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Antitumor effect of VEGFR2-targeted microbubble destruction with gemcitabine using an endoscopic ultrasound probe:In vivo mouse pancreatic ductal adenocarcinoma model

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 478-485页

作者： Nana Shimamoto Masaki Ito Masafumi Chiba Sadamu Honma Hiroo Imazu kazuki Sumiyama Department of Endoscopy The Jikei University School of Medicine3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Oncology Research Center for Medical Science3-25-8 Nishi ShinbashiMinato-kuTokyo 105-8461Japan Division of Gastroenterology and Hepatology Department of MedicineNihon University School of Medicine30-1 Oyaguchikami-choItabashi-kuTokyo 173-8610Japan

Background:Ultrasound-targeted microbubble destruction(UTMD)induces cellular inflow of drugs at low intensity,while high intensity eradicates tumor *** vascular endothelial growth factor receptor 2(VEGFR2)is highly expressed in pancreatic ductal adenocarcinoma(PDAC),VEGFR2-targeted microbubble(MB)might additionally increase the tissue specificity of drugs and thus improve antitumor *** addition,fixing the dual pulse intensity could maximize MB *** study evaluated the one-off(experiment 1)and cumulative(experiment 2)treatment effect of UTMD by regulating the dual pulse output applied to PDAC using VEGFR2-targeted ***:C57BL/6 mice inoculated with Pan-02 cells were allocated to five groups:VEGFR2-targeted MB+gemcitabine(GEM),VEGFR2-targeted MB,non-targeted MB+GEM,GEM,and control *** injection of GEM or GEM and either VEGFR2-targeted or non-targeted MB,UTMD was applied for several minutes at low intensity followed by high intensity *** experiment 1,mice were treated by the protocol described above and then euthanized immediately or at the tumor diameter doubling time(TDT).In experiment 2,the same protocol was repeated weekly and mice were euthanized at TDT regardless of protocol *** analysis by CD31 and VEGFR2 staining provided microvascular density(MVD)and VEGFR2 expression along vessels(VEGFR2v)or intra/peripheral cells(VEGFR2c).Results:In experiment 1,TDT was significantly longer in the VEGFR2-targeted MB+GEM group compared to the non-targeted MB+GEM,GEM,and control groups,while the VEGFR2-targeted MB group showed no statistical *** and VEGFR2v in the immediate euthanasia was significantly lower in the VEGFR2-targeted MB+GEM and VEGFR2-targeted MB groups than other *** experiment 2,the VEGFR2-targeted MB+GEM group produced significantly longer TDT than the GEM or control groups,whereas the VEGFR2-targeted MB group showed no significant *** revealed sign

关键词： Ultrasound-targeted microbubble destruction VEGFR2-targeted microbubble Pancreatic ductal adenocarcinoma Gemcitabine

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Recent progress in upgrading metallurgical-grade silicon to solar-grade silicon via pyrometallurgical routes

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International Journal of Minerals,Metallurgy and Materials 2022年第4期29卷 767-782页

作者： Yun Lei Xiaodong Ma Ye Wang Zhiyuan Chen Yongsheng Ren Wenhui Ma kazuki Morita Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Sustainable Minerals Institute The University of QueenslandSt Lucia 4072QLDAustralia School of Chemical Engineering Sichuan UniversityChengdu 610065China Separation and Conversion Technology Flemish Institute for Technological ResearchMol 2400Belgium Department of Materials Engineering Graduate School of EngineeringThe University of TokyoTokyo 113-8656Japan

Si-based photovoltaic solar power has been rapidly developed as a renewable and green energy *** widespread use of Sibased solar cells requires large amounts of solar-grade Si(SoG-Si)to manufacture Si *** routes,mainly the modified Siemens process,have dominated the preparation of polycrystalline SoG-Si;however,traditional chemical techniques employ a series of complex chemical reactions involving various corrosive and hazardous *** addition,large amounts of complex waste solar cells and Si kerf slurry waste gradually accumulate and are difficult to recycle using these *** methods are required to meet the demand for SoGSi preparation and Si waste *** metallurgical route shows promise but is hindered by the problem of eliminating B and P from metallurgical-grade Si(MG-Si).Various pyrometallurgical treatments have been proposed to enhance the removal of B and P from *** article reviews Si refining with slag treatment,chlorination,vacuum evaporation,and solvent refining,and summarizes and discusses the basic principles and recent representative studies of the four *** these,solvent refining is the most promising and environmentally friendly approach for obtaining low-cost SoG-Si and is a popular research ***,a simple and green approach,i.e.,a combination of solvent refining,slag treatment,or vacuum directional solidification,is proposed for low-cost SoG-Si preparation using MG-Si or Si wastes as raw materials.

关键词： silicon refining solar-grade silicon solvent refining vacuum evaporation slag treatment Si kerf slurry waste

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Portable rainfall simulator for plot-scale investigation of rainfall-runoff,and transport of sediment and pollutants

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International Journal of Sediment Research 2019年第1期34卷 38-47页

作者： Julien Boulange Farag Malhat Piyanuch Jaikaew kazuki Nanko Hirozumi Watanabe Department of International Environmental and Agricultural SciencesGraduate School of AgricultureTokyo University of Agriculture and Technology Department of Pesticide Residues and Environmental Pollution Central Agricultural Pesticide LaboratoryAgriculture Research Center Department of Agricultural and Environmental Engineering United Graduate School of Agricultural ScienceTokyo University of Agriculture and Technology Department of Civil and Environmental Engineering Faculty of Science and engineeringKasetsart UniversityChalermphrakiat Sakon Nakhon Provice Campus Department of Disaster Prevention Meteorology and HydrologyForestry and Forest Products Research Institute

A low-cost, simple to use portable rainfall simulator is developed for use over a 5 m2plot. The simulator is easy to transport and assemble in the field, thereby allowing for necessary experimental replicates to be done. It provides rainfall intensities of between 20 and 100 mm/h by changing the number and type of silicon nozzles used. The Christiansen coefficient of uniformities obtained in the field are appropriate and vary from 79 to 94% for rainfall intensities ranging from 30 to 70 mm/h. In addition, the median volumetric drop diameters measured for rainfall intensities of 30, 50, and 70 mm/h are in the lower range of that of natural rainfall and equal to 1.10 ± 0.08,1.69 ± 0.21, and 1.66 ± 0.20 mm, respectively. The velocities of the raindrops with diameters less than 1.2 mm reached terminal velocities, while raindrops less than 2.0 mm achieved velocities reasonably close to the terminal velocity of natural rainfall. Furthermore,the average time-specific kinetic energy(KET) for rainfall intensities of 30, 50, and 70 mm/h are 257.7,760.1, and 1645.2 J/m2/h, respectively accounting for about 78.0 and 86.5% of the KET of natural rainfall for50 and 70 mm/h rainfall intensity, respectively. The applicability of the portable rainfall simulator for herbicide transport study is investigated using two herbicides(atrazine and metolachlor); herbicide losses in runoff and sediment samples are in the ranges reported in the literature. As a percentage of the amount of herbicide applied, 5.29% of atrazine and 2.15% of metolachlor are lost due to combined water and sediment runoff. The results show that the portable rainfall simulator can be effectively used in studying processes such as pesticide runoff, infiltration mechanisms, and sediment generation and transport at a field plot scale with an emphasis on how surface characteristics such as slope and soil properties affect these processes.

关键词： Rainfall simulator Rainfall intensity Raindrop energy Raindrop size distribution Rainfall uniformity

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Minimally invasive surgery for upper gastrointestinal cancer: Our experience and review of the literature

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World Journal of Gastroenterology 2016年第19期22卷 4626-4637页

作者： Koichi Suda Masaya Nakauchi kazuki Inaba Yoshinori Ishida Ichiro Uyama Division of Upper GI Department of Surgery Fujita Health University

Minimally invasive surgery (MIS) for upper gastrointestinal (GI) cancer, characterized by minimal access, has been increasingly performed worldwide. It not only results in better cosmetic outcomes, but also reduces intraoperative blood loss and postoperative pain, leading to faster recovery; however, endoscopically enhanced anatomy and improved hemostasis via positive intracorporeal pressure generated by CO2 insufflation have not contributed to reduction in early postoperative complications or improvement in long-term outcomes. Since 1995, we have been actively using MIS for operable patients with resectable upper GI cancer and have developed stable and robust methodology in conducting totally laparoscopic gastrectomy for advanced gastric cancer and prone thoracoscopic esophagectomy for esophageal cancer using novel technology including da Vinci Surgical System (DVSS). We have recently demonstrated that use of DVSS might reduce postoperative local complications including pancreatic fistula after gastrectomy and recurrent laryngeal nerve palsy after esophagectomy. In this article, we present the current status and future perspectives on MIS for gastric and esophageal cancer based on our experience and a review of the literature.

关键词： Stomach neoplasms Esophageal neoplasms Minimally invasive surgical procedures Postoperative complications Robotic surgical procedures

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A promoting nitric oxide-releasing coating containing copper ion on ZE21B alloy for potential vascular stent application

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Journal of Magnesium and Alloys 2023年第12期11卷 4542-4561页

作者： Qianying Jia Qinggong Jia Shijie Zhu Yufeng Zheng Yoji Mine kazuki Takashima Shaokang Guan School of Materials Science and Engineering&Henan Key Laboratory of Advance Magnesium Alloy&Key Laboratory of Materials Processing and Mold Technology(Ministry of Education) Zhengzhou UniversityZhengzhou 450001China Department of Materials Science and Engineering Kumamoto University2-39-1 KurokamiChuo-kuKumamoto 860-8555Japan International Research Organization for Advanced Science and Technology(IROAST) Kumamoto University2-39-2 Kumamoto 860-8555Japan School of Materials Science and Engineering Peking UniversityBeijing 100871China

Magnesium-based biodegradable metals as cardiovascular stents have shown a lot of excellent performance, which have been used to treat coronary artery diseases. However, the excessive degradation rate, imperfect biocompatibility and delayed re-endothelialization still lead to a considerable challenge for its application. In this work, to overcome these shortcomings, a compound of catalyzing nitric oxide(NO) generation containing copper ions(Cu^(2+)) and hyaluronic acid(HA), an important component of the extracellular matrix, were covalently immobilized on a hydrofluoric acid(HF)-pretreated ZE21B alloy via amination layer for improving its corrosion resistance and endothelialization. Specifically,the Cu^(2+) chelated firmly with a cyclen 1,4,7,10-tetraazacyclododecane-N’, N’’, N’’’, N-tetraacetic acid(DOTA) could form a stability of hybrid coating, avoiding the explosion of Cu^(2+). The chelated Cu^(2+) enabled the catalytic generation of NO and promoted the adhesion and proliferation of endothelial cells(ECs) in vascular micro-environment. In this case, the synergistic effect of NO-generation and endothelial glycocalyx molecules of HA lead to efficient ECs promotion and smooth muscle cells(SMCs) inhibition. Meanwhile, the blood compatibility also had achieved a marked improvement. Moreover, the standard electrochemical measurements indicated that the functionalized ZE21B alloy had better anti-corrosion ability. In a conclusion, the dual-functional coating displays a great potential in the field of biodegradable magnesium-based implantable cardiovascular stents.

关键词： ZE21B alloy Functional coating Hyaluronic acid Nitric oxide Cardiovascular stent

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Flat friction spot joining of aluminum alloy to carbon fiber reinforced polymer sheets:Experiment and simulation

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Journal of Materials Science & Technology 2022年第12期107卷 266-289页

作者： Peihao Geng Ninshu Ma Hong Ma Yunwu Ma kazuki Murakami Huihong Liu Yasuhiro Aoki Hidetoshi Fujii Joining and Welding Research Institute Osaka University11-1 MihogaokaOsaka 567-0047IbarakiJapan MOE Key Lab for Liquid-Solid Structure Evolution and Material Processing Institute of Materials JoiningShandong UniversityJinan 250061China

The Al alloy and carbon fiber reinforced polymer(CFRP)hybrid structures,incorporating the performance advantages of the two materials,have been attracting more attention in high-end manufacturing *** the current investigation,the flat friction spot joining(FSJ)was employed in joining the AA6061-T6 alloy and CFRP *** significance of temperature distribution in influencing joint quality was highlighted through analyzing interface microstructural features,weld defect formation as well as *** understand the role of thermal energy generation and conduction in the process comprehensively,a 3D thermal-mechanical coupling finite element model was *** interfacial temperature was characterized by an uneven distribution behavior due to the inhomogeneous heat *** peak temperatures on the top surface and Al alloy to CFRP interface at 1500 rpm rotational speed with 0.1 mm/s plunging speed were 498℃and 489°C,*** peak interface temperature was reduced to286℃at 250 rpm,which produced an extremely small melted *** with the plunging speed,rotational speed was found to be the predominant parameter for determining the joint property,which could be optimized to simultaneously realize the avoidance of thermal decomposition of CFRP,the sufficient melting duration time,and the wide enough melted *** thermal histories and melted area profiles were in agreement with experimental *** findings could be utilized to provide some feasible guidance for process optimization of dissimilar FSJ of metals and composites.

关键词： Friction spot joining Numerical simulation CFRP/Al alloy Interface microstructure Thermal conduction

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Gastric cancer mortality related to direct radiographic and endoscopic screening:A retrospective study

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World Journal of Gastroenterology 2021年第33期27卷 5595-5609页

作者： Hiroaki Hagiwara Fumitaka Moki Yukiko Yamashita kazuki Saji Keigo Iesaki Hiromitsu Suda Department of Internal Medicine Hagiwara ClinicMaebashi 379-2106GunmaJapan Maebashi Medical Association Maebashi 371-0035GunmaJapan Gunma Health Foundation Maebashi 371-0005GunmaJapan Department of Internal Medicine and Surgery Yamashita ClinicMaebashi 371-0016GunmaJapan Department of Internal Medicine Saji ClinicMaebashi 371-0133GunmaJapan Department of Internal Medicine Iesaki ClinicMaebashi 371-0805GunmaJapan Department of Pediatrics Suda Kids ClinicMaebashi 371-0813GunmaJapan

BACKGROUND Despite its decreased incidence in Japan,gastric cancer continues among the leading causes of cancer-related deaths in both men and ***,efforts are still required to lower the mortality rate of gastric cancer in *** City introduced endoscopic gastric cancer screening in 2004,and participants are able to choose between direct radiography and ***,we expected to see a decrease in mortality rate from gastric cancer after introducing endoscopic screening and a difference in mortality rate reduction between screening *** To evaluate the impact on gastric cancer mortality rate of two types of gastric cancer screening in Maebashi City,*** Participants aged 40 to 79 years of the Maebashi City gastric cancer screening program in 2006 who were screened by direct radiography(n=11155)or endoscopy(n=10747)were *** were followed until March 31,2012,by cross-referencing their data against the Gunma Prefecture cancer registry *** compared the detection rate of gastric ***,we compared the mortality rate between the two *** Cox proportional hazards model was used to estimate the hazard ratio(HR)of gastric cancer ***,the reduction in gastric cancer mortality rate associated with each screening method was *** Gastric cancer was detected in 22 participants undergoing direct radiography(detection rate,0.20%)and in 52 participants undergoing endoscopy(detection rate,0.48%).However,most gastric cancers detected by endoscopic screening were early cancers that may not have resulted in *** found no significant difference in gastric cancer mortality rate between participants receiving annual screening and those who do *** the number of gastric cancer deaths in the direct radiography group was set as 1 in the Cox proportional hazard analysis,the HR of gastric cancer death was 1.368(95%CI:0.7308-2.562)in the overall group of *** results showed no s

关键词： Gastric cancer Radiography Endoscopy Population-based cancer screening Mortality reduction

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Laparoscopic approach to suspected T1 and T2 gallbladder carcinoma

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World Journal of Gastroenterology 2017年第14期23卷 2556-2565页

作者： Yusuke Ome kazuki Hashida Mitsuru Yokota Yoshio Nagahisa Michio Okabe Kazuyuki Kawamoto Department of Surgery Kurashiki Central Hospital

AIM To evaluate a laparoscopic approach to gallbladder lesions including polyps, wall-thickening lesions, and suspected T1 and T2 gallbladder cancer(GBC).METHODS We performed 50 cases of laparoscopic whole-layer cholecystectomy(LCWL) and 13 cases of laparoscopic gallbladder bed resection(LCGB) for those gallbladder lesions from April 2010 to November 2016. We analyzed the short-term and long-term results of our laparoscopic approach. RESULTS The median operation time was 108 min for LCWL and 211 min for LCGB. The median blood loss was minimal for LCWL and 28 ml for LCGB. No severe morbidity occurred in either procedure. Nine patients who underwent LCWL and 7 who underwent LCGB were postoperatively diagnosed with GBC. One of these patients had undergone LCGB for pathologically diagnosed T2 GBC after LCWL. All of the final surgical margins were negative. Three of these 15 patients underwent additional open surgery. The mean follow-up period was 26 mo, and only one patient developed *** LCWL and LCGB are safe and useful procedures that allow complete resection of highly suspected or earlystage cancer and achieve good short-term and longterm results.

关键词： Laparoscopic cholecystectomy Whole-layer cholecystectomy Gallbladder bed resection Radical cholecystectomy Gallbladder carcinoma

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Adaptive-sampling near-Doppler-limited terahertz dual-comb spectroscopy with a free-running single-cavity fiber laser

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Advanced Photonics 2020年第3期2卷 50-60页

作者： Jie Chen kazuki Nitta Xin Zhao Takahiko Mizuno TakeoMinamikawa Francis Hindle Zheng Zheng Takeshi Yasui Beihang University School of Electronic and Information EngineeringBeijingChina Tokushima University Graduate School of Advanced Technology and ScienceTokushimaJapan JST ERATO MINOSHIMA Intelligent Optical SynthesizerTokushimaJapan Tokushima University Institute of Post-LED PhotonicsTokushimaJapan Tokushima University Graduate School of TechnologyIndustrial and Social SciencesTokushimaJapan Tokushima University Research Cluster on“Multi-scale VibrationalMicroscopy forComprehensive Diagnosis and Treatment of Cancer”TokushimaJapan Universitédu Littoral Côte d’Opale Laboratoire de Physico-Chimie de l’AtmosphèreDunkerqueFrance Beihang University Beijing Advanced Innovation Center for Big Data-based Precision MedicineBeijingChina

Dual-comb spectroscopy(DCS)is an emerging spectroscopic tool with the potential to simultaneously achieve a broad spectral coverage and ultrahigh spectral resolution with rapid data ***,the need for two independently stabilized ultrafast lasers significantly hampers the potential application of *** demonstrate mode-resolved DCS in the THz region based on a free-running singlecavity dual-comb fiber laser with the adaptive sampling *** the use of a free-running single-cavity dual-comb fiber laser eliminates the need for two mode-locked lasers and their frequency control,the adaptive sampling method strongly prevents the degradation of spectroscopic performance caused by the residual timing jitter in the free-running dual-comb ***-limit-approaching absorption features with linewidths down to 25 MHz are investigated for low-pressure acetonitrile/air mixed gas by comb-mode-resolved THz *** successful demonstration clearly indicates its great potential for the realization of lowcomplexity,Doppler-limited THz spectroscopy instrumentation.

关键词： optical comb terahertz dual-comb spectroscopy molecular spectroscopy

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Balloon overtube-guided colorectal endoscopic submucosal dissection

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World Journal of Gastroenterology 2009年第48期15卷 6086-6090页

作者： Tomohiko Ohya Ken Ohata kazuki Sumiyama Yousuke Tsuji Ikuro Koba Nobuyuki Matsuhashi Hisao Tajiri Department of Endoscopy The Jikei University School of Medicine Division of Gastroenterology Kanto Medical Center NTT EC Division of Gastroenterology and Hepatology Yamaga Chou Hospital Department of Endoscopy Department of Gastroenterology and HepatologyThe Jikei University School of Medicine

AIM:To evaluate the usefulness of a balloon overtube to assist colorectal endoscopic submucosal dissection(ESD)using a ***:The results of 45 consecutive patients who underwent colorectal ESD were analyzed in a single tertiary endoscopy *** preoperative evaluation of access to the lesion,difficulties were experienced in the positioning and stabilization of a gastroscope in 15 patients who were thus assigned to the balloonguided ESD group.A balloon overtube was placed with a gastroscope to provide an endoscopic channel to the lesion in cases with preoperatively identified difficulties related to *** ESD was performed following standard procedures.A submucosal fluid bleb was created with hyaluronic acid solution.A circumferential mucosal incision was made to marginate the *** isolated lesion was finally excised from the deeper layers with repetitive electrosurgical dissections with needle *** success of colorectal ESD,procedural feasibility,and procedure-related complications were the main outcomes and ***:The overall en bloc excision rate of colorectal ESD during this study at our institution was 95.6%.En bloc excision of the lesion was successfully achieved in 13 of the 15 patients(86.7%)in the balloon overtube-guided colorectal ESD group,which was comparable to the results of the standard ESD group with better accessibility to the lesion(30/30,100%,not statistically significant).CONCLUSION:Use of a balloon overtube can improve access to the lesion and facilitate scope manipulation for colorectal ESD.

关键词： Balloon overtube Colorectal neoplasm Early colorectal cancer En bloc tumor excision Endoscopic submucosal dissection Laterally spreading tumor

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