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Comparison of non-cycloplegic photorefraction,cycloplegic photorefraction and cycloplegic retinoscopy in children

International Journal of Ophthalmology(English edition) 2015年第1期8卷 128-131页

作者： Ozdemir Ozdemir Zuhal Ozen Tunay Ikbal Seza Petricli Damla Ergintürk Acar Muhammet kazim erol Department of Ophthalmology Zekai Tahir Burak Women's Health Education and Research Hospital Department of Ophthalmology Etlik Zubeyde Hanim Maternity and Women's Health Research Hospital Department of Ophthalmology Antalya Education and Research Hospital

AIM: To compare the results of noncycloplegic photorefraction, cycloplegic photorefraction and cycloplegic refraction in preschool and non-verbal ***: One hundred and ninety-six eyes of 98children(50 females, 48 males) were included in the study. Firstly, non-cycloplegic photorefraction was achieved with Plusoptix A09; secondly, cycloplegic photorefraction was carried out with Plusoptix A09 after10 min cyclopentolate. Finally, 30 min after instillation of twice cyclopentolate, cycloplegic refraction was obtained with autorefraction and/or standard retinoscopy. Spheric equivalent, spheric power, cylindric power and cylindrical axis measurements were statistically ***: The mean age was 28.8±18.5mo(range12-72mo). The differences in spherical equivalent, spheric power and cylindrical power measured by the three methods were found statistically significant(P 0.05).CONCLUSION: For the determination of refractive errors in children, the Plusoptix A09 measurements give incorrect results after instillation of ***, the cylindrical power measured by Plusoptix A09 with or without cycloplegia is higher. However, the non-cycloplegic Plusoptix A09 measures spheric equivalent and spheric power similar to cycloplegic refraction measurements in preschool and non-verbal children.

关键词： cyclopentolate cycloplegia photorefraction photoretinoscopy Plusoptix retinoscopy refraction

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Does Anti-Vascular Endothelial Growth Factor Treatment Delay Photoreceptor Maturation in Preterm Infants?

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Open Journal of Ophthalmology 2020年第1期10卷 10-20页

作者： Elcin Süren,Ersan Cetinkaya Mehmet Fatih Kücük Musatafa Kalayci Muhammet kazim erol Antalya Training and Research Hospital Department of OphthalmologyAntalyaTurkey

Purpose: To investigate the effects of intravitreal anti-vascular endothelial growth factor (VEGF) for treatment of type-1 or aggressive posterior retinopathy of prematurity (ROP) on photoreceptor maturation in preterm infants using spectral domain optical coherence tomography (SD-OCT). Methods: A study group of 36 patients with ROP treated with anti-VEGF therapy was compared to a control group of 80 patients with ROP. All patients had undergone SD-OCT imaging at least once between 40 and 44 weeks post-menstrual age (PMA). Two imaging specialists evaluated the images for ellipsoid zone (EZ) development, cystoid macular edema (CME), sub-retinal fluid (SRF) at the fovea, and cone outer segment tips (COST). The outer nuclear layer thickness and the distance from the EZ to the central fovea was measured. Results: EZ development was observed in 18 (50%) patients in the study group and 68 (85%) in the control group (p = 0.002). CME was observed in 17 (47.2%) patients in the study group and 17 (21.2%) in the control group. The distance between the EZ and central fovea was 868 ± 440 μm in the study group and 725 ± 380 μm in the control group (p = 0.02). COST was not observed in any patient. Regression analysis indicated that anti-VEGF treatment and CME affect EZ development. Conclusions: Early photoreceptor maturation is correlated with preterm birth week but not ROP stage. Anti-VEGF treatment delays photoreceptor maturation in preterm infants.

关键词： Cystoid Macular Edema Photoreceptor Retinopathy of Prematurity Vascular Endothelial Growth Factor

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Three Consecutive Monthly Intravitreal Ranibizumab for Choroidal Neovascularization in Central Serous Choriorethinopathy:A Case Report

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Open Journal of Ophthalmology 2012年第3期2卷 93-96页

作者： kazim erol Esin Sogutlu Sari Arif Koytak A.Karacor D.T.Coban M.Bulut Ophthalmology Department Antalya Training and Research HospitalAntalyaTurkey Ophthalmology Department Kartal Training and Research HospitalIstanbulTurkey Ophthalmology Department Bezmialem Vakif UniversityIstanbulTurkey

Purpose: The author report the result of three consecutive monthly intravitreal ranibizumab injection for choroidal neovascularization (CNV) after bevacizumab injection for chronic central serous rethinopathy (CSR). Methods: A 48 year old man with chronic CSR was treated with intravitreal single dose 2.5 mg bevacizumab. One year after CNV was occurred, and three consecutive monthly intravitreal ranibizumab injections were performed. Results: Four weeks later the first ranibizumab dose, best corrected visual acuity was improved 20/80 to 20/20 and remained stable within one year. Conclusion: Repeat intravitreal ranibizumab injection in CNV after bevacizumab injection for chronic CSR appeared to be an effective treatment option.

关键词： Central Serous Choriorethinopathy Choroidal Neovascularization Ranibizumab

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CSCR中盐皮质激素受体基因-2G/C的多态性及其与血浆皮质醇水平的关系（英文）

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国际眼科杂志 2016年第7期16卷 1203-1206页

作者： Alper Yazici Esin Sogutlu Sari Betul Eser Gozde Sahin Medine Alpdemir Adil Kilic Muhammet kazim erol Sitki Samet Ermis 土耳其巴勒凯西尔巴勒凯西尔大学医学院眼科 10150 土耳其巴勒凯西尔巴勒凯西尔大学医学院遗传学系 10150 土耳其巴勒凯西尔比格达奇州医院生物化学系 10010 土耳其安塔利亚安塔利亚培训与研究医院眼科

目的:评估中心性浆液性脉络膜视网膜(CSCR)病变中盐皮质激素受体基因-2G/C单核苷酸多态性,以及基因多态性和血浆皮质醇水平的关系。方法:选取60例中心性浆液性脉络膜视网膜病变患者和50例正常人作为研究对象。患者皆患有急性中心性浆液... 详细信息

目的:评估中心性浆液性脉络膜视网膜(CSCR)病变中盐皮质激素受体基因-2G/C单核苷酸多态性,以及基因多态性和血浆皮质醇水平的关系。方法:选取60例中心性浆液性脉络膜视网膜病变患者和50例正常人作为研究对象。患者皆患有急性中心性浆液性脉络膜视网膜病变,即浆液性视网膜脱离和视网膜色素上皮脱离或功能障碍(排除其它可能导致渗出的疾病,比如脉络膜新生血管、炎症或浸润病变)。为避免皮质醇水平的昼夜变化,上午8时到10时之间采集外周血样,检测盐皮质激素受体基因多态性(rs2070951)和血浆皮质醇水平。结果:CSCR组的基因型频率分布为G/C(46.6%),G/G(26.7%)和C/C(26.7%)。两组间基因型分布无统计学差异(P=0.96)。研究结果显示,CSCR组的血浆皮质醇水平为401.2±162.1 nmol/L,对照组为296.8±130.1nmol/L,两组间差异有统计学意义(P<0.01)。血浆皮质醇水平在G/C(345.0±137.0 nmol/L),G/G(369.2±165.3 nmol/L)和C/C(395.3±188.8 nmol/L)基因型之间不存在差异(P=0.50)。结论:盐皮质激素受体基因多态性与中心性浆液性脉络膜视网膜病变和血浆皮质醇水平无关。

关键词：盐皮质激素黄斑中心性浆液性脉络膜视网膜病变多态性遗传学

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