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Threshold dynamics of reaction-diffusion partial differential equations model of Ebola virus disease

International Journal of Biomathematics 2018年第8期11卷 235-264页

作者： kazuo yamazaki University of Rochester Department of Mathematics Rochester NY 14627 USA

We study the reaction-diffusion Ebola PDE model that consists of equations that govern the evolution of susceptible, in fee ted, recovered and deceased human individuals, as well as Ebola virus pathogens in the environment, with diffusive terms in all except the equation of the deceased human individuals. Under the setting of a spatial domain that is bounded, we prove the global well-posedness of the system;in contrast to the previous work on similar models such as cholera, avian influenza, malaria and dengue fever, diffusion coefficients may be different. Moreover, we derive its basic reproduction number, and under the condition that the diffusion coefficients of the susceptible and infected hosts are same, we prove the global stability of the disease-free-equilibrium, and uniform persistence in cases when the basic reproduction number lies beneath and above one, respectively. Again, we do not require that the diffusion coefficients of the recovered hosts be the same as the diffusion coefficients of the susceptible and infected hosts, in contrast to previous work on other models of infectious diseases. Another technical difficulty in our model is that the solution semiflow is not compact due to the lack of diffusion in the equation of the deceased human individuals;we overcome this difficulty using functional analysis techniques concerning Kura to wski measure of non-compactness.

关键词： Basic reproduction number Ebola persistence stability

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Pneumatosis cystoides intestinalis associated with toxic epidermal necrolysis: A case report

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World Journal of Clinical Cases 2014年第9期2卷 469-473页

作者： Si-Yuan Yao Ryutaro Seo Tohru Nagano kazuo yamazaki Departments of Surgery Kobe City Medical Center General HospitalChuo-ku Kobe 650-0047 Japan Departments of Anesthesiology Kobe City Medical Center General HospitalChuo-ku Kobe 650-0047 Japan Departments of Dermatology Kobe City Medical Center General HospitalChuo-ku Kobe 650-0047 Japan

Toxic epidermal necrolysis(TEN) is a severe adverse drug reaction, which is characterized by erythema, blisters, and/or erosions of the mucous membranes and skin, but intestinal involvement is rare. In contrast, pneumatosis cystoides intestinalis(PCI) is a rare condition associated with a wide variety of underlying diseases, but to date no patient has presented with PCI associated with TEN. A 55-year-old man was admitted to intensive care unit for treatment of TEN caused by phenobarbital. On day 8 after admission, he presented with progressive abdominal distention and hypotension. Computed tomography(CT) showed gas in the superior mesenteric vein and air filled cysts in the walls of the small intestine. He was suspected of having septic shock due to PCI. As there were no indications of bowel ischemia or necrosis, the patient was managed conservatively with antibiotics and oxygen therapy. On day 10 after admission, he was weaned off catecholamines, with CT on day 11 showing complete resolution of gas in the superior mesenteric vein and air filled cysts. To our knowledge, this article describes the first patient presenting with PCI associated with TEN.

关键词： Toxic epidermal necrolysis Intestinal involvement Pneumatosis cystoids intestinalis Septic shock Conservative treatment

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Temporal Changes in Transboundary Air Pollutants in Bottom Sediments of Lakes in East Asia

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Journal of Environmental Science and Engineering(B) 2013年第11期2卷 629-639页

作者： Shlntaro Mura Ryosuke Sato Masaki Hashimoto Akiko Murakami-Kitase Hideo yamazaki Shusaku Yoshikawa Ju-Yong Kim kazuo Kamura Faculty of Science and Engineering Waseda University Tokyo 169 8555 Japan Mitsubishi Materials Corporation Fukushima 971 8101 Japan Faculty of Science and Engineering Kinki University Osaka 577 8502 Japan Graduate School of Science Osaka Sity University Osaka 558 8585 Japan Korean Institute of Geoscience and Mineral Resources Gwahangro Yuseong-gu Daejeon Metropolitan City Korea

To clarify temporal changes in the transboundary pollution, we analyzed SCPs （spheroidal carbonaceous particles） in bottom sediments of lakes in China, South Korea and Japan. SCPs provide an unambiguous record of anthropogenic atmospheric pollution in bottom sediments. Recently deposited SCPs in air and unmelted snow on Mt. Fuji were also characterized. The concentrarion and characteristics of SCPs reflected the environmental and industrial history of the area. Evidence of transboundary air pollution was observed after the 1980s in Yashagaike and Kotaniike ponds in Japan, which are located on the coast of the Sea of Japan. The concentration suggests that the pollutants originated from continental Asia, particularly after the 1980s. The chemical composition of the SCPs allowed the source of emissions to be identified. Chinese SCPs were found at Yashagaike and Kotaniike ponds in Japan, and at Songiiho and Urimji lakes in Korea. The size distributions showed that small SCPs are transported over long distances. On the summit of Mr. Fuji, SCPs transported by the prevailing westerlies from China were found in addition to SCPs emitted in Japan.

关键词： Bottom sediments transboundary air pollution SCPs.

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Right colon cancer presenting as hemorrhagic shock

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World Journal of Gastrointestinal Pathophysiology 2011年第1期2卷 15-18页

作者： Tomoyuki Iwata kazuo Konishi Takahisa yamazaki Katsuya Kitamura Atsushi Katagiri Takashi Muramoto Yutaro Kubota Yuichiro Yano Yoshiya Kobayashi Toshiko Yamochi Nobuyuki Ohike Masahiko Murakami Takehiko Gokan Nozomi Yoshikawa Michio Imawari Division of Gastroenterology Department of MedicineShowa University School of Medicine Second Department of Pathology Showa University School of Medicine First Department of Pathology Showa University School of Medicine Division of Gastroenterogical Surgery Department of SurgeryShowa University School of Medicine Department of Radiology Showa University School of Medicine Endoscopic Center Showa University HospitalShowa University School of Medicine

A 67-year-old man visited our hospital with a history of continuous hematochezia leading to hemorrhagic *** abdominal computed tomography scan re-vealed a large mass in the ascending colon invading the duodenum and pancreatic head as well as extra-vasation of blood from the gastroduodenal artery(GDA) into the *** revealed an irregular ulcerative lesion and stenosis in the ascending ***,right hemicolectomy combined with pylorus-preser ving pancreaticoduodenectomy was ***,the tumor was classified as a moderately differentiated ***,cancer cells were mainly located in the colon but had also invaded the duode-num and pancreas and involved the ***,the tumor cells were positive for cytokeratin(CK)20 and carcinoembryonic antigen(CEA)but not forCK7 and carbohydrate antigen(CA)*** patient died 23 d after the surgery because he had another episode of arterial bleeding from the anastomosis *** En bloc resection of the tumor with pancreatico duodenectomy and colectomy performed for locally advanced colon cancer can ensure long-term survival,patients undergoing these procedures should be carefully monitored,particularly when the tumor involves the main artery.

关键词： Colon cancer Hemorrhagic shock Adjacent organs invasion En bloc resection Complication

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