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Endoscopic characteristics of small intestinal malignant tumors observed by balloon-assisted enteroscopy

World Journal of Gastrointestinal Endoscopy 2019年第5期11卷 373-382页

作者： Tomofumi Horie Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Kenji JL Limpias Kamiya Ryoichi Miyanaga Shinta Mizuno kayoko fukuhara Seiichiro fukuhara Makoto Naganuma Masayuki Shimoda Haruhiko Ogata Takanori Kanai Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of MedicineKeio University Center for Diagnostic and Therapeutic Endoscopy School of MedicineKeio University Department of Pathology School of MedicineKeio University

BACKGROUND Capsule endoscopy and balloon-assisted enteroscopy(BAE) enable visualization of rare small bowel conditions such as small intestinal malignant ***,details of the endoscopic characteristics of small intestinal malignant tumors are still *** To elucidate the endoscopic characteristics of small intestinal malignant *** From March 2005 to February 2017,1329 BAE procedures were performed at Keio University Hospital. Of these procedures,malignant tumors were classified into three groups,Group 1: epithelial tumors including primary small intestinal cancer,metastatic small intestinal cancer,and direct small intestinal invasion by an adjacent organ cancer; Group 2: small intestinal malignant lymphoma; and Group 3,small intestinal gastrointestinal stromal tumors. We systematically collected clinical and endoscopic data from patients' medical records to determine the endoscopic characteristics for each *** The number of patients in each group was 16(Group 1),23(Group 2),and 6(Group 3),and the percentage of solitary tumors was 100%,43.5%,and 100%,respectively(P < 0.001). Patients' clinical background parameters including age,symptoms,and laboratory data were not significantly different between the groups. Seventy-five percent of epithelial tumors(Group 1) were located in the upper small intestine(duodenum and ileum),and approximately 70% of gastrointestinal stromal tumors(Group 3) were located in the jejunum. Solitary protruding or mass-type tumors were not seen in malignant lymphoma(Group2)(P < 0.001). Stenosis was seen more often in Group 1,(68.8%,27.3%,and 0%;Group 1,2,and 3,respectively; P = 0.004). Enlarged white villi inside and/or surrounding the tumor were seen in 12.5%,54.5%,and 0% in Group 1,2,and 3,respectively(P = 0.001).CONCLUSION The differential diagnosis of small intestinal malignant tumors could be tentatively made based on BAE findings.

关键词： Small intestine Malignant Tumor Double balloon enteroscopy Balloon enteroscopy Video capsule endoscopy Endoscopy

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Endoscopic removal of foreign bodies:A retrospective study in Japan

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World Journal of Gastrointestinal Endoscopy 2020年第1期12卷 33-41页

作者： Kenji JL Limpias Kamiya Naoki Hosoe Kaoru Takabayashi Yukie Hayashi Xi Sun Ryoichi Miyanaga kayoko fukuhara Seiichiro fukuhara Makoto Naganuma Atsushi Nakayama Motohiko Kato Tadateru Maehata Rieko Nakamura Koichi Ueno Junichi Sasaki Yuko Kitagawa Naohisa Yahagi Haruhiko Ogata Takanori Kanai Division of Gastroenterology and Hepatology Department of Internal MedicineKeio University School of MedicineTokyo 160-8582Japan Center for Diagnostic and Therapeutic Endoscopy Keio University School of MedicineTokyo 160-8582Japan Department of Gastroenterology and Hepatology Chinese PLA General HospitalBeijing 100853China Division of Research and Development for Minimally Invasive Treatment Cancer CenterKeio University School of MedicineTokyo 160-8582Japan Department of Surgery Keio University School of MedicineTokyo 160-8582Japan Department of Emergency and Critical Care Medicine Keio University School of MedicineTokyo 160-8582Japan

BACKGROUND The ingestion of foreign bodies(FBs)and food bolus impaction(FBI)in the digestive tract are commonly encountered clinical *** to handle such problems continue to evolve offering advantages,such as the avoidance of surgery,reduced cost,improved visualization,reduced morbidity,and high removal success ***,to date,no studies have evaluated the endoscopic management of FBs in *** To elucidate level of safety and efficacy in the endoscopic management of FBs and *** A total of 215 procedures were performed at Keio University Hospital between November 2007 and August *** were collected from medical charts,and endoscopic details were collected from an endoscopic reporting *** performed with a flexible gastrointestinal endoscope were only taken into *** who underwent a technique involving FB or FBI from the digestive tract were only *** on patient sex,patient age,outpatient,inpatient,FB type,FB location,procedure time,procedure type,removal device type,success,and technical complications were reviewed and analyzed *** Among the 215 procedures,136(63.3%)were performed in old adults(≥60 years),180(83.7%)procedures were performed in *** most common type of FBs were press-through-pack(PTP)medications[72(33.5%)cases],FBI[47(21.9%)],Anisakis parasite(AP)[41(19.1%)cases].Most FBs were located in the esophagus[130(60.5%)cases]followed by the stomach[68(31.6%)cases].AP was commonly found in the stomach[39(57.4%)cases],and it was removed using biopsy forceps in 97.5%of the *** most common FBs according to anatomical location were PTP medications(40%)and dental prostheses(DP)(40%)in the laryngopharynx,PTP(48.5%)in the esophagus,AP(57.4%)in the stomach,DP(37.5%)in the small intestine and video capsule endoscopy device(75%)in the colon.A transparent cap with grasping forceps was the most commonly used device[82(38.1%)cases].The success rate of the procedure was

关键词： Anisakis parasite Endoscopic removal Food bolus impaction Foreign body Grasping forceps

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One-Dimensional Analysis of Supersonic Two-Stage HVOF Process

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Journal of Thermal Science 2009年第4期18卷 332-337页

作者： Hiroshi KATANODA Junichi HAGI Minoru fukuhara Dept.Mechanical Engineering Kagoshima University

The one-dimensional calculation of the gas/particle flows of a supersonic two-stage high-velocity oxy-fuel(HVOF) thermal spray process was performed. The internal gas flow was solved by numerically integrating theequations of the quasi-one-dimensional flow including the effects of pipe friction and heat transfer. As for the supersonicjet flow, semi-empirical equations were used to obtain the gas velocity and temperature along the centerline. The velocity and temperature of the particle were obtained by an one-way coupling method. The material ofthe spray particle selected in this study is ultra high molecular weight polyethylene (UHMWPE). The temperaturedistributions in the spherical UHMWPE particles of 50 and 150 m accelerated and heated by the supersonic gasflow was clarified.

关键词： Compressible Flow Supersonic Flow Two-Stage HVOF Thermal Spray One-Dimensional Analysis UHMWPE

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Cooling Curve's Effect on Hardening Behavior of Steel

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材料热处理学报 2004年第5期25卷 462-464页

作者： Kazuto fukuhara Shigeru Asada Yoshihiro Tomita Syusaku Maeda Nippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka JapanNippon Grease Co. Ltd. Osaka Japan

Quenching Oils are comprised mostly of mineral oil as major component, but mineral oil alone result in lower cooling performance. Therefore, various additives are formulated as required for each particular case. Cooling curves of mineral oil as determined by JIS method can be divided into three stages, vapor film stage, boiling stage and convection stage. And there are many types of additives used for quenching oil, one effective to shorten vapor film stage and another to shift boiling stage toward lower temperature side. As rapid quenching required temperature range for particular steel varies pending on its shape of CCT curve"1, it is possible to provide higher quench hardening performance using quenching oil formulated of adequate additives.

关键词：淬火油冷却效果硬化性能钢

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Catalytic liquid phase oxidation of 1,4-dioxane over a Pt/CeO_(2)-ZrO_(2)-Bi_(2)O_(3)/SBA-16 catalyst

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Journal of Advanced Ceramics 2015年第1期4卷 71-75页

作者： Pil-Gyu CHOI Takanobu OHNO Nashito fukuhara Toshiyuki MASUI Nobuhito IMANAKA Department of Applied Chemistry Faculty of EngineeringOsaka University2-1 YamadaokaSuitaOsaka 565-0871Japan

A Pt/CeO_(2)-ZrO_(2)-Bi_(2)O_(3)/SBA-16(Santa Barbara Amorphous No.16)catalyst was prepared by hydrothermal and wet impregnation methods for catalytic purification of 1,4-dioxane in ***-16 has a number of mesopores and the average size of the pores is 9.4 *** the present catalyst,platinum and CeO_(2)-ZrO_(2)-Bi_(2)O_(3)were successfully dispersed in the pores of the SBA-16 support,and the temperature dependence of the liquid phase oxidation of 1,4-dioxane was *** oxidation reaction proceeded effectively in the air atmosphere in the temperature range of 40-80℃.

关键词： composite materials oxidation porous materials 1,4-dioxane catalyst

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Characterization of a Microhollow Cathode Discharge Plasma in Helium or Air with Water Vapor

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Plasma Science and Technology 2013年第2期15卷 129-132页

作者： D. fukuhara S. NAMBA K. KOZUE T. YAMASAKI K. TAKIYAMA Graduate school of Engineering Hiroshima University1-4-1 KagamiyamaHigashi-HiroshimaHiroshima 739-8527Japan

Microhollow cathode discharge （MHCD） plasmas were generated in gas mixtures containing water vapor at pressures of up to 100 kPa of He or 20 kPa of air. The cathode diameter was 1.0 mm with a length of 2.0 ram. The electricM characteristics showed an abnormal glow mode. Spectroscopic measurements were carried out to examine the plasma and radicals. An analysis of the spectral profile of Ha at 656.3 nm enabled a derivation of the electron densities, namely 2× 1014 cm-3 （at 10 kPa） and 6× 1014 cm-3 （at 4 kPa） for the helium and air atmospheres, respectively, in the negative glow region. By comparing the observed OH radical spectra with those calculated by the simulation code L[FBASE, the gas temperature was deduced to be 900 K for 4 kPa of He at a discharge current of 50 mA.

关键词： microhollow cathode discharge atmospheric pressure plasma plasma spec-troscopy

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Physical multimorbidity patterns and depressive symptoms:a nationwide cross-sectional study in Japan

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Family Medicine and Community Health 2020年第1期8卷 14-19页

作者： Takuya Aoki Yosuke Yamamoto Sayaka Shimizu Shunichi fukuhara Department of Healthcare Epidemiology Kyoto UniversityKyotoJapan Institute for Health Outcomes and Process Evaluation Research(iHope International) KyotoJapan Department of General Medicine Fukushima Medical UniversityFukushimaJapan Center for Innovative Research for Communities and Clinical Excellence(CIRC2LE) Fukushima Medical UniversityFukushimaJapan

Objective The associations of physical multimorbidity with depressive symptoms have been investigated in a number of ***,whether patterns of chronic physical conditions have comparatively different associations with depressive symptoms remains *** study aimed to investigate the associations of physical multimorbidity patterns with depressive *** This study was designed as a nationwide cross-sectional survey in *** General sample of the Japanese *** Adult Japanese residents were selected by a quota sampling *** were analysed from 1788 residents who reported one or more chronic health *** Among four physical multimorbidity patterns:cardiovascular-renal metabolic(CRM),skeletal-articular digestive(SAD),respiratory-dermal(RDE)and malignant-digestive urologic(MDU),multivariable logistic regression analyses revealed that the RDE pattern showed the strongest association with depressive symptoms(aOR=1.68,95%CI:1.21 to 2.31 for the pattern score highest quartile,compared with the lowest quartile),followed by SAD and MDU patterns(aOR=1.41,95%CI:1.01 to 1.98 for the SAD pattern score highest quartile;1.41,95%CI:1.01 to 1.96 for the MDU pattern score highest quartile,compared with the lowest quartile).In contrast,the CRM pattern score was not significantly associated with depressive symptoms(aOR=1.31,95%CI:0.90 to 1.89 for the pattern score highest quartile,compared with the lowest quartile).Conclusions Physical multimorbidity patterns have different associations with depressive *** these patterns,patients with the RDE pattern may be at a higher risk for developing depressive *** study reinforces the evidence that cluster pattern of chronic health conditions is a useful measure for clinical management of multimorbidity as it is differently associated with mental health status,which is one of the crucial outcomes for multimorbid patients.

关键词： pattern nationwide sectional

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Unsedated transnasal small-caliber esophagogastroduoden oscopy in elderly and bedridden patients

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World Journal of Gastroenterology 2009年第44期15卷 5586-5591页

作者： Mika Yuki Yuji Amano Yoshinori Komazawa Hiroyuki fukuhara Toshihiro Shizuku Shun Yamamoto Yoshikazu Kinoshita Division of Internal Medicine Izumo-City General Medical Center613 Nadabunn-choIzumo-shi Shimane 693-0003Japan Division of Endoscopy Shimane University Hospital89-1 Enya-choIzumo-shiShimane 693-8501Japan Division of Internal Medicine Unnan Municipal General Hospital96-1 Iida-choUnnan-shiShimane 699-1221Japan Second Department of Internal Medicine Shimane UniversitySchool of Medicine89-1 Enya-choIzumo-shiShimane 693-8501Japan

AIM： To evaluate the safety of unsedated transnasal small-caliber esophagogastroduodenoscopy （EGD） for elderly and critically ill bedridden patients. METHODS： One prospective randomized comparative study and one crossover comparative study between transnasal small-caliber EGD and transoral conventional EGD was done （Study 1）. For the comparative study, we enrolled 240 elderly patients aged 〉 65 years old. For the crossover analysis, we enrolled 30 bedridden patients with percutaneous endoscopic gastrostomy （PEG）（Study 2）, We evaluated cardiopulmonary effects by measuring arterial oxygen saturation （SpO2） and calculating the rate-pressure product （RPP）（pulse rate x systolic blood pressure/100） at baseline, 2 and 5 min after endoscopic intubation in Study 1. To assess the risk for endoscopy-related aspiration pneumonia during EGD, we also measured blood leukocyte counts and serum C-reactive protein （CRP） levels before and 3 d after EGD in Study 2. RESULTS： In Study 1, we observed significant decreases in SpO2 during conventional transoral EGD, but not during transnasal small-caliber EGD （0.24% vs -0.24% after 2 min, and 0.18% vs -0.29% after 5 min, P = 0.034, P = 0.044）. Significant differences of the RPP were not found between conventional transoral and transnasal small-caliber EGD. In Study 2, crossover analysis showed statistically significant increases of the RPP at 2 min after intubation and the end of endoscopy （26.8 and 34.6 vs 3.1 and 15.2, P = 0.044, P = 0.046）, and decreases of SpO2 （-0.8% vs -0.1%, P = 0.042） during EGD with transoral conventional in comparison with transnasal small-caliber endoscopy. Thus, for bedridden patients with PEG feeding, who were examined in the supine position, transoral conventional EGD more severely suppressed cardiopulmonary function than transnasal small-caliber EGD. There were also significant increases in the markers of inflammation, blood leukocyte counts and serum CRP values, in bedridden patients after transoral co

关键词： Aged Aspiration pneumonia Gastrointestina endoscopy Critical illness

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System identification and parameter estimation in mathematical medicine： examples demonstrated for prostate cancer

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Frontiers of Electrical and Electronic Engineering in China 2016年第1期4卷 13-19页

作者： Yoshito Hirata Kai Morino Taiji Suzuki Qian Guo Hiroshi fukuhara Kazuyuki Aihara Institute of Industrial Science The University of Tokyo Tokyo 153-8505 Japan Graduate School of Information Science and Technology The University of Tokyo Tokyo 113-8656 Japan Department of Mathematical and Computing Sciences Graduate School of Information Science and Engineering Tokyo Institute of Technology Tokyo 152-8552 Japan Department of Mathematics Shanghai Normal University Shanghai 200234 China Department of Urology Graduate School of Medicine The University of Tokyo Tokyo 113-8655 Japan

We review our studies on how to identify the most appropriate models of diseases, and how to determine their parameters in a quantitative manner given a short time series of biomarkers, using intermittent androgen deprivation therapy of prostate cancer as an example. Recently, it has become possible to estimate the specific parameters of individual patients within a reasonable time by employing the information concerning other previous patients as a prior. We discuss the importance of using multiple mathematical methods simultaneously to achieve a solid diagnosis and prognosis in the future practice of personalized medicine.

关键词： mathematical medicine dynamical model parameter estimation

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Nitrogen Discharged from the Earth’s Interior Regions

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Journal of Modern Physics 2014年第2期5卷 75-81页

作者： Mikio fukuhara 1Research Institute for Electromagnetic Materials Sendai Japan 2Fracture and Reliability Research Institute Tohoku University Sendai Japan 3Green Device Laboratory Waseda University Tokyo Japan

The abundant nitrogen in the Earth’s atmosphere can be interpreted as the result of endothermic nuclear transmutation of carbon and oxygen atom pairs in (Ca, D) CO3 or CaCO3 aragonite lattice of Earth’s crust from the Archean era to the present time, by physical catalytic help of excited electrons e* generated by stick sliding due to plate tectonics and geoneutrinos ν by the radioactive decay of elements such as uranium and thorium in Earth’s mantle: through a nuclear attraction effect that is due to deuteron catalysis of nitrogen formation. The relationship between the critical temperature T and the critical pressure P for the nuclear transmutation is expressed as 7253 × e-0.014P, and the formation of nitrogen in the mantle is possible at temperatures ≥ 2510 K and pressure ≥ 58 GPa.

关键词： Nitrogen Earth Nuclear Transmutation Calcium Carbonate Geoneutrinos Excited Electrons Tectonics

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