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Nigerian antimalarial plants and their anticancer potential:A review

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Journal of Integrative Medicine 2020年第2期18卷 92-113页

作者： kayode Ezekiel Adewole Department of Biochemistry Faculty of Basic Medical SciencesUniversity of Medical SciencesOndoOndo State 234Nigeria

Cancer is a leading cause of death globally, while malaria is the leading cause of death from parasitic diseases in Nigeria. Historically, plant remedies have been used to manage both cancer and ***, the possibility of treating cancer with antimalarial remedies has long been reported, even though the two diseases appear to have little in common. However, a body of research has indicated the potential anticancer activity of both synthetic and nature-derived antimalarials. In Nigeria, over 100 plants are used for the management of malaria, but little is known for their potential role in combatting cancer. Therefore, this review is to highlight the documented anticancer activities of plants used to treat malaria in Nigeria, with the goal of supporting anticancer drug discovery. Scientific databases were used to search for antimalarial plants using selected keywords. Of over 100 plants used to treat malaria in Nigeria, 56 have documented anticancer properties, containing alkaloids, flavonoids, tannins, terpenes,terpenoids, quinones, anthraquinones, saponins, steroids, sterols, organosulfur compounds and other polyphenols as the major bioactive components. The major mechanisms of anticancer activity include induction of apoptosis and autophagy, arrest of cell growth, generation of reactive oxygen species and inhibition of angiogenesis. However, mechanistic and clinical investigations of the anticancer properties of most of these plants are still lacking. Notwithstanding, the huge anticancer potential uncovered by the in vitro or in vivo studies and a few clinical studies, Nigerian antimalarial plants may provide a valuable resource, ready to be harnessed for anticancer drug development.

关键词： Anticancer Cytotoxicity Antimalarial Medicinal plants Nigeria

Non-Relativistic Treatment of a Generalized Inverse Quadratic Yukawa Potential

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Chinese Physics Letters 2017年第11期34卷 1-5页

作者： Oluwatimilehin Oluwadare kayode Oyewumi Department of Physics Federal University Oye-EkitiEkiti StateNigeria Department of Physics University of IlorinKwara StateNigeria

A bound state solution is a quantum state solution of a particle subjected to a potential such that the particle＇s energy is less than the potential at both negative and positive infinity. The particle＇s energy may also be negative as the potential approaches zero at infinity. It is characterized by the discretized eigenvalues and eigenfunctions, which contain all the necessary information regarding the quantum systems under consideration. The bound state problems need to be extended using a more precise method and approximation scheme. This study focuses on the non-relativistic bound state solutions to the generalized inverse quadratic Yukawa potential. The expression for the non-relativistic energy eigenvalues and radial eigenfunctions are derived using proper quantization rule and formula method, respectively. The results reveal that both the ground and first excited energy eigenvalues depend largely on the angular momentum numbers, screening parameters, reduced mass, and the potential depth. The energy eigenvalues, angular momentum numbers, screening parameters, reduced mass, and the potential depth or potential coupling strength determine the nature of bound state of quantum particles. The explored model is also suitable for explaining both the bound and continuum states of quantum systems.

关键词： In Non-Relativistic Treatment of a Generalized Inverse Quadratic Yukawa Potential

Conservation of indigenous medicinal botanicals in Ekiti State, Nigeria

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2006年第9期7卷 713-718页

作者： kayode Joshua Department of Plant Science University of Ado-Ekiti P.M.B.5363 Ado-Ekiti Ekiti State Nigeria

The rapid appraisal method was used to identity the botanicals used ethnomedicinally from a total of 300 randomly selected respondents drawn from the existing three geo-political zones of Ekiti State, Nigeria. The results obtained revealed that about 40% of the 71 botanicals identified presently rare. Most of the presently abundant botanicals are species primarily cultivated for other purpose other than medicine. Most of the identified species are valued for their curative effects on malaria and fever, the predominant diseases in the study area. The need for the conservation of the rare species cannot be over emphasised as most rural dwellers in the study area depend mostly on herbs from these species. Strategies towards the attainment of this goal are proposed.

关键词： Conservation Medicinal botanicals Nigeria

A Wavelet Neural Network Based Non-linear Model Predictive Controller for a Multi-variable Coupled Tank System

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International Journal of Automation and computing 2015年第2期12卷 156-170页

作者： kayode Owa Sanjay Sharma Robert Sutton School of Marine Science and Engineering University of Plymouth Marine and Industrial Dynamic Analysis (MIDAS) Research Group University of Plymouth

In this paper, a novel real time non-linear model predictive controller(NMPC) for a multi-variable coupled tank system(CTS) is designed. CTSs are highly non-linear and can be found in many industrial process applications. The involvement of multi-input multi-output(MIMO) system makes the design of an effective controller a challenging task. MIMO systems have inherent couplings,interactions in-between the process input-output variables and generally have an complex internal structure. The aim of this paper is to design, simulate, and implement a novel real time constrained NMPC for a multi-variable CTS with the aid of intelligent system techniques. There are two major formidable challenges hindering the success of the implementation of a NMPC strategy in the MIMO case. The first is the difficulty of obtaining a good non-linear model by training a non-convex complex network to avoid being trapped in a local minimum solution. The second is the online real time optimisation(RTO) of the manipulated variable at every sampling time.A novel wavelet neural network(WNN) with high predicting precision and time-frequency localisation characteristic was selected for an MIMO model and a fast stochastic wavelet gradient algorithm was used for initial training of the network. Furthermore, a genetic algorithm was used to obtain the optimised parameters of the WNN as well as the RTO during the NMPC strategy. The proposed strategy performed well in both simulation and real time on an MIMO CTS. The results indicated that WNN provided better trajectory regulation with less mean-squared-error and average control energy compared to an artificial neural network. It is also shown that the WNN is more robust during abnormal operating conditions.

关键词： Wavelet neural network(WNN) non-linear model predictive control(NMPC) real time practical implementation multi-input multi-outpu

Transport model for shale gas well leakage through the surrounding fractured zones of a longwall mine

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International Journal of Mining Science and Technology 2020年第5期30卷 635-641页

作者： kayode M.Ajayi Steven J.Schatzel Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthPittsburghPA 15236USA

The environmental risks associated with casing deformation in unconventional(shale)gas wells positioned in abutment pillars of longwall mines is a concern to many in the mining and gas well *** the recent interest in shale exploration and the proximity to longwall mining in Southwestern Pennsylvania,the risk to mine workers could be catastrophic as fractures in surrounding strata create pathways for transport of leaked ***,this research by the National Institute for Occupational Safety and Health(NIOSH)presents an analytical model of the gas transport through fractures in a low permeable *** derived equations are used to conduct parametric studies of specific transport conditions to understand the influence of stratum geology,fracture lengths,and the leaked gas properties on subsurface *** results indicated that the prediction that the subsurface gas flux decreases with an increase in fracture length is specifically for a non-gassy *** sub-transport trend could be significantly impacted by the stratum gas generation rate within specific fracture lengths,which emphasized the importance of the stratum *** findings provide new insights for improved understanding of subsurface gas transport to ensure mine safety.

关键词： Subsurface gas transport Longwall mining Shale gas well Analytical modeling Environmental risk Shale gas casing failure

Numerical investigation of the effectiveness of radon control measures in cave mines

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International Journal of Mining Science and Technology 2019年第3期29卷 469-475页

作者： kayode Ajayi Khosro Shahbazi Purushotham Tukkaraja Kurt Katzenstein Department of Mechanical Engineering SDSM & TRapid City SD 57701USA Department of Mining Engineering and Management SDSM & TSD 57701USA Department of Geology and Geological Engineering SDSM & TSD 57701USA

Ventilation is one of the radon control measures in an underground working ***,the dynamics related to the cave mining methods particularly in block/panel cave mines,complicate the design of effective ventilation system,and *** such as hang ups(in the drawbells),leakage from old workings,and changes in cave porosity lead to differing response of an existing ventilation ***,it is difficult to investigate these conditions at the mine or with a laboratory scale ***,this study develops a discrete model to investigate the impact of different radon control measures in cave mines using computational fluid dynamics *** considered two ventilation conditions for a fully developed cave:with and without the undercut *** each of the two conditions,we studied four parameters:airflow distribution through the production drifts,radon distribution through the production drifts,the effect of increasing airflow on radon concentration,and the effect of a cave top negative pressure on radon *** results show that:the undercut ventilation significantly increases the radon concentration in the production drift;the growth of radon concentration through the production drift is nonlinear(oscillating pattern);maintaining a negative pressure on top of the cave is more effective at mitigating radon exposure,when the undercut ventilation is active;and increase in air volume flow rate decreases radon concentration in most regions,however,there might be regions with significant radon accumulation due to pressure variation across the *** findings provide vital information for designing an effective ventilation system and for proactive implementation of radon control measures in cave mines.

关键词： Radon gas Underground mining Panel cave mines Broken rocks Computational fluid dynamics(CFD) Porous media Cave mining method

Insecticidal toxicity of two bruchid-resistant cowpea cultivar powders as cowpea seed protectants against Callosobruchus maculatus(Fab.)(Coleoptera:Chrysomelidae)

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Food Quality and Safety 2019年第1期3卷 35-39页

作者： kayode D.Ileke Department of Biology School of ScienceFederal University of TechnologyOndo StateNigeria

Toxicity of bruchid-resistant cultivars MIT04K-399-1 and MIT07K-299-92 powders as cowpea protectants against Callosobruchus maculatus(Fab.)was investigated at an ambient temperature of 28±2°C and a relative humidity of 75±5%.Their efficacy was tested at dosage,0.5,1.0,1.5,2.0,2.5,and 3.0 g/20 g of cowpea seeds on adult mortality,oviposition,adult emergence,progeny development,seed damage,weight loss,and Beetle Perforation Index(BPI)by cowpea *** result showed that toxicity of the bruchid-resistant cowpea cultivar powders on adult bruchid is dosage-and *** a dosage of 3.0 g/20 g,cultivars MIT04K-399-1 and MIT07K-299-92 powders achieved 70%and 72.5%lethal effect on adult *** after 4 days of treatment,*** and percentage adult emergence of *** decrease with an increase in powder ***,reduction in progeny development of *** increases with an increase in powder *** mean number of adult emergence decreased at 2 g/20 g,2.5 g/20 g and 3 g/20 *** MIT04K-399-1 and MIT07K-299-92 powders significantly affected egg *** MIT07K-299-92 powder was more effective against oviposition and adult emergence at higher concentrations than MIT04K-399-1 powder,an effect that was not significantly different(P>0.05)from each *** BPI of 9.1 and 6.2 was recorded on cowpea seeds treated with MIT04K-399-1 and MIT07K-299-92 powders at a dosage of 3 g/20 g,*** fear of residual toxicity on nontargeted organisms is not associated with the use of resistant cowpea cultivars as seed *** farmers are familiar with the technology involved in the preparation and application of powders as *** of bruchid-resistant cowpea cultivars MIT04K-399-1 and MIT07K-299-92 powders into the management of coleopteran pests will ensure availability of viable seeds for future farming in developing nations such as Nigeria.

关键词： bruchid resistant cultivar MIT04K-399-1 cultivar MIT07K-299-92 Callosobruchus maculatus Vignia unguiculata

Ethylacetate extract of red onion(Allium cepa L.)tunic affects hemodynamic parameters in rats

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Food Science and Human Wellness 2015年第3期4卷 115-122页

作者： Olanrewaju Sam Olayeriju Mary Tolulope Olaleye Olamide Olajusi Crown kayode Komolafe Aline Augusti Boligon Margareth Linde Athayde Akintunde afolabi Akindahunsi Department of Biochemistry School of SciencesThe Federal University of TechnologyPMB 704AkureNigeria Department of Biochemistry Faculty of ScienceFederal University Oye-EkitiPMB 373Oye-EkitiNigeria Department of Industrial Pharmacy Federal University of Santa Maria97105-900 Santa MariaRSBrazil

The effects of ethylacetate extract of red onion(Allium cepa)tunic(ACTE)on some hemodynamic and biochemical parameters were evaluated in normotensive albino *** pressure parameters were determined in anaesthetized rats orally administered ACTE(10-,20-,or 40 mg/kg)or ramipril(1 mg/kg)once daily for 14 ***,10-,20-,or 40 mg/kg ACTE produced significant(P<0.01),dose-dependent fall in systolic blood pressure,SBP(21%,27%,33%),diastolic blood pressure,DBP(6%,10%,16%),pulse pressure,PP(42%,49%,56%),mean arterial blood pressure,MAPB(13%,18%,23%)and heart rate,HR(4%,5%,7%).The highest effective dose(40 mg/kg)compared well with ramipril(1 mg/kg)with regards to SBP(41%),DBP(19%),PP(70%),MABP(29%)and HR(10%).Similar trends(decreases)were recorded for 40 mg/kg ACTE and ramipril,respectively,as regards the activities of serum enzymes:creatine kinase(60%and 65%),ALT(18%and 14%)and ALP(28%and 16%).HPLC fingerprints of the flavonoid-rich ACTE revealed that flavonols:quercetin,quercitrin,isoquercitrin,rutin and kaempferol are the active *** results demonstrate the hypotensive effect of *** tunic flavonoids initiating further investigation of their individual or synergistic contribution(s)to the observed effects.

关键词： acetate Blood rats

An evaluation of digital elevation modeling in GIS and Cartography

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Geo-Spatial Information Science 2014年第2期17卷 139-144页

作者： Bola AYENI kayode Julius SAMUEL Department of Geography University of IbadanIbadanNigeria Department of Geography&Resource Management Osun State UniversityOkukuNigeria

This study considers seven commonly used surface fitting methods within Golden Software and ArcGIS^(TM) *** grid sizes of 68 rows by 100 columns(6800 grids)and 680 rows by 1000 columns(680,000 grids)and 294,208 elevation points covering the entire landmass of Nigeria,the study evaluates the performance of these methods in terms of execution time and faithfulness in the representation of the spatial *** show marked differences in time taken to execute the fitting and that Inverse Distance,the Natural Neighbor,the Nearest Neighbor,and Triangulation with Linear Interpolation seem to give the highest level of correspondence or faithfulness.

关键词： image surface fitting digital elevation modelling GIS cartography