crystal structure of Co41Ni32Al24Sb3 alloy is still L10 type. Both martensitic transformation temperature Tm and Curie point Tc are in linear relation to quenching temperature. Tm increases by 9 K and Tc increases by 7.5 K for every 10 K increasing in quenched temperature. Quenched from same temperature, Tm of Co41Ni32Al24Sb3 alloy is higher than that of Co41Ni32Al27 alloy by 76 K, meanwhile Tc is higher by 18 K. The melting point of Co-Ni-Al alloy is decreased by the Sb addition, eutectic structure appears in Co41Ni32Al24Sb3 alloy annealed at 1 573 K, which indicates that the alloy is partially melted, whereas Co41Ni32Al27 alloy can be annealed at 1 623 K without melted. The martensitic transformation temperature range of Co41Ni32Al24Sb3 alloy is 22?29 K, only half that of Co41Ni32Al27 alloy. This is a very important result to benefit the achievement of large magnetic field induced strain on Co-Ni-Al based alloy. The results of Tm and Tc were explained by total average s+d electron concentration and magnetic valence number Zm respectively.

关键词：形状记忆合金 Co-Ni-Al-Sb 马氏体转变居里点