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World Journal of Gastroenterology 2017年第35期23卷 6534-6539页

作者： Tetsu Yamamoto Yoshitsugu Tajima Ryoji Hyakudomi Takanori Hirayama Takahito Taniura kazunari ishitobi Noriyuki Hirahara Department of Digestive and General Surgery Shimane University Faculty of Medicine

A 27-year-old man with recurrent right lower quadrant pain was admitted to our hospital. Ultrasonography and computed tomography examination of the abdomen revealed a target sign in the ascending colon, which was compatible with the diagnosis of cecal intussusception. The intussusception was spontaneously resolved at that time, but it relapsed 6 mo later. The patient underwent a successful colonoscopic disinvagination; there was no evidence of neoplastic or inflammatory lesions in the colon and terminal ileum. The patient underwent laparoscopic surgery for recurring cecal intussusception. During laparoscopy, we observed an unfixed cecum on the posterior peritoneum(i.e. a mobile cecum). Thus, we performed laparoscopic appendectomy and cecopexy with a lateral peritoneal flap using a barbed wound suture device. The patient's post-operative course was uneventful, and he continued to do well without recurrence at 10 mo after surgery. Laparoscopic cecopexy using a barbed wound suture device is a simple and reliable procedure that can be the treatment of choice for recurrent cecal intussusception associated with a mobile cecum.

关键词： Colonic intussusception Adult Mobile cecum Cecopexy Barbed wound suture device

Altemeier perineal rectosigmoidectomy with indocyanine green fluorescence imaging for a female adolescent with complete rectal prolapse:A case report

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World Journal of Clinical Cases 2021年第4期9卷 847-853页

作者： Tetsu Yamamoto Ryoji Hyakudomi Kiyoe Takai Takahito Taniura Yuki Uchida kazunari ishitobi NoriyukiHirahara Yoshitsugu Tajima Department of Digestive and General Surgery Shimane University Faculty of MedicineIzumo 693-8501ShimaneJapan

BACKGROUND Rectal prolapse in young women is *** laparoscopic ventral mesh rectopexy is the standard procedure because of its lower recurrence rate,postoperative infertility is a *** rectosigmoidectomy(Altemeier procedure)is useful for these ***,the risk of anastomotic leakage should be ***,the usefulness of fluorescence imaging with indocyanine green(ICG)to prevent anastomotic leakage was *** report a case of an adolescent woman with complete rectal prolapse who underwent ICG fluorescence imaging-assisted Altemeier *** SUMMARY A 17-year-old woman who had a mental disorder was admitted to our hospital for treatment for water *** patient also suffered from rectal prolapse,approximately 3 mo before *** was referred to our surgical department because recurrent rectal prolapse could worsen her psychiatric *** 10 cm of complete rectal prolapse was ***,the mean maximum anal resting and constriction pressures were within normal limits on anorectal *** she had the desire to bear children in the future,she underwent Altemeier perineal rectosigmoidectomy to prevent surgery-related *** performed ICG fluorescence imaging at the same time as surgery to reduce the risk of anastomotic *** postoperative course was uneventful,and the rectal prolapse was completely *** continued to do well 18 mo after surgery,without recurrence of the rectal *** ICG fluorescence imaging-assisted Altemeier perineal rectosigmoidectomy is useful in preventing postoperative anastomotic leakage in young as well as elderly patients.

关键词： Indocyanine green fluorescence imaging Rectal prolapse Altemeier operation Young women Mental disorder Perineal rectosigmoidectomy Case report

Improved performance of direct methanol fuel cells with the porous catalyst layer using highly-active nanofiber catalyst

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Carbon Resources Conversion 2018年第1期1卷 61-72页

作者： Yosuke Tsukagoshi Hirokazu ishitobi Nobuyoshi Nakagawa Department of Environmental Engineering Science Graduate School of Science and TechnologyGunma University1-5-1TenjinchoKiryuGunma 376-8515Japan Division of Environmental Engineering Science Gunma University1-5-1TenjinchoKiryuGunma 376-8515Japan

PtRu supported on TiO2-embedded carbon nanofibers(PtRu/TECNF),which was recently reported as a highly-active catalyst for methanol oxidation,was applied to a direct methanol fuel cell(DMFC),and the power generation performance was compared to that using the commercial PtRu/*** the comparison,the effect of the catalyst loading on the power density of the DMFC was investigated using PtRu(18 wt%)/*** DMFC power density showed a maximum at about a 1.5 mg cm2 PtRu loading that corresponds to about an 80 mm layer thickness.A catalyst layer thicker than this value reduced the power density probably due to the concentration *** PtRu content in the PtRu/TECNF was then increased to 30 wt%or more to reduce the layer thickness and to increase the power *** DMFC performance was compared to that of different anode catalysts at a 1 mg cm2 PtRu *** power density was maximized using the PtRu30 wt%/TECNF,which showed a 173 mW cm2 at 353 K and had 66 mm layer thick,that was 26%higher than that of commercial PtRu/*** current–voltage curve of the DMFC with the PtRu/TECNF suggested an improved mass transport overvoltage,but a little improvement in the activation one despite using the catalyst with about a 2 times higher activity compared to that of the commercial PtRu/*** was attributed to the lower Pt utilization of the nanofiber catalyst layer.

关键词： Direct methanol fuel cell Catalyst layer structure PtRu catalyst TiO2-embedded carbon nanofiber support Methanol oxidation reaction Power density Precious metal loading Concentration overvoltage

Increased utilization and mass activity of PtRu on reduced graphene oxide by heat treatment of its aerogel followed by composite with nanomaterials

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Carbon Resources Conversion 2023年第3期6卷 205-214页

作者： Kenta Dejima Hirokazu ishitobi He Gao Mai Saito Nobuyoshi Nakagawa Graduate School of Science and Technology Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan Division of Environmental Engineering Science Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan Faculty of Science and Technology Gunma University1-5-1Tenjin-choKiryuGunma 376-8515Japan

The method to increase PtRu utilization and its catalytic activity of PtRu nanoparticles supported on reduced graphene oxide(RGO)by avoiding its restacking was proposed with the aim of developing an active catalyst for a direct methanol fuel *** heat treatment at 200◦C of the GO aerogel(GOA)prepared by freeze drying of GO ice was introduced to weaken the attractive force of the hydrogen bonding between the GO sheets followed by the composite with the nanoparticles,i.e.,ketjenblack(KB),TiO_(2)and Ti_(4)O_(7),at different weight *** catalyst supported on the heat-treated GOA(RGOA),PtRu/RGOA,improved the PtRu utilization to some extent and also increased the ECSA and mass activity compared to that of PtRu/*** had fewer oxygen functional groups,especially the epoxy *** to the treatment and composite,the PtRu utilization was increased from 66.5%for PtRu/RGO to 128.6%for PtRu/RGOA+Ti_(4)O_(7)(4:1)and the mass activity was improved from 50.7 A/g-PtRu for PtRu/RGO to 130.5 A/g-PtRu for PtRu/RGOA+Ti_(4)O_(7)(1:1).The Ti_(4)O_(7)nanoparticles showed the best catalytic performance for the composite suggesting that the strong interaction between Ti_(4)O_(7)and the Pt nanoparticles was effective due to its high electronic conductivity.

关键词： Reduced graphene oxide Restacking Catalyst utilization Mass activity Composite catalyst Methanol oxidation Ti4O7

Abiotic degradation of four phthalic acid esters in aqueous phase under natural sunlight irradiation

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Journal of Environmental Sciences 2009年第3期21卷 285-290页

作者： Ruttapol Lertsirisopon Satoshi Soda kazunari Sei Michihiko Ike Division of Sustainable Energy and Environmental Engineering Graduate School of Engineering Osaka University 2-1 Yamada-okaSuita 565-0871 Osaka Japan

Abiotic degradability of four phthalic acid esters （PAEs） in the aquatic phase was evaluated over a wide pH range 5-9. The PAE solutions in glass test tubes were placed either in the dark and under the natural sunlight irradiation for evaluating the degradation rate via hydrolysis or photolysis plus hydrolysis, respectively, at ambient temperature for 140 d from autumn to winter in Osaka, Japan. The efficiency of abiotic degradation of the PAEs with relatively short alkyl chains, such as butylbenzyl phthalate （BBP） and di-nbutyl phthalate （DBP）, at neutral pH was significantly lower than that in the acidic or alkaline condition. Photolysis was considered to contribute mainly to the total abiotic degradation at all pH. Neither hydrolysis nor photolysis of di-ethylhexyl phthalate （DEHP） proceeded significantly at any pH, especially hydrolysis at neutral pH was negligible. On the other hand, the degradation rate of di- isononyl phthalate （DINP） catalyzed mainly by photolysis was much higher than those of the other PAEs, and was almost completely removed during the experimental period at pH 5 and 9. As a whole, according to the half-life （t1/2） obtained in the experiments, the abiotic degradability of the PAEs was in the sequence： DINP （32-140 d）〉 DBP （50-360 d）, BBP （58-480 d）〉 DEHP （390-1600 d） under sunlight irradiation （via photolysis plus hydrolysis）. Although the abiotic degradation rates for BBP, DBP, and DEHP are much lower than the biodegradation rates reported, the photolysis rate for DINP is comparable to its biodegradation rate in the acidic or alkaline condition.

关键词： phthalic acid esters abiotic degradation photolysis hydrolysis first-order kinetics

Effect of tumor necrosis factor-α antagonists on oxidative stress in patients with Crohn's disease

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World Journal of Gastroenterology 2015年第35期21卷 10208-10214页

作者： kazunari Yamamoto Toshimi Chiba Takayuki Matsumoto Division of Gastroenterology Department of Internal MedicineSchool of MedicineIwate Medical University

AIM: To investigate changes in oxidative stress in Crohn's disease(CD) before and after anti-tumor necrosis factor(TNF)-α ***: A total of 42 patients with active CD, who were scheduled to be treated by anti-TNF-α antibodies, were enrolled. Serum levels of diacron-reactive oxygen metabolites(d-ROM), biological antioxidant potential(BAP), and modified ratio of oxidative stress and antioxidant capacity(m-OA) were measured using the Free Radical Analytical System before and 8 wk after induction of therapy with infliximab or adalimumab. The values for oxidative stress were correlated with disease activity and clinical response as determined by the CD activity index(CDAI) at 8 and 54 wk after the ***: Prior to treatment, d-ROM showed significant correlations with CDAI(r = 0.42, P < 0.01). There was a significant negative correlation between m-OA and CDAI before and after treatment(r =-0.48 vs r =-0.42, P < 0.01). CDAI and d-ROM had decreased significantly by 8 wk after treatment(CDAI; 223.3 ± 113.2 vs 158.3 ± 73.4, P < 0.01, d-ROM; 373 ± 133 vs 312 ± 101, P < 0.05). However, neither BAP nor m-OA had changed significantly. In patients who had responded to the treatment at 8 wk, d-ROM, BAP, and m-OA levels before treatment did not differ significantly between patients with and without loss of ***: Anti-TNF-α therapy decreases oxi-dative stress in patients with CD, but does not alter the production of antioxidants. Dysregulation of antioxidants may be associated with the disease.

关键词： Crohn’s disease Severity Oxidative stress Anti-tum

Synthesis and visible-light-induced sacrificial photocatalytic water oxidation of quinary oxynitride BaNb_(0.5)Ta_(0.5)O_2N crystals

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Journal of Energy Chemistry 2018年第5期27卷 1415-1421页

作者： Kenta Kawashima Mirabbos Hojamberdiev Kunio Yubuta kazunari Domen Katsuya Teshima Department of Chemistry The University of Texas at Austin Department of Materials Physics Nagoya University Institute for Materials Research Tohoku University Department of Chemical System Engineering School of Engineering The University of Tokyo Department of Environmental Science and Technology Faculty of Engineering Shinshu University Center for Energy and Environmental Science Shinshu University

Quinary oxynitride BaNb_0.5Ta_0.5O_2N crystals were fabricated through the partial nitridation and acidifica- tion of the KCI flux grown Ba_5Nb_2Ta_2O_15 crystals. The parameters of both the solute concentrations and cooling rates are optimized for the KCI flux growth of the larger Ba_5Nb_2Ta_2O_15 crystals with clearer crystal habits. Here, the optimal Ba_5Nb_2Ta_2O_15 crystals mainly have a hexagonal plate-like shape. After the par- tial nitridation and acidification, the porous BaNb_0.5Ta_0.5O_2N crystals maintained the crystal shape of the oxide precursor and had a single-crystalline nature. For the BasNb2Ta2015 crystals, the wavelength of the absorption edge was about 707 nm. Especially, the CoOx-Ioaded BaNb_0.5Ta_0.5O_2N photocatalyst demon- strated the comparatively high amount of O_2 gas （150.7 μmol） during the 5 h visible-light-induced sacri- ficial water oxidation half-reaction, which might be achieved due to the high crystallinity and visible-light absorotion property.

关键词： Substitution Flux method Perovskite Oxygen Photocatalyst Solar energy

Imaging characteristics of hypervascular focal nodular hyperplasialike lesions in patients with chronic alcoholic liver disease

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World Journal of Gastroenterology 2025年第2期31卷 61-70页

作者： Atsushi Urase Masakatsu Tsurusaki Ryohei Kozuki Atsushi Kono Keitaro Sofue kazunari Ishii Department of Radiology Kindai UniversityFaculty of MedicineOsakasayama 589-8511OsakaJapan Department of Radiology Kansai Medical University Medical CenterMoriguchi 570-8507OsakaJapan Department of Radiology Kobe University Graduate School of MedicineKobe 650-0017HyogoJapan

BACKGROUND Focal nodular hyperplasia(FNH)-like lesions are hyperplastic formations in patients with micronodular cirrhosis and a history of alcohol *** pathologically similar to hepatocellular carcinoma(HCC)lesions,they are *** such,it is important to develop methods to distinguish between FNH-like lesions and *** To evaluate diagnostically differential radiological findings between FNH-like lesions and *** We studied pathologically confirmed FNH-like lesions in 13 patients with alco-holic cirrhosis[10 men and 3 women;mean age:54.5±12.5(33-72)years]who were negative for hepatitis-B surface antigen and hepatitis-C virus antibody and underwent dynamic computed tomography(CT)and magnetic resonance imaging(MRI),including superparamagnetic iron oxide(SPIO)and/or gadoxetic acid-enhanced *** patients also underwent angiography-assisted *** The evaluated lesion features included arterial enhancement pattern,washout appearance(low density compared with that of surrounding liver parenchyma),signal intensity on T1-weighted image(T1WI)and T2-weighted image(T2WI),central scar presence,chemical shift on in-and out-of-phase images,and uptake pattern on gadoxetic acid-enhanced MRI hepatobiliary phase and SPIO-enhanced *** patients had multiple small lesions(<1.5 cm).Radiological features of FNH-like lesions included hypervascularity despite small lesions,lack of“corona-like”enhancement in the late phase on CT during hepatic angiography(CTHA),high-intensity on T1WI,slightly high-or iso-intensity on T2WI,no signal decrease in out-of-phase images,and complete SPIO uptake or incomplete/partial uptake of gadoxetic ***,similar to HCC,FNH-like lesions showed many unpaired arteries and sinusoidal *** Overall,the present study showed that FNH-like lesions have unique radiological findings useful for differential ***,SPIO-and/or gadoxetic acid-enhanced MRI and CTHA features might facili

关键词： Focal nodular hyperplasia Alcoholic liver disease Hepatocellular carcinoma Magnetic resonance imaging Liver

Liver resection for hepatocellular carcinoma using a microwave tissue coagulator: Experience of 1118 cases

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World Journal of Gastroenterology 2015年第36期21卷 10400-10408页

作者： kazunari Sasaki Masamichi Matsuda Masaji Hashimoto Goro Watanabe Department of Digestive Surgery Hepato-pancreatobiliary Surgery UnitToranomon Hospital

A I M : To present our extensive experience of hepatectomy for hepatocellular carcinoma using a microwave tissue coagulator to demonstrate the effectiveness of this device. METHODS: A total of 1118 cases(1990-2013) were reviewed,with an emphasis on intraoperative blood loss,postoperative bile leakage and fluid/abscess formation,and adaptability to anatomical resection and hepatectomy with hilar ***: The median intraoperative blood loss was 250 m L; postoperative bile leakage and fluid/abscess formation were seen in 3.0% and 3.3% of cases,respectively. Anatomical resection was performed in 275 cases,including 103 cases of hilar dissection that required application of microwave coagulation near the hepatic hilum. There was no clinically relevant biliary tract stricture or any vascular problems due to heat injury. Regarding the influence of cirrhosis on intraoperative blood loss,no significant difference was seen between cirrhotic and non-cirrhotic patients(P = 0.38),although cirrhotic patients tended to have smaller tumors and underwent less invasive operations. CONCLUSION: This study demonstrated outcomes of an extensive experience of hepatectomy using heat coagulative necrosis by microwave tissue coagulator.

关键词： Hepatectomy Hepatocellular carcinoma Microwave Mic

COVID-19 vaccination and liver disease

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World Journal of Gastroenterology 2022年第48期28卷 6791-6810页

作者： Sotaro Ozaka Takashi Kobayashi Kazuhiro Mizukami kazunari Murakami Department of Gastroenterology Faculty of MedicineOita UniversityYufu 879-5593OitaJapan Department of Infectious Disease Control Faculty of MedicineOita UniversityYufu 879-5593OitaJapan

Various vaccines against severe acute respiratory syndrome coronavirus 2 have been developed in response to the coronavirus disease 2019(COVID-19)global pandemic,several of which are highly effective in preventing COVID-19 in the general *** with chronic liver diseases(CLDs),particularly those with liver cirrhosis,are considered to be at a high risk for severe COVID-19 and *** the increased rates of disease severity and mortality in patients with liver disease,there is an urgent need to understand the efficacy of vaccination in this ***,the data regarding efficacy and safety of COVID-19 vaccination in patients with CLDs is ***,several organ-specific or systemic immune-mediated side effects following COVID-19 vaccination,including liver injury similar to autoimmune hepatitis,have been recently *** the number of cases of vaccine-related liver injury is increasing,its frequency,clinical course,and mechanism remain ***,we review the current findings on COVID-19 vaccination and liver disease,focusing on:(1)The impact of COVID-19 in patients with CLD;(2)The efficacy,safety,and risk-benefit profiles of COVID-19 vaccines in patients with CLD;and(3)Liver injury following COVID-19 vaccination.

关键词： COVID-19 vaccine Liver disease Side effect Liver injury Immune-related hepatitis Autoimmune hepatitis