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Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening

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Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： Katsuhisa Horimoto Yuki Suyama Tadamasa Sasaki kazuhiko Fukui Lili Feng Meiling Sun Yamin Tang Yixuan Zhang Dongyin Chen Feng Han SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We have developed a protein array system,named"Phospho-Totum",which reproduces the phosphorylation state of a sample on the *** protein array contains 1471 proteins from 273 known signaling *** to the activation degrees of tyrosine kinases in the sample,the corresponding groups of substrate proteins on the array are phosphorylated under the same *** addition to measuring the phosphorylation levels of the 1471 substrates,we have developed and performed the artificial intelligence-assisted tools to further characterize the phosphorylation state and estimate pathway activation,tyrosine kinase activation,and a list of kinase inhibitors that produce phosphorylation states similar to that of the *** Phospho-Totum system,which seamlessly links and interrogates the measurements and analyses,has the potential to not only elucidate pathophysiological mechanisms in diseases by reproducing the phosphorylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inhibitors.

关键词： Phospho-Totum protein array signal transduction pathways artificial intelligence tools drug screening

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化学泵浦的碘激光器

中国激光 1983年第Z1期 589-589页

作者： kazuhiko serizawa Akira Otsuka Hiroshi Murata Taro Uchiyama Tomoo Fujioka 日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系日本庆应大学电工系

本文给出了使用小尺寸真空泵的在低流速（2米/秒）下运转的横流化学泵浦碘激光器的性能。由化学发生器射出的气流经一个干冰乙醇吸附器,从而除去作为受激体的有效猝灭剂的水蒸气。激光器部分由一个70×2cm的管道组成,1m长的腔安装在离I... 详细信息

本文给出了使用小尺寸真空泵的在低流速（2米/秒）下运转的横流化学泵浦碘激光器的性能。由化学发生器射出的气流经一个干冰乙醇吸附器,从而除去作为受激体的有效猝灭剂的水蒸气。激光器部分由一个70×2cm的管道组成,1m长的腔安装在离I2注入点大约0.8cm的下游处,共振腔由两块反射镜组成:一块曲率半径为5米的全反射镜,另一块部分透过（T=1.5％）的平面镜。喉高为0.6cm的喷嘴放置在腔轴处,以便使分子碘和氧有效地混合。在90％（重量）H2O2,为1.1升和25％（重量）NaOH为0.5升时,采用大于40％的

关键词：碘激光器吸附器气体净化设备碘分子

Light is an Important Limiting Factor for the Vertical Distribution of the Largest Extant Benthic Foraminifer Cycloclypeus carpenteri

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Journal of Earth Science 2022年第6期33卷 1460-1468页

作者： kazuhiko Fujita Yoji Kanda Takashi Hosono Department of Physics and Earth Sciences University of the RyukyusOkinawa903-0213Japan Tropical Biosphere Research Center University of the RyukyusOkinawa903-0213Japan Japan Agency for Marine-Earth Science and Technology(JAMSTEC) Global Oceanographic Data Center(GODAC)Kanagawa236-0001Japan

Cycloclypeus carpenteri is the largest extant benthic foraminifer,dwelling in the deep euphotic zone(a water depth between 60 and 130 m)of the warm oligotrophic Indo-West *** foraminifer harbors diatom endosymbionts and the foraminifer-microalgal association acts like a *** verify that light is an important limiting factor controlling the vertical(depth)distribution of living Cycloclypeus holobionts,their physiological responses to light intensity were examined by short-term metabolic measurements and long-term *** oxygen production(OP)rates measured under different light levels using an oxygen microelectrode indicate that Cycloclypeus holobionts are daily net primary producers adapted to low light levels,with slight photoinhibition(reduced net OP rates relative to a light-saturated rate)over 100μmol photons m^(−2)s^(−1).Long-term growth increments of asexually reproduced juveniles incubated for two months at different light levels ranging from 0 to 100μmol photons m^(−2)s^(−1) show that Cycloclypeus holobionts are adapted to a low light level(∼5μmol photons m^(−2)s^(−1)),but can be acclimatized to a certain low light ranges(<50μmol photons m^(−2)s^(−1)).These experimental results confirm that light is an important environmental gradient affecting the vertical distribution of Cycloclypeus holobionts.

关键词： algal symbiosis diatom large benthic foraminifer oxygen production photosynthesis

Efficacy of adhesive strapping on umbilical hernia in children:a systematic review and meta-analysis of cohort studies

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World Journal of Pediatric Surgery 2023年第4期6卷 206-216页

作者： Takuya Sugimoto Kazunori Tahara Koshi Uchida kazuhiko Yoshimoto Department of Pediatric Surgery Japanese Red Cross Kumamoto HospitalKumamotoJapan

Background Although adhesive strapping(AS)for pediatric umbilical hernia(UH),which was once obsolete,has been reconsidered as a common practice in Japan,its efficacy is still *** study aimed to evaluate its efficacy by reviewing related *** A comprehensive literature search of PubMed,Cochrane,Google Scholar,and Igaku Chuo Zasshi via Ichushi-Web was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses *** studies reporting on the UH closure rate after AS compared with observation-only management were *** A total of 10 cohort studies were included,and the overall UH closure rate was not statistically significant(p=0.31,risk ratio(RR)=0.76,95%confidence interval(CI)0.45 to 1.28).However,there were significant differences in the UH closure rate at the age of 6 months(p<0.01,RR=0.55,95%CI 0.41 to 0.75)and the efficacy of preventing protruding umbilici with redundant skin(p=0.049,RR=0.16,95%CI 0.03 to 0.99).Conclusions Although the efficacy of AS on UH compared with observation-only management did not differ in terms of the UH closure rate,the application of AS may be effective for faster UH closure and the prevention of protruding ***,due to the high heterogeneity of the study,further large-scale studies,particularly randomized controlled trials,are warranted to reach a conclusion.

关键词： hernia prevention closure

Dorsal approach for isolated volar fracture-dislocation of the base of the second metacarpal:A case report

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世界临床病例杂志 2023年第28期11卷 6871-6876页

作者： Taketo Kurozumi Masato Saito kazuhiko Odachi Fumiaki Masui Trauma Center Toranomon HospitalTokyo 105-8470Japan Department of Orthopedic Surgery Chiba-Nishi General HospitalChiba 270-2251Japan

BACKGROUND We report a case with the displacement of an articular fracture fragment of the base of the second metacarpal from the ulnar to the volar side,treated via the dorsal *** dorsal approach can be a good option not only because it allows direct observation of ligament damage and fixation of bone fragments but also because the thin subcutaneous tissue makes the approach *** SUMMARY A 45-year-old man with a right hand injury visited the hospital.A small bone fragment was identified using plain *** radiography revealed the fragment as lying over the volar aspect of the carpometacarpal(CMC)*** tomography revealed that approximately one-third of the CMC joint surface of the second metacarpal was *** provisionally diagnosed an intra-articular fracture with significant CMC joint instability and performed open reduction and internal *** made a dorsal longitudinal incision over the CMC joint between the second and third *** dorsal ligament of the third CMC joint was *** thought it had been dislocated to the volar side and spontaneously reduced to that *** are only few reports of volar dislocation of CMC joint fractures,particularly of the second and third metacarpals;our report is unique as our patient had an intact interosseous ligament between the second and third *** Although past reports have used a palmar approach,the dorsal approach is a good option for these cases.

关键词： Metacarpal bone Fracture-dislocation Mechanism Dorsal approach Carpometacarpal joint Case report

Progress in particle-beam-driven inertial fusion research: Activities in Japan

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Matter and Radiation at Extremes 2018年第1期3卷 12-27页

作者： kazuhiko Horioka Department of Energy Sciences Tokyo Institute of TechnologyNagatsuta 4259Yokohama 226-8502Japan

Research activities in Japan relevant to particle beam inertial fusion are briefly *** activities can be ascended to the *** the past three decades,significant progress in particle beam fusion,pulsed power systems,accelerator schemes for intense beams,target physics,and high-energy-density physics research has been made by a number of research groups at universities and accelerator facilities in ***-flux ions have been extracted from laser ablation *** of the ion velocity distribution in the plasma by an axial magnetic and/or electric field has realized a stable high-flux low-emittance beam *** dynamics have been studied both theoretically and *** efforts have been concentrated on the beam behavior during the final compression stage of intense beam accelerators.A novel accelerator scheme based on a repetitive induction modulator has been proposed as a cost-effective particle-beam driver ***-plasma interaction and pulse-powered plasma experiments have been investigated as relevant studies of particle beam inertial *** irradiation method to mitigate the instability in imploding target has been proposed using oscillating heavy-ion *** new irradiation method has reopened the exploration of direct drive scheme of particle beam fusion.

关键词： Particle beam Inertial confinement fusion Pulse power Heavy ion Laser ion source Beam dynamics Final bunching Induction synchrotron High energy density Warm dense matter

Full-scale dynamic testing of response-controlled buildings and their components:concepts,methods,and findings

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 167-181页

作者： kazuhiko Kasai Kazuhiro Matsuda Structural Engineering Research Center Tokyo Institute of Technology Director and Professor Assistant Professor

A series of shake-table tests was conducted by inserting and replacing 4 different types of dampers,or by removing them in a full-scale 5-story steel frame building. The objective is to validate response-control technologies that are increasingly adopted for major Japanese buildings without being attested to-date by a major earthquake. Test results are briefly described,and good performance of the dampers and frame demonstrated. The concepts of the full-scale building tests and various contributions are discussed. The difficulty associated with full-scale dynamic testing is explained.

关键词： response-controlled building steel frame steel damper viscous damper oil damper viscoelastic damper

A meta-analysis of responses of wheat yield formation to elevated ozone concentration

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Chinese Science Bulletin 2009年第2期54卷 249-255页

作者： KOBAYASHI kazuhiko Department of Global Agricultural Sciences Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo 113-8657 Japan

The meta-analysis method was applied to quantitatively investigate effects of the elevated ozone concentration ([O3]) on chlorophyll concentration, gas exchange and yield components of wheat. There were 39 effective references through Web of Science (ISI, USA) and Chinese journal full-text database (CNKI, China). The results of meta-analysis indicated that elevated [O3] decreased grain yield, grain weight, grain number per ear, ear number per plant and harvest index by 26%, 18%, 11%, 5% and 11%, respectively, relative to ambient air. The decrease in leaf physiological characters was much greater than that in yield when wheat was expose to elevated [O3], while light-saturated photosynthetic rate (Asat), stomatal conductance (Gs) and chlorophyll content (Chl) decreased by 40%, 31%, and 46%, respectively. The responses to elevated [O3] between spring wheat and winter wheat were similar. Most of the variables showed a linear decrease trend with an increase of [O3]. The most significant decrease for Asat, Gs and Chl was found in grain filling stage. Elevated [CO2] could significantly ameliorated or offset the detrimental effects caused by elevated [O3].

关键词：小麦二氧化碳浓度臭氧气体交换

Eastern Asian endemic seed plant genera and their paleogeographic history throughout the Northern Hemisphere

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Journal of Systematics and Evolution 2009年第1期47卷 1-42页

作者： Steven R.MANCHESTER kazuhiko UEMURA Florida Museum of Natural History University of Florida National Museum of Nature and Science

We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the "eastern Asian endemic" genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions al- lowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Ketel-eeria, Metasequoia, Nothotsuga, Pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Em-menopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, Paulownia, Phellodendron, Platycarya, Pteroceltis, Rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, Pteroceltis, and Toricellia.

关键词： Cretaceous eastern Asia endemic paleobotany phytogeography Tertiary