检索结果-南通市图书馆

Selected Aspects of Camel Immune System and Immune Responses

Open Journal of Veterinary medicine 2021年第6期11卷 177-211页

作者： Saeed Y. al Ramadan kazem.t. al-m.ham.ed salem.ibrahim.h. alshubaith Ahmed m. al-ali Salah Abohelaika m.ham.ed S. moqbel Ahmed m. alluwaimi Department of Anatomy College of Veterinary Medicine King Faisal University Al-Ahsaa Saudi Arabia Animal Resources management Ministry of Environment Water and Agriculture Al-Ahsaa Saudi Arabia Environmental health Department Al-Ahsaa Municipality Al-Ahsa Saudi Arabia Central Biotechnology Laboratory Veterinary Teaching Hospital College of Veterinary Medicine King Faisal University Al-Ahsaa Saudi Arabia Clinical Pharmacology Department Qatif Central Hospital Ministry of Health Saudi Arabia Department of microbiology and Parasitology College of Veterinary Medicine King Faisal University Al-Ahsaa Saudi Arabia

the camel economy is of considerable importance for arid countries. In the last decade, studies about camel immune system and immune responses have recorded increasing interest. However, drawing a comprehensive picture of the camel immune system remains far from reached. A major part of this review is to cover the studies of the primary and secondary immune organs and the markers of the camel immune cells and certain lymphoid tissues. At the same time, immune responses to different diseases and the nature of effective immunity were included, with an emphasis on the most important zoonotic diseases in camels such as MERS CoV;brucellosis. New findings on the diversity mechanisms of camel immunoglobulin genes were addressed. However, detail of the mechanism of MHC-restricted cellular immunity and the mechanism of B lymphocyte activation in camels await further attention. Interestingly, the gross and the histological structure of the lymphoid tissues of the camel’s thymus, tonsils, and peyer’s patches have indicated significant differences from other animals in terms of structure and function. The most peculiar CD expression, such as LPAM-I, MAdCAM-1 and CX3CR1, in certain camel cells and tissues refers to possible extraordinary mechanisms of immune hemostasis in camel in comparison to other ruminants. The widely applied immunodiagnostic techniques to control camel diseases and to assist in improving the camel resistance were considered. Extensive studies of the camel immune system were greatly hampered by lack of specific reagents to camel markers and low funds in the field of camel i

关键词： Camel CX3CR1 heavy Chain Antibody mERS-CoV Peyer’s Patches

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effect of quercetin on secretion and gene expression of leptin in breast cancer

引用

Journal of traditional Chinese medicine 2017年第3期37卷 321-325页

作者： Rahimifard maryam Sadeghi Faegheh Asadi-Samani majid Nejati-Koshki kazem Cellular and molecular Biology De-partment Faculty of ScienceAhar Islamic Azad UniversityAhar ***Iran Student Research Committee Shahrekord University of Medical SciencesShahrekord ***Iran Student Research Committee Zan-jan University of Medical SciencesZanjan ***Iran

OBJECtIVE: to investigate the possible inhibitory action of pure quercetin on secretion and gene expression of leptin in the t47 D breast cancer cell ***: In this experimental study, t47 D cells were cultured in monolayers in RPmI 1640. IC50 was determined by mtt(3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay after 24 h treatment at different concentrations of *** levels of leptin gene expression were measured by reverse-transcription real-time polymerase chain reaction(PCR). Secreted leptin was measured in the supernatant of cells by an enzyme-linked immuno sorbent ***: Analysis of mtt assay data showed that quercetin has a cytotoxic effect on t47 D breast cancer cells with 40 μm IC50 after 24 h exposure. Dataanalysis of real-time PCR showed that with increases in quercetin concentration, a decreasing trend was seen in m RNA levels of leptin of treated cells compared with the control cells(P also,measurement of secreted leptin in the culture media showed a similar decreasing trend in the amount of leptin protein in the treated cells compared with the control cells(P tin significantly inhibits the growth of t47 D cells through inhibition of leptin secretion and gene expression in t47 D breast cancer cells. therefore, it might be an alternative approach to breast cancer therapy through leptin targeting.

关键词： Quercetin, Cytotoxicity Real-time poly-merase chain reaction Breast neoplasms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：