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Dietary Effect of Squalene on Lipid Metabolism of Obese/Diabetes KK-AyMice and Wild-Type C57BL/6J Mice

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Food and Nutrition Sciences 2018年第12期9卷 1498-1513页

作者： Shaokai Liu Masashi Hosokawa kazuo miyashita Faculty of Fisheries Sciences Hokkaido University Hakodate Japan

The purpose of this study was to evaluate the influence of squalene (SQ) on plasma and hepatic lipid levels of obese/diabetic KK-Ay mice and wild-type C57BL/6J mice. SQ supplementation significantly increased the HDL cholesterol of KK-Ay mice, which was paralleled with no significant difference in the total and non-HDL cholesterol levels. The increase in HDL cholesterol was also found in the plasma of normal C57BL/6J mice, but the difference was not significant. SQ administration significantly increased neutral lipids (NL) in the liver of KK-Ay mice, while no significant difference was observed in the polar lipids and the total cholesterol levels. The increase in NL was primarily due to the increase in TAG. However, the cholesterol level significantly increased due to SQ intake in the liver of C57BL/6J mice, while no significant difference was found in other lipid levels. The present study suggests that SQ may effectively increase HDL cholesterol level, an important anti-atherosclerotic factor, especially in subjects with metabolic disorders.

关键词： Squalene KK-Ay Mice C57BL/6J Mice HDL Cholesterol Atherosclerosis

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Comparison of Oxidative Stability of Monogalactosyl Diacylglycerol, Digalactosyl Diacylglycerol, and Triacylglycerol Containing Polyunsaturated Fatty Acids

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Food and Nutrition Sciences 2018年第3期9卷 221-234页

作者： Noor Yuslida Binti Hazahari Masashi Hosokawa kazuo miyashita Faculty of Fisheries Sciences Hokkaido University Hakodate Japan

Oxidative stability of three different lipid classes, namely, monogalactosyl diacylglycerol (MGDG) and digalactosyl diacylglycerol (DGDG) from spinach and edible brown seaweed (Akamoku) and triacylglycerol (TAG) of linseed oil was compared. Analysis of oxygen consumption and polyunsaturated fatty acid (PUFA) composition demonstrated that spinach DGDG had the highest oxidative stability, followed by Akamoku DGDG, Akamoku MGDG, spinach MGDG, and linseed TAG. These results disagree with the order of oxidative stability expected from the average number of bis-allylic positions of each lipid. Additionally, DGDG constituents of both spinach and Akamoku showed higher oxidative stability than their MGDG constituents. The unusual oxidative stability of MGDG and DGDG could be conferred by the protection of bis-allylic positions of the PUFA against oxidative attack by the galactosyl moiety of the GL.

关键词： Oxidative Stability Glyceroglycolipids Monogalactosyl Diacylglycerol Digalactosyl Diacylglycerol Triacylglycerol Polyunsaturated Fatty Acids

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In VivoAntioxidant Activity of Fucoxanthin on Obese/Diabetes KK-AyMice

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Food and Nutrition Sciences 2012年第11期3卷 1491-1499页

作者： Sayaka Iwasaki Made Airanthi Kusum Widjaja-Adhi Ai Koide Takerou Kaga Seita Nakano Fumiaki Beppu Masashi Hosokawa kazuo miyashita Laboratory of Bio-Functional Material Chemistry Division of Marine Bioscience Faculty of Fisheries Sciences Hokkaido University Hakodate Japan Laboratory of Bio-Functional Material Chemistry Division of Marine Bioscience Faculty of Fisheries Sciences Hokkaido University Hakodate Japan.

Dietary intake of 0.1% fucoxanthin significantly reduced lipid hydroperoxide levels of liver and abdominal white adipose tissue (WAT) of obese/diabetes KK-Ay mice. The fucoxanthin supplementation also significantly reduced blood glucose level and hepatic lipid contents of the mice. Oxidative stress is known to be induced in hyperglycemia and high fat conditions. Therefore, in vivo antioxidant activity of fucoxanthin found in the present study could be attributed to its anti-diabetic effect and its decreasing effect on hepatic lipids. On the other hand, little effect of fucoxanthin on lipid hydroperoxide levels was found in normal ICR mice. Although the content of fucoxanthin metabolites in the abdominal WAT of KK-Ay mice was about 50 times higher that in the liver, there was little difference in its In Vivo antioxidant activity between in the liver and in the abdominal WAT. These results suggest that well-known ability of fucoxanthin to scavenge active oxygen species and/or free radicals would not be a main reason to explain its In Vivo antioxidant activity.

关键词： Fucoxanthin In Vivo Antioxidant Activity Anti-Diabetic Effect KK-Ay Mice

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