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High mobility group box-1 protein as a therapeutic target in perinatal hypoxic-ischemic brain injury

Neural Regeneration Research 2021年第10期16卷 2006-2007页

作者： kazuki hatayama Barbara S.Stonestreet Department of Pediatrics Women&Infants hospital of Rhode IslandThe Alpert Medical School of Brown UniversityProvidenceRIUSA

Perinatal hypoxic-ischemic(HI)brain injury is a leading cause of morbidity and longstanding disability in newborns(Millar et al.,2017).Improved neonatal intensive care has increased survival in infants with pregnancy and birth related ***,many surviving neonates exhibit neurological abnormalities that can persist throughout life(Millar et al.,2017).Early neuroprotective strategies have the potential to improve neurological outcomes and attenuate developmental delay in ***,hypothermia is the only currently approved intervention for HI encephalopathy in fullterm infants,which is only partially protective(Millar et al.,2017).Findings in preterm and full-term infants suggest that elevations in proinflammatory cytokines are important in the pathogenesis of HI-related brain injury(Millar et al.,2017).The high mobility group box-1(HMGB1),a representative damage associatedmolecular pattern(DAMP)protein,has been reported to be implicated in a variety of brain related inflammatory diseases including traumatic brain injury,epilepsy,and stroke(Nishibori et al.,2019).Anti-HMGB1 therapies have gained increasing interest to treat inflammation related disorders in the brain(Nishibori et al.,2019).However,there is a paucity of information regarding the pathology of HMGB1 in HI-related brain injury during the perinatal *** current perspective discusses the potential contributions of HMGB1 to HI-related brain injury during the perinatal period and also addresses the potential of HMGB1 as a therapeutic target of the brain ***,this perspective emphasizes the potential for combinational therapeutics for hypothermia with anti-HMGB1 monoclonal antibodies(mAb)in perinatal HI brain injury.

关键词： protective therapeutic epilepsy

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Electric Potential in Surface Produced Negative Ion Source with Magnetic Field Increasing Toward a Wall

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Plasma Science and Technology 2013年第3期15卷 266-270页

作者： Azusa FUKANO Akiyoshi hatayama Monozukuri Department Tokyo Metropolitan College of Industrial Technology Faculty of Science and Technology Keio University

Electric potential near a wall for plasma with the surface produced negative ions with magnetic field increasing toward a wall is investigated analytically. The potential profile is derived analytically by using a plasma-sheath equation, where negative ions produced on the plasma grid （PG） surface are considered in addition to positive ions and electrons. The potential profile depends on the amount and the temperature of the surface produced negative ions and the profile of the magnetic field. The negative potential peak is formed in the sheath region near the PG surface for the case of strong surface production of negative ions or low temperature negative ions. As the increase rate of the magnetic field near the wall becomes large, the negative potential peak becomes small.

关键词： negative ion source surface produced negative ion sheath potential cusp magnetic field electric potential plasma-sheath equation extraction region

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Analysis on EAST LHCD Operation Space by Using Simple Core-SOL-Divertor Model

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Plasma Science and Technology 2009年第4期11卷 389-393页

作者： R.HIWATARI A.hatayama S.ZHU Y.TOMITA Central Research Institute of Electric Power Industry Faculty of Science and Technology Keio University Institute of Plasma Physics Chinese Academy of Sciences National Institute for Fusion Science

A simple core-SOL-divertor model （CSD model） was developed to investigate qual- itatively the overall features of the operational space for the integrated core and edge plasma. In the CSD model, the core plasma model of ITER physics guidelines and the two-point SOL-divertor model are applied, This CSD model is validated by the two dimensional divertor transport code （B2-EIRINE） and by the JT-60U divertor recycling database, and this model is applicable to the low- and high-recycling state of the divertor plasma. The CSD model is applied to the study of the EAST operational space with lower hybrid current drive under various kinds of trade-off for the basic plasma parameters, and the relationship between the operational space and the plasma discharge duration is also discussed.

关键词： core transport SOL-divertor transport operation space EAST LHCD

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Predictions for EAST Divertor Performance

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Plasma Science and Technology 2006年第1期8卷 118-121页

作者：朱思铮 R.HIWATARI A.hatayama Y.TOMITA Institute of Plasma Physics Chinese Academy of SciencesHefei 230031China Central Research Institute of Electric Power Industry TokyoJapan Faculty of Science and Technology Keio UniversityYokohamaJapan National Institute for Fusion Science TokiJapan

A detailed study of the divertor performance in EAST has been performed for both its double null （DN） and single null （SN） configurations. The results of application of the SOLPS （B2-Eirene） code package to the analysis of the EAST divertor are summarized. In this work, we concentrate on the effects of increased geometrical closure and of magnetic topology variation on the scrape-off layer （SOL） and divertor plasma behavior. The results of numerical predictions for the EAST divertor operational window are also described in this paper. A simple Core-SOL- Divertor （C-S-D） model was applied to investigate the possibility of extending plasma operational space of low hybrid current drive （LHCD） experiments for EAST.

关键词： EAST divertor SOLPS Core-SOL-Divertor model

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Overall Features of EAST Operation Space by Using Simple Core-SOL-Divertor Model

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Plasma Science and Technology 2006年第1期8卷 114-117页

作者： R.HIWATARI A.hatayama 朱思铮 T.TAKIZUKA Y.TOMITA Oentral Research Institute of Electric Power Industry TokyoJapan Faculty of Science and Technology Keio UniversityYokohamaJapan Institute of Plasma Physics Chinese Academy of SciencesHefei230031 China Naka Fusion Energy Establishment Japan Atomic Energy Research InstituteIbarakiJapan National Institute for Fusion Science TokiJapan

A simple Core-SOL-Divertor （C-S-D） model has been developed to investigate qualitatively the overall features of the operational space for the integrated core and edge plasma. To construct the simple C-S-D model, a simple core plasma model of ITER physics guidelines and a two-point SOL-divertor model are used. The simple C-S-D model is applied to the study of the EAST operational space with lower hybrid current drive experiments under various kinds of trade-off for the basic plasma parameters. Effective methods for extending the operational space are also presented, From this study for the EAST operational space, it is evident that the C-S-D model is a useful tool for understanding qualitatively the overall features of the plasma operational space.

关键词： divertor modeling particle balance core-edge interface EAST

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Evaluation of Cs uptake and accmulation by vegetables and sunflower, 137Cs-accumulator, in agar and hydroponic system

Evaluation of Cs uptake and accmulation by vegetables and su...

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Environmental Pollution and Public Health(EPPH 2012)

作者： kazuki Sugawara Masayoshi hatayama Zhenyi Zhang Xuan Zhao Chihiro Inoue Graduate School of Environmental Studies Tohoku University Institute of Nuclear and New Technology Tsinghua University

Radioactive ingredients were spread by accident of Fukushima nuclear power plant, especially 137Cs was the most concerned contamination in wide range of Tohoku region in Japan. Cs uptake and accumulation by seedlings of common vegetables such as cabbage （Brassica oleracea var. capitata） and broccoli （Brassica oleracea var. italica） were compared with that of sunflower （Helianthus annuus）, which exhibites high 137Cs accumulation, in agar and hydroponics system. In the uptake experiment on agar medium, sunflower accumulated 10-fold higher stable Cs than cabbage and broccoli in shoots and roots. Compared with hydroponics experiment, the Cs accumulation of the sunflower was several fold higher in the agar experiment. However, cabbage and broccoli exhibited at the same level of Cs accumulation to each other in both experiments. Additionally, Cs absorption of cabbage and broccoli was terminated within the first 2 hours in hydroponics. It was suggested that Cs was adsorbed abruptly on the root surface of these vegetables, then terminated because of slow Cs uptake by them and saturation of the Cs adsorption sites available on the plant surface. The vegetables accumulated only small amount of Cs into edible parts compared with sunflower.

关键词： component cesium seedling plant food safety Helianthus annuus Brassica oleracea var. capitata Brassica oleracea var. italica

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Decrease in Serum Amyloid a Protein Levels Following Three-month Stays in Negatively Charged Particle-dominant Indoor Air Conditions

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Biomedical and Environmental Sciences 2018年第5期31卷 335-342页

作者： Suni Lee Shoko Yamamoto Yasumitsu Nishimura Hidenori Matsuzaki Kei Yoshitome Tamayo hatayama Miho Ikeda YU Min Nagisa Sada Naoko Kumagai-Takei Takemi Otsuki Department of Hygiene Kawasaki Medical School 577 Mastushima Kurashiki 701-0192 Japan Department of Occupational and Environmental Health Science School of Public Health School of Public Health Peking University Health Science Center Beijing 100191 China Department of Occupational Diseases Zhejiang Academy of Medical Sciences＇ Hangzhou 310013 Zhejiang China Department of Biophysical Chemistry Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama University 1-1-1 Tsushimanaka Kita-Ku Okayama 700-8530 Japan

Objective The changes in serum adipokines and cytokines related to oxidative stress were examined during 3 months ‘Off to On’ and ‘On to Off’ periods using negatively charged particle-dominant indoor air conditions（NCPDIAC）.Methods Seven volunteers participated in the study,which included ‘OFF to 3 months ON’ periods（ON trials） for a total of 16 times,and ‘ON to 3 months OFF’（OFF trials） periods for a total of 13 *** With the exception of one case,serum amyloid A（SAA） levels decreased significantly during the ON *** Considering that SAA is an acute phase reactive protein such as C reactive protein（CRP）,this observed decrease might indicate the prevention of cardiovascular and atherosclerotic changes,since an increase in high-sensitive CRP is associated with the subsequent detection of these events.

关键词： Negatively charged particle Indoor air Serum amyloid A Biomarker Cardiovascular disease

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Characterization of a Human 105-kDa Heat Shock Protein, HSP105

Characterization of a Human 105-kDa Heat Shock Protein, HSP1...

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Third Congress of the Asian-Pacific Organization for Cell Biology

作者： Keiichi Ishihara Kunihiko Yasuda Takumi hatayama Department of Biochemistry Kyoto Pharmaceutical UniversityYamashina-kuKyoto 607-8414Japan

We have characterized two members of mouse high molecular mass heat shock protein (HMM HSP) family, HSP105 (HSP105α) and 42 ℃-specific HSP (HSP105β). In this study, to characterize human homologue of H M M

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Biological Effects of Cloth Containing Specific Ore Powder in Patients with Pollen Allergy

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Biomedical and Environmental Sciences 2016年第8期29卷 563-573页

作者： Suni LEE Hitoshi OKAMOTO Shoko YAMAMOTO Tamayo hatayama Hidenori MATSUZAKI Naoko KUMAGAI-TAKEI Kei YOSHI-TOME Yasumitsu N1SHIMURA Toshiaki SATO Yasuzo KIRITA Yoshio FUJII Takemi OTSUKI Biological Sciences Universidad De Los Andes Bogota 111711 Col. Department of Hygiene Kawasaki Medical School 577 Mastushima Kurashiki 701-0192 Japan Cosmic Garden Co. Ltd. 1-2-25 Ima Kita-Ku Okayama 700-0975 Japan Coordinator Specified Nonprofit Organiztion MEDICAL TECHNO OKA YAMA 1st Floor General Education Research Building Shikata Campus 2-5-1 Shikata Kita-ku Okayama 700-8558 Japan Okayama University Organization for Research Promotion and Collaboration 3rd Floor Basie Medicine Building Shikata Campus 2-5-1 Shikata Kita-ku Okayama 700-8558 Japan

Objective The custom-homebuilding company, Cosmic Garden Co. Ltd., located in Okayama City, Japan was established in 1997 and uses specific natural ore powder （SNOP） in wall materials and surveys customers in order to improve allergic symptoms. Methods To investigate the biological effects of SNOP, patients with a pollen allergy were recruited to stay in a room surrounded by cloth containing SNOP （CCSNOP）, and their symptoms and various biological parameters were compared with those of individuals staying in a room surrounded by control non-woven cloth （NWC）. Each stay lasted 60 min. Before and immediately after the stay, a questionnaire regarding allergic symptoms, as well as POMS （Profile of Mood Status） and blood sampling, was performed. Post-stay minus pre-stay values were calculated and compared between CCSNOP and NWC groups. Results Results indicated that some symptoms, such as nasal obstruction and lacrimation, improved, and POMS evaluation showed that patients were calmer following a stay in CCSNOP. Relative eosinophils, non-specific Ig E, epidermal growth factor, monocyte chemotactic protein-I, and tumor necrosis factor-a increased following a stay in CCSNOP. Conclusion This ore powder improved allergic symptoms, and long-term monitoring involving 1 to 2 months may be necessary to fully explore the biological and physical effects of SNOP on allergic patients.

关键词： Specific Mineral Cloth, Indoor air Immunological effects Pollen allergy

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后叉韧带保留型假体术中后叉韧带紧张的影响因素

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临床骨科杂志 2018年第1期21卷 58-58页

作者： hatayama K Terauchi M Hashimoto S 胡孔足

作者分析了225例内翻性膝关节骨性关节炎，进行后叉韧带保留型假体置换术。术中截骨完成后，如果测试垫片前方翘起，就进行后叉韧带松解。采用多因素回归分析后叉韧带紧张的影响因素。

关键词：假体置换术影响因素叉韧带保留型紧张膝关节骨性关节炎多因素回归分析作者分析

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