检索结果-南通市图书馆

The link between intracellular calcium signaling and exosomal PD-L1 in cancer progression and immunotherapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第1期11卷 321-334页

作者： md Rakibul alam md Mizanur Rahman Zhiguo Li Department of Toxicology and Cancer Biology College of MedicineUniversity of KentuckyLexingtonKY 40506USA Department of Medicine(Nephrology) Faculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6E2H7Canada

Exosomes are small membrane vesicles containing microRNA,RNA,DNA fragments,and proteins that are transferred from donor cells to recipient *** cells release exo-somes to reprogram the factors associated with the tumor microenvironment(TME)causing tu-mor metastasis and immune *** evidence revealed that cancer cell-derived exosomes carry immune inhibitory molecule program death ligand 1(PD-L1)that binds with re-ceptor program death protein 1(PD-1)and promote tumor progression by escaping immune ***,some FDA-approved monoclonal antibodies are clinicallyused for cancer treatment by blocking PD-1/PD-L1 *** notable treatment outcomes,some pa-tients show poor drug *** PD-L1 plays a vital role in lowering the treatment response,showing resistance to PD-1/PD-L1 blockage therapy through recapitulating the ef-fect of cell surface *** enhance therapeutic response,inhibition of exosomal PD-L1 is *** signaling is the central regulator of tumorigenesis and can regulate exosome biogenesis and secretion by modulating Rab GTPase family and membrane fusion ***-mune checkpoints are also connected with calcium signaling and calcium channel blockers like amlodipine,nifedipine,lercanidipine,diltiazem,and verapamil were also reported to suppress cellular PD-L1 ***,to enhance the PD-1/PD-L1 blockage therapy response,the reduction of exosomal PD-L1 secretion from cancer cells is in our therapeutic *** this review,we proposed a therapeutic strategy by targeting calcium signaling to inhibit the expression of PD-L1-containing exosome levels that could reduce the anti-PD-1/PD-L1 therapy resistance and increase the patient's drug response rate.

关键词： Calcium signaling CD8^(+)T cells Exosomal PD-L1 Exosomes biogenesis Immunosuppression Immunotherapy

Turning Trash into Treasure: Developing an Intelligent Bin for Plastic Bottle Recycling

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Social Computing 2024年第1期5卷 1-14页

作者： Sirajam Munira Niloy Paul md Ashraful alam md.Mahmudur Rahman M.Shamim Kaiser Institute of Information Technology Jahangirnagar UniversityDhaka 1342Bangladesh

Plastic pollution has emerged as a major global concern due to its enduring nature and limited recycling *** response to this critical challenge,this paper presents a novel approach utilizing a Detection-Based Reward System(DBRS)alongside an innovative business model to promote effective plastic waste management,reduce plastic waste accumulation in the nature,and uphold environmental *** the YOLOv5 algorithm for its exceptional accuracy,speed,and open-source availability,plastic bottle detection becomes a pivotal aspect of this *** seamlessly enroll in the system,triggering an automated detection process that computes reward points corresponding to their deposited plastic *** reward points are meticulously stored within a centralized *** its operational facets,this comprehensive system encompasses a robust business model,strategically poised to capture widespread engagement with waste disposal practices,thereby contributing to the realization of Sustainable Development Goals(SDGs)geared towards fostering a healthier ***,the DBRS attains cutting-edge performance in plastic bottle detection,boasting an impressive mean Average Precision(mAP)of 0.973,underscoring its efficacy in tackling plastic pollution.

关键词： smart environment reward system YOLOv5 deep learning business model

Energy Harvesting in the Wake of An Inverted C-Shaped Bluff Body

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Ocean Engineering 2024年第1期38卷 68-80页

作者： WANG Jun-lei LI Shen-fang md.Mahbub alam ZHU Hong-jun HU Guo-biao School of Mechanical and Power Engineering Zhengzhou UniversityZhengzhou 450000China Center for Turbulence Control Harbin Institute of Technology(Shenzhen)Shenzhen 518055China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China Internet of Things Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China

This paper proposes a novel wake-induced vibration(WIV)-based energy harvesting system consisting of two bluff *** inverted C-shaped bluff body is stationary installed at the upstream position to generate an interference wake street,and a cylinder bluff body equipped with a transducer is elastically suspended at the downstream position to harness WIV *** hydrodynamics and energy harvesting(EH)performance of the proposed system are investigated via experimental *** reduced velocity(U*)ranging from 2 to 14(the corresponding Reynolds number ranging from 15100 to 106200)is considered in the present *** is found that the wake generated by the inverted C-shaped bluff body significantly affects the EH *** the opening angle(α)of the C-shaped bluff body increases the vibration amplitude of the downstream cylinder,thereby increasing the harvested *** the spacing(L)between two bluff bodies is two times the cylinder diameter(D),the wake-induced vibration(WIV)mode is observed,while the combined WIV and wake galloping(WG)mode occurs whenαis 150°,and L equals 3D or *** average drag coefficient becomes negative when L is 2D,3D,or *** carefully configuring a C-shaped bluff body,the wake generated by it can bring an augmenting effect on the vibration of the downstream EH *** example,the RMS power output of the proposed EH system reaches a maximum of 0.31 W at U*=8 and L=4D,which is 300%greater than that of its traditional ***,after a number of case stud-ies,it is identified that the proposed EH system can achieve the best performance whenαis 150°and L=2D.

关键词： wake-induced vibration vortex-induced vibration galloping energy harvesting bluff body

Repercussion of salinity on hematological parameters and tissue morphology of gill and kidney at early life of tilapia

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第2期9卷 256-264页

作者： Azhar Ali md Golam Azom Bhakta Supratim Sarker Hasu Rani md Samsul alam m.sadiqul islam*department of fisheries biology and genetics bangladesh agricultural universitymymensingh2202bangladesh

This study was attempted to reveal the changes in three hematological parameters such as blood hemoglobin,number of white blood cells(WBCs)and number of red blood cells(RBCs)and one biochemical(e.g.,glucose)parameter along with the changes in histomorphological structures of gills and kidney of Nile tilapia fry reared in saline *** experimental set up were used for two different age groups-5 days-after-hatch(5DAH)and 15 days-after-hatch(15DAH)-to test a novel hypothesis:if a little difference in the age during the first exposure to saline water could produce any variation in the *** were placed into 6 plastic drums having six different salinity levels:0,5,10,15,20 and *** 60 days,at least 5 individuals were taken out from each drum to observe the above-hematological and histomorphological parameters.A two-way-ANOVA revealed that,except for hemoglobin,all the observed parameters have been affected the effect of age×salinity interaction(P<0.05).Between the two age groups,only the overall average glucose value and RBC count were significantly *** various salinity levels,only RBC and WBC counts differed ***,the mean glucose value,RBC counts and WBC count at different salinities differed significantly from the base mean value of each *** regard to the histomorphological structure of the gills and kidney,various malformations were *** hypertrophy,epithelial uplifting and epithelial necrosis were present as gill degenerations,hyperplasia was prevalent across almost all salinity *** the other hand,glomerular necrosis,pyknotic nucleus,hyaline droplets degeneration,shrinking of the glomeruli,*** observed in kidney *** assisting to understand the effects of salinity stress,all these data on tilapia fry will help to determine the prospects and scope of culturing the species in high-salinity water.

关键词： Nile tilapia Salinity Blood parameters Histomorphology Age groups

Assessing the pomfret stock for setting catch limits in the northern Bay of Bengal,Bangladesh

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Aquaculture and Fisheries 2024年第2期9卷 324-335页

作者： Mohammed Shahidul alam Qun Liu md Mostafa Monwar md Enamul Hoque Suman Barua md Leion Hassan Abdullah Munzer College of Fisheries Ocean University of ChinaQingdao266003China Department of Fisheries University of ChittagongChattogram4331Bangladesh Institute of Marine Sciences University of ChittagongChattogram4331Bangladesh Department of Oceanography University of ChittagongChattogram4331Bangladesh Department of Fisheries Ministry of Fisheries and LivestockDhaka1215Bangladesh

Pampus argenteus and Pampus chinensis form the high-value demersal Pomfret fishery of ***,due to a monotonic decline in catches over the last five years,it is essential to explore the current stock status concerning the removal rate to ensure the sustainability of this ***,given the reliability and minimal data requirements,this study employed an extended Bayesian State-Space Surplus Production Model,JABBA(Just Another Bayesian Biomass Assessment),to assess the stock *** results revealed that the stock biomass of the Pomfret fishery in the final year of the time series is significantly lower than BMSY,the biomass required to produce ***,this study recommends a yearly catch limit(TAC)of 10,000 metric tons to prevent further depletion of the stock ***,to avoid growth overfishing by allowing all immature fishes to reproduce at least once before being caught,this study also calculated the optimum length(Lopt)for catch for both species at which biologically maximum yield and revenue can be *** estimated Lopt is 25 cm for *** and 30 cm for ***,and not to capture fishes with lengths lower than these limits,this study further calculated the minimum mesh size limits for gill and set bag nets is 7.5 *** the mesh size regulation was estimated using length-based reference points derived from an empirical equation,this regulation can be used as an associate reference point when TAC is applied to assure the sustainability of this fishery.

关键词： Pomfret fishery Stock assessment JABBA TAC Lower length limits for catches Mesh size regulation

Coleus forskohlii shows anti-psoriatic activity in imiquimod-induced psoriasis rats

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Pacific Journal of Tropical Biomedicine 2024年第9期14卷 382-390,I0002-I0007页

作者： Sagarika Majhi Iti Chauhan Deepak Kumar md.Niyaz alam md.Sarfaraj Hussain Muzaffar Iqbal Faculty of Pharmacy I.T.S College of PharmacyMuradnagarGhaziabadU.P.India Lord Buddha Koshi Pharmacy College of Pharmacy BaijanathpurNH 107Saharsa(Bihar)852201India Department of Pharmaceutical Chemistry College of PharmacyKing Saud UniversityP.O.Box 2457Riyadh 11451Saudi Arabia

Objective:To evaluate anti-psoriatic activity of Coleus forskohlii in rats with imiquimod-induced ***:Imiquimod was used to induce psoriasis in *** weight,skin thickness,erythema,scaling,spleen weight,and histological alternations were measured to assess the effect of Coleus ***,an emulgel formulation containing Coleus forskohlii 10%was prepared and characterized along with its ex vivo permeation ***:The emulgel formulation containing Coleus forskohlii 10%had a pH of 5.40±0.36,with optimum spreadability of(31.67±2.08)g/(cm·s)and viscosity of(15966.67±1274.10)cps,and enhanced both the rate and the extent of drug permeation through psoriatic *** an ex vivo study,the quantity of drug permeated(19.18%),deposited(52.38%),and drug remaining in the donor compartments(28.31%)was *** forskohlii significantly alleviated imiquimod-induced psoriasis by increasing glutathione and superoxide dismutase activity,decreasing malondialdehyde and nitric oxide levels,and alleviating histological alternations in rat ***:Coleus forskohlii can alleviate imiquimod-induced psoriasis,which may be used as a therapeutic candidate for the treatment of psoriasis.

关键词： Psoriasis Coleus forskohlii Emulgel Ex vivo Imiquimod Carbopol

An Enhanced Hybrid Model Based on CNN and BiLSTM for Identifying Individuals via Handwriting Analysis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第8期140卷 1689-1710页

作者： md.Abdur Rahim Fahmid Al Farid Abu Saleh Musa Miah Arpa Kar Puza md.Nur alam md.Najmul Hossain Sarina Mansor Hezerul Abdul Karim Department of Computer Science and Engineering Pabna University of Science and TechnologyPabna6600Bangladesh Faculty of Engineering Multimedia UniversityCyberjaya63100Malaysia Department of Computer Science and Engineering Bangladesh Army University of Science and TechnologySaidpur5311Bangladesh Department of Mathematics Pabna University of Science and TechnologyPabna6600Bangladesh Department of Electrical Electronic and Communication EngineeringPabnaUniversity of Science and TechnologyPabna6600Bangladesh Department of Electrical and Communication Engineering Pabna University of Science and TechnologyPabna6600Bangladesh

Handwriting is a unique and significant human feature that distinguishes them from one *** are many researchers have endeavored to develop writing recognition systems utilizing specific signatures or symbols for person identification through ***,such systems are susceptible to forgery,posing security *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** response to these challenges,we propose an innovative hybrid technique for individual identification based on independent handwriting,eliminating the reliance on specific signatures or *** innovative method is intricately designed,encompassing five distinct phases:data collection,preprocessing,feature extraction,significant feature selection,and *** key advancement lies in the creation of a novel dataset specifically tailored for Bengali handwriting(BHW),setting the foundation for our comprehensive ***-preprocessing,we embarked on an exhaustive feature extraction process,encompassing integration with kinematic,statistical,spatial,and composite *** meticulous amalgamation resulted in a robust set of 91 *** enhance the efficiency of our system,we employed an analysis of variance(ANOVA)F test and mutual information scores approach,meticulously selecting the most pertinent *** the identification phase,we harnessed the power of cutting-edge deep learning models,notably the Convolutional Neural Network(CNN)and Bidirectional Long Short-Term Memory(BiLSTM).These models underwent rigorous training and testing to accurately discern individuals based on their handwriting ***,our methodology introduces a groundbreaking hybrid model that synergizes CNN and BiLSTM,capitalizing on fine motor features for enhanced individual ***,our experimental results unde

关键词： Bengali handwriting(BHW) person identification convolutional neural network(CNN) BiLSTM

Microstrip Patch Antenna with an Inverted T-Type Notch in the Partial Ground for Breast Cancer Detections

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & Sciences 2024年第2期138卷 1301-1322页

作者： Nure alam Chowdhury Lulu Wang md Shazzadul Islam Linxia Gu Mehmet Kaya Department of Biomedical Engineering and Science Florida Institute of TechnologyMelbourneFL 32901USA Biomedical Device Innovation Center Shenzhen Technology UniversityShenzhen518118China Department of Electrical and Computer Engineering International Islamic University MalaysiaJalan GombakSelangor53100Malaysia

This study designs a microstrip patch antenna with an inverted T-type notch in the partial ground to detect tumorcells inside the human *** size of the current antenna is small enough(18mm×21mm×1.6mm)todistribute around the breast *** operating frequency has been observed from6–14GHzwith a minimumreturn loss of−61.18 dB and themaximumgain of current proposed antenna is 5.8 dBiwhich is flexiblewith respectto the size of *** the distribution of eight antennas around the breast phantom,the return loss curveswere observed in the presence and absence of tumor cells inside the breast phantom,and these observations showa sharp difference between the presence and absence of tumor *** simulated results show that this proposedantenna is suitable for early detection of cancerous cells inside the breast.

关键词： Antenna microwave wideband cancer breast phantom tumor detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

外商直接投资对南盟国家经济增长的影响研究

外商直接投资对南盟国家经济增长的影响研究

作者： md RASUL kazi 山东师范大学

学位级别：硕士

外商直接投资(FDI)对于任何国家的经济发展都是一个重要因素。FDI影响国民经济增长率的因素有很多。当FDI进入东道国时,会产生大量的商业机会。东道国员工就业机会也会随之增加,从而降低失业率,最终会提高其国内生产总值的增长率。通过... 详细信息

外商直接投资(FDI)对于任何国家的经济发展都是一个重要因素。FDI影响国民经济增长率的因素有很多。当FDI进入东道国时,会产生大量的商业机会。东道国员工就业机会也会随之增加,从而降低失业率,最终会提高其国内生产总值的增长率。通过获得外资,企业可以将业务拓展到世界各地,不同领域的基础设施也会得到发展,所有这些因素都会影响经济的扩张。因此,本文进行了研究以确定FDI对南亚区域合作联盟国家经济增长的影响。本文首先分析了南盟国家FDI和经济增长的现状特点。研究发现南盟国家的FDI和国内生产总值增长各不相同。印度的FDI在2020年达到646.6亿美元的峰值,然后下降。2022年,孟加拉国和阿富汗的FDI分别增加至15.6亿美元和130亿美元。而斯里兰卡、巴基斯坦和尼泊尔分别降至10.8亿、13.4亿和950亿美元,不丹和马尔代夫几乎没有FDI。此外,南盟各国的国内生产总值增长差异很大,反映了经济困境和复苏。然后,从直接影响和间接影响两个方面,理论分析了FDI对经济增长的影响。研究发现,FDI可以直接造成资本冲击,并通过影响其他经济因素间接影响东道国经济增长。FDI将直接或间接增加出口,弥补发展中国家进口资金短缺,建立外部经济平衡。接着,采用2013-2022年的数据,选取出口规模、进口规模、通货膨胀率和失业率作为控制变量,运用最小二乘法(OLS)、随机效应模型、固定效应模型和可行广义最小二乘法(FGLS)等实证方法分析了FDI对南盟国家经济增长的影响。通过实证结果发现,FDI会对南盟国家经济增长产生显著的正向影响,FDI规模越大,经济增长率越高。因此,可以说FDI是国民经济增长率的重要贡献者。最后,根据以上分析,得到如下政策启示:东道国需要简化各种类型的监管要求,以便设立和经营企业;采取保护措施,解决外国投资者在法律问题和争端方面的各种担忧;加强职业培训和适当的教育,培养适应能力强、熟练的劳动力;提供一些税收激励和免税政策;改善产业结构,提高人力资本水平,增强竞争力;为了更好地吸引FDI,政府需要进一步扩大向外界开放的经济部门,提高整体经济的国际化水平。

关键词：外商直接投资经济增长南盟国家可行广义最小二乘法(FGLS)