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Apoptosis and non-alcoholic fatty liver diseases

World Journal of Gastroenterology 2018年第25期24卷 2661-2672页

作者： Tatsuo Kanda Shunichi Matsuoka Motomi Yamazaki Toshikatsu Shibata Kazushige Nirei Hiroshi Takahashi Tomohiro Kaneko Mariko Fujisawa Teruhisa Higuchi Hitomi Nakamura Naoki Matsumoto Hiroaki Yamagami Masahiro Ogawa Hiroo Imazu kazumichi kuroda Mitsuhiko Moriyama Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine

The number of patients with nonalcoholic fatty liver diseases(NAFLD) including nonalcoholic steatohepatitis(NASH), has been increasing. NASH causes cirrhosis and hepatocellular carcinoma(HCC) and is one of the most serious health problems in the world. The mechanism through which NASH progresses is still largely unknown. Activation of caspases, Bcl-2 family proteins, and c-Jun N-terminal kinase-induced hepatocyte apoptosis plays a role in the activation of NAFLD/NASH. Apoptotic hepatocytes stimulate immune cells and hepatic stellate cells toward the progression of fibrosis in the liver through the production of inflammasomes and cytokines. Abnormalities in glucose and lipid metabolism as well as microbiota accelerate these processes. The production of reactive oxygen species, oxidative stress, and endoplasmic reticulum stress is also involved. Cell death, including apoptosis, seems very important in the progression of NAFLD and NASH. Recently, inhibitors of apoptosis have been developed as drugs for the treatment of NASH and may prevent cirrhosis and HCC. Increased hepatocyte apoptosis may distinguish NASH from NAFLD, and the improvement of apoptosis could play a role in controlling the development of NASH. In this review, the association between apoptosis and NAFLD/NASH are discussed. This review could provide their knowledge, which plays a role in seeing the patients with NAFLD/NASH in daily clinical practice.

关键词： Apoptosis Autophagy c-Jun N-terminal kinase Nonalcoholic fatty liver diseases Nonalcoholic steatohepatitis

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Asphericalizing the Light Collection Mirror for the 200-Point Thomson Scattering Diagnostic Installed on the Large Helical Device

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Plasma Science and Technology 2011年第4期13卷 415-419页

作者： kazumichi NARIHARA Hiroshi HAYASHI National Institute for Fusion Science

Shown is a possibility to make the image of a laser beam over a distance of 2.5 m, formed by the spherical multi-segment mirror installed in LHD, twice sharper by suitably adjusting the inclination of each segment mirror, which is equivalent to making the mirror surface aspherical. This will further enhance the attractiveness of a mirror-based Thomson scattering system.

关键词： Thomson scattering LHD aspherical mirror

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Novel Fe/glass composite adsorbent for As(V) removal

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Journal of Environmental Sciences 2009年第4期21卷 434-439页

作者： WANG Ying ZHU Kongjun WANG Fen YANAGISAWA kazumichi College of Materials Science and Engineering Shaanxi University of Science and Technology Shaanxi 710021 China The Aeronautical Key Laboratory for Smart Materials and Structures Nanjing University of Aeronautics and Astronautics Nanjing 210016 China Research Laboratory of Hydrothermal Chemistry Kochi University Kochi 780-8520 Japan

An effective adsorbent for arsenic removal was synthesized by hydrothermal treatment of waste glass powder （GP）, followed by loading Fe（Ⅲ） oxyhydroxide onto the surface of waste glass powder. The =Si-O-H group was formed on the surface of GP and the specific surface area of GP powder was slightly increased after hydrothermal treatment. FeOOH was loaded onto the surface of hydrothermally treated waste glass powder （HGP） by the hydrolysis of FeC13. The formation conditions of FeOOH were also investigated. The ability of this new adsorbent for arsenic （As（V）） removal was evaluated. The results indicated that the highest removal efficiency was about 97% for 1 mg/L As（V） solution at pH 6 and keeping time 2 h.

关键词： arsenic removal adsorbent iron oxide hydrothermal treatment

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The simplest route to generating a train of attosecond pulses

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Light(Science & Applications) 2013年第1期2卷 204-208页

作者： kazumichi Yoshii John Kiran Anthony Masayuki Katsuragawa Department of Engineering Science University of Electro-CommunicationsTokyoJapan

We report on two novel routes to generating a train of attosecond pulses from a broad discrete spectrum in the near-infrared–visible–ultraviolet *** extends an integer-temporal-Talbot(ITT)concept to include high-order spectral dispersions and generates a pulse train that completely satisfies the transform-limited *** other numerically explores the optimum conditions under which we can obtain an attosecond pulse train that approximately satisfies the transform-limited *** second method is more practical than the *** of these methods is extremely simple and robust;we need only to place a few thin dispersive materials in the optical path and to adjust their thicknesses without spatially dispersing the frequency *** numerically demonstrate the generation of a train of attosecond pulses with a transform-limited pulse duration of 728 as and a repetition period of 8.03 fs in gaseous parahydrogen.

关键词： adiabatic excitation of Raman transition attosecond pulse generation integer-temporal-Talbot(ITT)method molecular modulation

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Effects of Cr Content and Annealing Temperature on Microstructure and Wear Characteristics of Cast Ausferrite Nodular Iron

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Journal of Iron and Steel Research International 2015年第11期22卷 1049-1054页

作者： Jia-peng ZOU kazumichi SHIMIZU Qi-zhou CAI State Key Laboratory of Materials Processing and Die & Mould Technology Huazhong University of Science and Technology Department of Materials Science and Engineering Muroran Institute Technology

The effects of Cr content and annealing temperature on abrasive wear characteristics of cast ausferrite nodular iron were investigated with Suga type abrasive wear tester. The surface morphology and Vickers hardness of the tested samples were analyzed by scanning electron microscopy（SEM）, digital microscope and Vickers hardness tester. The results show that the cast ausferrite nodular iron could be obtained by alloying with Cr in the as-cast ductile cast iron and permanent mold casting, and the bainite content in the matrix increased with increasing Cr content. However, the decomposition of bainite took place during annealing at 500 °C to 800 °C; especially, at 800 °C, the bainite transformed into a mixture of fine lamellar pearlite and ferrite matrix structure. The wear loss of specimens was reduced with increasing Cr content in the cast ausferrite nodular iron. The wear loss of the sample cast ausferrite nodular iron with 0.4mass% Cr is the least. The wear loss began to increase while the Cr content is 0.6mass%. The wear loss of annealed ductile irons at different annealing temperatures was higher than that of as-cast samples. During the abrasive wear, the shear stress transformed austenite to martensite, and the hardness of specimens increased and the wear resistance of as-cast ductile cast iron was improved.

关键词： cast ausferrite nodular iron Cr content annealing temperature microstructure wear characteristics

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Synthesis of WC powder through microwave heating of WO_3–C mixture

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International Journal of Minerals,Metallurgy and Materials 2017年第2期24卷 202-207页

作者： Amir Karimzadeh Behnami Arman Hoseinpur Masoud Sakaki Mohammad Sh. Bafghi kazumichi Yanagisawa School of Metallurgy and Materials Engineering Iran University of Science and Technology (IUST) Narmak Tehran 16846-13114 Iran Department of Materials Engineering Faculty of Engineering Malayer University Malayer 65719-95863 Iran Research Laboratory of Hydrothermal Chemistry Faculty of Science Kochi University Kochi 780-8073 Japan

A simple, easy, and low-cost process for the fabrication of tungsten carbide （WC） powder through microwave heating of WO3-C mixtures was developed. Thermodynamic calculations and experimental investigations were carried out for WO3-and W-C systems, and a formation mechanism was proposed. In the results, for the synthesis of WC, the use of over stoichiometric amount of C together with a spe- cially assembled experimental setup （which effectively retains heat in the system） is necessary. The WC powder is successfully obtained by heating WO3：5C mixture for 900 s in a domestic microwave oven.

关键词： tungsten carbide microwave heating carbothermic reduction thermodynamic analysis

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Plasma-based X-ray laser speckle and its application on ferroelectric material

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Nuclear Science and Techniques 2005年第4期16卷 193-200页

作者： TAI Ren-Zhong NAMIKAWA kazumichi Shanghai Institute of Applied Physics the Chinese Academy of Sicenees Shanghai 201800 China Department of Physics Tokyo Gakugei University. 4-1-1 Nukui-Kita Machi Koganei-Shi Tokyo 184-8501 Japan

A new type of soft X-ray source, i.e. a plasma-based X-ray laser, is found to be promising to conduct transient measurement. By means of picosecond X-ray laser speckles, the dynamic microscopic polarization clusters within cubic (paraelectric) BaTiO3 was directly observed and characterized in a microscopic scale for the first time. This opens a way to study this type of clusters, which usually manifest large external-field response for ferroelectric materials.

关键词： X射线激光铁电物质 BaTiO3

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Plasma-based x-ray laser speckle and its application on ferroelectric material

Plasma-based x-ray laser speckle and its application on ferr...

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2004年全国强场激光物理会议

作者： kazumichi Namikawa Department of Physics Tokyo Gakugei University4-1-1 Nukui-Kita MachiKoganei-ShiTokyo 184-8501Japan

Picosecond x-ray laser speckle is a powerful tool to study dynamic disordered microscopic structures of materials, which are usually invisible for visible lasers and even for current synchrotron x-ray radiation. As a demonstration, a prototype ferroelectric material BaTiO3 was studied by this technique, where, some new insights were first obtained on its structure change accompanying phase transition.

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Recent advances in endoscopic ultrasonography-guided biliary interventions

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World Journal of Gastroenterology 2015年第32期21卷 9494-9502页

作者： kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani Shin Haba Shuhei Kawahata Yoko Abe Yoshimasa Kubota Kimitoshi Kubo Hiroyuki Isayama Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Department of Gastroenterology Graduate School of Medicine The University of Tokyo

Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives.

关键词： Endosonography-guided biliary intervention Choledo

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超胞材料β-Li_2TiO_3的结构、制备及应用

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中国有色金属学报 2014年第6期24卷 1474-1485页

作者：于成龙高丹鹏王斐郝欣 kazumichi YANAGISAWA Sumio KAMIYA Takahiro KOZAWA 陕西科技大学材料科学与工程学院西安710021 高知大学理学院附属水热化学研究所重庆理工大学材料科学与工程学院重庆400054 陕西科技大学管理学院西安710021 丰田汽车公司大阪大学焊接研究所

综述近几年国内外有关β-Li_2TiO_3材料的结构、制备方法以及应用的研究进展。详细阐述β-Li_2-TiO_3材料的超胞结构,讨论可能存在的点缺陷,研究不同点缺陷对其超胞结构发育的影响;通过比较固相法、溶胶-凝胶法、燃烧合成法和水热合成... 详细信息

综述近几年国内外有关β-Li_2TiO_3材料的结构、制备方法以及应用的研究进展。详细阐述β-Li_2-TiO_3材料的超胞结构,讨论可能存在的点缺陷,研究不同点缺陷对其超胞结构发育的影响;通过比较固相法、溶胶-凝胶法、燃烧合成法和水热合成法等制备β-Li_2TiO_3粉体的典型方法,指出关键在于改善湿化学工艺方法,使能获得超细粉体且保证超胞发育良好。分析β-Li_2TiO_3材料在氚增殖剂、锂离子电池、发光材料和微波介质材料等领域的重要应用。

关键词： β-Li2TiO3 超胞结构缺陷固相法湿化学法应用

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