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Time-dependent effects of castration on the bladder function and histological changes in the bladder and blood vessels

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Asian Journal of Andrology 2014年第3期16卷 457-460页

作者： Tomohiro Magari Yasuhiro Shibata Seiji Arai Bunzo Kashiwagi Keiji Suzuki kazuhiro Suzuki Department of Urology Gunma University Graduate School of Medicine Maebashi Department of Urology Kurosawa Hospital Takasaki Department of Pathology Gunma University Graduate School of Health Sciences Maebashi Japan

We examined the effect of androgens on bladder blood flow （BBF）, bladder function and histological changes in castrated male rats. Male Wistar rats were classified into unoperated group （control group）, groups castrated at the age of 8weeks （group 8wPC） and groups castrated at the age of 4weeks （group 4wPC）. Each rat was used at the age of 20weeks. BBF was measured using fluorescent microspheres. Bladder cystometry was performed without anesthesia or restraint; the bladder was first irrigated with saline and then with 0.25% acetic acid （AA） solution. Maximum voiding pressure and voiding interval were measured. The bladder and lilac artery were histologically examined for differences in smooth muscle and quantity of collagen fiber to analyze the effect of castration on the smooth muscle content. No differences were noted in BBF following castration. The voiding intervals for all groups were shortened （P 〈 0.001） following AA irrigation. No significant difference was noted in the maximum voiding pressure. Histological changes were observed in bladder and lilac artery. Smooth muscle/collagen ratio at the bladder was lower in groups 8wPC and 4wPC compared to the control group （P 〈 0.01）, while that at the lilac artery was decreased in group 4wPC compared to the control group （P〈 0.001）. In conclusion, our findings indicate that castration does not alter BBF, but leads to histological changes in the bladder as well as its associated blood vessels.

关键词： bladder blood flow bladder function castration fluorescent microsphere method histological changes smooth muscle/collagen ratio

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Research Activities of Nanodimensional Standards Using Atomic Force Microscopes,Transmission Electron Microscope,and Scanning Electron Microscope at the National Metrology Institute of Japan

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Nanomanufacturing and Metrology 2022年第2期5卷 83-90页

作者： Ichiko Misumi Ryosuke Kizu Hiroshi Itoh kazuhiro Kumagai Keita Kobayashi Tomoo Sigehuzi National Institute of Advanced Industrial Science and Technology AIST Tsukuba Central 51-1-1 HigashiIbaraki305-8565TsukubaJapan

With the progress in nanotechnology,the importance of nanodimensional standards is *** nanodimensional standards requires multiple types of high-precision microscopy *** National Metrology Institute of Japan(NMIJ),one of the research domains in the National Institute of Advanced Industrial Science and Technology(AIST),is developing nanodimensional standards using atomic force,transmission electron,and scanning electron *** current status of nanodimensional standards in NMIJ is introduced herein.

关键词： Nanodimensional standards Calibration Uncertainty AFM TEM SEM

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Pasting properties by near-infrared re flectance analysis of whole grain paddy rice samples

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Journal of Innovative Optical Health Sciences 2015年第6期8卷 45-52页

作者： Pornarree Siriphollakul Sirichai Kanlayanarat Ronnarit Rittiron Jaitip Wanitchang Thongchai Suwonsichon Panida Boonyaritthongchai kazuhiro Nakano Division of Postharvest Technology KingMongkut's University of Technology Thonburi 126 Pracha-Utid Road Bangmod ToongkruBangkok 10140Thailand Department of Food Engineering Faculty of Engineering at Kamphaengsaen Kasetsart UniversityNakhonpathomThailand Division of Agricultural Engineering and Technology Rajamungala University of Technology Tawan-ok 43/6 BangphaSrirachaChonburiThailand Department of Product Development Kasetsart University 50 Ngam Wong Wan Rd LadyaoChatuchak BangkokThailand Graduate School of Science and Technology Niigata University 8050 Ikarashi 2-no-cho Nishi-kuNiigata950-2181 Japan

A rapid predictive method based on near-infrared re flectance spectroscopy(NIRS)of paddy rice was developed to measure the pasting properties of *** paddy rice samples were scanned by a near-infrared re flectance spectrometer in the wavelength region of 1400–2400 nm and preprocessed by mathematical pretreatments prior to pasting properties analysis using a rapid visco-analyzer(RVA).The results indicated that the developed models of setback(SB),peak viscosity(PV),breakdown(BD)and consistency(CS)provided good prediction results with relatively high correlation coe±cients(0.81–0.96).In addition,the validity of the calibration models was statistically *** error of prediction(SEPT) and bias were small enough without any significance at 95% confidence ***,this study proved that the use of NIRS for predicting pasting properties was feasible in paddy rice and could be applied in commercial trade and research.

关键词： Pasting properties near-infrared spectroscopy paddy rice

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Nicotine Treatment Induces Expression of Matrix Metalloproteinases in Human Osteoblastic Saos-2 Cells

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Acta Biochimica et Biophysica Sinica 2006年第12期38卷 874-882页

作者： Tomoko KATONO Takayuki KAWATO Natsuko TANABE Naoto SUZUKI kazuhiro YAMANAKA Hitoshi OKA Masafumi MOTOHASHI Masao MAENO Kanda Surugadai Chiyoda-kuTokyo 101-8310Japan Department of Oral Health Sciences Nihon UniversitySchool of DentistryTokyo 101-8310Japan Japan Department of Biochemistry Nihon University School of Dentistry.Tokyo 101-8310Japan

Tobacco smoking is an important risk factor for the development of severe ***,we showed that nicotine affected mineralized nodule formation,and that nicotine andlipopolysaccharide stimulated the formation of osteoclast-like cells by increasing production of macrophagecolony-stimulating factor （M-CSF） and prostaglandin E2（PGE2） by human osteoblastic Saos-2 *** thepresent study,we examined the effects of nicotine on the expression of matrix metalloproteinases （MMPs）,tissue inhibitors of matrix metalloproteinases （TIMPs）,the plasminogen activation system including thecomponent of tissue-type plasminogen activator （tPA）,urokinase-type PA （uPA）,and PA inhibitor type 1（PAI-1）,α7 nicotine receptor,and *** also examined the effect of the nicotine antagonist D-tubocurarineon nicotine-induced expression of *** expression was examined using real-time polymerase chainreaction （PCR） to estimate mRNA *** addition,expression of the MMP,TIMP,uPA,tPA,and PAI-1proteins was determined by Western blotting *** treatment caused expression of MMP-1,2,3,and 13,but not MMP-14,to increase significantly after 5 or 10 d of culture;MMP-14 expression did notchange through day *** of MMP-1 expression by nicotine treatment was eliminated bysimultaneous treatment with *** the presence of nicotine,expression of uPA,PAI-1,orTIMP-1,2,3,or 4 did not change over 14 d of culture,whereas expression of tPA increased significantly byday *** also increased expression of the α7 nicotine receptor and c-fos *** results suggestthat nicotine stimulates bone matrix turnover by increasing production of tPA and MMP-1,2,3,and 13,thereby tipping the balance between bone matrix formation and resorption toward the latter process.

关键词： nicotine matrix metalloproteinase tissue inhibitor of matrix metalloproteinase plasminogen activation system

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Involvement of Sphingosine 1-Phosphate (S1P) Receptor Type 1 and Type 4 in Migratory Response of Mouse T Cells toward S1P

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Cellular & Molecular Immunology 2006年第6期3卷 429-437页

作者： Hirofumi Matsuyuki Yasuhiro Maeda kazuhiro Yano Kunio Sugahara Kenji Chiba Takayuki Kohno Yasuyuki Igarashi Research Laboratory III (Immunology) Pharmaceuticals Research Division Mitsubishi Pharma Corporation Yokohama Japan Discovery Technology Laboratory Pharmaceuticals Research Division Mitsubishi Pharma Corporation Yokohama Japan Department of Biomembrane and Biofunctional Chemistry Graduate School of Pharmaceutical Sciences Hokkaido University Sapporo Japan

Sphingosine 1-phosphate （S1P）, a pleiotropic lysophospholipid, regulates signal transduction pathway via Gprotein-coupled receptors termed S1P1-5 in several types of the cells including lymphocytes. Higher levels of S1P4 mRNA as well as S1P1 mRNA are expressed in lymphoid tissues such as the spleen, thymus, lymph nodes, and Payer＇s patches. In contrast to S1P1 that plays an essential role in lymphocyte egress, little is known about the role of S1P4 in immune system. In this study, we found that S1P at 10 to 100 nM significantly induced the cell migration and the significant levels of S1P1 and S1P4 mRNA were expressed in mouse CD4 T cells, D10.G4.1 mouse Th2 cells, and ***-2 mouse thymoma cells. In D10.G4.1 and ***-2 cells, S1P-induced migration was almost completely inhibited by pretreatment with pertussis toxin, Clostoridium difficile toxin B, and （S）-enantiomer of FTY720-phosphate, a potent agonist at S1P1 and S1P4. The members of the Rho family small GTPase, Cdc42 and Rac were activated by S1P stimulation in these cells. The transfection with dominant negative or constitutively active forms of Cdc42 and Rac revealed that the activation of both Cdc42 and Rac is essential for S1P-induced migration of these cells. The immunoprecipitation assays using CHO cells co-expressing both S1P4 and S1P1 receptors indicated that S1P4 and S1P1 are associated on the cell surface. These results suggest that the association of S1P4 and S1PI plays an important role in migratory response of mouse T cells toward S1P.

关键词： S1Pi S1P4 S1P FTY720 T cell migration

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Eustachian tube involvement in a patient with relapsing polychondritis detected by magnetic resonance imaging:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1441-1446页

作者： Daisuke Yunaiyama Akiko Aoki Hiroshi Kobayashi Miwako Someya Mitsuru Okubo kazuhiro Saito Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Radiology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Rheumatology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan

BACKGROUND Relapsing polychondritis(RP)is a rare inflammatory disease involving the systemic cartilage,such as the auricle,trachea,and bronchiole,among others.A patient with RP shows variable symptoms based on the involved *** SUMMARY A 72-year-old Japanese woman with a history of redness of the bilateral auricles for 3 d was referred to a *** clinician prescribed antibiotics to the patient;however,the symptoms worsened;thus,she was referred to our *** and neck magnetic resonance imaging(MRI)showed edematous auricle with remarkable contrast,fluid collection in the bilateral mastoid cells,suggesting otitis *** eustachian tube(ET)on the right side was also edematous with contrast *** patient was suspected of RP according to the diagnostic criteria.A biopsy of the auricular cartilage was performed by an otorhinolaryngologist,confirming pathological proof of *** with steroids were immediately administered *** We highlight a rare case of RP with radiologically confirmed involvement of ET in the MRI.

关键词： Relapsing polychondritis Magnetic resonance imaging Contrast enhancement Otitis media with effusion Eustachian tube Case report

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Self-Restoration Properties of VWP Networks by Spare Wavelength Optimization

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光学学报 2003年第S1期23卷 751-752页

作者： Yu Sasaki Kiyoshi Nakagawa Katsumi Takano kazuhiro Kondo Graduate School of Science and Engineering Yamagata University 4-3-16 Jonan Yonezawa Yamagata 992-8510 JapanGraduate School of Science and Engineering Yamagata University 4-3-16 Jonan Yonezawa Yamagata 992-8510 JapanGraduate School of Science and Engineering Yamagata University 4-3-16 Jonan Yonezawa Yamagata 992-8510 JapanGraduate School of Science and Engineering Yamagata University 4-3-16 Jonan Yonezawa Yamagata 992-8510 Japan

The self-restoration properties in VWP networks are investigated with optimization about spare wavelength by simulations. Rapid restoration can be achieved by selection of rerouting path with long delay and no delay-l... 详细信息

关键词： of VWP work in et it link by

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Causal role of Helicobacter pylori infection in gastric cancer

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World Journal of Gastroenterology 2006年第2期12卷 181-186页

作者： Takafumi Ando Yasuyuki Goto Osamu Maeda Osamu Watanabe kazuhiro Ishiguro Hidemi Goto Department of Gastroenterology Nagoya University Graduate School of MedicineJapan

Gastric cancer is the second most frequent cancer in the world, accounting for a large proportion of all cancer cases in Asia, Latin America, and some countries in Europe. Helicobacter pylori（H pylori） is regarded as playing a specific role in the development of atrophic gastritis, which represents the most recognized pathway in multistep intestinal-type gastric carcinogenesis. Recent studies suggest that a combination of host genetic factors, bacterial virulence factors, and environmental and lifestyle factors determine the severity of gastric damage and the eventual clinical outcome of H pylori infection. The seminal discovery of Hpylori as the leading cause of gastric cancer should lead to effective eradication strategies. Prevention of gastric cancer requires better screening strategies to identify candidates for eradication.

关键词： Gastric cancer Host genetic factors Hpylori Bacterial virulence factors

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Dietary habits and behaviors associated with nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第7期20卷 1756-1767页

作者： Kenichiro Yasutake Motoyuki Kohjima kazuhiro Kotoh Manabu Nakashima Makoto Nakamuta Munechika Enjoji Department of Health and Nutrition Sciences Faculty of Health and Social Welfare SciencesNishikyushu UniversityKanzaki 842-8585Japan Department of Gastroenterology and Clinical Research Center Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-8563Japan Department of Hepatology and Pancreatology Kyushu University HospitalFukuoka 812-8582Japan Faculty of Pharmaceutical Sciences Fukuoka UniversityFukuoka 814-0180Japan Health Care Center Fukuoka UniversityFukuoka 814-0180Japan

Nonalcoholic fatty liver disease(NAFLD)is one of the most frequent causes of health problems in Western(industrialized)***,the incidence of infantile NAFLD is increasing,with some of these patients progressing to nonalcoholic *** trends depend on dietary habits and *** particular,overeating and its associated obesity affect the development of *** problems in patients with NAFLD include excess intake of energy,carbohydrates,and lipids,and shortages of polyunsaturated fatty acids,vitamins,and *** nutritional therapeutic approaches are required for prophylaxis and treatment of NAFLD,continuous nutrition therapy is difficult for many patients because of their dietary habits and lifestyle,and because the motivation for treatment differs among ***,it is necessary to assess the nutritional background and to identify nutritional problems in each patient with *** assessing dietary habits,it is important to individually evaluate those that are consumed excessively or insufficiently,as well as inappropriate eating *** nutrition therapy requires patient education,based on assessments of individual nutrients,and continuing the *** this article,we update knowledge about NAFLD,review the important aspects of nutritional assessment targeting treatment success,and present some concrete nutritional care plans which can be applied generally.

关键词： Nonalcoholic fatty liver disease Nutritional therapy Carbohydrates Fatty acids Cholesterol

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Confirmation of Novel Quantitative Trait Loci for Seed Dormancy at Different Ripening Stages in Rice

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Rice science 2013年第3期20卷 207-212页

作者： kazuhiro SASAKI Yuri KAZAMA Youn CHAE Tadashi SATO Graduate School of Life Sciences Tohoku University Plant Breeding Genetics and Biotechnology DivisionInternational Rice Research Institute

Seed dormancy contributes resistance to pre-harvest sprouting. Effects on respective quantitative trait loci （QTLs） for dormancy should be assessed by using fresh seeds before germinability altered through storage. We investigated QTLs related to seed dormancy using backcross inbred lines derived from a cross between Nipponbare and Kasalath. Four putative QTLs for seed dormancy were detected immediately after harvest using composite interval mapping. These putative QTLs were mapped near C1488 on chromosome 3 （qSD-3.1）, R2171 on chromosome 6 （qSD-6.1）, R1245 on chromosome 7 （qSD-7.1） and C488 on chromosome 10 （qSD-IO.1）. Kasalath alleles promoted dormancy for qSD-3.1, qSD-6.1 and qSD-7.1, and the respective proportions of phenotypic variation explained by each QTL were 12.9%, 9.3% and 8.1%. We evaluated the seed dormancy harvested at different ripening stages during seed development using chromosome segment substitution lines （CSSLs） to confirm gene effects. The germination rates of CSSL27 and CSSL28 substituted with the region including qSD-6.1 were significantly lower than those of Nipponbare and other CSSLs at the late ripening stage. Therefore, qSD-6.1 is considered the most effective novel QTL for pre-harvest sprouting resistance among the QTLs detected in this study.

关键词： chromosome segment substitution line heading date quantitative trait locus rice seeddormancy

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