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A COMPREHENSIVE SOFTWARE SUITE FOR THE ANALYSIS OF CDNAS

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Genomics, Proteomics & Bioinformatics 2005年第3期3卷 179-188页

作者： kazuharu arakawa HARUO SUZUKI KOSUKE FUJISHIMA KENJI FUJIMOTO SHO UEDA MOTOMU MATSUI MASARU TOMITA INSTITUTE FOR ADVANCED BIOSCIENCES KEIO UNIVERSITY FUJISAWA 252-8520 JAPAN BIOINFORMATICS PROGRAM OF THE GRADUATE SCHOOL OF MEDIA AND GOV- ERNANCE KEIO UNIVERSITY FUJISAWA 252-8520 JAPAN INSTITUTE FOR ADVANCED BIOSCIENCES KEIO UNIVERSITYFUJISAWA 252-8520 JAPAN

We have developed a comprehensive software suite for bioinformatics research of cDNAs; it is aimed at rapid characterization of the features of genes and the proteins they code. Methods implemented include the detection of translation initia- tion and termination signals, statistical analysis of codon usage, comparative study of amino acid composition, comparative modeling of the structures of product proteins, prediction of alternative splice forms, and metabolic pathway reconstruction. The software package is freely available under the GNU General Public License at http： / /***/ data/cdna/.

关键词： cDNA bioinformatics, software

维普期刊数据库

Repeat laparoscopic anatomical liver resection in a hepatocellular carcinoma patient:a case report

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Hepatoma Research 2022年第1期8卷 248-253页

作者： kazuharu Igarashi Kohei Mishima Takahiro Ozaki Go Wakabayashi Department of Surgery Ageo Central General HospitalAgeoSaitama 362-8588Japan Department of General-Pediatric Hepatobiliary Pancreatic Surgery Kitasato University School of MedicineSagamiharaKanagawa 252-0374Japan

Anatomical resection(AR)has been reported to achieve better long-term outcomes than non-anatomical resection for the treatment of hepatocellular carcinoma(HCC).The surgical feasibility and oncological significance of laparoscopic AR(LAR),especially“subsegment resection”,“cone unit resection”,and repeat LAR for HCC,remain *** present a 67-year-old patient with alcoholic liver cirrhosis and HCC who underwent full LAR three times,focusing on the technical aspects of the Glissonean *** LAR for recurrent HCC could be a safe and feasible ***,HCC recurred in the neighboring segment twice,even though pathological vascular invasion and marginal remnants were not *** should investigate the oncological significance and advancements in subsegmentectomy and cone unit resection,in the future.

关键词： Repeat laparoscopic anatomical liver resection HCC Glissonean approach subsegmentectomy cone unit resection

Effect of Antiemetic Agents on Hiccups during Chemotherapy in Patients with Lung Cancer

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Pharmacology & Pharmacy 2018年第4期9卷 124-133页

作者： Shinya Toriumi kazuharu Nakazawa Masaru Shoji Department of Pharmacy National Hospital Organization East Saitama Hospital Hasuda Saitama Japan Department of Pharmacy National Hospital Organization Kanagawa Hospital Hadano Kanagawa Japan Department of Pharmacodynamics Meiji Pharmaceutical University Kiyose Tokyo Japan

Hiccups commonly occur in patients undergoing chemotherapy for lung cancer and may diminish their motivation for treatment. Therefore, it is important to characterize the hiccups and their risk factors. We examined the medical records of 120 patients with lung cancer during their initial chemotherapy and extracted data on the patients’ profiles and the onset, duration, and severity of their hiccup episodes. We found the incidence of hiccups to be 19.2% among the patients. Hiccups appeared within 3 days of beginning the chemotherapy and disappeared within 4 days. Hiccups hindered sleep in two patients. The characteristics of the hiccups episodes in our study were not different from those of previous studies. We also investigated distinctive features of the patients who developed hiccups. The occurrence of hiccups was associated with gender, age, and the treatment with platinum agents. Antiemetic agents, dexamethasone and neurokinin-1 receptor antagonists, also showed significant effects on hiccup episodes. Although the dose-responsive effect of dexamethasone on hiccups was insignificant and the effects of two neurokinin-1 receptor antagonists, aprepitant and fosaprepitant, on hiccups appeared identical. From these results, we suggest that a high incidence of hiccups may be anticipated with a prophylactic use of antiemetic agents, dexamethasone and neurokinin-1 receptor antagonists.

关键词： Hiccups Dexamethasone Neurokinin-1 Receptor Antagonist Antiemetic Agents Lung Cancer

Scurvy in the Postoperative Oropharyngeal Cancer Patient

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International Journal of Clinical Medicine 2016年第9期7卷 577-584页

作者： kazuharu Kamachi Kazuko Doi Momoka Ishida Masaharu Miyahara Shinya Kimura Department of Internal Medicine Karatsu Red Cross Hospital Japan Department of Dermatology Karatsu Red Cross Hospital Japan Division of Hematology Respiratory Medicine and Oncology Department of Internal Medicine Faculty of Medicine Saga University Saga Japan

Scurvy is now an almost forgotten disease, but it hasn’t yet disappeared entirely. Here, we report the case of a patient with scurvy who presented with multiple hemorrhages about 5 years after undergoing pharyngeal surgery and radiochemotherapy for oropharyngeal cancer. This 60-year-old man was admitted to our hospital because of sudden onset of dyspnea and purpura. A physical examination and computed tomography revealed multifocal hemorrhages, namely, purpuras and petechiae on the legs and intramuscular and alveolar hemorrhages. Coagulation tests indicated a normal bleeding time and mild extension of the activated partial thromboplastin time. The coagulation factor activities were not low enough to account for such severe hemorrhages. No new hemorrhages were observed after admission. On questioning about his past eating habits, the patient reported having long had an extremely unbalanced diet, namely, a diet that was composed largely of carbohydrates with few fresh fruits and vegetables. This was due to the development of mechanical dysphagia after the operation. Since his vitamin C level was 0.5 μg/mL (normal range: 5.5 - 16.8 μg/mL), a diagnosis of scurvy was established. Thus, scurvy can still occur in modern times due to poor eating habits that arise from unusual settings. We must keep in mind that scurvy may be the cause when a patient presents with an apparently inexplicable tendency to hemorrhage.

关键词： Scurvy Vitamin C Oropharyngeal Cancer

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一种小型高性能铷频率标准

宇航计测技术 1983年第S1期 276-281页

作者： Toshio Hashi kazuharu Chiba Chikao Takeuchi 谢蔚文

业已研制出一种小型通用铷气泡频率标准,来满足在各种应用中对精密振荡器日益增长的需要。本文介绍一种新的已研制成功的频率标准的设计原理和性能特性。新型铷频率标准在电气和结构设计上都体现了新的特点和改进,例如,不带滤光泡的小... 详细信息

业已研制出一种小型通用铷气泡频率标准,来满足在各种应用中对精密振荡器日益增长的需要。本文介绍一种新的已研制成功的频率标准的设计原理和性能特性。新型铷频率标准在电气和结构设计上都体现了新的特点和改进,例如,不带滤光泡的小型双气泡型光学微波部件,采用了许多集成电路的一种改进型的伺服电子仪器,而且采用了母板和插入式组件,因此结构简单,适于制作。由于在吸收泡内采用了天然铷来取代同位素Rb87,因此,取消了滤光泡,实现了光学微波部件的小型化。上述特点使新型铷频率标准具有体积小（2升）、重量轻（2.9公斤）和工作温度范围宽（-20℃—+60℃）的特点。已经进行一系列测量来表征新型铷频率标准的性能。尽管尺寸已显著缩小,但是和实验室所使用的大得多的铷频率标准相比较,它已显示出极好的长期、短期稳定度和在长期工作条件下具有高的环境稳定性。

关键词：频率标准光学性能特性实验室振荡器电子设备稳定度微波部件频标

High-throughput simple sequence repeat (SSR) markers development for the kelp grouper (<i>Epinephelus bruneus</i>) and cross-species amplifications for Epinephelinae species

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Advances in Bioscience and Biotechnology 2014年第2期5卷 117-130页

作者： Satoshi Kubota Qi Liu Kanonkporn Kessuwan Nobuaki Okamoto Takashi Sakamoto Yoji Nakamura Yuya Shigenobu Takuma Sugaya Motohiko Sano Susumu Uji kazuharu Nomura Akiyuki Ozaki Faculty of Marine Science Tokyo University of Ma-rine Science and Technology Tokyo Japan Faculty of Marine Science Tokyo University of Ma-rine Science and Technology Tokyo Japan National Research Institute of Fisheries Science Fi-sheries Research Agency Kanagawa Japan National Research Institute of Aquaculture Fisheries Research Agency Mie Japan National Research Institute of Fisheries Science Fi-sheries Research Agency Kanagawa Japan

The kelp grouper (Epinephelus bruneus), belonging to one of the largest genera among the subfamily Epinephelinae, is a commercially important fish in Japan. There are limited data about the genomics of this species. To provide tools for addressing both population genetics studies and gene mapping, dito pentanucleotide simple sequence repeat (SSR) markers were developed using 454 pyrosequencing. Among the 1466 SSR markers developed, 1244 primer sets produced strong PCR products, of which 905 (72.7%) were polymorphic in kelp grouper. Cross-species utility of the 905 polymorphic SSR markers was tested in four additional Epinephelinae species of Hyporthodus septemfasciatus, Plectropomus leopardus, Epinephelus lanceolatus and Epinephelus coioides. Results revealed that, respectively, 401 (44.3%), 136 (15.0%), 434 (49.0%) and 538 (59.4%) SSRs showed specific polymorphic products. Of these, 40 SSR markers (33 di-, 1 tri- and 6 tetra-nucleotides) showed polymorphism in all species tested. Additionally, three AGAT SSR motifs which accounted for 42.9% of the nondi-nucleotide markers were found in the 40 SSR markers. This indicates that the AGAT SSR motif has a high potential as a highly versatile SSR marker in grouper Epinephelinae. The SSR markers developed in this study can be employed to obtain reliable genetic variability estimates for groupers (Epinephelinae).

关键词： Kelp Grouper Epinephelus bruneus Repeat Motif Simple Sequence Repeat (SSR) 454 Pyrosequencing Cross-Species Amplification

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矾土陶瓷制人工股骨头的实验研究

宁夏医学杂志 1988年第5期 319-320页

作者：贾刚田

已知人工股骨头置换术的主要合并症有髓臼关节软骨及骨质破坏或中心性脱位,其原因多认为是人工股骨头的机械性刺激或其所含金属成分导致关节软骨或其周围骨质的破坏。而陶瓷的生物相容性优于金属,化学稳定性高,耐磨性能强,对周围组织无... 详细信息

已知人工股骨头置换术的主要合并症有髓臼关节软骨及骨质破坏或中心性脱位,其原因多认为是人工股骨头的机械性刺激或其所含金属成分导致关节软骨或其周围骨质的破坏。而陶瓷的生物相容性优于金属,化学稳定性高,耐磨性能强,对周围组织无化学刺激性,故近年来陶瓷制人工股骨头应用较普遍。作者用金属和陶瓷制人工股骨头分别植入成年犬髋关节,比较观察了对关节软骨的组织学影响。

关键词：人工股骨头金属成年金属材料关节软骨

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矾土陶瓷制人造股骨头的实验研究

黑龙江医药科学 1987年第3期 313-313页

作者： kazuharu Yoshihaga 贾刚田

已知人造股骨头置换术的并发症有关节窝浸蚀和中心性脱位等,一般认为,人造骨头的金属材料因组织反应和机能性应激反应易导致软骨损坏。而陶瓷对机体亲和性优于金属,化学稳定性高,耐摩性也极其优异,故近年来陶瓷人造股骨头应用较普遍。... 详细信息

已知人造股骨头置换术的并发症有关节窝浸蚀和中心性脱位等,一般认为,人造骨头的金属材料因组织反应和机能性应激反应易导致软骨损坏。而陶瓷对机体亲和性优于金属,化学稳定性高,耐摩性也极其优异,故近年来陶瓷人造股骨头应用较普遍。作者用

关键词：股骨头金属金属材料运动器官软骨股关节矾土