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Journal of Biomedical Science and Engineering 2011年第2期4卷 83-89页

作者： Masanori Nakamura kazunori nozaki Haruka Takimoto Kazuya Nagamune Motoharu Fujigaki Shigeo Wada 不详

In order to understand the contribution of teeth vibration to the production of sibilant/s/, the pre-sent study was designed to develop a method of simultaneously measuring aeroacoustic sounds and the vibration of an obstacle. To measure the vibration without disturbing flow, the Michelson interferometer was employed. The flow channel, which had an obstacle wall inside of it, was fabricated such that it morphologically mimicked the simplified geometry of the oral cavity. Given airflows at a flow rate of 7.5 × 10–4 m3/s from the inlet, aeroacoustic sounds were generated. A spectrum analy-sis of the data demonstrated two prominent peaks in the sound at 1,300 and 3,500 Hz and one peak in the wall vibration at 3,500 Hz. The correlation in peak frequencies between the sound and wall vibration suggests that the sound at 3,500 Hz was induced by the wall vibration. In fact, the sound amplitude at 3,500 Hz decreased when the obstacle wall was thickened, which increased its rigidity (p < 0.05, t-test). The experimental results demonstrate that the developed techniques are capable of measuring aeroacoustic sound and obstacle wall vibration simultaneously, and suggest the potential to pave the way for detailed analysis of the production of sibilant sounds /s/.

关键词： Acoustic Measurement Vibration Measurement Michelson Interferometer Aeroacoustics Sibilant/s/

Hybrid Strategy of Partitioned and Monolithic Methods for Solving Strongly Coupled Analysis of Inverse and Direct Piezoelectric and Circuit Coupling

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1371-1386页

作者： Daisuke Ishihara Syunnosuke nozaki Tomoya Niho Naoto Takayama Department of Intelligent and Control Systems Kyushu Institute of TechnologyFukuokaJapan

The inverse and direct piezoelectric and circuit coupling are widely observed in advanced electro-mechanical systems such as piezoelectric energy *** strongly coupled analysis methods based on direct numerical modeling for this phenomenon can be classified into partitioned or monolithic *** formulation has its advantages and disadvantages,and the choice depends on the characteristics of each coupled *** study proposes a new option:a coupled analysis strategy that combines the best features of the existing formulations,namely,the hybrid partitioned-monolithic *** analysis of inverse piezoelectricity and the monolithic analysis of direct piezoelectric and circuit interaction are strongly coupled using a partitioned iterative hierarchical *** a typical benchmark problem of a piezoelectric energy harvester,this research compares the results from the proposed method to those from the conventional strongly coupled partitioned iterative method,discussing the accuracy,stability,and computational *** proposed hybrid concept is effective for coupled multi-physics problems,including various coupling conditions.

关键词： Structure-piezoelectric-circuit interaction energy harvesting partitioned method monolithic method hybrid method

Silicon-Based Molecular Switch Junctions

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Nano Research 2009年第8期2卷 648-659页

作者： Daijiro nozaki Gianaurelio Cuniberti Institute for Material Science and Max Bergmann Center of Biomaterials Dresden University of TechnologyD-01062 DresdenGermany

In contrast to the static operations of conventional semiconductor devices,the dynamic conformational freedom in molecular devices opens up the possibility of using individual molecules as new types of devices such as a molecular conformational switch or for molecular data *** molecules such as those having two stable cis and trans isomeric confi gurations could provide,once clamped between two electrodes,a switching phenomenon in the non-equilibrium current ***,we model molecular switch junctions formed at silicon contacts and demonstrate the potential of such tunable molecular switches in electrode/molecule/electrode confi *** the non-equilibrium Green function(NEGF)approach implemented with the density-functional-based tight-binding(DFTB)theory,a series of properties such as electron transmissions,current voltage characteristics in the different isomer conformations,and potential energy surfaces(PESs)as a function of the reaction coordinates along the trans to cis transition were calculated for two azobenzene-based model ***,in order to investigate the stability of molecular switches under ambient conditions,molecular dynamics(MD)simulations at room temperature were performed and time-dependent fl uctuations of the conductance along the MD pathways were *** numerical results show that the transmission spectra of the cis isomers are more conductive than trans counterparts inside the bias window for both model *** currentvoltage characteristics consequently show the same ***,calculations of the time-dependent transmission fluctuations along the MD pathways have shown that the transmission in the cis isomers is always signifi cantly larger than that in their trans counterparts,showing that molecular switches can be expected to work as robust molecular switching components.

关键词： Molecular electronics molecular switches charge transport silicon–molecule interface

Biliary wound healing, ductular reactions, and IL-6/gp130 signaling in the development of liver disease

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World Journal of Gastroenterology 2006年第22期12卷 3512-3522页

作者： A J Demetris John G Lunz Ⅲ Susan Specht Isao nozaki The Thomas E.Starzl Transplantation Institute Departments of Pathology Division of TransplantationUniversity of Pittsburgh Medical CenterPittsburghPA 15213United States National Shikoku Cancer Center Hospital Department of Surgery 13 HorinouchiMatsuyama790-0007Japan

Basic and translational wound healing research in the biliary tree lag significantly behind similar studies on the skin and gastrointestinal tract. This is at least partly attributable to lack of easy access to the biliary tract for study. But clinical relevance, more interest in biliary epithelial cell （BEC） pathophysiology, and widespread availability of BEC cultures are factors reversing this trend. In the extra-hepatic biliary tree, ineffectual wound healing, scarring and stricture development are pressing issues. In the smallest intra-hepatic bile ducts either impaired BEC proliferation or an exuberant response can contribute to liver disease. Chronic inflammation and persistent wound healing reactions in large and small bile ducts often lead to liver cancer. General concepts of wound healing as they apply to the biliary tract, importance of cellular processes dependent on IL-6/gp130/STAT3 signaling pathways, unanswered questions, and future directions are discussed.

关键词： Biliary wound healing Ductular reactions IL-6/gp130 signaling

Gamete Dialogs in Green Lineages

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Molecular Plant 2015年第10期8卷 1442-1454页

作者： Toshiyuki Mori Hiroko Kawai-Toyooka Tomoko Igawa Hisayoshi nozaki Department of Biological Sciences Graduate School of Science The University of Tokyo 7-3-1 Hongo Bunkyo-ku Tokyo 113-0033 Japan Graduate School of Horticulture Chiba University 648 Matsudo Matsudo Chiba 271-8510 Japan

Gamete fusion is a core process of sexual reproduction and, in both plants and animals, different sex gametes fuse within species. Although most of the molecular factors involved in gamete interaction are still unknown in various sex-possessing eukaryotes, reports of such factors in algae and land plants have been increasing in the past decade. In particular, knowledge of gamete interaction in flowering plants and green algae has increased since the identification of the conserved gamete fusion factor GENERATIVE CELL SPECIFIC 1/HAPLESS 2 （GCS1/HAP2）. GCSl was first identified as a pollen generative cell-specific transmembrane protein in the lily （Lilium Iongiflorum）, and was then shown to function not only in flowering plant gamete fusion but also in various eukaryotes, including unicellular protists and metazoans. In addition, although initially restricted to Chlamydomonas, knowledge of gamete attachment in flowering plants was also acquired. This review focuses on recent progress in the study of gamete interaction in volvocine green algae and flowering plants and discusses conserved mechanisms of gamete recognition, attachment, and fusion leading to zygote formation.

关键词： sexual reproduction gamete fusion flowering plants green algae evolution

Transcriptomic analysis of epigenetic modification genes in the termite Reticulitermes speratus

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Insect Science 2020年第2期27卷 202-211页

作者： Yuki Mitaka Eisuke Tasaki Tomonari nozaki Taro Fuchikawa Kazuya Kobayashi Kenji Matsuura Laboratory of Insect Ecology Graduate School of AgricultureKyoto UniversitySakyo-kuKyotoJapan Applied Entomology Laboratory Center for Bioresource Field ScienceKyoto Institute of TechnologyUkyo-kuKyotoJapan Laboratory of Animal Physiology Graduate School of ScienceOsaka City UniversitySumiyoshi-kuOsakaJapan Hokkaido Forest Research Station Field Science Education and Research CenterKyoto UniversityKawakami-gunHokkaidoJapan

Eusocial insects display a caste system in which different castes are morpho-logically and physiologically specialized for different *** studies have revealed that epigenetic modifications,including DNA methylation and histone modification,me-diate caste determination and differentiation,longevity,and polyethism in eusocial *** there has been a growing interest in the relationship between epigenetic mech-anisms and phenotypic plasticity in termites,there is ltte information about differential expression levels among castes and expression sites for these genes in *** we show royaltissuc-specific expression of epigenetic modification genes in the termite Reticulitermes *** RNA-seq,we identified 74 genes,including three DNA methyltransferases,seven sirtuins,48 Trithorax group proteins,and 16 Polycomb group *** these genes,15 showed king-specific expression,and 52 showed age-dependent differential expression in kings and *** real-time PCR revealed that DNA methyltransferase 3 is expressed specifically in the king's testis and fat body,whereas some histone modification genes are remarkably expressed in the king's testis and queen's *** findings imply that epigenetic modification plays important roles in the gamete production process in termite kings and queens.

关键词： aging division of labor fat body king ovary testis

Differentiation of focal liver lesions using three-dimensional ultrasonography: Retrospective and prospective studies

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World Journal of Gastroenterology 2010年第17期16卷 2109-2119页

作者： Kazushi Numata Manabu Morimoto Akito nozaki Michio Ueda Masaaki Kondo Satoshi Morita Katsuaki Tanaka Gastroenterological Center Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan Department of Biostatistics and Epidemiology Yokohama City University Medical Center4-57 Urafune-choMinami-kuYokohamaKanagawa 232-0024Japan

AIM: To differentiate focal liver lesions based on enhancement patterns using three-dimensional ultrasonography (3D US) with perflubutane-based contrast ***: Two hundred and eighty two patients with focal liver lesions,including 168 hepatocellular carcinomas (HCCs),63 metastases,40 hemangiomas and 11 focal nodular hyperplasias (FNHs),were examined by 3D US with perflubutane-based contrast *** ultrasound images and sonographic angiograms were *** 282 lesions,enhancement patterns of 163 lesions between January 2007 and October 2007 were analyzed *** from November 2007 to May 2008,compared with contrast-enhanced (CE) 2D US,CE 3D US was performed on 119 lesions for prospective differential ***,specificity,area under receiver operating characteristic curve (Az) and inter-reader agreement were ***: With the tridimensional view,dominant enhancement patterns were revealed as diffuse enhancement or peripheral ring-like enhancement,followed with washout change for HCCs or metastases,respectively,and peripheral nodular enhancement or diffuse enhancement with spoke-wheel arteries,followed by persistent enhancement for hemangiomas or FNHs,*** CE 3D US,the prospective differentiation of lesions showed sensitivity 92% (mean for two readers),specificity 91% and Az value 0.95 for HCCs,84%,97%,and 0.95 for metastases,91%,98%,and 0.98 for hemangiomas and 80%,99%,and 0.99 for FNHs,respectively,while good to excellent inter-reader agreement was *** significant difference exists between prospective diagnosis accuracy at CE 3D US and that at CE 2D ***: CE 3D US provides a spatial perspective for liver tumor enhancement,and could help in differentiating focal liver lesions.

关键词： Three-dimensional Ultrasonography Contrast agent Liver Neoplasms

Plasma brain natriuretic peptide level in older outpatients with heart failure is associated with physical frailty, especially with the slowness domain

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Journal of Geriatric Cardiology 2016年第7期13卷 608-614页

作者： Shu Nishiguchi Yuma nozaki Masayuki Yamaji Kanako Oya Yuki Hikita Tomoki Aoyama Hiroshi Mabuchi Department of Physical Therapy School of Health Sciences Tokyo University of Technology Tokyo Japan Department of Physical Therapy Human Health Sciences Graduate School of Medicine Kyoto University Kyoto Japan Department of Cardiovascular Medicine Koto Memorial Hospital Shiga Japan Department of Rehabilitation Unit Koto Memorial Hospital Shiga Japan

Objective To determine the association between plasma brain natriuretic peptide （BNP） level in patients with heart failure （HF） and physical frailty as well as with each domain of physical frailty. Methods Two hundred and six outpatients of cardiovascular medicine aged 60 years and older who had been hospitalized for HF or had been given a prescription medication for HF were included. Physical frailty was assessed using the following five domains： slowness, weakness, exhaustion, low activity, and shrinking, according to the Cardiovascular Health Study. Patients were divided into nonfi-ailty and frailty groups according to frailty scores. Plasma BNP level was measured. The 6-min walk test was performed to measure endurance. Results Plasma BNP was significantly different between the two groups （frailty group： 158.0 i 214.7 pg/mL, nonfrailty group： 65.2 ~ 88.0 pg/mL, P 〈 0.01）. Multivariate logistic regression analysis revealed log-transformed plasma BNP （Log BNP） was significantly associated with physical frailty （OR： 1.68, 95% CI： 1.11-2.56）, and Log BNP was significantly associated with the slowness domain （walking speed 〈 1.0 m/s） of physical frailty （OR： 1.75, 95% Ch 1.15-2.67）. Additionally, Log BNP was negatively correlated to the 6-minute walk distance （6MWD）（p=0.37, P 〈 0.01）, while 6MWD was positively correlated to walking speed （p = 0.66, P 〈 0.01）. Conclusions Plasma BNP level was related to physical frailty, especially in the slowness domain. Endurance may intervene in the associations between plasma BNP level and walking speed.

关键词： Brain natriuretic peptide Heart failure Physical frailty Walking speed

Interaction between basigin and monocarboxylate transporter 2 in the mouse testes and spermatozoa

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Asian Journal of Andrology 2016年第4期18卷 600-606页

作者： Cheng Chen Mamiko Maekawa Kenji Yamatoya Masami nozaki Chizuru Ito Toshihiko Iwanaga Kiyotaka Toshimori Department of Anatomy and Developmental Biology Graduate School of Medicine Chiba University Chiba Japan Department of Cell Biology Research Institute for Microbia Diseases Osaka University Osaka Japan Laboratory of Histology and Cytology Department of Anatomy Graduate School of Medicine Hokkaido University Hokkaido Japan

Basigin is a member of the immunoglobulin superfamily and plays various important roles in biological events including spermatogenesis. To examine the basigin molecular variants during spermatogenesis and sperm maturation in the mouse, immunoprecipitated basigin samples from testis and epididymal spermatozoa were analyzed by liquid chromatography-mass spectrometry/mass spectrometry （LC-MS/MS）. The results demonstrated that basigin molecules from the testis and spermatozoa were separable into two major bands and that the differences in the molecular sizes were possibly because of an endoproteolytic cleavage. Since basigin is known to be a chaperone for the monocarboxylate transporter 1 （MCT1）, the localization of basigin, MCT1 and MCT2 was examined during postnatal testicular development. Immunohistochemical studies showed different expression patterns of MCT1 and MCT2. MCT1 was localized on the surface of spermatogonia, spermatocytes, and spermatids. In contrast, MCT2 appeared on the principal piece of spermatozoa in the testis, where basigin was also observed. In mature epididymal spermatozoa, MCT2 was located on the midpiece, where basigin co-localized with MCT2 but not with MCT1. Furthermore, MCT2 was immunoprecipitated with basigin in mouse testes and sperm. These results suggest that basigin has a functional role as a binding partner with MCT2 in testicular and epididymal spermatozoa.

关键词： basigin monocarboxylate transporter sperm maturation spermatogenesis spermatozoa testis

Effectiveness of entecavir in preventing hepatocellular carcinoma development is genotype-dependent in hepatitis B virus-associated liver cirrhosis

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World Journal of Hepatology 2021年第1期13卷 144-150页

作者： Kazuo Tarao Akito nozaki Makoto Chuma Masataka Taguri Shin Maeda Department of Gastroenterology Tarao’s Gastroenterological ClinicYokohama City 241-0821Japan Gastroenterological Center Yokohama City University Medical CenterYokohama 232-0024Japan Department of Data Science Yokohama City University School of Data ScienceYokohama 236-0004Japan Division of Gastroenterology Yokohama City University Graduate School of MedicineYokohama 236-0004Japan

BACKGROUND The oral nucleos(t)ide analogue,entecavir(ETV)was demonstrated to reduce the rate of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)-associated liver ***,the reduction of HCC differs in various regions of the *** To investigate the reduction of HCC development due to ETV therapy by *** We surveyed the differences in HCC development following ETV treatment based on published articles using PubMed(2004-2019).RESULTS The regions with the most marked reduction in HCC development due to ETV therapy were Spain(1.0%/year)and Canada(Southern part,1.3%/year),and the most ineffective areas were South Korea(3.6%-3.8%/year),China(3.3%/year),Taiwan(2.4%-3.1%/year),and Hong Kong(2.8%/year).Following ETV administration,the incidence of HCC in genotype D regions(1.89%±0.28%/year,mean±SE)was significantly lower than that in genotype C regions(2.91%±0.24%/year,P<0.01).With regard to the initial HBV-DNA level,in genotype C patients(average:5.61 Log10IU/mL)this was almost the same as that in genotype D patients(average:5.46 Log10IU/mL).Moreover,there was no association between the prevalence ratio of HBV and the incidence of HCC on ETV *** The effectiveness of ETV in preventing HCC development in HBV-associated liver cirrhosis is genotype-dependent.

关键词： Hepatocellular carcinoma Entecavir Genotype of hepatitis B virus Oral nucleos(t)ide analogue