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How utilizing the genes involved in drought tolerance could tackle the climate change-related food crisis?

Molecular Plant 2021年第10期14卷 1601-1603页

作者： Angela Fernando Michael Selvaraj Manabu Ishitani kazuo nakashima kazuo Shinozaki Kazuko Yamaguchi-Shinozaki Crops for Nutrition and Health Alliance of Bioversity International and International Center for Tropical Agriculture(CIAT)Km 17 Recta Cali-PalmiraApartado Aereo 6713763537 CaliColombia Japan International Research Center for Agricultural Sciences(JIRCAS) TsukubaJapan Stable Agricultural Production Program Japan International Research Center for Agricultural Science(JIRCAS)TsukubaIbarakiJapan Graduate School of Agricultural and Life Sciences University of TokyoTokyoJapan Gene Discovery Research Group RIKEN Center for Sustainable Resource ScienceTsukubaIbarakiJapan

The global population is expected to increase by 10 billion by 2050,the demand for food and water is also likely to *** factors intensify the growing water scarcity,such as inefficient water use in the food value chain and inadequate infrastructure to save *** changing climate also exacerbates the rising temperature by making the drier areas drier and negatively impacting agriculture production in most parts of the world.A decrease in precipitation has been observed in the tropics and sub-tropics,such as the Sahel region of Southern Africa,the Mediterranean,South Asia,and the Southwest of US since 1970(https://***).

关键词： utilizing drought likely

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Simultaneous augmentation of muscle and bone by locomomimetism through calcium-PGC-1αsignaling

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Bone Research 2022年第4期10卷 770-783页

作者： Takehito Ono Ryosuke Denda Yuta Tsukahara Takashi Nakamura kazuo Okamoto Hiroshi Takayanagi Tomoki nakashima Department of Cell Signaling Graduate School of Medical and Dental SciencesTokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Orthopaedic Surgery The Jikei University School of Medicine3-25-8 Nishi-ShimbashiMinato-kuTokyo 105-8461Japan School of Dentistry Tokyo Medical and Dental University(TMDU)Yushima 1-5-45Bunkyo-kuTokyo 113-8549Japan Department of Biochemistry Tokyo Dental CollegeKandamisakicho 2-9-18Chiyoda-kuTokyo 101-0061Japan Department of Osteoimmunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan Department of Immunology Graduate School of Medicine and Faculty of MedicineThe University of TokyoHongo 7-3-1Bunkyo-kuTokyo 113-0033Japan

Impaired locomotion has been extensively studied worldwide because those afflicted with it have a potential risk of becoming *** exercise at times can be an effective remedy for frailty,but exercise therapy cannot be applied in all clinical *** is safer than exercise,but there are no drugs that reinforce both muscle and bone when administered *** medications increase the risk of adverse events;thus,there is a need for individual drugs targeting both *** this end,we established a novel sequential drug screening system and identified an aminoindazole derivative,locamidazole(LAMZ),which promotes both myogenesis and osteoblastogenesis while suppressing *** of this drug enhanced locomotor function,with muscle and bone significantly ***,LAMZ induced Mef2c and PGC-1αin a calcium signaling–dependent *** this signaling is activated upon physical exercise,LAMZ mimics physical ***,LAMZ is a promising therapeutic drug for locomotor diseases,including sarcopenia and osteoporosis.

关键词： drugs clinical diseases

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H_∞Loop Shaping Control for Plasma Vertical Position Instability on QUEST

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Plasma Science and Technology 2013年第3期15卷 295-299页

作者：刘晓龙 kazuo NAKAMURA Tatsuya YOSHISUE Osamu MITARAI Makoto HASEGAWA Kazutoshi TOKUNAGA 薛二兵 Hideki ZUSHI Kazuaki HANADA Akihide FUJISAWA Hiroshi IDEI Shoji KAWASAKI Hisatoshi nakashima Aki HIGASHIJIMA Kuniaki ARAKI IGSES Kyushu University RIAM Kyushu University Tokai University

QUEST has a divertor configuration with a high and a negative n-index, and the problem of plasma vertical position instability control in QUEST is still under extensive study for achieving high efficiency plasma. The instability we considered is that the toroidal plasma moves either up or down in the vacuum chamber until it meets the vessel wall and is extinguished. The actively controlled coils （HCU and HCL） outside the vacuum vessel are serially connected in feedback with a measurement of the plasma vertical position to provide stabilizing control. In this work, a robust controller is employed by using the loop synthesis method, and provides robust stability over a wide range of n-index. Moreover, the gain of the robust controller is lower than that of a typical proportional derivative （PD） controller in the operational frequency range; it indicates that the robust controller needs less power consumption than the PD controller does.

关键词： vertical position instability robust control loop shaping QUEST

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