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World Journal of Gastroenterology 2005年第47期11卷 7457-7460页

作者： Mei-Juan Zou Gang Cheng Hirokazu Okamoto Xiu-Hua Hao Feng An Fu-De Cui kazumi danjo School of Pharmacy Shenyang Pharmaceutical University Shenyang 110016 Liaoning Province China Faculty of Pharmacy Meijo University 150 Yagotoyama Tempaku-ku Nagoya 468-8503 Japan

AIM: To investigate the release of cyclodextrin-5-amino salicylic acid (CyD-5-ASA) in cecum and ***: An anti-inflammatory drug 5-ASA was conjugated onto the hydroxyl groups of α-, β- and γ-cyclodextrins (CyDs) through an ester linkage, and the in vivo drug release behavior of these prodrugs in rat' s gastrointestinal tract after the oral administration was ***: The 5-ASA concentration in the rat's stomach and small intestine after the oral administration of CyD5-ASA conjugate was much lower than that after the oral administration of 5-ASA alone. The lower concentration was attributable to the passage of the conjugate throughthe stomach and small intestine without significant degradation or absorption, followed by the degradation of the conjugate site-specific in the cecum and colon. The oral administration of CyD-5-ASA resulted in lower plasma and urine concentration of 5-ASA than that of 5-ASA ***: CyD-5-ASA conjugates may be used as prodrugs for colon-specific drug delivery system.

关键词：环式糊精结肠疾病药物治疗胃疾病

Analysis for Effects of Temperature Rise of PV Modules upon Driving Distance of Vehicle Integrated Photovoltaic Electric Vehicles

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Energy and Power Engineering 2024年第4期16卷 131-150页

作者： Masafumi Yamaguchi Yasuyuki Ota Taizo Masuda Christian Thiel Anastasios Tsakalidis Arnulf Jaeger-Waldau Kenji Araki Kensuke Nishioka Tatsuya Takamoto Takashi Nakado kazumi Yamada Tsutomu Tanimoto Yosuke Tomita Yusuke Zushi Kenichi Okumura Takashi Mabuchi Akinori Satou Kyotaro Nakamura Ryo Ozaki Nobuaki Kojima Yoshio Ohshita Toyota Technological Institute Nagoya Japan Faculty of Engineering Miyazaki University Miyazaki Japan Toyota Motor Corporation Susono Japan European Commission— Joint Research Centre Ispra Italy Sharp Corporation Nara Japan Toyota Motor Corporation Toyota Japan Nissan Motor Corporation Yokosuka Japan

The development of vehicle integrated photovoltaics-powered electric vehicles (VIPV-EV) significantly reduces CO2 emissions from the transport sector to realize a decarbonized society. Although long-distance driving of VIPV-EV without electricity charging is expected in sunny regions, driving distance of VIPV-EV is affected by climate conditions such as solar irradiation and temperature rise of PV modules. In this paper, detailed analytical results for effects of climate conditions such as solar irradiation and temperature rise of PV modules upon driving distance of the VIPV-EV were presented by using test data for Toyota Prius and Nissan Van demonstration cars installed with high-efficiency InGaP/GaAs/InGaAs 3-junction solar cell modules with a module efficiency of more than 30%. The temperature rise of some PV modules studied in this study was shown to be expressed by some coefficients related to solar irradiation, wind speed and radiative cooling. The potential of VIPV-EV to be deployed in 10 major cities was also analyzed. Although sunshine cities such as Phoenix show the high reduction ratio of driving range with 17% due to temperature rise of VIPV modules, populous cities such as Tokyo show low reduction ratio of 9%. It was also shown in this paper that the difference between the driving distance of VIPV-EV driving in the morning and the afternoon is due to PV modules’ radiative cooling. In addition, the importance of heat dissipation of PV modules and the development of high-efficiency PV modules with better temperature coefficients was suggested in order to expand driving range of VIPV-EV. The effects of air-conditioner usage and partial shading in addition to the effects of temperature rise of VIPV modules were suggested as the other power losses of VIPV-EV.

关键词： Vehicle Integrated Photovoltaics (VIPV) VIPV-Powered Electric Vehicles Driving Distance PV Modules Solar Irradiation Temperature Rise Radiative Cooling

Suppression of postprandial blood glucose elevation by buckwheat(Fagpopyrum esculentum) albumin hydrolysate and identification of the peptide responsible to the function

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Food Science and Human Wellness 2022年第4期11卷 992-998页

作者： kazumi Ninomiya Yusuke Yamaguchi Fumie Shinmachi Hitoshi Kumagai Hitomi Kumagai Department of Food Science and Nutrition Kyoritsu Women’s University2-2-1 HitotsubashiChiyoda-kuTokyo 101-8347Japan College of Bioresource Sciences Nihon University1866 KameinoFujisawa-shi 252-0880Japan

The objective of this study is to evaluate the suppressive effect of buckwheat-albumin hydrolysate on postprandial hyperglycemia and identify the peptide responsible to the function. Buckwheat-albumin hydrolysate was prepared by using digestive enzymes and was orally administered to rats together with soluble starch. The blood was taken from the tail vein up to 90 min after oral administration to measure blood-glucose and plasma-insulin levels. The peptide with α-amylase inhibitory activity was purified from the buckwheathydrolysate by gel-filtration chromatography, α-amylase affinity chromatography, and high performance liquid chromatography(HPLC). The amino-acid sequence of the peptide was identified by a protein sequencer and was compared with that in the buckwheat-genome database. Buckwheat-albumin hydrolysate significantly suppressed the elevation of blood glucose level 15 min after starch administration. The amino-acid sequence of the peptide with α-amylase inhibitory activity was YVEPDCGNLGCCYHC in the parental protein of molecular mass 17.8 k Da and theoretical pI 4.77. The amino-acid sequence, molecular weight, and pI of the parental protein in buckwheat albumin were different from those of α-amylase inhibitor in wheat albumin. This study suggests that the novel α-amylase inhibitor identified in buckwheat albumin is a potential candidate for a functional food material to suppress postprandial blood glucose elevation.

关键词： Buckwheat-albumin hydrolysate Bioactive peptide α-Amylase inhibitor Postprandial hyperglycemia Type 2 diabetes

Using eye drops in compliance may improve the symptoms and quality of life in patients with seasonal allergic conjunctivitis: analysis of a two-season web survey

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 988-991页

作者： Asako Kodama Dogru Murat Hiroshi Fujishima kazumi Fukagawa Department of Ophthalmology Eiju General HospitalTokyo 110-8645Japan Department of Ophthalmology Tsurumi University School of Dental MedicineKanagawa 230-0063Japan Ryogoku Eye Clinic Tokyo 130-0062Japan

Dear Editor,Allergic conjunctivitis is the most common ocular surface allergic disease, affecting more than 30% of the population[1-2]. In the immediate phase of the allergic reactions(type Ⅰ) in patients with seasonal allergic conjunctivitis(SAC), the binding of antigen with the reaginic antibody leads to the formation and release of chemical mediators, such as histamines, in the local anaphylactic reaction[3].

关键词： allergic patients seasonal

Monazite age spectra in the Late Cenozoic strata of the Changjiang delta and its implication on the Changjiang run-through time

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Science China Earth Sciences 2005年第10期48卷 1718-1727页

作者： Yokoyama kazumi Department of Geology National Science Museum Tokyo Japan

The Late Cenozoic strata are 313 m thick, revealed by the drilling core PD-99 in the south Changjiang delta. Monazite chemical dating shows that 350-500-Ma monazites predominate in the Pliocene and 100-275-Ma monazites in the Quaternary, indicating a great change of their provenance. The first presence horizon of monazites younger than 25 Ma is just above the Matruyama/Gauss boundary (~2.58 Ma), whch is exactly when uplift of the Tibetan Plateau began to influence deposition in the East China Sea. Variations in contents of monazites younger than 25 Ma can be divided into two sections. The Early-Middle Pleistocene with less <25 Ma monazites corresponds with rapid uplift of the Tibetan Plateau, and the Late Pleistocene with more <25 Ma monazites parallels the peak uplift of the Tibetan Plateau. This study demonstrates that chemical dating of monazites in the river-mouth strata is a useful method to explore changes of river drainage basins, and deconvolute multistage tectonic and magmatic activity histories in the provenance areas.

关键词： delta, monazite, electron microprobe, chemical dating, formation of the Changjiang, uplift of the Tibetan Plateau.

Direct Evaluation of Transition Amplitude Using Determinant of Wave Operator in One-Dimensional Potential Scattering System

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Chinese Physics Letters 2007年第11期24卷 3032-3035页

作者： Itsuki Banno kazumi Fujima Interdisciplinary Graduate School of Medicine and Engineering University of Yamanashi 4-3-11 Takeda Kofu Yamanashi 400-8511 Japan

A determinantal formula is developed for direct evaluation of transition amplitude without solving the wave equation in a one-dimensional potential scattering system. Our formulation is 5ased on the principle that a desired quantity can be extracted from the wave operator, which is the master operator maintaining all the information of the system. This principle is tested in a simplified system, i.e,, in a one-dimensional potential scattering system. We are now developing a formula for direct evaluation of near-field amplitude to design a system, in which local field enhancement is desired.

关键词： coated conductor buffer layer self-epitaxy CeO2

Hydrodynamic performance of spouted beds with different types of draft tubes

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Particuology 2013年第5期11卷 475-482页

作者： Hiroshi Nagashima kazumi Suzukawa Toshifumi Ishikura Department of Chemical Engineering Fukuoka University19-1Nanakuma 8-chomeJonan-kuFukuoka 814-0180Japan

Hydrodynamic performance of spouted beds with four different types of draft tubes has been investigated experimentally. In this work, irregular and angular particles were used as the spouting solids and the results were compared with those of the previous work in which regular and round particles had been used. It was found that the conical-cylindrical porous draft tube was the best option for solid-gas contact and solids circulation as in the case of round particles. Moreover, by using conical-cylindrical porous draft tube, the gas flow rate through the annulus reached 65-70%, equal to the level of a conventional spouted bed.

关键词： Spouted bedConical-cylindrical porous draft tubeAngular sandGas-solid contactSolids circulation rate

Kinetic Studies of Solvent and Pressure Effects on the Thermal Isomerization of Palladium Dithizonate

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Chemical Research in Chinese Universities 2000年第2期16卷 141-145页

作者： Yoshimi Sueishi kazumi Matsumoto Okayama University 日本 Okayama 70 0 -8530

The isomerization of mercury bisdithizonate having tetrahedral stereochemistry occurs in each ligand independently and is unaffected by the presence of the second ligand attached to the same central metal. The effects of solvent and pressure on the thermal isomerization of the square-planar Pd dithizonate complex were studied to determine the influence of ligand on the isomerization rate. The results were compared to those obtained with Hg(HDz)2. The mechanistic implications for the thermal isomerization of Pd(HDz)2 were presented.

关键词： Metal dithizonate Kinetic study Solvent effect Pressure effect

Therapeutic potential of AMPA receptor antagonist perampanel against cerebral ischemia: beyond epileptic disorder

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Neural Regeneration Research 2019年第9期14卷 1525-1526页

作者： Satoshi Suda kazumi Kimura Department of Neurology Graduate School of Medicine Nippon Medical School

Stroke is a leading cause of mortality and severe neurological disability worldwide;however,curative therapeutic options are *** recanalization therapy using endovascular thrombectomy has demonstrated great benefits in the functional outcome of patients with acute ischemic stroke,the rate of excellent clinical outcomes remains ***,the current recanalization therapeutic approach may require adjunctive therapy to improve outcomes.

关键词： Stroke is a leading neurological disability improve outcomes

Parallel-core-type polarization rotator for silicon wire waveguide platform

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Photonics Research 2014年第3期2卷 S0014-S0018页

作者： Hiroshi Fukuda kazumi Wada The University of Tokyo School of Material Engineering7-3-1 HongoChiyodaTokyoJapan NTT Microsystem Integration LaboratoriesMorinosato-WakamiyaAtsugiKanagawaJapan

We describe a polarization rotator based on a parallel-core structure consisting of a silicon nanowire waveguide and a silicon-nitride *** 60-μm-long rotator provides a polarization extinction ratio of more than 10 dB with excess loss of less than 1 *** addition,the extremely wide bandwidth of more than 150 nm expected from calculations is confirmed in experiments.A study of the fabrication tolerance of our rotator indicates that fabrication error of around 25 nm is allowable.

关键词： polarization extinction fir