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Biodecoloration of Reactive Black 5 by the methylotrophic yeast Candida boidinii MM 4035

Journal of Environmental Sciences 2017年第3期29卷 78-87页

作者： Maria M.Martorell Hipo1ito F.Pajot Pablo M.Ahmed Lucia I.C.de Figueroa Antarctic Argentinian Institute Balcarce 290CABAArgentina PROIMI-CONICET TucumánArgentina department of Products Quality IV San Pablo University-TucumdnTucumánArgentina Agroindustrial Experimental Station Obispo Colombres TucumánArgentina department of Superior Microbiology Faculty of BiochemistryChemistry and PharmacyNational University of TucumánTucumánArgentina

Azo dyes are extensively used in textile dyeing and other industries. Effluents of dying industries are specially colored and could cause severe damage to the environment. The anaerobic treatment of textile dying effluents is nowadays the preferred option, but it could generate carcinogenic aromatic amines. Recently, yeasts have become a promising altemative, combining unicellular growth with oxidative mechanisms. This work reports the characterization of the first methylotrophic yeast with dye decolorizing ability, Candida boidinii MM 4035 and some insights into its decoloration mechanism. The analysis of two selected media revealed a possible two stages mechanism of Reactive Black 5 decoloration. In glucose poor media, decoloration is incomplete and only the first stage proceeds, leading to the accumulation of a purple compound. In media with higher glucose concentrations, the yeast is able to decolorize totally an initial concentration of 200 mg/L. The entire process is co-metabolic, being largely dependent on glucose concentration but being able to proceed with several nitrogen sources. Manganese dependent peroxidase but not laccase activity could be detected during decoloration. Aromatic amines do not accumulate in culture media, supporting an oxidative decoloration mechanism of unknown ecophysiological relevance.

关键词： Biodecoloration DyesMethylotrophic yeasts Medium optimization

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Visible light-curable polymers for biomedical applications

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Science China Chemistry 2014年第4期57卷 510-521页

作者： ZHOU Di ito Yoshihiro Emergent Bioengineering Materials Research Team RIKEN Center for Emergent Matter Science Jiangsu Key Laboratory of Advanced Functional Materials School of Chemistry and Material EngineeringChangshu Institute of Technology

Photocurable systems, which offer advantages such as microfabrication and in situ fabrication, have been widely used as dental restorative materials. Because the visible light-curable(VLC) system causes no biological damage, it is popular as a dental material and is being investigated by many researchers for other medical applications. Here, the principle of the VLC system is explained and recent progress in key components including photoinitiators, monomers, macromers, and prepolymers is discussed. Finally, biomedical applications for drug delivery and soft tissue engineering are reviewed. Considering the recent development of VLC systems, its importance in the field of medical applications is expected to continue to increase in the future.

关键词：医疗应用光固化聚合物医学领域大分子单体固化系统生物医学应用牙科材料微细加工

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Turning Industrial Waste into a Valuable Bioproduct:Starch from Mango Kernel derivative to Oil Industry Mango Starch derivative in Oil Industry

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Journal of Renewable Materials 2019年第2期7卷 139-152页

作者： Nívia do Nascimento Marques Caroline Suzy do Nascimento Garcia Liszt Yeltsin Coutinho Madruga Marcos Antônio Villetti Men de SáMoreira de Souza Filho Edson Noriyuki ito Rosangela de Carvalho Balaban Instituto de Química Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil departamento de Física Universidade Federal de Santa Maria-UFSMSanta Maria97105900Brazil Embrapa Agroindústria Tropical Fortaleza60511-110Brazil departamento de Engenharia de Materiais Universidade Federal do Rio Grande do Norte-UFRNNatal59078970Brazil

After industrial mango processing,tons of residues such as peels and kernels are discarded as ***,almost 60% of the mango kernel is due to starch on a dry weight ***,starch from mango(Manguifera Indica L.)kernel was applied to obtain a starch fatty ester with vinyl laurate,in DMSO,under basic ***,1H and 13C NMR confirmed that a starch ester with a degree of modification of 2.6 was *** showed that the modified starch has higher thermal stability than its precursors and higher than a vinyl laurate/starch physical *** data showed that granular shape and smooth surface on mango starch changed after chemical modification to a continuous and shapeless *** industrial reject derivative behaved as an efficient alternative environmentally friendly fluid loss controller in oil drilling fluids,even in conditions of high temperatures and high pressures(HTHP)drilling.

关键词： Mango Starch oil drilling fluid transesterification vinyl laurate

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Uneven Distribution of Pseudotormentus de Wever et Caridroit(Radiolaria,Protozoa):Provincialism of a Permian Planktonic Microorganism

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Acta Geologica Sinica(English Edition) 2016年第5期90卷 1598-1610页

作者： ito Tsuyoshi FENG Qinglai MATSUOKA Atsushi State Key Laboratory of Geo-processes and Mineral Resources China University of Geosciences Graduate School of Science and Technology Niigata University Research Institute of Geology and Geoinformation Geological Survey of Japan department of Geology Faculty of ScienceNiigata University

The Permian planktonic distribution is not well known,in contrast to other fossil distributions of nekton and *** are representative microfossils of plankton in the Permian *** study compares both correlated radiolarian occurrences（Pseudotormentus de Wever et Caridroit and Quadriremis Nazarov et Ormiston） in literature data from the Pacific Rim and quantitative data from the Liuhuang and Gujingling sections in South *** distributions are concentrated in the Panthalassa,whereas Quadriremis occurrences are distributed over both the Panthalassa and the *** uneven distribution of Pseudotormentus seems to have been controlled by a difference in the oceanic basins,indicating the presence of faunal differences in Permian planktonic microorganisms between the Panthalassa and the *** other words,this study infers the provincialism of Permian planktonic *** uneven distribution is explainable by a hypothesis that Pseudotormentus was strongly affected by a Panthalassan equatorial current.

关键词： palaeobiogeography Palaeotethys Panthalassa Permian radiolaria Pseudotormentus Quadriremis

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Chemogenetic activation of G12 signaling enhances adipose tissue browning

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Signal Transduction and Targeted Therapy 2023年第9期8卷 3923-3926页

作者： Yuki Ono Ryo ito Kaito Arai Gurdeep Singh Tsuyoshi Saitoh Robert BRussell Francesco Raimondi Junken Aoki Juro Sakai Asuka Inoue Molecular and Cellular Biochemistry Graduate School of Pharmaceutical SciencesTohoku UniversitySendaiMiyagi 980-8578Japan Division of Molecular Physiology and Metabolism Graduate School of MedicineTohoku UniversitySendaiMiyagi 980-8574Japan Bioquant Heidelberg UniversityIm Neuenheimer Feld 26769120 HeidelbergGermany Biochemie Zentrum Heidelberg(BZH) Heidelberg UniversityIm Neuenheimer Feld 32869120 HeidelbergGermany International Institute for Integrative Sleep Medicine(WPI-IIIS) University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8575Japan Graduate School of Comprehensive Human Sciences University of Tsukuba1-1-1 TennodaiTsukubaIbaraki 305-8575Japan Laboratorio di Biologia Bio@SNS Scuola Normale SuperiorePiazza dei Cavalieri 7Pisa 56126Italy department of Health Chemistry Graduate School of Pharmaceutical SciencesThe University of TokyoBunkyo-kuTokyo 113-0033Japan Division of Metabolic Medicine Research Center for Advanced Science and TechnologyThe University of TokyoMeguro-kuTokyo 153-8904Japan

dear Editor,Beige adipocytes,which increase energy expenditure by dissipating energy as heat,have gained attention as a therapeutic target for combating obesity.1 Adipocytes express many types of G-protein-coupled receptors(GPCRs),each of which has a unique preference for the Gs,Gi,Gq,and G12 *** the function of Gs-coupledβ-adrenergic receptors in beige adipocyte induction is well established,2 little is known about the function of G12-coupled GPCRs beyond its suppressive roles in white adipocyte maturation.3 In this study,we generated transgenic mice conditionally expressing a G12-coupled designer GPCR using a Cre-loxP system and investigated the potential effects of G12 signaling on adipocyte biology.

关键词： activation gained expressing

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Diagnosis of Zollinger-Ellison syndrome:Increasingly difficult

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World Journal of Gastroenterology 2012年第39期18卷 5495-5503页

作者： Tetsuhide ito Guillaume Cadiot Robert T Jensen department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Hepato-Gastroenterology Service Centre hospitalier universitaire de ReimsHospital Robert DebreF-51092 ReimsFrance Digestive Diseases Branch National Insitutes of DiabetesDigestive and Kidney DiseasesNational Institutes of HealthBethesdaMD 20892United States

In the present paper the increasing difficulty of diag-nosis of Zollinger-Ellison syndrome (ZES) due to issues raised in two recent papers is discussed. These issues involve the difficulty and need to withdraw patients suspected of ZES from treatment with Proton Pump Inhibitors (omeprazole, esomeprazole, lansoprazole, rabeprazole, pantoprazole) and the unreliability of many gastrin radioimmunoassays. The clinical context of each of these important issues is reviewed and the conclusions in these articles commented from the per-spective of clinical management.

关键词：综合征诊断质子泵抑制剂临床管理放射免疫法奥美拉唑兰索拉唑胃泌素

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Temporal bone anatomy characteristics in superior semicircular canal dehiscence

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Journal of Otology 2017年第4期12卷 185-191页

作者： Marrigje A. de Jong David J. Carpenter David M. Kaylie Erin G. Piker dennis O. Frank-ito department of Otorhinolaryngology/Head and Neck Surgery Hadassah Hebrew University Hospital Jerusalem Israel Division of Head and Neck Surgery & Communication Sciences Duke University Medical Center Durham NC USA department of Communication Sciences and Disorders James Madison University Harrisonburg VA USA Computational Biology & Bioinformatics Duke University Durham NC USA department of Mechanical Engineering and Materials Science Duke University Durham NC USA

Introduction: Superior semicircular canal dehiscence(SCD) remains difficult to diagnose despite advances in high-resolution computed tomography(HRCT) imaging. We hypothesize possible associations between gross temporal bone anatomy and sub-millimeter pathology of the semicircular canals, which may supplement imaging and clinical suspicion. This pilot study investigates differences in gross temporal bone anatomic parameters between temporal bones with and without ***: Records were reviewed for 18 patients referred to an otology clinic complaining of dizziness with normal caloric stimulation results indicative of non-vestibular findings. Eleven patients had normal temporal bone anatomy while seven had SCD. Three-dimensional reconstruction of every patient's temporal bone anatomy was created from patient-specific computational tomography images. Surface area(SA),volume(V), and SA to V ratios(SA:V) were computed across temporal bone anatomical ***: SCD temporal bones have significantly smaller V, and larger temporal bone SA. Mean(±SD) V was 21,484 ± 3,921 mm^3 in temporal bones without SCD and 16,343 ± 34,471 mm^3 for those with SCD. Their respective SA were 13,733 ± 1,603 mm^2 and 18,073 ± 3,002 mm^*** bone airspaces and lateral semicircular canals did not demonstrate significant differences where SCD was and was not present. Plots of MV_(warm)response against computed SCD temporal bone anatomic parameters(SA, V and SA:V) showed moderate to strong correlations:temporal bone SA:V(r= 0.64), temporal bone airspace V(r= 0.60), temporal bone airspace SA(r= 0.55), LSCC SA(r= 0.51), and LSCC-toTM Distance(r= 0.65).Conclusions: This analysis demonstrated that SCD is associated with decreased temporal bone volume and density. The defect in SCD does not appear to influence caloric responses.

关键词： Temporal bone Anatomy Superior canal dehiscence Superior semicircular canal dehiscence

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development and validation of an artificial intelligence model for predicting post-transplant hepatocellular cancer recurrence

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Cancer Communications 2023年第12期43卷 1381-1385页

作者： Quirino Lai Carmine de Stefano Jean Emond Prashant Bhangui Toru Ikegami Benedikt Schaefer Maria Hoppe-Lotichius Anna Mrzljak Takashi ito Marco Vivarelli Giuseppe Tisone Salvatore Agnes Giuseppe Maria Ettorre Massimo Rossi Emmanuel Tsochatzis Chung Mau Lo Chao-Long Chen Umberto Cillo Matteo Ravaioli Jan Paul Lerut the EurHeCaLT and the West-East LT Study Group General Surgery and Organ Transplantation Unit AOU Policlinico Umberto I Sapienza University of Rome Rome Italy Data Science and Engineering Polytechnic of Turin Turin Italy Division of Liver Transplantation and Hepatobiliary Surgery Department of Surgery Weill Cornell Medicine-Columbia University New York US Medanta Institute of Liver Transplantation and Regenerative Medicine Medanta-The Medicity Gurgaon India department of Surgery and Science Kyushu University Fukuoka Japan department of Medicine I Gastroenterology Hepatology and Endocrinology Medical University of Innsbruck Innsbruck Austria Klinik für Allgemein- Viszeral- und Transplantationschirurgie Universitätsmedizin Mainz Mainz Germany Liver Transplant Centre Merkur University of Zagreb Zagreb Croatia Division of Hepato-Biliary-Pancreatic and Transplant Surgery Department of Surgery Graduate School of Medicine Kyoto Japan Unit of Hepatobiliary Surgery and Transplantation AOU Ospedali Riuniti Polytechnic University of Marche Ancona Italy department of Surgical Sciences and Medical Sciences University of Rome-Tor Vergata Rome Italy Liver Unit Department of Surgery Catholic University-Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy department of Transplantation and General Surgery San Camillo Hospital Rome Italy UCL Institute for Liver and Digestive Health and Royal Free Sheila Sherlock Liver Centre Royal Free Hospital London UK Hong Kong University–department of Surgery Queen Mary Hospital University of Hong Kong Hong Kong P. R. China department of Surgery Kaohsiung Chang Gung Memorial Hospital Chang Gung University College of Medicine Kaohsiung Taiwan P. R. China department of Surgery Oncology and Gastroenterology University of Padua Padua Italy department of General Surgery and Transplantation IRCCS Azienda Ospedaliero-Universitaria di Bologna Bologna University Bologna Italy Institut de Recherche Clinique Université catholique de Louvain Brussels Belgium 不详

dear Editor,In recent years,criteria based on the combinationof morphology and biology have been proposed forimproving the selection of hepatocellular cancer(HCC)patients waiting for liver transplantation(LT)[1,2].Since all the proposed models showed suboptimalresults in predicting the risk of postLT recurrence,aprediction model constructed using artificial intelligence(Al)could be an attractive way to surpass this limit[3,4].Therefore,the Time_Radiological-response_Alpha-fetoproteIN_Artificial-Intelligence(TRAIN-AI)modelwas developed,combining morphology and biology tumorvariables.

关键词： hepatocellular cancer artificial

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Atypical Hemolytic Uremic Syndrome in a Post-COVID-19 Child: Its Differential Diagnosis with COVID-19, Multisystemic Inflammatory Syndrome and Outcome

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Open Journal of Pediatrics 2022年第4期12卷 657-664页

作者： Fernanda Aparecida de Oliveira Peixoto Célia Regina Malveste ito André Luís Elias Moreira Paulo Alex N. Silva Mônica Oliveira Santos Isabela Jubé Wastowski Liana de Medeiros Machado Braga Vivian Da Cunha Rabelo Lilian Carla Carneiro Melissa Ameloti Gomes Avelino department of Pediatrics Neonatal ICU of Clinical Hospital of Federal University of Goiás/Ebserh Goiania Brazil Microorganism Biotechnology Laboratory of Institute of Tropical Pathology and Public Health Federal University of Goiás Goiania Brazil Molecular Immunology Laboratory of Goiás State University Anápolis Brazil Pediatrics ICU of State Emergency Hospital Governor Otávio Lage of Siqueira Goiania Brazil Surgical department of Pediatrics Medical School Federal University of Goiás Goiania Brazil

Pediatric Multisystemic Inflammatory Syndrome (MIS-C) is one of the most severe manifestations of SARS-CoV-2 in pediatrics [1]. This is a report of MIS-C with clinical presentation in infants with atypical Hemolytic U... 详细信息

关键词： MISC COVID-19 aHUS Children Critical Care

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Priorities for research and control of cestode zoonoses in Asia

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Infectious Diseases of Poverty 2013年第1期2卷 126-136页

作者： Ning Xiao Jia-Wen Yao Wei Ding Patrick Giraudoux Philip S Craig Akira ito National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionWHO Collaborative Center for MalariaSchistosomiasis and FilariasisKey Laboratory of Parasite and Vector BiologyMinistry of HealthShanghai 200025People’s Republic of China department of ChronoEnvironment University of Franche-Comté/CNRS and Institut Universitaire de FranceBesançonFrance Cestode Zoonoses Research Group School of Environment and Life SciencesUniversity of SalfordManchesterUK department of Parasitology Asahikawa Medical UniversityAsahikawa 078-8510Japan

Globally,cestode zoonoses cause serious public health problems,particularly in *** all neglected zoonotic diseases,cestode zoonoses account for over 75%of global disability adjusted life years(DALYs)*** international symposium on cestode zoonoses research and control was held in Shanghai,China between 28th and 30th October 2012 in order to establish joint efforts to study and research effective approaches to control these *** brought together 96 scientists from the Asian region and beyond to exchange ideas,report on progress,make a gap analysis,and distill prioritizing settings with a focus on the Asian *** objectives of this international symposium were to agree on solutions to accelerate progress towards decreasing transmission,and human mortality and morbidity caused by the three major cestode zoonoses(cystic echinococcosis,alveolar echinococcosis,and cysticercosis);to critically assess the potential to control these diseases;to establish a research and validation agenda on existing and new approaches;and to report on novel tools for the study and control of cestode zoonoses.

关键词： Neglected diseases Cestode zoonoses Asia Priority Gap Research Control

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