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Amidine-bearing lipoplex targeting to hepatocyte cells

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Chinese Chemical Letters 2008年第9期19卷 1115-1118页

作者： Yasuya Kudo Kazunori Koiwai Kazuhiro Shimizu Shota Kusuki Mina Sakuragi Naohiko Shimada Yoichi Takeda kazuo Sakurai Department of Chemical Process & Environments Faculty of Environmental EngineeringThe University of Kitakyushu1-1HibikinoWakamatsu-kuKitakyushuFukuoka 808-0135Japan TERUMO Corporation R & D Center 1500 InokuchiNakai-machiAshigarakami-gun Kanagawa 259-0151Japan

A lipoplex （i.e., pDNA#1/lipid complex and transfection reagent for pDNA delivery） containing galactosylceramide （GalCer） and an amidine-bearing lipid （TRX） was examined whether the bound pDNA was specifically ingested by hepatocyte via asialoglycoprotein receptor （ASGPR） and then expressed protein. Gel electrophoresis and small-angle X-ray scattering （SAXS） confirmed that the TRX-GalCer liposome#2 complexed with pDNA and the resultant lipoplex took a hexagonally packed inverted cylinder structure when the GalCer composition was less than 20 wt.% of the total lipid. When the lipoplex carrying pGL3 （luciferase-cording pDNA） was administrated to HepG2, the luciferase activity was increased with increasing the GalCer composition until it reached 3 wt.% and then decreased upon further addition of GalCer. When we added galactose itself as a competitor, the luciferase activity was decreased, while glucose did not show such decrease, suggesting that HepG2 ingested the lipoplex via ASGPR-mediated endocytosis. This paper indicated that the hexagonally packed inverted cylinder structures of lipoplex may not always provide excellent transfection and presented a possibility that the TRX lipoplex#3 can obtain a cellulartargeting ability through the receptors for oligosaccharide.

关键词： Gene theraphy Amidine Galactosylceramide Targeting

Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients

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Asian Journal of Andrology 2012年第4期14卷 580-583页

作者： Toshinobu Miyamoto Aldra Tsujimura Yasushi Miyagawa Eitetsu Koh Mikio Namiki Michiharu Horikawa Yasuaki Saijo kazuo Sengoku Department of Obstetrics and Gynecology Asahikawa Medical University Asahikawa Hokkaido 078-8510 Japan Department of Urology Osaka University Graduate School of Medicine Suita 565-0871 Japan Department of Integrated Cancer Therapy and Urology Kanazawa University Graduate School of Medical Science Kanazawa 920-1192 Japan Division of Community Medicine and Epidemiology Department of Health Science Asahikawa Medical University Asahikawa 078-8510 Japan

Genetic mechanisms are implicated as a cause of some male infertility, yet are poorly understood. Meiosis is unique to germ cells and essential for reproduction. The synaptonemal complex is a critical component for chromosome pairing, segregation and recombination. Hormadl is essential for mammalian gametogenesis as knockout male mice are infertile. Hormadl-deficient testes exhibit meiotic arrest in the early pachytene stage and synaptonema! complexes cannot be visualized. To analyze the hypothesis that the human HORMAD1 gene defects are associated with human azoospermia caused by meiotic arrest, mutational analysis was performed in all coding regions by direct sequence analysis of 30 Japanese men diagnosed with azoospermia resulting from meiotic arrest. By the sequence analysis, three polymorphism sites, Single Nucleotide Polymorphism 1 （c. 163A〉G）, SNP2 （c. 501T〉G） and SNP3 （c. 918C〉T）, were found in exons 3, 8 and 10. The 30 patients with azoospermia and 80 normal pregnancy-proven, fertile men were analyzed for HORMAD1 polymorphisms. Both SNP1 and SNP2 were associated with human azoospermia caused by complete early meiotic arrest （P〈0.0S）. We suggest that the HORMAD1 has an essential meiotic function in human spermatogenesis.

关键词： azoospermia HORMAD1 male infertility male meiosis SNP

Brief history of the Asian International Seminars on Atomic and Molecular Physics

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原子与分子物理学报 2006年第6期23卷 1162-1163页

作者： TAKAYANAGI kazuo Institute of Space and Astronatucial Science Professor Emeritus University of Tokyo

中日原子与分子物理讨论会是由中国著名学者清泉教授与日本著名学者高柳和夫教授共同发起创办的。第一次会议于1985年8月在成都举行。第二次会议于1988年10月在日本富士山北面脚下会议中心举行。第三次会议于1990年10月在山东泰安举... 详细信息

中日原子与分子物理讨论会是由中国著名学者清泉教授与日本著名学者高柳和夫教授共同发起创办的。第一次会议于1985年8月在成都举行。第二次会议于1988年10月在日本富士山北面脚下会议中心举行。第三次会议于1990年10月在山东泰安举行。第四次会议于1992年10月在日本东京举行。此次会议又称为第一届亚洲国际原子与分子物理讨论会。从此以后,会议规模扩大了,改称为亚洲国际原子分子论坛。现将高柳和夫教授所写的会议发展简史发表在本学报。供大家参考。

关键词：亚洲国际原子与分子物理 Brief history of the Asian International Seminars on Atomic and Molecular Physics 会议

Third-Order Optical Nonlinearities of Squarylium Dyes with Benzothiazole Donor Groups Measured Using the Picosecond Z-Scan Technique

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Chinese Physics Letters 2011年第8期28卷 126-129页

作者： LI Zhong-Yu XU Song CHEN Zi-Hui ZHANG Fu-Shi KASATANI kazuo College of Petrochemical Engineering Changzhou UniversityChangzhou 213164 Department of Chemistry Tsinghua UniversityBeijing 100084 Department of Advanced Materials Science and Engineering Faculty of EngineeringYamaguchi UniversityTokiwadaiUbe 755-8611Japan

Third-order optical nonlinearities of two squarylium dyes with benzothiazole donor groups(BSQ1 and BSQ2)in chloroform solution are measured by a picosecond Z-scan technique at 532 *** is found that the two compounds show the saturation absorption and nonlinear self-focus refraction *** molecular second hyperpolarizabilities are calculated to be 7.46×10^(−31) esu and 5.01×10^(−30) esu for BSQ1 and BSQ2,*** large optical nonlinearities of squarylium dyes can be attributed to their rigid and intramolecular charge transfer *** difference inγvalues is attributed to the chloro group of benzene rings of BSQ2 and the one−photon resonance *** is found that the third-order nonlinear susceptibilities of two squarylium dyes are mainly determined by the real parts ofχ(3),and the large optical nonlinearities of studied squarylium dyes can be attributed to the nonlinear refraction.

关键词： structure effect attributed

Prognostic value of post-treatment ^(18)F-FDG PET/CT for advanced head and neck cancer after combined intra-arterial chemotherapy and radiotherapy

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Chinese Journal of Cancer Research 2014年第1期26卷 30-37页

作者： Kimiteru Ito Keigo Shimoji Yoko Miyata Kouhei Kamiya Ryogo Minamimoto kazuo Kubota Momoko Okasaki Miyako Morooka Jyunkichi Yokoyama Department of Radiology National Center of Neurology and Psychiatry Department of Radiology Juntendo University Graduate School of Medicine Division of nuclear Medicine International Medical Center of Global Health Department of Otolaryngology Head and Neck SurgeryJuntendo University Graduate School of Medicine

Objective：To clarify the prognostic value of post-treatment 18F-fluorodeoxyglucose （FDG） positron emission tomography （PET）/computed tomography （CT） in patients with advanced head and neck squamous cell carcinoma （HNSCC） after combined intra-arterial chemotherapy and radiotherapy （IACR）.Methods：Thirty-six patients with HNSCC who underwent IACR were *** period from the end of IACR to the last post-treatment 18F-FDG PET/CT examination was 8-12 *** patient-based and lesion-based analyses were used to evaluate the PET/CT *** lesion-based analysis,36 regions （12 lesions of recurrences and 24 scars at primary sites） were *** Kaplan-Meier method was used to assess the overall survival （OS） stratified by 18F-FDG uptake or visual interpretation ***：Twelve patients with recurrence were identified by six months after *** sensitivity and specificity in the patient-based analysis were 67％（8/12） and 88％（21/24）,*** mean OS was estimated to be 12.1 months （95％ CI,6.3-18.0 months） for the higher maximum standardized uptake value （SUVmax） group （n=7） and 44.6 months （95％ CI,39.9-49.3 months） for the lower SUVmax group （n=29）.OS in the higher SUVmax group （cut-off point,6.1） or positive visual interpretation group was significantly shorter than that in the lower SUVmax or negative visual interpretation group （P＜0.001 and P＜0.05,respectively）.Conclusions：The SUVmax and visual interpretation of HNSCC on post-IACR 18F-FDG PET/CT can provide prognostic survival estimates.

关键词： 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) head and neck cancer recurrence survival time intra-arterial chemotherapy and radiotherapy (IACR)

Dynamic Gratings in Optical Fibers： Synthesis and Sensing Applications

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Photonic Sensors 2012年第1期2卷 60-64页

作者： Zuyuan HE kazuo HOTATE Department of Electrical Engineering and Information Systems School of Engineering The University of Tokyo Tokyo113-8656 Japan

We proposed two schemes of generating and localizing dynamic gratings in optical fibers： one is based on the gain saturation in erbium-doped fiber; the other is based on Brillouin scattering in the fiber. By using these dynamic gratings, fully distributed strain/temperature sensors have been demonstrated. In this presentation, we review the principles, basic schemes, and experimental demonstrations of the novel dynamic grating techniques.

关键词： Dynamic grating fiber-optic sensor distributed strain sensor temperature sensor

To Explore High Magnetoelectrochemical Chirality

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Journal of Iron and Steel Research International 2012年第S2期19卷 1133-1136页

作者： MOGI Iwao AOGAKI Ryoichi MORIMOTO Ryoichi WATANABE kazuo IMR Tohoku University Polytechnic University Sagamihara Kanagawa 252-5196Japan Saitama Prefectural Okubo Water Filtration Plant

Cu films were electrodeposited under a magnetic field of 5 T on the Pt disc electrodes with diameters of 3 mm ~ 25 μ*** magnetoelectrodeposited(MED) Cu films were employed as an electrode,and cyclic voltammograms were measured for the electrochemical reactions of an amino acid of *** behavior was observed as oxidation current difference between the *** magnetoelectrochemical chirality was observed on the micro-disk electrode and on the kinetic-controlled electrode process of *** chiral response was durable for more than 10 cycles of the consecutive voltammetric measurements of the enantiomers.

关键词： magnetoelectrodeposition chirality MHD effect micro-electrode copper

Non-motor signs and symptoms in Parkinson’s disease

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Health 2012年第11期4卷 1133-1137页

作者： kazuo Abe Clinical Research Center Osaka Health Science University Osaka Japan

Motor symptoms are cardinal clinical features of Parkinson’s disease (PD). Progress in drug therapy and rehabilitation has been presenting beneficial effect for motor symptoms. However, non-motor symptoms and signs in PD have been accumulated growing attentions and its amelioration may also give beneficial effect for PD patients’ and their care givers’ quality of life. In this mini-review, I overviewed non-motor symptoms and signs in PD.

关键词： Parkinson’s Disease (PD) Non-Motor Signs and Symptoms Activities of Daily Livings (ADL) Quality of Life (QOL)

Automatic &Safe Oxytocin Induction of Labor

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Open Journal of Obstetrics and Gynecology 2018年第9期8卷 812-815页

作者： kazuo Maeda Department of Obstetrics and Gynecology Tottori University Mdical School Yonago Japan

Aims: To prevent fetal damage by excess oxytocin administration of manually controlled infusion, by automatic and safe increasing infusion setting with monitoring uterine contraction and fetal heart rate. Methods: Starting infusion level was 2 milliU/ml, as oxytocin sensitivity of a pregnant uterus is unknown, to avoid hyper contraction and fetal bradycardia caused by unexpected excess oxytocin sensitivity. The infusion automatically increased with automatic monitoring of uterine contraction curve, then the increasing stopped when contraction reached to normal labor level, where the infusion level maintained, which continued until delivery, if there is no trouble. However, the infusion continued until expiring all fluid in case of insensitive uterus, where the induction was performed in another day. The infusion stopped automatically when contraction was too strong, or fetal heart rate is abnormal. Thus, oxytocin sensitive case is protected from excess contraction and fetal asphyxia. Results: Normal vaginal delivery was achieved in 28/33 cases (85%), which was more than manually controlled infusion. No case was abnormal in successful oxytocin infusion. Conclusion: The automated technique will be applied to oxytocin labor induction.

关键词： Labor Induction Oxytocin Automatic Infusion Monitoring of Fetal Heart Rate and Contraction Increasing Infusion