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Comparison of DWI and PET/CT in evaluation of lymph node metastasis in uterine cancer

World Journal of Radiology 2012年第5期4卷 207-214页

作者： kazuhiro kitajima Erena Yamasaki Yasushi Kaji Koji Murakami Kazuro Sugimura Department of Radiology Kobe University Graduate School of Medicine Kobe 650-0017 Japan Department of Radiology Dokkyo University School of Medicine Mibu 321-0293 Japan Division of Nuclear Medicine Department of Diagnostic Radiology Keio University School of Medicine Tokyo 160-8582 Japan

AIM: To investigate diffusion-weighted imaging (DWI) and positron emission tomography and computed tomography (PET/CT) with Ⅳ contrast for the preoperative evaluation of pelvic lymph node (LN) metastasis in uterine cancer. METHODS: Twenty-five patients with endometrial or cervical cancer who underwent both DWI and PET/CT before pelvic lymphadenectomy were included in this study. For area specific analysis, LNs were divided into eight regions: both common iliac, external iliac, internal iliac areas, and obturator areas. The classification for malignancy on DWI was a focally abnormal signal intensity in a location that corresponded to the LN chains on the T1WI and T2WI. The criterion for malignancy on PET/CT images was increased tracer uptake by the ***: A total of 36 pathologically positive LN areas were found in 9 patients. With DWI, the sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detecting metastatic LNs on an LN area-by-area analysis were 83.3%, 51.2%, 27.3%, 93.3% and 57.0%, respectively, while the corresponding values for PET/CT were 38.9%, 96.3%, 70.0%, 87.8% and 86.0%. Differences in sensitivity, specificity and accuracy were significant (P < 0.0005). CONCLUSION: DWI showed higher sensitivity and lower specificity than PET/CT. Neither DWI nor PET/CT were sufficiently accurate to replace lymphadenectomy.

关键词： Uterine cancer Lymph node metastasis Magnetic resonance imaging Diffusion-weighed imaging Positron emission tomography and computed tomography

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Findings of <sup>18</sup>F-Fluorodeoxyglucose Positron-Emission Tomography in Methotrexate-Related Lymphoproliferative Disorder

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Open Journal of Radiology 2014年第4期4卷 293-300页

作者： Atsushi K. Kono kazuhiro kitajima Hiroshi Mmatsuoka Kyoko Otani Tomoo Itoh Kazuro Sugimura Department of Radiology Kobe University Hospital Kobe Japan Department of Radiology Kobe University Graduate School of Medicine Kobe Japan Division of Medical Oncology/Hematology Department of Medicine Kobe University Graduate School of Medicine Kobe Japan Department of Diagnostic Pathology Kobe University Hospital Kobe Japan

Introduction: The use of methotrexate (MTX) for rheumatoid arthritis (RA) is increasing. However, the immune suppression state leads to the occurrence of lymphoproliferative disorder (MTX-LPD). The purpose of this study was to describe the findings of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in MTX-LPD patients, and compare it with non-MTX-related malignant lymphoma (ML). Materials and Methods: We retrospectively reviewed 11 MTX-LPD patients (9 female, mean age 68.3 years) and 21 ML patients (7 female, mean age 60.6 years) with a histopathological diagnosis. FDG-PET imaging was performed using a standard oncology procedure. We assessed the disease distribution based on FDG-PET images and measured the maximum standardized up take values (SUVmax) for each region. Results: Mean values of SUVmax in MTX-LPD and ML were 14.6 and 17.2, respectively (p = 0.49). In MTX-LPD, 55 lesions met the Cotswold classification, consisting of 37 nodal and 18 extranodal lesions. In ML, 82 lesions were found, consisting of 68 nodal and 14 extranodal lesions. MTX-LPD showed a higher incident of the involvement in extranodal lesions throughout the whole body (p < 0.001). Conclusion: Because this disease occurs widely throughout the whole body, we need to pay attention to the less frequent sites as well when performing PET imaging in patients with MTX-LPD.

关键词： Fluorodeoxyglucose (FDG) F 18 Lymphoma Methotrexate Positron-Emission Tomography (PET) Rheumatoid Arthritis

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Usability of Deformable Image Registration for Adaptive Radiotherapy in Head and Neck Cancer and an Automatic Prediction of Replanning

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第1期6卷 10-20页

作者： Masao Tanooka Hiroshi Doi Toshihisa Ishida kazuhiro kitajima Tsukasa Wakayama Toshiyuki Sakai Hiroyuki Inoue Noriko Kotoura Kengo Kosaka Kazuo Tarutani Masayuki Fujiwara Norihiko Kamikonya Department of Radiological Technology Hyogo College of Medicine College Hospital Nishinomiya Japan Department of Radiology Hyogo College of Medicine Hyogo Nishinomiya Japan

Deformable image registration (DIR) has been an important component in adaptive radiotherapy (ART). Our goal was to examine the accuracy of ART using the dice similarity coefficient (DSC) and to determine the optimal timing of replanning. A total of 22 patients who underwent volume modulated arc therapy (VMAT) for head and neck (H&N) cancers were prospectively analyzed. The planning target volume (PTV) was to receive a total of 70 Gy in 33 fractions. A second planning CT scan (rescan) was performed at the 15th fraction. The DSC was calculated for each structure on both CT scans. The continuous variables to predict the need for replanning were assessed. The optimal cut-off value was determined using receiver operating characteristic (ROC) curve analysis. In the correlation between body weight loss and DSC of each structure, weight loss correlated negatively with DSC of the whole face (rs = -0.45) and the face surface (rs = -0.51). Patients who required replanning tended to have experienced rapid weight loss. The threshold DSC was 0.98 and 0.60 in the whole face and the face surface, respectively. Patients who showed low DSC in the whole face and the face surface required replanning at a significantly high rate (P < 0.05 and P < 0.01). Weight loss correlated with DSC in both the whole face and the face surface (P < 0.05 and P < 0.05). The DSC values in the face predicted the need for replanning. In addition, weight loss tended to correlate with DSC. DIR during ART was found to be a useful tool for replanning.

关键词： Deformable Image Registration Adaptive Radiotherapy Head and Neck Can-cer Dice Similarity Coefficient Volume Modulated Arc Therapy

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乳腺癌FDG PET显像和DWI的预后预测价值

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中华核医学与分子影像杂志 2018年第7期38卷 517-517页

作者：唐军 kazuhiro kitajima Yasuo Miyoshi Toshiko Yamano Soichi Odawara Tomoko Higuchi Koichiro Yamakado 上海交通大学医学院附属苏州九龙医院核医学科 Division of Nuclear Medicine and PET Center Department of RadiologyHyogo College of Medicine

目的研究乳腺癌患者术前;F-脱氧葡萄糖（FDG）PET/CT显像和磁共振弥散加权成像（DWI）的预后预测价值。方法 73例新近诊断为浸润性乳腺癌的患者术前进行了全身FDG PET/CT显像和含DWI的3 T磁共振成像。使用对数秩和检验及Cox分析法回顾... 详细信息

目的研究乳腺癌患者术前;F-脱氧葡萄糖（FDG）PET/CT显像和磁共振弥散加权成像（DWI）的预后预测价值。方法 73例新近诊断为浸润性乳腺癌的患者术前进行了全身FDG PET/CT显像和含DWI的3 T磁共振成像。使用对数秩和检验及Cox分析法回顾性评价了原发肿瘤PET显像参数[最大标准摄取值(SUV;)、平均SUV(SUV;)、代谢性肿瘤体积（MTV）和病灶糖酵解总量（TLG）]、DWI参数[平均表观扩散系数(ADC;)和最小ADC(ADC;)]及与无病生存（DFS）率有关的临床病理因数在预后预测中的作用。结果所有患者的中位总随访时间为32.3个月,6例（8.2%）患者有复发。受试者工作特征曲线分析和对数秩和检验发现原发肿瘤SUV;≥3.60、MTV≥3.15和TLG≥16.0的患者DFS低于SUV;<3.60、MTV<3.15和TLG<16.0的患者（P=0.005 4、P=0.005 4和P<0.000 1）。SUV;、ADC;和ADC;与复发无相关性。单因素分析结果显示,SUV;（P=0.005 4）、MTV（P=0.005 4）、TLG（P<0.000 1）、肿瘤大小（P=0.008 3）、雌激素受体阴性（P=0.046）、孕激素受体阴性（P=0.002 3）、人上皮生长因子受体2阳性（P=0.043）和腋窝淋巴结转移（P=0.003 7）与复发相关。但是,多因素分析发现以上因素无一是独立预测因子。结论乳腺癌原发病灶术前的SUV;、MTV和TLG是复发的预后预测因子,而ADC不是。

关键词：乳腺癌预后 PET DWI TLG

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A divide & conquer approach to liveness model checking under fairness & anti-fairness assumptions

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Frontiers of Computer Science 2019年第1期13卷 51-72页

作者： kazuhiro OGATA School of Information Science Japan Advanced Institute of Science and Technology (JAIST) 1-1 AsahidaiNomiIshikawa 923-1292Japan

This paper proposes an approach to making livehess model checking problems under fairness *** proposed method divides such a problem into smaller ones that can be *** is not superior to existing tools dedicated to model checking liveness properties under fairness assumptions in terms of model checking performance but has the following positive aspects:1)the approach can be used to model check liveness properties under anti-fairness assumptions as well as fairness assumptions,2)the approach can help humans better understand the reason why they need to use fairness and/or anti-fairness assumptions,and 3)the approach makes it possible to use existing linear temporal logic model checkers to model check liveness properties under fairness and/or anti-fairness assumptions.

关键词： anti-fairness fairness liveness property Maude model checking

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Molecular Integral for the Double Electron-Repulsion Potential： A Closed Form Underived for Forty Years

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Chinese Physics Letters 2005年第12期22卷 3052-3053页

作者： kazuhiro Ishida Department of Chemistry and Frontier Research Centre for Computational Sciences Faculty of ScienceTokyo University of Science Shinjuku-ku Tokyo 162-8601 Japan

A closed form of the title integral formula over the Gaussian-type orbitals is derived for the first time. The present closed form is analytical as the multiple hyper-geometric function of five variables.

关键词： 3-BODY INTERACTION INTEGRALS MATHEMATICAL METHODS SHELL ATOMS IONS

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Positively Expansive Differentiable Maps

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Acta Mathematica Sinica,English Series 2010年第10期26卷 1839-1846页

作者： kazuhiro SAKAI Department of Mathematics Utsunomiya University

We study the space of positively expansive differentiable maps of a compact connected C ∞ Riemannian manifold without boundary. It is proved that （i） the C1-interior of the set of positively expansive differentiable maps coincides with the set of expanding maps, and （ii） Cl-generically, a differentiable map is positively expansive if and only if it is expanding.

关键词： Positively expansive maps expanding marts

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Strategies to enhance hydrogen storage performances in bulk Mg-based hydrides

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Journal of Materials Science & Technology 2023年第22期153卷 139-158页

作者： Xin F.Tan Manjin Kim kazuhiro Yasuda kazuhiro Nogita School of Mechanical and Mining Engineering The University of QueenslandSt.LuciaQLD 4072Australia Department of Applied Quantum Physics and Nuclear Engineering Kyushu UniversityFukuoka 819-0395Japan John de Laeter Centre Curtin UniversityGPO Box U1987PerthWA 6845Australia

Bulk Mg-based hydrogen storage materials have the potential to provide a low-cost solution to diversify energy storage and *** to nano powders which require handling and processing under hydrogen or an inert gas atmosphere,bulk Mg-based alloys are safer and are more oxidation *** methods and existing infrastructures can be used to process and handle these ***,bulk Mg alloys have smaller specific surface areas,resulting in slower hydrogen sorp-tion kinetics,higher equilibrium temperatures,and enthalpies of hydride *** work reviews the effects of the additions of a list of alloying elements and the use of innovative processing meth-ods,e.g.,rapid solidification and severe plastic deformation processes,to overcome these *** challenges,advantages,and weaknesses of each method and future perspectives for the development of Mg-based hydrogen storage materials are discussed.

关键词： Hydrogen storage Metal hydrides Mg alloys Mg hydrides

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Tight glycemic control using an artificial endocrine pancreas may play an important role in preventing infection after pancreatic resection

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World Journal of Gastroenterology 2012年第29期18卷 3787-3789页

作者： kazuhiro Hanazaki Department of Surgery Kochi Medical SchoolKochi UniversityKohasuOkochoNankoku-CityKochi 783-8505Japan

It is well known that perioperative hyperglycemia is the main cause of infectious complications after *** improve perioperative glycemic control,we wish to highlight and comment on an interesting paper published recently by the Annals of Surgery entitled:"Early postoperative hyperglycemia is associated with postoperative complications after pancreatoduodenectomy(PD)" by Eshuis et *** authors concluded that early postoperative glucose levels more than 140 mg/dL was significantly associated with complications after *** we recommend that perioperative tight glycemic control(TGC) is an effective method to prevent postoperative complications including surgical site infection after distal,proximal,and total pancreatic resection,we support strongly this conclusion drawn in this ***,if early postoperative glucose control in patients undergoing PD was administrated by conventional method such as sliding scale approach as described in this article,it is difficult to maintain ***,we introduce a novel perioperative glycemic control using an artificial endocrine pancreas against pancreatogenic diabetes after pancreatic resection including PD.

关键词： Tight glycemic control Pancreatic resection Surgical site infection Artificial endocrine pancreas

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Full-scale dynamic testing of response-controlled buildings and their components:concepts,methods,and findings

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 167-181页

作者： Kazuhiko Kasai kazuhiro Matsuda Structural Engineering Research Center Tokyo Institute of Technology Director and Professor Assistant Professor

A series of shake-table tests was conducted by inserting and replacing 4 different types of dampers,or by removing them in a full-scale 5-story steel frame building. The objective is to validate response-control technologies that are increasingly adopted for major Japanese buildings without being attested to-date by a major earthquake. Test results are briefly described,and good performance of the dampers and frame demonstrated. The concepts of the full-scale building tests and various contributions are discussed. The difficulty associated with full-scale dynamic testing is explained.

关键词： response-controlled building steel frame steel damper viscous damper oil damper viscoelastic damper

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