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Five-year survival following a medial pancreatectomy for an invasive ductal carcinoma from the body of the pancreas

World Journal of Gastroenterology 2006年第5期12卷 822-824页

作者： Hideki Abe Kouichi Tsuneyama kazuhiro tsukada Masatoshi Makuuchi Hepatobiliarypancreatic Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyoJapan Department of Pathology Toyama Medical and Pharmaceutical UniversityToyamaJapan Second Department of Surgery Toyama Medical and Pharmaceutical University.ToyamaJapan

We report a rare case of a patient who survived for 5 years after undergoing a medial pancreatectomy for invasive ductal carcinoma originating from the body of the pancreas. A 63-year-old woman was diagnosed as a small cancer of the pancreatic body, and surgery was performed. Even though the tumor was a carcinoma, its small size prompted us to perform a medial pancreatectomy with regional lymph nodes dissection. Additional chemoradiation was performed and, five years after surgery, the patient is well with no signs of recurrence. Medial pancreatectomy for invasive ductal carcinoma has not ever been reported. Furthermore, long-term survival after a lumpectomy for invasive ductal carcinoma has never been reported in the literatures. The current case suggests that long-term survival in patients with invasive ductal carcinoma of the pancreas may be associated with the pathological or biological features of pancreatic carcinoma.

关键词： Ductal carcinoma Medial pancreatectomy Pancreatic carcinoma

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Expression Analysis of Aquaporin-1 (Aqp-1) in Human Biliary Tract Carcinoma

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Journal of Cancer Therapy 2016年第1期7卷 17-23页

作者： Shinichi Sekine Tomoyuki Okumura Takuya Nagata Kazuto Shibuya Isaku Yoshioka Koshi Matsui Ryouta Hori kazuhiro tsukada Department of Surgery and Science University of Toyama Toyama Japan

Background: Aquaporins (AQPs) are important in controlling bile water secretion. AQP is related to the invasion and metastasis of cancer. However, the relationship of biliary tract cancer is not clear. The role of AQP-1 in cancer cell is also unknown. Methhods: We analyzed AQP-1 expression using tissue microarray (TMA) in 99 samples immunohistochemically (50 gallbladder carcinoma, 39 bile duct carcinoma and 10 Papilla Vater carcinoma patients who underwent surgery at our department from 1997 to 2011). Gene expressions were evaluated by the combination of the immunohistological intensity and distribution. The expression level is compared to the clinico-pathological data of the patients. Results: In the TMA, depth of tumor invasion and histological type are associated with AQP-1 expression. The group of patients with high AQP-1 expression is associated with higher rates of disease specific survival (log-rank p = 0.013). Cox’s proportional hazard model reveals that AQP-1 expression is an independent prognostic factor (RR, 0.324;p = 0.001) in multivariate analysis. There is a correlation between AQP-1 expression and tumor invasion. Conclusions: These observations of this study suggest that AQP-1 expression may be favorable biomarkers associated with prognosis and tumor invasion in biliary tract carcinoma.

关键词： Aquaporin Biliary Tract Carcinoma Tissue Microarray Immunohistochemistry

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