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Ansa pancreatica as a predisposing factor for recurrent acute pancreatitis

World Journal of Gastroenterology 2016年第40期22卷 8940-8948页

作者： Takana Yamakawa hayashi Wataru Gonoi Takeharu Yoshikawa Naoto hayashi Kuni Ohtomo Department of Radiology Graduate School of Medicine The University of Tokyo Department of Computational Diagnostic Radiology and Preventive Medicine The University of Tokyo

AIM To determine the non-biased prevalence and clinical significance of ansa pancreatica in patients with acute pancreatitis using magnetic resonance imaging(MRI).METHODS Our institutional review board approved this crosssectional study, which consisted of a community-based cohort of 587 consecutive participants in a whole-body health-check program, and 73 subjects with episode of acute pancreatitis(55 patients with a single episode of acute pancreatitis, and 18 patients with recurrent acute pancreatitis). All of the subjects underwent abdominal MRI including magnetic resonance cholangiopancreatography, medical examinations, and blood tests. Two board-certified, diagnostic, abdominal radiologists evaluated the images, and ansa pancreatica was diagnosed based on its characteristic anatomy on *** Compared with the community group [5/587(0.85%)], patients with recurrent acute pancreatitis had a significantly higher frequency of ansa pancreatica [2/18(11.1%)](P = 0.016; OR = 14.3; 95%CI: 1.27-96.1), but not compared with patients with single-episode acute pancreatitis [1/55(1.8%)](P = 0.42; OR = 2.1; 95%CI: 0.44-19.7). Multiple logistic regression analysis using age, alcohol intake, presence of ansa pancreatica, and presence of autoimmune disease as independent covariates, revealed a significant relationship between the presence of ansa pancreatica and recurrent acute pancreatitis. The presence of autoimmune disease was also significantly associated with the onset of recurrent acute pancreatitis. On the other hand, neither age nor alcohol intake were significantly related to the onset of recurrent acute *** The present study is the first to provide robust evidence that the presence of ansa pancreatica is significantly associated with recurrent acute pancreatitis.

关键词： Anatomy Cholangiopancreatography Pancreatitis Magnetic resonance imaging Pancreatic duct

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Influence of texture feature size on spherical silicon solar cells

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Rare Metals 2006年第z1期25卷 115-120页

作者： hayashi Shota MINEMOTO Takashi TAKAKURA Hideyuki HAMAKAWA Yoshihiro College of Science and Engineering Ritsumeikan University 1-1-1 Nojihigashi Kusatsu Shiga 525-8577 Japan

The effects of surface texturing on spherical silicon solar cells were investigated. Surface texturing for spherical Si solar cells was prepared by immersing p-type spherical Si crystals in KOH solution with stirring. Two kinds of texture feature sizes (1 and 5 μm pyramids) were prepared by changing stirring speed. After fabrication through our baseline processes, these cells were evaluated by solar cell performance and external quantum efficiency. The cell with 1 and 5 μm pyramids shows the short circuit current density (Jsc) value of 31.9 and 33.2 mA·cm-2, which is 9% and 13% relative increase compared to the cell without texturing. Furthermore, the cell with 5 μm pyramids has a higher open-circuit voltage (0.589 V) than the cell with 1 μm pyramids (0.577 V). As a result, the conversion efficiency was improved from 11.4% for the cell without texturing to 12.1% for the cell with 5 μm pyramids.

关键词： solar cell spherical silicon texturing alkali etching

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RadonPy:automated physical property calculation using all-atom classical molecular dynamics simulations for polymer informatics

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npj Computational Materials 2022年第1期8卷 2155-2169页

作者： Yoshihiro hayashi Junichiro Shiomi Junko Morikawa Ryo Yoshida The Institute of Statistical Mathematics(ISM) Research Organization of Information and Systems10-3 Midori-choTachikawaTokyo190-8562Japan Department of Mechanical Engineering The University of Tokyo7-3-1 HongoBunkyoTokyo113-8656Japan Institute of Engineering Innovation The University of Tokyo2-11 YayoiBunkyo-kuTokyo113-0032Japan Department of Materials Science and Engineering School of Materials and Chemical TechnologyTokyo Institute of Technology2-12-1 OokayamaMeguro-kuTokyo152-8552Japan Research and Services Division of Materials Data and Integrated System(MaDIS) National Institute for Materials Science(NIMS)1-2-1 SengenTsukubaIbaraki305-0047Japan Department of Statistical Science School of Multidisciplinary ScienceThe Graduate University of Advanced Studies(SOKENDAI)10-3 Midori-choTachikawaTokyo190-8562Japan

The spread of data-driven materials research has increased the need for systematically designed materials property ***,the development of polymer databases has lagged far behind other material *** present RadonPy,an open-source library that can automate the complete process of all-atom classical molecular dynamics(MD)simulations applicable to a wide variety of polymeric ***,15 different properties were calculated for more than 1000 amorphous *** MD-calculated properties were systematically compared with experimental data to validate the calculation conditions;the bias and variance in the MD-calculated properties were successfully calibrated by a machine learning *** the high-throughput data production,we identified eight amorphous polymers with extremely high thermal conductivity(>0.4 W∙m^(–1)∙K^(–1))and their underlying *** to the advancement of materials informatics since the advent of computational property databases for inorganic crystals,database construction using RadonPy will promote the development of polymer informatics.

关键词： property calculation dynamics

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Mechanism of Tonal Noise Generation from Circular Cylinder with Spiral Fin

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Journal of Thermal Science 2014年第6期23卷 552-557页

作者： Ryo Yamashita Hidechito hayashi Tetsuya Okumura Hiromitsu Hamakawa Department of Mechanical Engineering Nagasaki University1-14 Bunkyo machiNagasaki852-8521Japan Department of Mechanical Engineering Oita University700 Dannoharu Oita870-1192Japan

The pitch of the spiral finned tube influences seriously to the acoustic resonance in the heat *** this research,the flow characteristics in relating to the aeolian tone from the finned cylinder are studied by the numerical *** is observed that the tonal noise generated from the finned tube at two pitch *** ratio of the fin pitch to the cylinder diameter is changed at 0.11 and *** tone level increases and the frequency decreases with the pitch *** separation flow from the cylinder generates the span-wise vortices,Karman vortices,and the separation flow from the fin generates the stream-wise *** the fin pitch ratio is small,the stream-wise vortices line up to span-wise and become weak *** the Karman vortices are remained and integrate in *** the Karman vortex became *** causes the low frequency and the large aeolian tone.

关键词： Aerodynamic Noise Aeolian Tone Karman Vortex Spiral Finned Tube

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Influence of the Karman Vortex Street on the Broadband Noise Generated from a Multiblade Fan

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Journal of Thermal Science 2005年第3期14卷 198-205页

作者： Souichi SASAKI Yoshio KODAMA Hidechito hayashi Makoto HATAKEYAMA Mechanical systems engineering Nagasaki University 1-14 Bunkyo-machi Nagasaki City 852-8521 Japan Doctor of EngineeringMechanical systems engineering Nagasaki University 1-14 Bunkyo-machi Nagasaki City 852-8521 JapanMechanical systems engineering Nagasaki University 1-14 Bunkyo-machi Nagasaki City 852-8521 JapanProducts R&D Laboratory TOTO Ltd. 2-8-1 Honson Chigasaki City 253-8577 Japan

In the prediction theory for the broadband noise generated from a multiblade fan, the vortices in the Karman vortex street was divided into n pieces. The frequency distribution of the noise was estimated so that the Strouhal number could become constant even if the wake is spread by the diffusion. From the results of the measurement of the internal flow of the fan, it was found that the noise was related to the wake characteristics of the specific location in the scroll casing where the relative flow velocity was high. The noise operating in the vicinity of the maximum efficiency point of the fan was distributed over the domain from 500 Hz to 1250 Hz. It was experimentally proved that the influence of the Karman vortex street on the noise in the domains of high and low frequencies did not exist when the distribution of the estimated sound pressure level corresponded to the measured broadband noise.

关键词： aerodynamic acoustic Karman vortex street turbo machinery blade internal flow

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Advances in polymer-stabilized Au nano-cluster catalysis : Interplay of theoretical calculations and experiments

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Chinese Journal of Catalysis 2016年第10期37卷 1588-1593页

作者： Hiroaki Koga Yoshinori Ato Akihide hayashi Kohei Tada Mitsutaka Okumura 京都大学催化剂与电池元素战略研究基地大阪大学科学研究院化学系

Polymer‐stabilized Au nano clusters （NCs） with mean diameters of 2–10 nm exhibit unique catalytic properties. Several studies have shown that the key factors affecting the catalytic activity of poly‐mer‐stabilized Au NCs are control of the Au NC size, appropriate selection of polymers and optimi‐zation of the reaction conditions. This is because polymer‐stabilized Au NCs exhibit a clear size effect in several catalytic reactions, and the catalytic activity differs with the type of polymer used and the reaction conditions. In order to elucidate the reason underlying the catalytic activity of the polymer‐stabilized Au NCs, much attention is being devoted to the interplay of theoretical calcula‐tions and experiments in catalysis by polymer stabilized Au NCs. The present article mainly summa‐rizes our progress in understanding this interplay in polymer‐stabilized Au NC catalysis.

关键词： Polymer-stabilized Au nano-clusterAerobic oxidation of alcoholsInterplay of theoretical calculations and experimentsSize effect ofAu nano-clusterRole of the polymers

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Influence of Diffuser on Aerodynamic Noise of a Forward Curved Fan

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Journal of Thermal Science 2013年第5期22卷 433-438页

作者： Soichi SASAKI Kota SUZUKI Yuta Onomichi Hidechito hayashi Division of System Science Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Advanced Engineering Graduate School of Engineering Nagasaki University1-14 Bunkyo-machi Nagasaki 852-8521 Japan

In order to clarify the influence of a diffuser on the charactersfics of a forward curved fan, the influence of the bare ratio and the outlet angle on the characteristics of the fan were measured through an experiment performed with an actual fan as well as through a numerical simulation, respectively. The mechanism of the discrete fre- quency noise generated by the separated flow of the diffuser was analyzed. The optimized bare ratio was ap- proximately 17%. The flow separated inside of the diffuser generated discrete frequency noise owing to the inter- action between the reversed flow from the diffuser and the impeller rotating at the blade passing frequency. The diffuser outlet angle influenced the pressure ratio more than that by the bare ratio. Furthermore, it was confirmed that restraining the separation in the diffuser effectively decreases the fan noise.

关键词： Pressure Drop Fan Aerodynamic Noise Internal Flow Separation

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Non-invasive prediction of non-alcoholic steatohepatitis in Japanese patients with morbid obesity by artificial intelligence using rule extraction technology

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World Journal of Hepatology 2018年第12期10卷 934-943页

作者： Daisuke Uehara Yoichi hayashi Yosuke Seki Satoru Kakizaki Norio Horiguchi Hiroki Tojima Yuichi Yamazaki Ken Sato Kazuki Yasuda Masanobu Yamada Toshio Uraoka kazunori Kasama Department of Medicine and Molecular Science Gunma University Graduate School of Medicine Department of Gastroenterology and Hepatology Gunma University Graduate School of Medicine Department of Computer Science Meiji University Tama-ku Weight Loss and Metabolic Surgery Center Yotsuya Medical Cube Department of Metabolic Disorder Diabetes Research Center Research Institute National Center for Global Health and Medicine Department of Internal Medicine Division of Endocrinology and Metabolism Gunma University Graduate School of Medicine

AIM To construct a non-invasive prediction algorithm for predicting non-alcoholic steatohepatitis(NASH), we investigated Japanese morbidly obese patients using artificial intelligence with rule extraction *** Consecutive patients who required bariatric surgery underwent a liver biopsy during the operation. Standard clinical, anthropometric, biochemical measurements were used as parameters to predict NASH and were analyzed using rule extraction technology. One hundred and two patients, including 79 NASH and 23 non-NASH patients were analyzed in order to create the predictionmodel, another cohort with 77 patients including 65 NASH and 12 non-NASH patients were analyzed to validate the *** Alanine aminotransferase, C-reactive protein, homeostasis model assessment insulin resistance, albumin were extracted as predictors of NASH using a recursive-rule extraction algorithm. When we adopted the extracted rules for the validation cohort using a highly accurate rule extraction algorithm, the predictive accuracy was 79.2%. The positive predictive value, negative predictive value,sensitivity and specificity were 88.9%, 35.7%, 86.2% and 41.7%, *** We successfully generated a useful model for predicting NASH in Japanese morbidly obese patients based on their biochemical profile using a rule extraction algorithm.

关键词： Non-alcoholic steatohepatitis Artificial intelligence Rule extraction Morbid obesity Liver biopsy Non-invasive prediction

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Expression of bcl-2 gene increases in apoptosis of vascular endothelial cells induced by rattlesnake venom

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Chinese Science Bulletin 2000年第13期45卷 1195-1198页

作者： Araki Satohiko hayashi Hiroshi Sugashima Marine Biological Laboratory School of ScienceNagoya UniversityTobaMie517JapanSugashima Marine Biological LaboratorySchool of ScienceNagoya UniversityTobaMie517Japan

Apoptosis of vascular endothelial cells (VEC) has been induced by deprivation of survival factors (aFGF and serum) and by rattlesnake venom. The expression of bcl-2 gene has been examined by Northern blotting in the two apoptosis inducing systems. Our results show that the expression of bcl-2 has not been detected in normal culture cells and in apoptotic cells induced by deprivation of survival factors. But in apoptotic cells induced by rattlesnake venom (10 μg/mL), the expression of bcl-2 increases, and its mRNA exhibits two bands. The data first suggest that increasing expression and splitting of bcl-2 mRNA may play an important role in apoptosis of VEC induced by rattlesnake venom, and this finding is helpful to understanding the role of bcl-2 in regulation of apoptosis.

关键词： bcl-2 gene rattlesnake venom apoptosis vascular endothelial cells.

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Insulin sensitivity and inhibition by forskolin,dipyridamole and pentobarbital of glucose transport in three L6 muscle cell lines

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Science China(Life Sciences) 2007年第6期50卷 739-747页

作者： Philip J BILAN Michiko hayashi Programme in Cell Biology Hospital for Sick Children Toronto Canada M5G 1X8

L6 skeletal muscle myoblasts stably overexpressing glucose transporter GLUT1 or GLUT4 with exofa- cial myc-epitope tags were characterized for their response to insulin. In clonally selected cultures, 2-deoxyglucose uptake into L6-GLUT1myc myoblasts and myotubes was linear within the time of study. In L6-GLUT1myc and L6-GLUT4myc myoblasts, 100 nmol/L insulin treatment increased the GLUT1 content of the plasma membrane by 1.58±0.01 fold and the GLUT4 content 1.96±0.11 fold, as well as the 2-deoxyglucose uptake 1.53±0.09 and 1.86±0.17 fold respectively, all by a wortmannin-inhibitable manner. The phosphorylation of Akt in these two cell lines was increased by insulin. L6-GLUT1myc myoblasts showed a dose-dependent stimulation of glucose uptake by insulin, with unaltered sensitiv- ity and maximal responsiveness compared with wild type cells. By contrast, the improved insulin re- sponsiveness and sensitivity of glucose uptake were observed in L6-GLUT4myc myoblasts. Earlier studies indicated that forskolin might affect insulin-stimulated GLUT4 translocation. A 65% decrease of insulin-stimulated 2-deoxyglucose uptake in GLUT4myc cells was not due to an effect on GLUT4 mobi- lization to the plasma membrane, but instead on direct inhibition of GLUT4. Forskolin and dipyridamole are more potent inhibitors of GLUT4 than GLUT1. Alternatively, pentobarbital inhibits GLUT1 more than GLUT4. The use of these inhibitors confirmed that the overexpressed GLUT1 or GLUT4 are the major functional glucose transporters in unstimulated and insulin-stimulated L6 myoblasts. Therefore, L6-GLUT1myc and L6-GLUT4myc cells provide a platform to screen compounds that may have differ- ential effects on GLUT isoform activity or may influence GLUT isoform mobilization to the cell surface of muscle cells.

关键词： L6 muscle cells, glucose transporter (GLUT), insulin, 2-deoxyglucose uptake

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