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Aging-induced memory loss due to decreased N1-acetyl-5-methoxykynuramine,a melatonin metabolite,in the hippocampus:a potential prophylactic agent for dementia

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Neural Regeneration Research 2025年第6期20卷 1705-1706页

作者： kazuki Watanabe Atsuhiko Hattori Department of Immunobiology Institute of Development Aging and CancerTohoku UniversitySendaiMiyagiJapan Department of Sport and Wellness College of Sport and WellnessRikkyo UniversityNiizaSaitamaJapan

Melatonin(N-acetyl-5-methoxytryptamine)is known as the hormone of darkness because it is synthesized at night and involved in regulating the circadian *** hormone is primarily synthesized by the vertebrate pineal gland,but is ubiquitous among invertebrates,unicellular organisms,plants,and even cyanobacteria(Hattori and Suzuki,2024).Melatonin is well-conserved evolutionarily and possesses several physiological functions,such as immune response,bone and glucose metabolism,and memory formation besides regulating the circadian rhythm.

关键词： metabolism primarily agent

Quantum Fibrations:Quantum Computation on an Arbitrary Topological Space

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Acta Mathematica Sinica,English Series 2024年第11期40卷 2693-2718页

作者： kazuki IKEDA Co-design Center for Quantum Advantage(C2QA)&Center For Nuclear Theory Department of Physics and AstronomyStony Brook UniversityStony BrookUSA Department of Mathematics and Statistics&Centre for Quantum Topology and Its Applications(quanTA) University of SaskatchewanSaskatoonCanada

Using operator algebras,we extend the theory of quantum computation on a graph to a theory of computation on an arbitrary topological *** computation is usually implemented on finite discrete sets,and the purpose of this study is to extend this to theories on arbitrary *** conventional theory of quantum computers can be viewed as a simplified algebraic geometry theory in which the action of SU(2)is defined on each point of a discrete *** this study,we extend this in general as a theory of quantum fibrations in which the action of the von Neumann algebra is defined on an arbitrary topological *** quantum channel is then naturally extended as a net of von Neumann *** allows for a more mathematically rigorous discussion of general theories,including physics and chemistry,which are defined on sets that are not necessarily discrete,from the perspective of quantum computer science.

关键词： Quantum computation operator algebra von Neumann algebra fibration quantum computational chemistry complexity theory

Subloading-friction model with saturation of tangential contact stress

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Friction 2023年第6期11卷 1107-1120页

作者： Koichi HASHIGUCHI Masami ueno Kyushu University Fukuoka 819-0395Japan MSC Software Ltd. Tokyo 101-0054Japan University of the Ryukyus Okinawa 903-0213Japan

The incorporation of the saturation of the tangential contact stress with the increase of the normal contact stress is required for the analysis of the friction phenomenon of solids and structures subjected to a high normal contact stress,which cannot be described by the Coulomb friction condition,in which the tangential contact stress increases linearly with the increase of the normal contact *** this article,the subloading-friction model,which is capable of describing the smooth elastic-plastic transition,the static-kinetic transition,and the recovery of the static friction during the cease of sliding,is extended to describe this ***,some numerical examples are shown,and the validity of the present model will be verified by the simulation of the test data on the linear sliding of metals.

关键词： high contact stress monotonic/reciprocal sliding static/kinetic friction subloading-friction model

Shared and distinct roles of T peripheral helper and T follicular helper cells in human diseases

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Cellular & Molecular Immunology 2021年第3期18卷 523-527页

作者： Hiroyuki Yoshitomi Hideki ueno Department of Immunology Graduate School of MedicineKyoto UniversitySakyo-kuf Kyoto 606-8501Japan lnstitute for the Advanced Study of Human Biology Kyoto UniversitySakyo-kuKyoto 606-8501Japan Department of Microbiology Icahn School of Medicine at Mount SinaiNew York 10029 NYUSA Global Health and Emerging Pathogens Institute Icahn School of Medicine at Mount SinaiNew York 10029 NYUSA

The interactions of CD4^(+)T cells and B cells are fundamental for the generation of protective antibody responses,as well as for the development of harmful autoimmune *** studies of human tissues and blood samples have established a new subset of CD4^(+)B helper T cells named peripheral helper T(Tph)*** T follicular helper(Tfh)cells,which interact with B cells within lymphoid organs,Tph cells provide help to B cells within inflamed *** cells share many B helper-associated functions with Tfh cells and induce B cell differentiation toward antibody-producing *** differentiation mechanism is also partly shared between Tph and Tfh cells in humans,and both Tfh and Tph cells can be found within the same tissues,including cancer ***,Tph cells display features distinct from those of Tfh cells,such as the expression of chemokine receptors associated with Tph cell localization within inflamed tissues and a low Bd-6/Blimp1 *** that of Tfh cells,current evidence shows that the target of Tph cells is limited to memory B *** this review,we first summarize recent findings on human Tph cells and discuss how Tph and Tfh cells play shared and distinct roles in human diseases.

关键词： peripheral helper T cells T follicular helper cells CXCL13,Autoantibodies autoimmune diseases

Posture Maintenance Control of 2-Link Object By Nonprehensile Two-Cooperative-Arm Robot Without Compensating Friction

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1397-1403页

作者： Changan Jiang Satoshi ueno Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashiKusatsuShiga 525-8577Japan

In this paper, a method to posture maintenance control of 2-link object by nonprehensile two-cooperative-arm robot without compensating friction is proposed. In details, a mathematical model of the 2-link object is firstly built. Based on the model, stable regions for holding motion of nonprehensile two-cooperative-arm robot are obtained while the 2-link object is kept stable on the robot arms with static friction. Among the obtained stable regions, the robust pairs of orientation angles of the 2-link object are found. Under the robust orientation angles, a feedback control system is designed to control the arms to maintain the 2-link object's posture while it is being held or lifted up. Finally, experimental results are shown to verify the effectiveness of the proposed method.

关键词： Nursing care nonprehensile robot posture maintenance static friction two-cooperative-arm robot

THE INTERACTION BETWEEN SHOCK WAVES AND SOLID SPHERES ARRAYS IN A SHOCK TUBE

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Acta Mechanica Sinica 2004年第3期20卷 219-227页

作者：施红辉 kazuki YAMAMURA State Key Laboratory of Nonlinear Mechanics Institute of MechanicsChinese Academy of SciencesBeijing 100080China College of Mechanical and Automatic Control EngineeringZhejiang University of SciencesXiasha Higher Education ZoneHangzhou 310018China Department of Mechanical Engineering Nagoya Institute of TechnologyGokiso-choShowa-kuNagoya 466-8555Japan

When a shock wave interacts with a group of solid spheres,non-linear aerodynamic behaviors come into *** complicated wave reflections such as the Mach reflection occur in the wave propagation *** wave interactions with vortices behind each sphere's wake cause fluctuation in the pressure profiles of shock *** paper reports an experimental study for the aerodynamic processes involved in the interaction between shock waves and solid spheres.A schlieren photography was applied to visualize the various shock waves passing through solid *** measurements were performed along different downstream *** experiments were conducted in both rectangular and circular shock *** data with respect to the effect of the sphere array, size,interval distance,incident Mach number,etc.,on the shock wave attenuation were obtained.

关键词： shock wave spheres arrays models schlieren visualization pressure measurement compressible multiphase flow

Hierarchically porous monoliths based on low-valence transition metal (Cu, Co, Mn) oxides:gelation and phase separation

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National Science Review 2020年第11期7卷 1656-1666页

作者： Xuanming Lu Kazuyoshi Kanamori kazuki Nakanishi Department of Chemistry Graduate School of ScienceKyoto University Institute for Integrated Cell-Material Sciences Kyoto University Institute for Advanced StudyKyoto University Division aof Materials Research Institute of Materials and Systems for Sustainability Nagoya University

Hierarchically porous monoliths based on copper (Cu), cobalt (Co) and manganese (Mn) oxides with three-dimensionally (3D) interconnected macropores and open nanopores were prepared using metal bromides as precursors via a sol–gel process accompanied by phase separation. The difficulty of gelation for low-valence metal cation was overcome by introducing a highly electronegative Br atom near to the metal atom to control the rates of hydrolysis and polycondensation. The 3D interconnected macropores were obtained using appropriate polymers to induce phase separation. The domain sizes of macropores and skeletons can be controlled by reaction parameters such as concentration and/or average molecular weight of polymers, and the amount of hydrochloric acid. The crystalline metal oxide monoliths with their 3D interconnected macroporous structure preserved were obtained after heat treatment in air.

关键词： hierarchically porous monolith low-valence transition metal oxide 3D interconnected macropore sol–gel process phase separation

An Experimental Study on Response and Control of a Flapping-Wing Aerial Robot Under Wind Gusts

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Journal of Bionic Engineering 2024年第1期21卷 209-223页

作者： kazuki Shimura Hikaru Aono Chang-kwon Kang Graduate School of Science and Technology Shinshu University3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical Engineering and Robotics 3-15-1 TokidaUedaNagano 3868567Japan Department of Mechanical and Aerospace Engineering University of Alabama in HuntsvilleTechnology Hall N266HuntsvilleAL35899USA

Bioinspired flapping-wing micro-air-vehicles(FWMAVs)have the potential to be useful aerial tools for gathering information in various *** recent advancements in manufacturing technologies and better understanding of aerodynamic mechanisms behind of the flapping flight,outdoor flights have become a ***,to fully realize the potential of FWMAVs,further improvements are necessary,particularly in terms of stability and robustness under gusty *** this study,the response and control of a tailless two-winged FWMAV under the wind gusts are *** experiments are conducted with a one-degree-of-freedom gimbal to focus on effects of wind gusts on the rotational motion of the ***-derivative and sliding-mode controls are adopted for the attitude *** present that the body angles changed in time and reached approximately 50°at the maximum due to the wing *** sliding-mode controller can more effectively control the rotational angle in the presence of disturbances and both the wing speed and changes in wind speed have an impact on the effectiveness of attitude *** results contribute to the development of of tailless two-winged,single-motor driven FWMAVs in terms of the design of attitude controller and testing apparatus.

关键词： Flapping-wing micro-air vehicles Sliding-mode control Pitch and roll angle-Wind gus

Rectification of 3D Data Obtained from Moving Range Sensor by Using Extended Projective Multiple View Geometry

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International Journal of Automation and computing 2008年第3期5卷 268-275页

作者： kazuki Kozuka Jun Sato Department of Computer Science and Engineering Nagoya Institute of Technology

To measure the 3D shape of large objects, scanning by a moving range sensor is one of the most efficient methods. However, if we use moving range sensors, the obtained data have some distortions due to the movement of the sensor during the scanning process. In this paper, we propose a method for recovering correct 3D range data from a moving range sensor by using the multiple view geometry under projective projections in space-time. We assume that range sensor radiates laser beams in a raster scan order, and they are observed from two cameras. We first show that we can deal with range data as 2D images, and show that the extended multiple view geometry can be used for representing the relationship between the 2D image of range data and the 2D image of cameras. We next show that the extended multiple view geometry can be used for rectifying 3D data obtained by the moving range sensor. The method is implemented and tested in synthetic images and range data. The stability of the recovered 3D shape is also evaluated.

关键词： Machine vision stereo vision shape measurement laser measurement applications image processing.