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Cdx2 expression and its promoter methylation during metaplasia-dysplasia-carcinoma sequence in Barrett's esophagus

World Journal of Gastroenterology 2013年第4期19卷 536-541页

作者： Kenji Makita Riko Kitazawa Shuho Semba Koto Fujiishi Miku nakagawa Ryuma Haraguchi Sohei Kitazawa Division of Molecular Pathology Ehime University Graduate School of MedicineToon 791-0295Japan Division of Pathology Kobe University Graduate School of MedicineKobe 650-0017Japan

AIM:To examine how the expression of caudal type homebox transcription factor 2(Cdx2) is regulated in the development of malignancy in Barrett's ***:Cdx2,mucin(MUC) series(MUC2,MUC5AC and MUC6),p53 and E-cadherin expression in Barrett's esophagus and adenocarcinoma specimens were examined by *** clusters of cells from(1) MUC2 and Cdx2-positive intestinal metaplastic mucosa;(2) MUC5AC and MUC6-positive,and MUC2 and Cdx2-negative high-grade dysplasia(HD),or intramucosal adenocarcinoma(IMC);and(3) MUC5AC,MUC6 and Cdx2-positive poorly-differentiated invasive adenocarcinoma(PDA) were analyzed by methylationspecific polymerase chain reaction using sets of primers for detecting methylation status of the Cdx2 ***:Most of the non-neoplastic Barrett's esophageal mucosa showing intestinal-type metaplasia with or without low-grade dysplasia was positive for E-cadherin,MUC series and Cdx2,but negative for p53.A portion of the low-grade to HD was positive for E-cadherin,MUC5AC,MUC6 and p53,but negative for MUC2 and *** definite IMC area was strongly positive for MUC5AC,MUC6 and p53,but negative for MUC2 and *** of the Cdx2 promoter was not observed in intestinal metaplasia,while hypermethylation of part of its promoter was observed in hot dipped and *** of a large fraction of the Cdx2 promoter was observed in ***:Cdx2 expression is restored irrespective of the methylation status of its *** positive immunohistochemical results can be a molecular mark for gene silencing memory.

关键词： Barrett ’s esophagus Caudal type homebox transcription factor 2 Intestinal metaplasia Promoter hypermethylation

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Anesthetic Management of a Child with Simpson-Golabi-Behmel Syndrome—A Case Report

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Open Journal of Anesthesiology 2015年第2期5卷 23-26页

作者： Yoshihiro Morita Kyoko Naito Natsuko Kimoto Eiji Kimoto Tetsuji Omata Nobuo Morita Masashi nakagawa Department of Anesthesiology Kinan Hospital Tanabe Japan Department of Oral and Maxillofacial Surgery Kinan Hospital Tanabe Japan Department of Oral and Maxillofacial Surgery Seichokai Hannan Municipal Hospital Han-nan Japan Department of Oral and Maxillofacial Surgery NS Medical & Healthcare Service General Incorporation Foundation Wakayama Japan

Simpson-Golabi-Behmel syndrome (SGBS) is an X-linked recessive condition associated with pre-natal and postnatal overgrowth with visceral and skeletal anomalies. Abnormal airway anatomy may complicate the perioperative management of SGBS. However, there have been few reports regarding the anesthetic management of children with SGBS. We present the preoperative evalua-tion and intraoperative management of a 1.5-year-old child with SGBS undergoing plastic surgery for cleft palate. Sevoflurane-fentanyl anesthesia without a neuromuscular blocker was planned, due to the preoperative evaluation that airway management would be complicated by the macroglossia and short neck characteristic of SGBS. Fortunately, there was no difficulty in endotracheal intubation in the present patient due to careful planning of general anesthesia and meticulous airway management. Appropriate preoperative preparation for a difficult airway by the anesthe-siologist can ameliorate the difficulties inherent to the anesthetic management of patients with SGBS.

关键词： Simpson-Golabi-Behmel Syndrome Anesthetic Management Macroglossia

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10.6MeV/u^(84)Kr+^(27)Al碰撞中粒子发射的方位角分布和方位角关联

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高能物理与核物理 1997年第1期21卷 1-7页

作者：叶巍沈文庆马余刚冯军 T.nakagawa K.Yuasa-nakagawa K.Furutaka K.Matsuda Y.Futami K.Yoshida J.Kasagi S.M.Lee 中国科学院上海原子核研究所上海201800 The Institute of Physical and Chemical Research RIKENWakoSaitama 351-01Japan Department of Physics Tokyo Institute of TechnologyMeguroToyko 152Japan Institute of Physics University of TsukubaTsukubaIbaraki 305Japan Laboratory of Nuclear Science Tohoku UniversitySendaiMiyagi 982Japan

研究了10.6MeV/u^(84)Kr+^(27)Al 反应中与碎片符合的轻带电粒子发射,重点研究了用二阶傅里叶级数拟合发射粒子的方位角分布和方位角关联得出的二阶各向异性系数的性质.结果证实了一个事件中的粒子都以相同方位角分布统计独立发射.发现... 详细信息

研究了10.6MeV/u^(84)Kr+^(27)Al 反应中与碎片符合的轻带电粒子发射,重点研究了用二阶傅里叶级数拟合发射粒子的方位角分布和方位角关联得出的二阶各向异性系数的性质.结果证实了一个事件中的粒子都以相同方位角分布统计独立发射.发现二阶各向异性系数同碎片的质量用微弱的依赖性,并随发射粒子质量的增加而增加.

关键词：方位角分布统计独立发射重离子反应离子碰撞

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The Number of Positive Tumor Marker Status Is Beneficial for the Selection of Therapeutic Modalities in Patients with Hepatocellular Carcinoma

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Journal of Clinical and Translational Hepatology 2017年第2期5卷 165-168页

作者： Toru Beppu Shigeki nakagawa Hidetoshi Nitta Hirohisa Okabe Takayoshi Kaida Katsunori Imai Hiromitsu Hayashi Yuki Koga Kunitaka Kuramoto Daisuke Hashimoto Yo-ichi Yamashita Akira Chikamoto Takatoshi Ishiko Hideo Baba Department of Surgery Yamaga City Medical Center Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan Department of Gastroenterological Surgery Graduate School of Life Sciences Kumamoto University Kumamoto Japan

Hepatic resection (HR) and radiofrequency ablation (RFA) are popular local therapies for early-stage hepatocellular carcinoma (HCC).Alpha-fetoprotein,Lens culinaris agglutininreactive fraction of alpha-fetoprotein,and des-c-carboxy prothrombin are well-known and useful tumor markers for *** positive number status of these tumor markers has recently been demonstrated as beneficial for predicting outcome for HCC patients treated with local *** the normal ranges reported have differed by institution,the positivity of tumor markers is consistent and can easily be *** and Wakayama's group clearly demonstrated the following:1) Regardless of the degree of tumor stage,a triple-positive tumor marker profile can predict poor outcome in HCC patients undergoing HR;2) For RFA alone,HCC patients with double-and triple-positive status,having less than three lesions and lesions ≤3 cm in diameter show comparably insufficient outcomes;3) For HCC patients with lesions ≤5 cm in Child-Pugh grade A,HR is preferred over RFA;4) Microvascular invasion rates increased even in the double-positive patients,while poorly differentiated HCC was frequently observed only in the triple-positive patients;and 5) RFA with chemoembolization,anatomical liver resection,and postoperative adjuvant chemoembolization or hepatic arterial chemotherapy might improve the outcome for patients with highly malignant HCC with multiple positive tumor ***,the impacts of these therapies still need to be evaluated in prospective comparative studies.

关键词： Triple-positive tumor markers Double-positive tumor markers Hepatocellular carcinoma Hepatic resection Radiofrequency ablation Alpha-fetoprotein Des-γ-carboxy prothrombin Lens culinaris agglutinin reactive fraction of alpha-fetoprotein

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A Half-Arc Multiple Deep-Inspiration Breath-Hold Volumetric Modulated Arc Therapy for a Lung Tumor with 10 MV Flattening-Filter-Free Beams and an Image Sensor Measuring a Distance Map to Thorax Surface: An Initial Clinical Experience

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2017年第1期6卷 31-35页

作者： Keiichi nakagawa Kanabu Nawa Masatoshi Hashimoto Shuri Aoki Yoshihiro Kaneko Hideomi Yamashita Akihiro Haga Department of Radiology University of Tokyo Hospital Tokyo Japan Department of Radiation Oncology The Cancer Institute Hospital of Japanese Foundation for Cancer Research Tokyo Japan

A technique for multiple deep-inspiration breath-hold (DIBH) volumetric modulated arc therapy (VMAT) for a lung tumor has been proposed with 10 MV flattening-filter-free beams and an image sensor measuring a distance map to thorax surface. Planning CT images were acquired under a DIBH condition and a clinical target volume (CTV) was contoured. This procedure was repeated five times and an internal target volume (ITV) among the multiple DIBHs was created by integrating the five CTVs. A planning target volume (PTV) was defined by adding an isotropic margin of 5 mm to the ITV. Immediately before treatment, a 30-second half-arc cone-beam computer tomography (CBCT) imaging was performed under another DIBH condition, and the couch was repositioned so that tumor may be located inside the PTV contours. An infrared distance measurement device having laser diodes and an image sensor was attached to the couch, and a distance map to the patient thorax surface was recorded as a reference during still another DIBH condition. A half-arc segmented VMAT beams with two beam interrupts were delivered to the patient under multiple DIBHs, where the delivery time of each of the three segmented beams was 30 seconds. During the beam delivery, the distance map was monitored in real time to confirm that the distance to the thorax surface remained unchanged. In-treatment CBCT images suggested that the tumor position at the time of tumor registration was accurately reproduced during the DIBH VMAT delivery.

关键词： Deep Inspiration Breath-Hold DIBH FFF VMAT Kinect Lung

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Neurobehavioral and Hemodynamic Evaluation of Cognitive Shifting in Children with Autism Spectrum Disorder

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Journal of Behavioral and Brain Science 2012年第4期2卷 463-470页

作者： Akira Yasumura Naomi Kokubo Hisako Yamamoto Yukiko Yasumura Yusuke Moriguchi Eiji nakagawa Masumi Inagaki Kazuo Hiraki Department of Child Neurology NCNP Hospital Tokyo Japan Department of Children Saitama Jyunshin College Saitama Japan Department of Developmental Disorders National Institute of Mental Health National Center of Neurology and Psychiatry (NCNP) Tokyo Japan Department of School Education Joetsu University of Education Niigata Japan Graduate School of Arts and Sciences The University of Tokyo Tokyo Japan

The restrictive, stereotyped behavior in autism spectrum disorder (ASD) is considered to be related to deficits in execu- tive function. In particular, cognitive shifting in executive function is deeply related to stereotyped behavior in ASD. Previous investigations have clarified that the lateral prefrontal cortex is involved in cognitive shifting when flexible changes in attention were needed. However, a few studies have revealed a direct association between cognitive shifting tasks and lateral prefrontal cortex activity in children with ASD. We examined cognitive shifting in 7- to 12-year-old children with ASD and typically developing children using the dimensional change card sort task. In addition, using near-infrared spectroscopy, we examined prefrontal brain activity in conjunction with cognitive shifting. The autistic children provided fewer correct answers and slower reaction times in the task than typically developing children. Fur- thermore, the autistic children displayed a decline in right lateral prefrontal cortex activity during the task compared with typically developing children. In addition, a negative correlation was observed between the severity of autism and brain activity during the task. These results suggest that the activity and physiological indices used in this study may be useful for identifying the symptoms of ASD and discriminating ASD from other disabilities.

关键词： Autism Spectrum Disorder Executive Function Cognitive Shifting Frontal Lobe Function Near-Infrared Spectroscopy

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日语的通感表达与其汉译 ——以吉本芭娜娜的作品为中心

日语的通感表达与其汉译 ——以吉本芭娜娜的作品为中心

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作者：中川麻美（nakagawa Asami）清华大学

学位级别：硕士

所谓通感表达，即为用言语表达五感（视觉、听觉、嗅觉、味觉、触觉）所感觉到的事物。例如“柔软的触感”、“甜甜的味道”属于较为常见的同种感官词汇所组短语。与此相反，“柔软的颜色”、“甜甜的气味”、“明亮的声音”等则属于不... 详细信息

所谓通感表达，即为用言语表达五感（视觉、听觉、嗅觉、味觉、触觉）所感觉到的事物。例如“柔软的触感”、“甜甜的味道”属于较为常见的同种感官词汇所组短语。与此相反，“柔软的颜色”、“甜甜的气味”、“明亮的声音”等则属于不同感官词汇所组词汇，学术界称这种表达方式为通感表达。所谓通感表达，就是将分处于两种不同感官领域的词句相组，并用作比喻表达的一种表达方式，且常见于日常生活及文学作品中。该领域以往的研究，都止步于通感表达出现的缘由，以及对隐喻表达或换喻表达的分析，而在以通感表达作为基调的文章分析上面，未能就相关表达效果做出详细的分析，且很少有与汉语之间的对比研究。在本论文中，将试图比较分析日语当中的通感表达如何被译成中文作为主要目的。因此，本文选择了被译成中文作品最多的日本作家——吉本芭娜娜的作品作为研究对象。研究方法为，抽出含有通感表达的文章原文，按五官进行分类，并从构想角度分析其成立的缘由。在吉本芭娜娜的作品中，通感表达的构想来源不局限于事物的虚实。而且她将同时类似于两种感官表达的情感用于隐喻;有具体构想的，且可根据经验换成其他感官表达的用作换喻。可见，吉本的作品中不仅单纯地包含感官表达，还融入了大量的情感于其中。通过这样的分析，也将能够探寻新的通感表达内容。其次，将根据对其构想的来源的分析和考察，进行与汉译版本的比较。在被译成中文的作品中，虽然能够找寻到隐喻及换喻与构想的关联性，但是未以通感表达的方式译出。有些则形异，但其含义却与原文基本相符。通过对日中版本中的相同或相异的表现效果进行分析，可发现吉本芭娜娜作品中，所用通感表达的一些新特征和规律性。

关键词：通感联想吉本芭娜娜日中比较

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STEM MoiréObservation of Lattice-Relaxed Germanium Grown on Silicon

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Journal of Materials Science and Chemical Engineering 2017年第1期5卷 102-108页

作者： Junji Yamanaka Chiaya Yamamoto Hiroki Nakaie Tetsuji Arai Keisuke Arimoto Kosuke O. Hara Kiyokazu nakagawa Center for Crystal Science and Technology University of Yamanashi Kofu Japan Center for Creative Technology University of Yamanashi Kofu Japan Center for Instrumental Analysis University of Yamanashi Kofu Japan

We deposited Ge films on Si substrates by molecular beam epitaxy (MBE) method. The specimens were annealed at around 750 C using microwave- plasma heating technique which we had reported before. After these pro- cesses, we carried out special scanning transmission electron microscopic (STEM) observation. The moiré between the crystal lattices and the scanning lines controlled by STEM was utilized to show lattice-spacing distribution. The results exhibited that we were succeeded in forming lattice-relaxed Ge thin films. It was also recognized that this STEM moiré technique is very useful to observe lattice-spacing distribution for large area with high resolution.

关键词： STEM Moiré Lattice Strain Ge on Si Plasma Heating

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Remain Aggressive Behavior in Children with Temporal Lobe Epilepsy after Surgery

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Journal of Behavioral and Brain Science 2015年第3期5卷 81-87页

作者： Sayuri Sukigara Eiji nakagawa Masanori Ishikawa Kenji Sugai Masayuki Sasaki Takanobu Kaido Akio Takahashi Taisuke Otsuki Department of Child Neurology National Center Hospital National Center of Neurology and Psychiatry (NCNP) Tokyo Japan Department of Psychiatry NCNP Tokyo Japan Department of Neurosurgery NCNP Tokyo Japan

Behavioral problems have a high rate in patients with temporal lobe epilepsy but there have been few detailed reports about pediatric patients. We report two children with temporal lobe epilepsy who manifest behavior abnormality remaining after surgery. One child developed complex partial seizures at 10 years and 3 months of age caused by a left temporal ganglioglioma and manifested behavioral problems of lability, aggression, impulsivity and disinhibition. Seizures were relieved after temporal lobe resection at 10 years and 8 months of age but behavioral symptoms had been remained. The second child developed epilepsy at 3 years of age. He manifested similar behavioral problems at 7 years old. Seizures were relieved after temporal lobe resection at 13 years old but behavioral symptoms had been remained. Their courses suggested that aggressive behavior might be associated with not only temporal lesion but also other lesions such as frontal lobe or neural circuitry between both lobes. It is important to inform families of patients that behavioral disorders may not improve after epileptic surgery.

关键词： Temporal Lobe Epilepsy Behavioral Disorder Aggression Epileptic Surgery

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Ta2O5薄膜的淀积及其在SAW器件中的应用

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压电与声光 1986年第5期 72-75页

作者： Yasuhiko nakagawa,秦玉建日·山梨大学工学院

用反应性直流二极溅射法在熔融石英基片上淀积了Ta2O5结晶薄膜。研究了Ta2O5薄膜的晶状结构和压电性能。测量了在熔融石英基片上的Ta2O5薄膜中传播的SAW的特性,其中包括:相速度、耦合系数、延迟温度系数和传输损耗。当hk=1.6时,耦合系... 详细信息

用反应性直流二极溅射法在熔融石英基片上淀积了Ta2O5结晶薄膜。研究了Ta2O5薄膜的晶状结构和压电性能。测量了在熔融石英基片上的Ta2O5薄膜中传播的SAW的特性,其中包括:相速度、耦合系数、延迟温度系数和传输损耗。当hk=1.6时,耦合系数K2为0.7％;当hk=1.78时,一阶延时温度系数为零。

关键词：薄膜淀积基片衬底 Ta2O5 SAW 器件

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