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Acta Pharmacologica Sinica 2005年第4期26卷 423-427页

作者： Eiko SAKURAI Yoshinobu KISO kazuhiko yanai Department of Pharmacology Tohoku University School of Medicine Sendai 980-8575 Japan Department of Pharmacology School of Medicine Zhejiang University Hangzhou 310031 China Department of Pharmacologv School of Medicine Zhejiang University Hangzhou 310031 China Department of Pharmacology Tohoku University School of Medicine Sendai 980-8575 Japan

Aim:To determine the role of dietary low histamine on the seizure development ofpentylenetetrazol (PTZ)-induced kindling in ***:After 14 d of feedingon a low histamine diet (LH,containing 0.145 μmol/g of histamine),the rats werechemically kindled by repeated intraperitoneal injection of a subconvulsant doseof PTZ (35 mg/kg) once every 48 h,and seizure activity of kindling was recordedfor 30 *** in brain samples was analyzed using a high performanceliquid chromatography system with a fluorescence ***:The LH diet induced an increase in seizure response (seizure susceptibility) to thefirst trial of PTZ,and resulted in facilitation of subsequent PTZ kindling process(seizure development).The histamine levels in the cortex,hippocampus,andhypothalamus of LH-treated rats decreased significantly and these changes cor-related well with seizure behavior (r=0.875,0.651,and 0.796,respectively).In addition,chronic kindled seizures resulted in a significant increase of the histamine contentin the cortex and hypothalamus in the LH-fed ***:These find-ings indicate that the histamine in daily food could influence the brain histaminer-gic function,and play an important role in regulating seizure susceptibility.

关键词： seizures pentylenetetrazol brain histamine diet

Influence of dietary low histamine diets in the development of chemical kindling induced by pentylenetetrazole in Sprague Dawley rats

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Influence of dietary low histamine diets in the development ...

THE HISTAMINERGIC NEURON SYSTEM: FROM STUDIES OF RECEPTOR KNOCKOUT MICE TO MOLECULAR PET IMAGING

第十一届全国神经药理学术会议

作者： yanai kazuhiko Department of Pharmacology Tohoku University School of Medicine Sendai 980 -- 8575 Japan

A role for dietary low histamine diets (LH) on the seizure development of pentylenetetrazole (PTZ) - induced kin-dling and excitatory behavior was examined in rats. The chemical kindling started after 14 days of dietary treatment with LH(containing 0.145mol/g of histamine).As compared with the basal histamine diets (BH, containing 7.28 mol/g of hista-mine), the LH produced no neurobehavioral differences,but created a severe seizure development in PTZ - induced kin-

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THE HISTAMINERGIC NEURON SYSTEM: FROM STUDIES OF RECEPTOR KN...

Pharmacological effects of carcinine on histaminergic neurons in the brain

中国药理学会第十届全国神经学术会议暨浙江省药理学会2002年年会

作者： kazuhiko yanai Takehiko Watanabe Tohoku University School of Medicine Department of PharmacologySendai 980-8575 Japan.

Histaminergic neurons are exclusively located at posterior hypothalamus,and they are shown to be involved in various physiological functions through H, H, and H receptors.A role for brain histamine has long been thought to exist in arousal,sleep-wake cycle,appetite control,seizures,learning and memory,aggressive behaviors and ***,hypocretin-containing neurons innervate and excite

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Pharmacological effects of carcinine on histaminergic neuron...

Sitagliptin in treatment of diabetes complicated by chronic hepatitis C

首届长三角科技论坛——长三角生物医药发展论坛

作者： Yoshinobu Kiso kazuhiko yanai Suntory Co.Ltd Shimamoto-choOsaka 618-0012Japan Department of Pharmacology Tohoku University School of MedicineSendai 980-8575Japan

1 Carcinine(beta-alanyl histamine)is an imidazole *** present study was designedto characterize the pharmacological effects of carcinine on histaminergic activity in the brain andon certain neurobehavior.2 Carcinine was highly selective for the histamine 1-I3 receptor over H1 or H2 receptor [Ki (laM)= 0.2939 0.2188 vs. 3621.2 583.9 or 365.3 232.8 M, respectively].3 Carcinine, at a dose of 20 mg kg-slightly increased histidine decarboxylase (HDC) activity inthe cortex (from 0.186 0.069 pmol mg protein"l min1 to 0.227 0.009 pmol mg protein"1 rein’l).In addition, carcinine (10, 20 and 50 mg kg"1) significantly decreased histamine levels in micebrain.4 Like thioperamide, a histamine Ha receptor antagonist, carcinine (20, 50 gM) significantlyincreased 5-HT release from mice cortex slices, but had no apparent effect on dopamine release.5 Carcinine (20 mg kg1) significantly inhibited pentylenetetrazole- induced kindling. Thisinhibition was completedly reversed by (R)-methylhistamine, a representative Ha receptoragonist, and ot-fluromethylhistidine, a selective histidine decarboxylase inhibitor.6 The results of this study provide first and direct evidence that carcinine, as a novel histamineHa receptor antagonist, plays an important role in histaminergic neurons activation and might beuseful in the treatment of certain diseases, such as epilepsy.

关键词： histamine carcinine histamine H3 receptor locomotor activity seizure learning

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Hepatobiliary & Pancreatic Diseases International 2010年第4期9卷 442-443页

作者： yanai H Department of Internal Medicine Kohnodai Hospital National Center for Global Health and Medicine

To the Editor: A high prevalence of glucose intolerance in patients with chronic hepatitis C has been reported, [1] and there is a significant association of chronic hepatitis C with diabetes mellitus (DM). [2] But DM... 详细信息

关键词： DPP Sitagliptin in treatment of diabetes complicated by chronic hepatitis C

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Distributed and Parallel Component Library

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Wuhan University Journal of Natural Sciences 2005年第2期10卷 375-379页

作者： XUZheng-quan XUYang yanai-ping CollegeofComputerScienceandTechnology HuazhongUniversityofScienceandTechnologyWuhan430074HubeiChina

Software component library is the essential part of reuse-based softwaredevelopment. It is shown that making use of a single component library to store all kinds ofcomponents and from which components are searched is very inefficient. We construct multi-librariesto support software reuse and use PVM as development environments to imitate large-scale computer,which is expected to fulfill distributed storage and parallel search of components efficiently andimprove software reuse.

关键词： software reuse component library parallel virtual machine distributedstorage parallel search

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Eth2Vec:Learning contract-wide code representations for vulnerability detection on Ethereum smart contracts

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Blockchain(Research and Applications) 2022年第4期3卷 109-122页

作者： Nami Ashizawa Naoto yanai Jason Paul Cruz Shingo Okamura School of Information Science and Technology Osaka UniversityOsaka 565-0871Japan Osaka University Osaka 565-0871Japan National Institute of Technology Nara CollegeNara 639-1080Japan

Ethereum smart contracts are computer programs that are deployed and executed on the Ethereum blockchain to enforce agreements among untrusting *** the most prominent platform that supports smart contracts,Ethereum has been targeted by many attacks and plagued by security ***,many smart contract vulnerabilities have been discovered in the past *** detect and prevent such vulnerabilities,different security analysis tools,including static and dynamic analysis tools,have been created,but their performance decreases drastically when codes to be analyzed are constantly being *** this paper,we propose Eth2Vec,a machine-learning-based static analysis tool that detects smart contract ***2Vec maintains its robustness against code rewrites;i.e.,it can detect vulnerabilities even in rewritten *** machine-learning-based static analysis tools require features,which analysts create manually,as *** contrast,Eth2Vec uses a neural network for language processing to automatically learn the features of vulnerable *** doing so,Eth2Vec can detect vulnerabilities in smart contracts by comparing the similarities between the codes of a target contract and those of the learned *** performed experiments with existing open databases,such as Etherscan,and Eth2Vec was able to outperform a recent model based on support vector machine in terms of well-known metrics,i.e.,precision,recall,and F1-score.

关键词： Ethereum Smart contracts Blockchain Neural networks Static analysis Code similarity Vulnerability detection

Role of colonoscopy in patients with persistent acute diverticulitis

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World Journal of Gastroenterology 2008年第17期14卷 2763-2766页

作者： Adi Lahat Henit yanai Emad Sakhnini Yoram Menachem Simon Bar-Meir Department of Gastroenterology ChaimSheba Medical Center and Sackler School of Medicine Tel AvivUniversity

AIM： To identify patients with persistent acute diverticulitis who might benefit from an early colonoscopy during their first hospitalization. METHODS： All patients hospitalized between July 2000 and December 2006 for acute diverticulitis who underwent colonoscopy were included in the study. Patients were followed during hospitalization and after discharge. Patients were considered to have a persistent course of acute diverticulitis if symptoms continued after 1 wk of conventional treatment with 1V antibiotics, or if symptoms recurred within 2 mo after discharge. Patients were considered to benefit from an early colonoscopy if the colonoscopy was therapeutic or if it changed a patient＇s outcome. RESULTS： Three hundred and six patients were hospitalized between July 2000 and December 2006 with the diagnosis of acute diverticulitis. Two hundred and twenty four of these were included in the study group. Twenty three patients （10.3%） fulfilled the criteria for a persistent course of acute diverticulitis. Of them, four patients （17.4%） clearly benefited from an early colonoscopy; these patients＇ clinical course is described. None of the patients with a regular non-persistent course demonstrated any benefit from colonoscopy. CONCLUSION： Early colonoscopy detected other significant pathology, which accounted for the clinical presentation in 17% of patients with persistent acute diverticulitis. Therefore, we believe an early colonoscopy should be considered in all patients with a persistent clinical course.

关键词： Persistent acute diverticulitis Early colonoscopy Clinical course

Flotillin-1 downregulates K^＋ current by directly ：oupling with Kv2.1 subunit

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Protein & Cell 2016年第6期7卷 455-460页

作者： Rui Liu Guang Yang MengHua Zhou Yu He yanai Mei Yu Ding School of Life Sciences Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200438 China. School of Life Sciences Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200438 China. yamei@***. School of Life Sciences Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200438 China. yuding@***.

Dear Editor,Flotillin-1 （Flotl, reggie-2） is a lipid raft-associated scaffolding protein that belongs to a family of proteins characterized by an evolutionarily conserved SPFH domain （Browman et al., 2007; Langhorst et al., 2008）. Although flotillin-1 is ubiquitously expressed, it is known to be highly expressed in brain tissue, and has been shown to serve distinct functions in the nervous system.

关键词： lipid scaffolding belongs

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Diverticulitis in the young patient-Is it different?

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World Journal of Gastroenterology 2006年第18期12卷 2932-2935页

作者： Adi Lahat Yoram Menachem Benjamin Avidan Henit yanai Emad Sakhnini Eytan Bardan Simon Bar-Meir Department of Gastroenterology Chaim Sheba Medical Center and Sackler School of MedicineTel Aviv UniversityTel AvivIsrael

AIM： To prospectively study the incidence and the natural history of acute diverticulitis in young patients. METHODS： A total of 207 patients hospitalized at our hospital between January 2000 to February 2005 with the diagnosis of acute diverticulitis were included. Their demographic characteristics, medical history, physical, radiographic and endoscopic findings as well as therapy were recorded. Patients were followed every 6 mo for the first year and later annually. RESULTS： The mean patients＇ age was 61 （range 27-92） years. Twenty- five patients （12%） were younger than 45 years. Acute diverticulitis was significantly more prevalent among male in the young age group as compared to the older age group （19/25, 76% vs 61/182, 33%, respectively, P = 0.0001）. Complications occurred more often in the young age group; 32% vs 13%, （P = 0.002）. During follow-up, 6 patients （28%） remained asymptomatic in the young age group as compared to 87 patients （55%） in the older age group （P = 0.024）. As a result, sigmoidectomies were performed twice as often in the young age group （38% vs 13%, P = 0.002）. CONCLUSION： Diverticulitis in young patients has a male predominance, a more aggressive course with a higher rate of complications and a higher recurrence rate. An earlier surgical approach might be considered in young patients with acute diverticulitis.

关键词： Diverticulitis Young patient Complications Sigmoidectomy