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Replicated association of the single nucleotide polymorphism in PNLIP with marbling in Niigata population of Japanese Black beef cattle

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Open Journal of Animal Sciences 2013年第2期3卷 89-92页

作者： Hideki Tanomura Youji muramatsu Takuji Yamamoto Takeshi Ohta Hiroyuki Kose Takahisa Yamada Central Pharmaceutical Research Institute Japan Tobacco Inc. Takatsuki Japan Department of Life Science Division of Natural Sciences International Christian University Mitaka Japan Department of Nutritional Sciences for Well-being Faculty of Health Sciences for Welfare Kansai University of Welfare Sciences Kashiwara Japan Laboratory of Animal Genetics Graduate School of Science and Technology Niigata University Nishi-ku Japan

Marbling is regarded as an economically important trait of beef cattle inJapan, and measured as a beef marbling score (BMS). Our previous study reported an association between a single nucleotide polymorphism (SNP), rs4164 8172, in the pancreatic lipase (PNLIP) gene and the BMS level, using the Japanese Black beef cattle population of Oita prefecture. Further, we showed that the T allele at the rs41648172 SNP is associated with a high level of the BMS. Thus, we suggested that the rs41648172 SNP seems to be a candidate marker for marker-assisted selection. Our present study was designed to investigate whether this association could be replicated in other independent Japanese Black cattle population and analyze the effect of the SNP genotypes on the carcass traits other than the BMS. We detected the marginally significant effect of the genotypes of the rs41648172 SNP on the BMS level by using the Japanese Black beef cattle population of Niigata prefecture (P = 0.0919), and obtained the result of the T allele associated with an increase in the BMS level, consistent with our previous data. In addition, we showed no significant association of the SNP with the subcutaneous fat thickness, carcass weight, rib eye area, rib thickness and yield estimate in the Japanese Black beef cattle population ofNiigataprefecture. Thus, we concluded that the rs41648172 SNP was useful for effective marker-assisted selection to increase the BMS level in Japanese Black beef cattle, based on the replicated association of the rs41648172 SNP with the BMS level in the other independent Japanese Black beef cattle population and no effect of the SNP genotypes on the carcass traits other than BMS.

关键词： Association PNLIP Japanese Black Breed Marbling Replication Study Single Nucleotide Polymorphism

Selective decrease in colonic CD56^+ T and CD161^+ T cells in the inflamed mucosa of patients with ulcerative colitis

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World Journal of Gastroenterology 2007年第45期13卷 5995-6002页

作者： Masaru Shimamoto Yoshitaka Ueno Shinji Tanaka Toshiko Onitake Rie Hanaoka Kyoko Yoshioka Tsuyoshi Hatakeyama kazuaki Chayama Department of Medicine and Molecular Science Hiroshima University Hiroshima 734-8551Japan Department of Endoscopy Hiroshima University Hospital Hiroshima Japan

AIM： To investigate the role of local colonic mucosal NK receptor-positive T （NKR＋ T） cells in the regulation of intestinal inflammation, we analyzed the population and function of these cells in ulcerative colitis （UC）. METHODS： Colonic mucosal tissues were obtained from colonoscopic biopsies of the descending colon from 96 patients with UC （51 endoscopically uninflamed, 45 inflamed） and 18 normal controls. Endoscopic appearance and histologic score at the biopsied site were determined by MaLts＇ classification. A single cell suspension was prepared from each biopsy by collagenase digestion. Two NKR^＋ T cell subsets, CD56^＋（CD56^＋CD3^＋） T cells and CD161＋（CD161^＋CD3^＋） T cells, were detected by flow cytometric analysis. Intracellular cytokine analysis for anti-inflammatory cytokine interleukin-10 （IL-10） was performed by in vitro stimulation with phorbol-myristateacetate （PMA） and ionomycin. RESULTS： CD56^＋ T cells and CD161^＋ T cells are present in the normal human colon and account for 6.7% and 21.3% of all mononuclear cells, respectively. The populations of both CD56＋ T cells and CD161^＋ T cells were decreased significantly in the inflamed mucosa of UC. In contrast, the frequency of conventional T cells （CD56 CD3^＋ cells and CD161CD3^＋ cells） was similar among the patient and control groups. The populations of NKR^＋ T cells were correlated inversely with the severity of inflammation, which was classified according to the endoscopic and histologic Marts＇ criteria. Interestingly, approximately 4% of mucosal NKR＋ T cells expressing IL-10 were detected by in vitro stimulation with PMA and ***： Selective reduction in the population of colonic mucosal NKR＋T cells may contribute to the development of intestinal inflammation in UC.

关键词： Natural killer T cells Ulcerative colitis Interleukin-10

Prevalence and impact of musculoskeletal pain in Japanese gastrointestinal endoscopists:A controlled study

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World Journal of Gastroenterology 2011年第11期17卷 1488-1493页

作者： Takayasu Kuwabara Yuji Urabe Toru Hiyama Shinji Tanaka Takako Shimomura Shiro Oko Masaharu Yoshi-hara kazuaki Chayama Department of Gastroenterology and Metabolism Hiroshima University HospitalHiroshima 739-8514Japan Health Service Center Hiroshima UniversityHigashihiroshima 739-8514Japan Department of Endoscopy Hiroshima University HospitalHiroshima 739-8514Japan

AIM:To examine the frequency and prevention of musculoskeletal pain in Japanese gastrointestinal endoscopists and non-endoscopist ***:Questionnaires were sent to 275 endoscopists and 173 non-endoscopists working in Hiroshima University Hospital and its affiliated ***:The completed questionnaires were returned by 190(69%)endoscopists and 120(69%)*** frequency of pain in the hand and wrist,and especially the left thumb,was significantly higher in endoscopists than in non-endoscopists(17%vs 6%,P=0.004).Using multivariate analysis,the only significant factor associated with this pain was the age of the endoscopist(odds ratio 2.77,95%confidence interval,1.23-6.71,P=0.018).Interestingly,endoscopists had made significantly fewer modifications to their endoscopic practices than non-endoscopists(12%vs 33%,P <0.0001)to prevent ***:Pain in the hand and wrist may be ***,endoscopists made little modifications in practice to prevent such *** attention to prevention appears necessary.

关键词： Endoscopy Musculoskeletal pain Pain prevention

一种经氟化和热处理在双壁碳纳米管上生成缺陷的方法(英文)

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催化学报 2014年第6期35卷 864-868页

作者： Hiroyuki muramatsu Kazunori Fujisawa Yong-Il Ko Kap-Seung Yang Takuya Hayashi Morinobu Endo Cheol-Min Yang Yong Chae Jung Yoong Ahm Kim Faculty of Engineering Shinshu University 4-17-1 Wakasato Nagano 380-8553 Japan School of Polymer Science and Engineering Chonnam National University 77 Yongbong-ro Buk-gu 500-757 Gwangju Korea Institute of Carbon Science and Technology Shinshu University 4-17-1 Wakasato Nagano 380-8553 Japan Institute of Advanced Composite Materials Korea Institute of Science and Technology Chudong-ro 92 Bongdong-eup Wanju-gun Jeonbuk 565-905 Korea

Nanoscale defects in the outer tube to preserve the electrical and optical features of the inner tube can be engineered to exploit the intrinsic properties of double walled carbon nanotubes (DWCNTs) for various promising applications. We demonstrated a selective way to make defects in the outer tube by the fluorination of DWCNTs followed by the thermal detachment of the F atoms at 1000 °C in argon. Fluorinated DWCNTs with different amounts of F atoms were prepared by reacting with fluorine gas at 25, 200, and 400 °C that gave the stoichiometry of CF0.20, CF0.30, and CF0.43, respectively. At the three different temperatures used, we observed preservation of the coaxial morphology in the fluorinated DWCNTs. For the DWCNTs fluorinated at 25 and 200 °C, the strong radial breathing modes (RBMs) of the inner tube and weakened RBMs of the outer tube indicated selective fluorine attachment onto the outer tube. However, the disappearance of the RBMs in the Raman spectrum of the DWCNTs fluorinated at 400 °C showed the introduction of F atoms onto both inner and outer tubes. There was no significant change in the morphology and optical properties when the DWCNTs fluorinated at 25 and 200 °C were thermally treated at 1000 °C in argon. However, in the case of the DWCNTs fluorinated at 400 °C, the recovery of strong RBMs from the inner tube and weakened RBMs from the outer tube indicated the selective introduction of substantial defects on the outer tube while preserving the original tubular shape. The thermal detachment of F atoms from fluorinated DWCNTs is an efficient way to make highly defective outer tubes for preserving the electrical conduction and optical activity of the inner tubes.

关键词：双壁碳纳米管热处理氟化缺陷光学特性 F原子化学计量呼吸模式

Sleep and Stress of Late Middle Age Males Who Are Forced to Live in Emergency Temporary Houses and Post-Earthquake Public Houses for a Long Period Due to the Fukushima Daiichi Nuclear Power Station Accident

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Health 2017年第13期9卷 1787-1800页

作者： Yuka Iwasa Yoshiyuki muramatsu Hagiko Aoki Chikako Tomiyama Tomoko Saito Mayumi Nishikata Mieko Uchiyama Department of Nursing School of Health Sciences Faculty of Medicine Niigata University Niigata Japan Department of Medical Technology School of Health Sciences Faculty of Medicine Niigata University Niigata Japan

It has been revealed that prolonged shelter life caused by Fukushima Daiichi Nuclear Power Station accident in conjunction with the Great East Japan Earthquake influences sleep and mental health of the residents, and therefore its influence on their physical and emotional health has become a concern. Therefore, in this study, the authors aimed at clarifying actual situations of sleep and stress of middle age males living in shelters for a long period in each of emergency temporary houses and post-earthquake public houses. For 5 males who moved from emergency temporary houses to post-earthquake public houses, their objective and subjective sleep states were measured with Actigraph and PSQI, respectively. Furthermore, their objective and subjective stresses were measured with saliva stress biomarkers and GHQ28, respectively. Their data were analyzed by paired t-test. As result, in comparison between the life in the emergency temporary houses and post-earthquake public houses, significant variation was not recognized in their objective sleep states and saliva stress biomarkers though their subjective sleep and subjective stress were significantly worsened after moving to the post-earthquake public houses.

关键词： Fukushima Daiichi Nuclear Power Station Accident Emergency Temporary House Actigraph Sleep Mental Stress

ABO incompatible renal transplants:Good or bad?

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World Journal of Transplantation 2014年第1期4卷 18-29页

作者： Masaki muramatsu Hector Daniel Gonzalez Roberto Cacciola Atsushi Aikawa Magdi M Yaqoob Carmelo Puliatti Department of Translational Medicine and Therapeutics William Harvey Research Institute Queen Mary University of London Department of Nephrology Toho University Faculty of Medicine Transplant Unit The Royal London Hospital

ABO incompatible kidney transplantation(ABOi-KT) was previously considered to be an absolute contraindication for patients with end-stage kidney disease(ESKD) due to hyperacute rejection related to blood type barrier. Since the first successful series of ABOi-KT was reported, ABOi-KT is performed increasingly all over the world. ABOi-KT has led to an expanded donor pool and reduced the number of patients with ESKD awaiting deceased kidney transplantation(KT). Intensified immunosuppression and immunological understanding has helped to shape current desensitization protocols. Consequently, in recent years, ABOi-KT outcome is comparable to ABO compatible KT(ABOc-KT). However, many questions still remain unanswered. In ABOi-KT, there is an additional residual immunological risk that maylead to allograft damage, despite using current diverse but usually intensified immunosuppressive protocols at the expense of increasing risk of infection and possibly malignancy. Notably, in ABOi-KT, desensitization and antibody reduction therapies have increased the cost of KT. Reassuringly, there has been an evolution in ABOiKT leading to a simplification of protocols over the last decade. This review provides an overview of the history, outcome, protocol, advantages and disadvantages in ABOi-KT, and focuses on whether ABOi-KT should be recommended as a therapeutic option of KT in the future.

关键词： Kidney transplantation ABO incompatible Antibody depletion Immunosuppression Desensitization protocols Living donor transplantation

A Comparative Study of the Hydroxyl and Saponification Values of Polysorbate 60 in International Food Additive Specifications

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American Journal of Analytical Chemistry 2014年第3期5卷 199-204页

作者： kazuaki Wakita Haruyoshi Kuwabara Noriko Furusho Chiye Tatebe Kyoko Sato Hiroshi Akiyama Division of Food Additives National Institute of Health Sciences Tokyo Japan Oleo & Specialty Chemicals Research Laboratory NOF Corporation Kawasaki-shi Japan Quality Assurance Department Gunma Complex Shin-Etsu Chemical Co. Ltd. Annaka-shi Japan

We investigated the hydroxyl and saponification values of 27 samples of Polysorbate 60 products that were commercially available worldwide. We observed that the values of most of the studied samples were not within the range established at the Joint FAO/WHO Expert Committee on Food Additives (JECFA), while they did agree with the specifications described in the USA, the EU and Japan. We believe that purities of the new commercial Polysorbate 60 samples are higher than those of the older products which were available when the JECFA specifications were discussed (around 1973). The present study suggests that the hydroxyl and saponification values of the current JECFA specifications for Polysorbate 60 should be re-evaluated.

关键词： Polysorbate 60 Polyoxyethylene Sorbitan Monostearate Hydroxyl Value Saponification Value Emulsifier Specification

深层滚压加工对高碳铬轴承钢超长寿命疲劳行为的影响

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金属学报 2006年第5期42卷 515-520页

作者：鲁连涛盐泽和章姜燕西南交通大学牵引动力国家重点实验室成都610031 富山大学工学部成都市公共交通集团公司成都610041

深层滚压加工对高碳铬轴承钢超长寿命疲劳行为的研究表明:与深层滚压加工前相同,在高应力幅短寿命区,疲劳裂纹萌生于试佯表面;由于表面压缩残余应力的影响,疲劳强度有所提高．在低应力幅长寿命区,疲劳裂纹萌生位置从未经深层滚压加工试... 详细信息

深层滚压加工对高碳铬轴承钢超长寿命疲劳行为的研究表明:与深层滚压加工前相同,在高应力幅短寿命区,疲劳裂纹萌生于试佯表面;由于表面压缩残余应力的影响,疲劳强度有所提高．在低应力幅长寿命区,疲劳裂纹萌生位置从未经深层滚压加工试样的次表面向深层滚压加工试样内部没有压缩残余应力和硬化层的位置转移;因弯曲应力梯度的影响,疲劳强度有了较大的提高．深层滚压加工可以提高高碳铬轴承钢在超长寿命区的旋转弯曲疲劳强度．

关键词：超长寿命疲劳滚压加工 S-N曲线残余应力轴承钢

パネルディスカッツヨソ·文学と宗教覚え书き

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日语学习与研究 2011年第2期 1-6页

作者：小峯和明立教大学

关键词：日语教学教学方法宗教史学日本