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Multiple Marker Effects of Single Nucleotide Polymorphisms in Two Genes, <i>NCAPG</i>and <i>PLAG1</i>, for Carcass Weight in Japanese Black Cattle

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Open Journal of Animal Sciences 2019年第1期9卷 129-134页

作者： Youji muramatsu Department of Nutritional Sciences for Well-being Faculty of Health Sciences for Welfare Kansai University of Welfare Sciences Kashiwara Osaka Japan

Carcass weight is an economically important trait for beef cattle breeding and markets. The previous studies detected two single nucleotide polymorphisms (SNPs) associated with carcass weight of Japanese Black: c.1326T>G in NCAPG gene and FJX_250879 in PLAG1 gene. Here, I carried out multiple marker association analysis for the two SNPs in Japanese Black population of 218 animals. The multiple marker analysis with the model including the main effects of the two SNPs and their interaction detected significant main effects of c.1326T>G and FJX_250879 and a significant interaction between the two SNPs, for carcass weight. These findings suggest the presence of inter-allelic interactions among genes affecting the variation of carcass weight. For effective marker-assisted selection for beef production, interaction between the two markers needs to be considered.

关键词： Association Beef Cattle Carcass Weight Interaction SNP

Stand-Up Assistive Devices Allowing Patients to Perform Voluntary Movements within the Safety Movement Tolerance

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Journal of Artificial Intelligence and Technology 2022年第4期2卷 164-173页

作者： Daisuke Chugo Satoshi muramatsu Sho Yokota Jinhua She Hiroshi Hashimoto Kwansei Gakuin University Japan Tokai University Japan Tokyo University Japan Advanced Institute of Industrial Technology Japan

This paper proposes a novel standing assistance robot,which realizes voluntary movements of the patient within a safety motion *** the previous studies,conventional assistive robots did not require patients to use their own physical strength to stand,which led to decreased strength in the *** general assistive robots helped patients by using a fixed motion reference pathway in spite of their original intention,and as a result,these robots failed to use the physical strength of the ***,this study proposes a novel method for assisting the patient to stand up safely while using their physical abilities,by determining the range of movements that can be safely performed from the patient’s physical condition and allowing the patient to move freely within this *** standing motion is a set of different movements:inclining the trunk forward,lifting the trunk,and extending the *** this study,the range of movements in which the patient can safely stand in each movement is determined in terms of body stability and the muscle output that the patient can ***,this study proposes a robot control method that allows movements based on the patient’s free will if the patient’s posture is within the safety tolerance,and it corrects the movements when the patient’s posture is estimated to fall outside of *** proposed idea is implemented in our new prototype,and its effectiveness is verified by experimental results with elderly subjects who live in the nursing care house.

关键词： standing assistance assistive robot safety tolerance musculoskeletal simulation

A dynamic database of solid-state electrolyte (DDSE) picturing all-solid-state batteries

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Evidence of spin density wave of CeOs_4Sb_(12)

纳米材料科学 2024年第2期 256页

作者： Fangling Yang Egon Campos dos Santos Xue Jia Ryuhei Sato kazuaki Kisu Yusuke Hashimoto Shin-ichi Orimo Hao Li

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Rare Metals 2006年第Z1期25卷 550-552页

作者： IWASA kazuaki SUGAWARA Hitoshi SATO Hideyuki Department of Physics Tohoku University Sendai 980-8578 Japan Department of Physics Tokyo Metropolitan University Tokyo 192-0397 Japan

Elastic neutron diffraction measurements were performed on single crystals to study the ground state below the mysterious exotic transition temperature 0.86 K. An antiferromagnetic order with a tiny moment of 0.027 μB per formula is formed as the ground state for CeOs4Sb12 below the transition point. Our neutron data gives the evidence of spin density wave state for CeOs4Sb12 in this work.

关键词： elastic neutron scattering skutterudite structure antiferromagnetic ordering spin density wave

Clinical significance of type V_I pit pattern subclassification in determining the depth of invasion of colorectal neoplasms

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World Journal of Gastroenterology 2008年第2期14卷 211-217页

作者： Hiroyuki Kanao Shinji Tanaka Shiro Oka Iwao Kaneko Shigeto Yoshida Koji Arihiro Masaharu Yoshihara kazuaki Chayama Department of Medicine and Molecular Science Hiroshima University Graduate School of Biomedical Science Hiroshima Japan Department of Endoscopy Hiroshima University Hospital Hiroshima Japan Department of Pathology Hiroshima University Hospital Hiroshima Japan Health Service Center Hiroshima University Hiroshima Japan

AIM: To clarify whether subclassification of the type VI pit pattern on the basis of magnifying colonoscopy findings is useful in determining the type and depth of invasion of colorectal ***: We retrospectively analyzed 272 colorectal neoplasms (117 dysplasias and 155 submucosal invasive carcinomas; 228 patients) with a type V pit pattern [type VI, n = 202; type VN, n = 70 (Kudo and Tsuruta classification system)]. We divided lesions with a type VI pit pattern into two subclasses, mildly irregular lesions and severely irregular lesions, according to the prominent and detailed magnifying colonoscopy findings. We examined the relation between these two subclasses and histology/invasion ***: One hundred and four lesions (51.5%) were judged to be mildly irregular, and 98 lesions (48.5%) were judged to be severely irregular. Ninety-seven (93.3%) mildly irregular lesions showed dysplasias or submucosal invasion of less than 1000 μm (SM < 1000 μm). Fifty-five (56.1%) severely irregular lesions showed submucosal invasion equal to or deeper than 1000 μm (SM ≥ 1000 μm). Mild irregularity was found significantly more often in dysplasias or lesions with SM < 1000 μm than in lesions with SM ≥ 1000 μm (P < 0.01).CONCLUSION: Subclassification of the type VI pit pattern is useful for identifying dysplasias or lesions with SM < 1000 μm.

关键词： Colorectal neoplasm Magnification Type VI pit pattern Depth of invasion

Irritable bowel syndrome evaluation using computed tomography colonography

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World Journal of Gastroenterology 2016年第42期22卷 9394-9399页

作者： Hideki Ohgo Hiroyuki Imaeda Minoru Yamaoka kazuaki Yoneno Naoki Hosoe Takeshi Mizukami Hidetomo Nakamoto Department of Gastroenterology Saitama Medical University Department of General Internal Medicine Saitama Medical University Center for Diagnostic and Therapeutic Endoscopy School of Medicine Keio University Endoscopy Center NHO Kurihama Medical and Addiction Center

AIM To evaluate the morphology of the colon in patients with irritable bowel syndrome(IBS) by using computed tomography colonography(CTC).METHODS Twelve patients with diarrhea type IBS(IBS-D), 13 patients with constipation type IBS(IBS-C), 12 patients with functional constipation(FC) and 14 control patients underwent colonoscopy following CTC. The lengths of the rectosigmoid colon, transverse colon and the total colon were measured. The diameters of the rectum, sigmoid colon, descending colon, transverse colon, and ascending colon were *** The mean length of the total colon was 156.5 cm in group C, 158.9 cm in group IBS-D, 172.0 cm in group IBS-C, and 188.8 cm in group FC. The total colon in group FC was significantly longer than that in group C(P < 0.05). The mean length of the rectosigmoid colon was 56.2 cm, 55.9 cm, 63.6cm, and 77.4 cm(NS). The mean length of the transverse colon was 49.9 cm, 43.1 cm, 57.0 cm, and 55.0 cm. The transverse colonin group IBS-D was significantly shorter than that in group IBS-C(P < 0.01) and that in group FC(P = 0.02). The mean diameter of the sigmoid colon was 4.0 cm, 3.3 cm, 4.2 cm, and 4.3 cm(NS). The mean diameter of the descending colon was 3.6 cm, 3.1 cm, 3.8 cm, and 4.3 cm. The descending colon diameter in group IBS-D was significantly less than that in group IBS-C(P = 0.03) and that in group FC(P < 0.001). The descending colon diameter in group FC was significantly greater than that in group C(P = 0.04). The mean diameter of the transverse colon was 4.4 cm, 3.3 cm, 4.2 cm, and 5.0 cm(NS).CONCLUSION CT colonography might contribute the clarification of subtypes of IBS.

关键词： Constipation Irritable bowel syndrome Computed tomography colonography

Role of hepatectomy for recurrent or initially unresectable hepatocellular carcinoma

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World Journal of Hepatology 2014年第12期6卷 836-843页

作者： Yoji Kishi kazuaki Shimada Satoshi Nara Minoru Esaki Tomoo Kosuge Hepatobiliary and Pancreatic Surgery Division National Cancer Center Hospital Tokyo 104-0045 Japan

As a result of donor shortage and high postoperative morbidity and mortality after liver transplantation,hepatectomy is the most widely applicable and reliable option for curative treatment of hepatocellular carcinoma(HCC).Because intrahepatic tumor recurrence is frequent after loco-regional therapy,repeated treatments are advocated provided background liver function is *** treatments including local ablation and transarterial chemoembolization,hepatectomy provides the best long-term outcomes,but studies comparing hepatectomy with other nonsurgical treatments require careful review for selection *** patients with initially unresectable HCC,transarterial chemo-or radio-embolization,and/or systemic chemotherapy can down-stage the tumor and conversion to resectable HCC is achieved in approximately 20%of ***,complete response is rare,and salvage hepatectomy is essential to help prolong patients’*** counter the short recurrence-free survival,excellent overall survival is obtained by combining and repeating different *** is important to recognize hepatectomy as a complement,rather than a contraindication,to other nonsurgical treatments in a mul-tidisciplinary approach for patients with HCC,including recurrent or unresectable tumors.

关键词： Hepatocellular carcinoma Hepatectomy Repeat hepatectomy Conversion therapy Multidisciplinary treatment

Mechanical Stress to Cell Nucleus Inhibits Proliferation and Differentiation of Vascular Smooth Muscle Cells

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Journal of Biosciences and Medicines 2020年第5期8卷 132-141页

作者： kazuaki Nagayama Micro-Nano Biomechanics Laboratory Department of Mechanical Systems Engineering Ibaraki University Ibaraki Japan

Cells sense the external environment such as a surface topography and change many cellular functions. Cell nucleus has been proposed to act as a cellular mechanosensor, and the changes in nuclear shape possibly affect the functional regulation of cells. This study demonstrated a large-scale mechanical deformation of the intracellular nucleus using polydimethylsiloxane (PDMS)-based micropillar substrates and investigated the effects of nuclear deformation on migration, proliferation, and differentiation of vascular smooth muscle cells (VSMCs). VSMCs spread completely between the fibronectin-coated pillars, leading to strong deformations of their nuclei resulted in a significant inhibition of the cell migration. The proliferation and smooth muscle differentiation of VSMCs with deformed nuclei were dramatically inhibited on the micropillars. These results indicate that the inhibition of proliferation and VSMC differentiation resulted from deformation of the nucleus with high internal stress, and this type of large-scale nuclear mechanical stress might lead the cells to a “quiescent state”.

关键词： Cell Biomechanics Mechanobiology Nuclear Mechanotransduction Microfabrication

玻尔兹曼分布研究辉光放电等离子体中铁原子谱线的激发机制

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冶金分析 2015年第1期35卷 13-18页

作者：张蕾 WAGATSUMA kazuaki 刘鑫日本东北大学未来科学技术共同研究中心日本东北大学金属材料研究所首钢股份公司迁安钢铁公司

采用玻尔兹曼分布法,通过不同的放电参数,例如外加电压、电流和气压等,研究了辉光放电等离子体中激发能量为4.1;.0eV的铁原子谱线激发机制。低激发能量曲线很好地拟合了正玻尔兹曼分布,然而较高激发能量的原子谱线与线性玻尔兹曼曲线有... 详细信息

采用玻尔兹曼分布法,通过不同的放电参数,例如外加电压、电流和气压等,研究了辉光放电等离子体中激发能量为4.1;.0eV的铁原子谱线激发机制。低激发能量曲线很好地拟合了正玻尔兹曼分布,然而较高激发能量的原子谱线与线性玻尔兹曼曲线有很大偏差。其结果可能是由于较低等级激发由热碰撞引起,而另一方面,铁原子高位等级的激发则是铁原子和氩或氖亚稳原子间的碰撞引起的。

关键词：辉光放电等离子体铁原子谱线氖氩玻尔兹曼分布