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Exploiting fly models to investigate rare human neurological disorders

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Neural Regeneration Research 2025年第1期20卷 21-28页

作者： Tomomi tanaka Hyung-Lok Chung Department of Neurology Houston Methodist Research InstituteHoustonTXUSA Department of Neurology Weill Cornell Medical CollegeNew YorkNYUSA

Rare neurological diseases,while individually are rare,collectively impact millions globally,leading to diverse and often severe neurological *** attributed to genetic mutations that disrupt protein function or structure,understanding their genetic basis is crucial for accurate diagnosis and targeted *** investigate the underlying pathogenesis of these conditions,researchers often use non-mammalian model organisms,such as Drosophila(fruit flies),which is valued for their genetic manipulability,cost-efficiency,and preservation of genes and biological functions across evolutionary *** tools available in Drosophila,including CRISPR-Cas9,offer a means to manipulate gene expression,allowing for a deep exploration of the genetic underpinnings of rare neurological *** boasts a versatile genetic toolkit,rapid generation turnover,and ease of large-scale experimentation,making it an invaluable resource for identifying potential drug *** can expose flies carrying disease-associated mutations to various compounds,rapidly pinpointing promising therapeutic agents for further investigation in mammalian models and,ultimately,clinical *** this comprehensive review,we explore rare neurological diseases where fly research has significantly contributed to our understanding of their genetic basis,pathophysiology,and potential therapeutic *** discuss rare diseases associated with both neuron-expressed and glial-expressed *** cases include mutations in CDK19 resulting in epilepsy and developmental delay,mutations in TIAM1 leading to a neurodevelopmental disorder with seizures and language delay,and mutations in IRF2BPL causing seizures,a neurodevelopmental disorder with regression,loss of speech,and abnormal *** we explore mutations in EMC1 related to cerebellar atrophy,visual impairment,psychomotor retardation,and gain-of-function mutations in ACOX1 causing Mitchell ***-of-fun

关键词： ACOX1 Drosophila melanogaster glia lipid metabolism model organisms neuroinflammation neurologic disorders neuron rare disease VLCFA

Return to work and resumption of driving after anterior minimally invasive total hip arthroplasty

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World Journal of Orthopedics 2025年第2期16卷 4-9页

作者： Hisatoshi Ishikura Yuji Masuyama Sho Fujita Takeyuki tanaka Sakae tanaka Toru Nishiwaki Department of Orthopaedic Surgery Shizuoka Red Cross HospitalShizuoka 420-0853Japan Department of Orthopaedic Surgery The University of TokyoBunkyo-ku 113-8655TokyoJapan

BACKGROUND Return to work(RTW)and resumption of driving(ROD)are critical factors that influence postoperative quality of life in patients undergoing total hip arthroplasty(THA).However,few studies have focused on the minimally invasive(MIS)approach and its effect on these *** To investigate RTW and ROD's timelines and influencing factors following anterior *** A retrospective analysis was conducted on 124 patients who underwent anterior *** on the demographics,occupational physical demands,and RTW/ROD timelines were also *** outcomes were measured using standardised scoring *** analyses were performed to evaluate the differences between the groups based on employment status and physical *** Among employed patients,the RTW rate was 94.7%,with an average return time of five *** average ROD time was 3.5 weeks across all *** similar postoperative clinical scores,RTW time was significantly influenced by occupations'physical workload,with heavier physical demands associated with delayed *** Anterior MIS-THA facilitates early RTW and ROD,particularly in occupations with lower physical *** findings highlight the importance of considering occupational and physical workload in postoperative care planning to optimize recovery outcomes.

关键词： Total hip arthroplasty Minimally invasive Work Driving Return to work Resumption of driving

Case of pseudo-Meigs' syndrome caused by gastric cancer-related metastatic ovarian tumor with prolonged survival

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World Journal of Gastrointestinal Oncology 2016年第11期8卷 801-804页

作者： Masaru Okamoto kazunori Maeda Atsushi Yanagitani Kiwamu tanaka Department of General Internal Medicine Tottori Prefectural Central Hospital Department of Gastroenterology Tottori Prefectural Central Hospital

A 48-year-old woman presented with bilateral enlarged ovaries, ascites, bilateral pleural effusion, and advanced gastric cancer. Pleural fluid cytology did not reveal malignant cells. Oophorectomy, performed as a palliative procedure, was followed by rapid resolution of the pleural effusion and ascites. The patient was diagnosed with pseudo-Meigs’ syndrome, and underwent chemotherapy followed by partial gastrectomy. At the last follow-up, 84 mo following oophorectomy, she was alive, and free of disease recurrence, despite not receiving any further treatment. Pseudo-Meigs’ syndrome should be considered in patients with bilateral ovarian tumors, ascites and pleural effusion, and treatment such as oophorectomy may result in symptomatic improvement and better prognosis in similar patients.

关键词： Pseudo-Meigs&rsquo syndrome Ovarian tumor Gastric cancer Pleural effusion Ascites

Hepatitis B virus infection and its treatment in Eastern Ethiopia

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World Journal of Hepatology 2025年第1期17卷 167-171页

作者： Tatsuo Kanda Reina Sasaki-tanaka Atsunori Tsuchiya Shuji Terai Division of Gastroenterology and Hepatology Uonuma Institute of Community MedicineNiigata University Medical and Dental HospitalMinamiuonuma 949-7302NiigataJapan Division of Gastroenterology and Hepatology Graduate School of Medical and Dental SciencesNiigata UniversityNiigata 951-8520Japan

Hepatitis B virus(HBV)infection causes acute and chronic hepatitis,compensated and decompensated cirrhosis,and hepatocellular carcinoma *** actual status of HBV infection and its treatment in certain regions of Asian and African countries,including Ethiopia,has not been well-documented thus *** therapy for HBV infection can prevent the progression of HBV-related liver diseases and decrease the HBV-related symptoms,such as abdominal symp-toms,fatigue,systemic symptoms and *** Eastern Ethiopia,HBV-infected patients with cirrhosis were found to be positive for the HBV e antigen and to have a higher viral load than those without ***,54.4%of patients practiced khat chewing and 18.1%consumed excessive amounts of ***-fovir disoproxil fumarate effectively suppressed HBV DNA in those infected with *** is important to elucidate the actual status of HBV infection in Eastern Ethiopia to eliminate HBV infection worldwide by *** vaccination and the educational programs for Health Science students that provide practical strategies could help to reduce HBV infection in Eastern Ethiopia.

关键词： Antivirals Ethiopia Hepatitis B virus Liver cirrhosis Vaccines

Evaluating Changes in Disaster Preparedness Awareness among Nursing Students in Japan: Insights after Three Years of Nursing Education

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Open Journal of Nursing 2025年第1期15卷 53-59页

作者： Yuriko Inoue Mikako tanaka Hiromitsu Ezure Junji Ito Akiko Sasaki Takashi Takaki Harumi Hata Masaaki Takayanagi Naruhito Otsuka Department of Anatomy School of Medicine Showa University Tokyo Japan Faculty of Engineering Yokohama National University Kanagawa Japan Department of Nursing School of Nursing and Rehabilitation Sciences Showa University Kanagawa Japan Department of Pharmacology School of Medicine Showa University Tokyo Japan Center for Electron Microscopy Showa University School Tokyo Japan Faculty of Pharmaceutical Sciences Teikyo Heisei University Tokyo Japan Center for University-Wide Education Saitama Prefectural University Saitama Japan

Background: Disaster preparedness is a critical aspect of nursing education, enhancing students’ ability to respond effectively in emergencies. However, the extent to which nursing curricula influence disaster preparedness awareness remains underexplored. Our study found that 39% of students reported improved awareness after three years, highlighting the need for targeted curriculum enhancements. Purpose: To evaluate changes in disaster preparedness awareness among nursing students over three years of education and identify gaps in current curricula impacting this awareness. Results: Findings indicate that while 39% of students showed improved awareness, significant gaps remain, suggesting the need for a dedicated course on emergency preparedness. Conclusions: This study emphasizes the importance of integrating comprehensive disaster preparedness education within nursing curricula to address these gaps and foster resilience in future healthcare professionals.

关键词： Disaster Preparedness Consciousness Nursing Students

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Open Journal of Nursing 2025年第1期15卷 60-66页

Background: For nursing students, gathering social information is essential for understanding healthcare and social issues and developing critical thinking and decision-making skills. However, the choice of information sources varies by age and individual habits. With the widespread use of the internet, there are notable differences between younger and older generations in their reliance on the internet versus traditional media sources like newspapers and television. Given the wide age range and diverse backgrounds of nursing students, understanding generational differences in information-gathering methods is important for implementing effective education. Purpose: The purpose of this study is to identify how nursing students in different age groups obtain social information and to examine media usage trends by age group. Additionally, we aim to use the findings to provide insights into effective information dissemination methods in nursing education. Results: The results showed that nursing students in their teens to forties, regardless of gender, primarily relied on the internet as their main information source, with television playing a secondary role. In contrast, students in their fifties tended to obtain information more often from newspapers and television than from the internet. This highlights an age-related difference in preferred information sources, with older students showing a greater reliance on traditional media. Conclusions: This study demonstrates that nursing students use different information-gathering methods based on their age, suggesting a need to custo-mize information dissemination strategies in nursing education. Digital media may be more effective for younger students, while traditional media or printed materials might better serve older students. Educational institutions should consider these generational differences in media usage and adopt strategies that meet the diverse needs of their student populations.

关键词： Nursing Students Social Information Sources Media Usage Trends Generational Differences

Volvulus of the gall bladder diagnosed by ultrasonography,computed tomography,coronal magnetic resonance imaging and magnetic resonance cholangio-pancreatography

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World Journal of Gastroenterology 2006年第28期12卷 4599-4601页

作者： Nobuhisa Matsuhashi Shinichi Satake kazunori Yawata Eri Asakawa Takashi Mizoguchi Masayuki Kanematsu Hiroshi Kondo Ichiro Yasuda Kenichi Nonaka Chihiro tanaka Atsushi Misao Shinji Ogura Department of Emergency and Disaster Medicine Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Radiology Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Gastroenterology Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Surgical Oncology Gifu University1-1 Yanagido501-1194Gifu CityJapan Department of Surgery Misao HospitalYotsuyachou500-8088Gifu CityJapan

A 54-year-old woman was admitted to our hospital with the complaint of right upper quadrant pain. Upon physical examination the vital signs of the patient were within normal ranges. Ultrasonography and computed tomography （CT） examination of the abdomen was obtained, which demonstrated a large dilatated cystic structure, measuring approximately 68.6 mm × 48.6 mm, with marked distension and inflammation. Additionally, the enhanced CT was characterized by the non-enhanced wall of the gallbladder. As the third examination in this study, magnetic resonance imaging （MRI）, namely coronal MRI and magnetic resonance cholangio-pancreatography （MRCP）, were performed. The MRCP demonstrated a dilatation of the gallbladder but detected no neck of the gallbladder. Simple cholecystectomy was performed. Macroscopic findings included a distended and gangrenous gallbladder, and closer examination revealed a counterclockwise torsion of 360 degrees on the gallbladder mesentery. Coronal MRI and MRCP showing characteristic radiography may be useful in making a definitive diagnosis.

关键词： Volvulus of the gallbladder Computed tomography Magnetic resonance imaging Magnetic resonance cholangio-pa ncreatography

The Fefferman-Stein-Type Inequality for the Kakeya Maximal Operator Ⅱ

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Acta Mathematica Sinica,English Series 2002年第3期18卷 447-454页

作者： Hitoshi tanaka Department of Mathematics Gakushuin University 1-5-1 Mejiro Toshima-ku Tokyo 171-8588 Japan

Let K, 0 ±1, be the Kakeya maximal operator defined as the supremum of averages over tubes of the eccentricity . The (so-called) Fefferman-Stein-type inequality: $|| {K_\delta f} ||_{L^d({{\rm R}^d,w})} \le C_d ({1 \over \delta})^{(d - 2)/2d}(\log ({1 \over \delta } ))^{\alpha_d} || f ||_{L^d ({\rm R}^d,K_{\delta}w})}$is shown, where Cd and d are constants depending only on the dimension d and w is a weight. The result contains the exponent (d-2)/2d which is smaller than the exponent (d-2)(d-1)/d(2d-3) obtained in [7].

关键词： Maximal functions Weighted inequalties

One-Dimensional Modeling of Multiple Scattering in the Upper Inner Core: Depth Extent of a Scattering Region in the Eastern Hemisphere

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Journal of Earth Science 2013年第5期24卷 706-715页

作者： Satoru tanaka Institute for Research on Earth Evolution Japan Agency for Marine-Earth Science and Technology

Attenuation of PKP（DF） in the Eastern Hemisphere is examined in terms of multiple scattering to simultaneously explain a puzzling relationship, a relatively fast velocity anomaly corre- sponding to strong attenuation. Reflectivity synthetics with one-dimensional random velocity fluctua- tions are compared with observations of PKP（DF）/PKP（Cdiff） amplitude ratios and differential travel times of PKP（Cdiff）-PKP（DF） for the equatorial paths. A Gaussian distribution of P-wave velocity fluctuations with the standard deviations of 5%, 6%, and 7% in the uppermost 200 km of the inner core is superimposed on the velocity structure that is slightly faster than the typical structure in the Eastern Hemisphere, which is likely to explain both the travel time and amplitude data as far as only the one-dimensional structure is considered. Further examinations of the statistic characteristic of scat- terer distribution in two and three-dimensions are required to obtain a realistic conclusion.

关键词： seismology the inner core attenuation scattering.