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Suppression of osteosarcoma progression by engineered lymphocyte-derived proteomes

Genes & Diseases 2023年第4期10卷 1641-1656页

作者： Kexin Li Xun Sun Hudie Li Hailan Ma Meng Zhou Kazumasa Minami Keisuke Tamari kazuhiko ogawa Pankita HPandya MReza Saadatzadeh Melissa AKacena Karen EPollok Bai-Yan Li Hiroki Yokota Department of Pharmacology School of PharmacyHarbin Medical UniversityHarbinHeilongjiang 150081China Department of Biomedical Engineering Indiana University Purdue University IndianapolisIndianapolisIN 46202USA Department of Radiation Oncology Osaka University Graduate School of MedicineSuitaOsaka 565-0871Japan Simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202USA Department of Pediatrics Indiana University School of MedicineIndianapolisIN 46202USA Department of Orthopaedic Surgery Indiana University School of MedicineIndianapolisIN 46202USA Indiana Center for Musculoskeletal Health Indiana University School of MedicineIndianapolisIN 46202USA

Cancer cells tend to develop resistance to chemotherapy and enhance aggressive-ness.A counterintuitive approach is to tame aggressiveness by an agent that acts opposite to chemotherapeutic *** on this strategy,induced tumor-suppressing cells(iTSCs)have been generated from tumor cells and mesenchymal stem ***,we examined the possi-bility of generating iTSCs from lymphocytes by activating PKA signaling for suppressing the pro-gression of osteosarcoma(OS).While lymphocyte-derived CM did not present anti-tumor capabilities,the activation of PKA converted them into *** PKA conversely gener-ated tumor-promotive *** a mouse model,PKA-activated CM suppressed tumorinduced bone *** analysis revealed that moesin(MSN)and calreticulin(Calr),which are highly expressed intracellular proteins in many cancers,were enriched in PKA-activated CM,and they acted as extracellular tumor suppressors through CD44,CD47,and *** study presented a unique option for cancer treatment by generating iTSCs that secret tumor-suppressive proteins such as MSN and *** envision that identifying these tu-mor suppressors and predicting their binding partners such as CD44,which is an FDA-approved oncogenic target to be inhibited,may contribute to developing targeted protein therapy.

关键词： Calreticulin Lymphocytes Moesin Osteosarcoma PKA Proteome

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Oxygens matter in the bilayer nickelate superconductor

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Science China(Physics,Mechanics & Astronomy) 2024年第10期67卷 177-178页

作者： kazuhiko Kuroki Department of Physics Graduate School of ScienceOsaka UniversityOsaka 560-0043Japan

The recent discovery of high T_(c) superconductivity under pressure in a bilayer Ruddlesden-Popper-type nickelate La_(3)Ni_(2)O_(7)[1] has attracted great interest both experimentally and ***,following this discovery,superconductivity in a trilayer nickelate La_(4)Ni_(3)O_(10) has also been discovered[2,3].These findings have confirmed the arrival of the nickel age of superconductivity[4],kicked off by the discovery of superconductivity in the thin films of infinite layer nickelates[5].

关键词： superconductivity nickel superconductor

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Study of Ship Propulsion Equipment Driven by High Pressure Gases

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武汉理工大学学报（交通科学与工程版） 1999年第S1期24卷 85-89页

作者： Michihisa Tsutahara 1) kazuhiko ogawa 2) (Graduate School of Science and Technology 1) ,Department of Mechanical Engineering 2) , Nada,Koba 657 8501,Kobe University,Japan)

A new type of nozzle which generates two phase water jet as a propulsion device for ships is *** high pressure gas accelerates the two phase fluid by locally generated pressure gradient,Therefore,the principle of accelerating water flow is different from that of jet *** structure of this device is very simple and there is no moving part,Two dimensional open type nozzles have been found effective and intensive studies have been performed to this type of nozzle by experiments and by numerical *** has been clarified that increase of the water flow rate is essential for improving the performance of this *** suitable shape of the nozzle has been *** was also used as the high pressure gas and higher performance was *** is also considered due to increase of the water flow rate because the steam condenses and the gas flow rate dramatically *** tests by model ships support good possibility for applying this device to actual ships.

关键词： propulsion device running test numerical simulation

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Phosphorylated protein chip combined with artificial intelligence tools for precise drug screening

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Journal of Biomedical Research 2024年第3期38卷 195-205页

作者： Katsuhisa Horimoto Yuki Suyama Tadamasa Sasaki kazuhiko Fukui Lili Feng Meiling Sun Yamin Tang Yixuan Zhang Dongyin Chen Feng Han SOCIUM Inc. Tokyo 1350064Japan International Medical Center Saitama Medical UniversitySaitama 350-1298Japan Artificial Intelligence Research Center National Institute of Advanced Industrial Science and TechnologyTokyo 1350064Japan Department of Informatics and Data Science Sanyo-Onoda City UniversityYamaguchi 7560884Japan International Joint Laboratory for Drug Target of Critical Illnesses School of PharmacyNanjing Medical UniversityNanjingJiangsu 211166China Department of Physiology School of Basic Medical SciencesNanjing Medical UniversityNanjingJiangsu 211166China Gusu School Nanjing Medical UniversitySuzhouJiangsu 215001China National Vaccine Innovation Platform Nanjing Medical UniversityNanjingJiangsu 211166China

We have developed a protein array system,named"Phospho-Totum",which reproduces the phosphorylation state of a sample on the *** protein array contains 1471 proteins from 273 known signaling *** to the activation degrees of tyrosine kinases in the sample,the corresponding groups of substrate proteins on the array are phosphorylated under the same *** addition to measuring the phosphorylation levels of the 1471 substrates,we have developed and performed the artificial intelligence-assisted tools to further characterize the phosphorylation state and estimate pathway activation,tyrosine kinase activation,and a list of kinase inhibitors that produce phosphorylation states similar to that of the *** Phospho-Totum system,which seamlessly links and interrogates the measurements and analyses,has the potential to not only elucidate pathophysiological mechanisms in diseases by reproducing the phosphorylation state of samples,but also be useful for drug discovery,particularly for screening targeted kinases for potential drug kinase inhibitors.

关键词： Phospho-Totum protein array signal transduction pathways artificial intelligence tools drug screening

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Is platinum-loaded titania the best material for dye-sensitized hydrogen evolution under visible light?

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Chinese Journal of Catalysis 2024年第8期63卷 124-132页

作者： Haruka Yamamoto Langqiu Xiao Yugo Miseki Hiroto Ueki Megumi Okazaki Kazuhiro Sayama Thomas E.Mallouk kazuhiko Maeda Department of Chemistry School of ScienceTokyo Institute of Technology2-12-1-NE-2 OokayamaMeguro-kuTokyo 152-8550Japan Department of Chemistry University of Pennsylvania231 S.34th Street PhiladelphiaPA 19104United States Global Zero Emission Research Center(GZR) National Institute of Advanced Industrial Science and Technology(AIST)West16-1OnogawaTsukubaIbaraki 305-8569Japan International Center for Materials Nanoarchitectonics(WPI-MANA) National Institute for Materials Science(NIMS)TsukubaIbaraki 305-0044Japan Research Center for Autonomous Systems Materialogy(ASMat) Tokyo Institute of Technology4259 Nagatsuta-choMidori-kuYokohamaKanagawa 226-8501Japan

A dye-sensitized photocatalyst combining Pt-loaded TiO_(2)and Ru(Ⅱ)tris-diimine sensitizer(RuP)was constructed and its activity for photochemical hydrogen evolution was compared with that of Pt-intercalated HCa_(2)Nb_(3)O_(10)*** the sacrificial donor ethylenediaminetetraacetic acid(EDTA)disodium salt dihydrate was used,RuP/Pt/TiO_(2)showed higher activity than RuP/Pt/HCa_(2)Nb_(3)O_(10).In contrast,when NaI(a reversible electron donor)was used,RuP/Pt/TiO_(2)showed little activity due to back electron transfer to the electron acceptor(I3-),which was gener-ated as the oxidation product of I-.By modification with anionic polymers(sodium poly(styrenesulfonate)or sodium polymethacrylate)that could inhibit the scavenging of conduction band electrons by I3-,the H_(2)production activity from aqueous NaI was improved,but it did not exceed that of RuP/Pt/HCa_(2)Nb_(3)O_(10).Transient absorption measurements showed that the rate of semiconductor-to-dye back electron transfer was slower in the case of TiO_(2)than HCa_(2)Nb_(3)O_(10),but the electron transfer reaction to I3-was much *** results indicate that Pt/TiO_(2)is useful for reactions with sacrificial reductants(e.g.,EDTA),where the back electron transfer reaction to the more reducible product can be ***,more careful design of the catalyst will be nec-essary when a reversible electron donor is employed.

关键词： Artificial photosynthesis Solar fuel Water splitting Z-scheme

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Gastric mixed adenoma-neuroendocrine tumor:A case report

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World Journal of Clinical Cases 2020年第22期8卷 5744-5750页

作者： Shuzo Kohno Hiroaki Aoki Masayuki Kato Masaich ogawa kazuhiko Yoshida Department of Surgery The Jikei University Katsushika Medical CenterTokyo 125-8506Katsushika-kuJapan Department of Endoscopy The Jikei University Katsushika Medical CenterTokyo 125-8506Katsushika-kuJapan

BACKGROUND Gastric mixed adenoma-neuroendocrine tumors(NETs)are quite *** the 2019 world health organization classification of tumors of the digestive system,these were designated as a combination of grade 1 or grade 2 NETs and adenomas or tubular *** are no treatment guidelines for these tumors,and pathological and clinical studies are ***,we review previous case reports and present a case of gastric mixed *** SUMMARY A 66-year-old man underwent gastrointestinal endoscopy for the evaluation of upper abdominal *** examination of the biopsy specimen indicated the possibility of gastric cancer.A histopathological examination by endoscopic submucosal dissection showed a mixed adenoma-NET that was completely excised by endoscopic submucosal *** recurrence was observed on gastrointestinal endoscopy at the 6-mo *** Clinicians'awareness of this rare tumor is important for its timely diagnosis and treatment.

关键词： Adenoma Neuroendocrine tumor Diagnosis Pathology Stomach treatment Case report

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Progress in particle-beam-driven inertial fusion research: Activities in Japan

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Matter and Radiation at Extremes 2018年第1期3卷 12-27页

作者： kazuhiko Horioka Department of Energy Sciences Tokyo Institute of TechnologyNagatsuta 4259Yokohama 226-8502Japan

Research activities in Japan relevant to particle beam inertial fusion are briefly *** activities can be ascended to the *** the past three decades,significant progress in particle beam fusion,pulsed power systems,accelerator schemes for intense beams,target physics,and high-energy-density physics research has been made by a number of research groups at universities and accelerator facilities in ***-flux ions have been extracted from laser ablation *** of the ion velocity distribution in the plasma by an axial magnetic and/or electric field has realized a stable high-flux low-emittance beam *** dynamics have been studied both theoretically and *** efforts have been concentrated on the beam behavior during the final compression stage of intense beam accelerators.A novel accelerator scheme based on a repetitive induction modulator has been proposed as a cost-effective particle-beam driver ***-plasma interaction and pulse-powered plasma experiments have been investigated as relevant studies of particle beam inertial *** irradiation method to mitigate the instability in imploding target has been proposed using oscillating heavy-ion *** new irradiation method has reopened the exploration of direct drive scheme of particle beam fusion.

关键词： Particle beam Inertial confinement fusion Pulse power Heavy ion Laser ion source Beam dynamics Final bunching Induction synchrotron High energy density Warm dense matter

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Full-scale dynamic testing of response-controlled buildings and their components:concepts,methods,and findings

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Earthquake Engineering and Engineering Vibration 2014年第S1期13卷 167-181页

作者： kazuhiko Kasai Kazuhiro Matsuda Structural Engineering Research Center Tokyo Institute of Technology Director and Professor Assistant Professor

A series of shake-table tests was conducted by inserting and replacing 4 different types of dampers,or by removing them in a full-scale 5-story steel frame building. The objective is to validate response-control technologies that are increasingly adopted for major Japanese buildings without being attested to-date by a major earthquake. Test results are briefly described,and good performance of the dampers and frame demonstrated. The concepts of the full-scale building tests and various contributions are discussed. The difficulty associated with full-scale dynamic testing is explained.

关键词： response-controlled building steel frame steel damper viscous damper oil damper viscoelastic damper

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A meta-analysis of responses of wheat yield formation to elevated ozone concentration

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Chinese Science Bulletin 2009年第2期54卷 249-255页

作者： KOBAYASHI kazuhiko Department of Global Agricultural Sciences Graduate School of Agricultural and Life Sciences The University of Tokyo Tokyo 113-8657 Japan

The meta-analysis method was applied to quantitatively investigate effects of the elevated ozone concentration ([O3]) on chlorophyll concentration, gas exchange and yield components of wheat. There were 39 effective references through Web of Science (ISI, USA) and Chinese journal full-text database (CNKI, China). The results of meta-analysis indicated that elevated [O3] decreased grain yield, grain weight, grain number per ear, ear number per plant and harvest index by 26%, 18%, 11%, 5% and 11%, respectively, relative to ambient air. The decrease in leaf physiological characters was much greater than that in yield when wheat was expose to elevated [O3], while light-saturated photosynthetic rate (Asat), stomatal conductance (Gs) and chlorophyll content (Chl) decreased by 40%, 31%, and 46%, respectively. The responses to elevated [O3] between spring wheat and winter wheat were similar. Most of the variables showed a linear decrease trend with an increase of [O3]. The most significant decrease for Asat, Gs and Chl was found in grain filling stage. Elevated [CO2] could significantly ameliorated or offset the detrimental effects caused by elevated [O3].

关键词：小麦二氧化碳浓度臭氧气体交换

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Eastern Asian endemic seed plant genera and their paleogeographic history throughout the Northern Hemisphere

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Journal of Systematics and Evolution 2009年第1期47卷 1-42页

作者： Steven R.MANCHESTER kazuhiko UEMURA Florida Museum of Natural History University of Florida National Museum of Nature and Science

We review the fossil history of seed plant genera that are now endemic to eastern Asia. Although the majority of eastern Asian endemic genera have no known fossil record at all, 54 genera, or about 9%, are reliably known from the fossil record. Most of these are woody (with two exceptions), and most are today either broadly East Asian, or more specifically confined to Sino-Japanese subcategory rather than being endemic to the Sino-Himalayan area. Of the "eastern Asian endemic" genera so far known from the fossil record, the majority formerly occurred in Europe and/or North America, indicating that eastern Asia served as a late Tertiary or Quaternary refugium for taxa. Hence, many of these genera may have originated in other parts of the Northern Hemisphere and expanded their ranges across continents and former sea barriers when tectonic and climatic conditions al- lowed, leading to their arrival in eastern Asia. Although clear evidence for paleoendemism is provided by the gymnosperms Amentotaxus, Cathaya, Cephalotaxus, Cunninghamia, Cryptomeria, Glyptostrobus, Ginkgo, Ketel-eeria, Metasequoia, Nothotsuga, Pseudolarix, Sciadopitys, and Taiwania, and the angiosperms Cercidiphyllum, Choerospondias, Corylopsis, Craigia, Cyclocarya, Davidia, Dipelta, Decaisnea, Diplopanax, Dipteronia, Em-menopterys, Eucommia, Euscaphis, Hemiptelea, Hovenia, Koelreuteria, Paulownia, Phellodendron, Platycarya, Pteroceltis, Rehderodendron, Sargentodoxa, Schizophragma, Sinomenium, Tapiscia, Tetracentron, Toricellia, Trapella, and Trochodendron, we cannot rule out the possibility that neoendemism plays an important role especially for herbaceous taxa in the present-day flora of Asia, particularly in the Sino-Himalayan region. In addition to reviewing paleobotanical occurrences from the literature, we document newly recognized fossil occurrences that expand the geographic and stratigraphic ranges previously known for Dipelta, Pteroceltis, and Toricellia.

关键词： Cretaceous eastern Asia endemic paleobotany phytogeography Tertiary

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