检索结果-南通市图书馆

Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Pathophysiology 2018年第2期9卷 37-46页

作者： kaylene barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan Department of Surgery State University of New YorkDownstate Medical CenterBrooklynNY 11203United States Department of Surgery and Pathology State University of New YorkDownstate Medical CenterBrooklynNY 11203United States College of Medicine State University of New YorkDownstate Medical CenterBrooklynNY 11203United States School of Graduate Studies State University of New YorkDownstate Medical CenterBrooklynNY 11203United States Greater New York Endoscopy Surgical Center State University of New YorkBrooklynNY 11235United States Department of Surgery and Cell Biology State University of New YorkDownstate Medical CenterBrooklynNY 11203United States

Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP.

关键词： Acute pancreatitis Endoplasmic reticulum stress Unfolded protein response Acinar cell injury Autophagy

Adult myelination: wrapping up neuronal plasticity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2014年第13期9卷 1261-1264页

作者： Megan O’Rourke Robert Gasperini kaylene M.Young Menzies Research Institute Tasmania University of Tasmania The School of Medicine University of Tasmania

In this review, we outline the major neural plasticity mechanisms that have been identified in the adult central nervous system （CNS）, and offer a perspective on how they regulate CNS function. In particular we examine how myelin plasticity can operate alongside neurogenesis and synaptic plasticity to influence information processing and transfer in the mature CNS.

关键词： oligodendrocyte OPC adult central nerrous system NG2 oligodendrogenesis plasticity remodelling myelination neural stem cells synapse

Model of Mediating Determinants of Time Differences in INDYCAR

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journalism and Mass Communication 2024年第4期14卷 232-240页

作者： Wilfrido Isidro Aldana Balderas Héctor Daniel Molina Ruiz Enrique Martínez Muñoz Eleazar Villegas González Tirso Javier Hernández Gracia Arturo Sánchez Sánchez Cruz García Lirios Alfredo barrera Escobar University of México HuehuetocaMèxico University of Hidalgo PachucaMèxico University of Tlaxcala Mèxico University of CDMX Mexico University of FV Mexico

The IndyCar series distinguishes itself by providing the same design and operation of the single-seater to its *** difference in times is then attributable to the skills of the drivers,but considering the data from the races could test this *** objective of this work was to establish a trajectory model to predict race times.A cross-sectional,correlational,and explanatory work was carried out with a sample of 18,474 records in the period from 2020 to 2023 of the IndyCar *** results show that the time span predicts the time *** relation to the studies of acceptance of the technology,the adjustment of this to human capacities to explain the time differences in the series of racing cars is discussed.

关键词： time differences ranking differences ranking race time laps completed

Influence of microbial priming and seeding depth on germination and growth of native wildflowers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ecological Processes 2021年第1期10卷 266-273页

作者： Daniela barrera Juan Luera Kaitlynn Lavallee Pushpa Soti Mathematics and Science Academy University of Texas-Rio Grande ValleyEdinburg 78539USA Sharyland Pioneer High School MissionTX 78573USA. Department of Biology University of Texas-Rio Grande ValleyEdinburgTX 78539USA. School of Earth Environmentand Marine SciencesUniversity of Texas-Rio Grande ValleyEdinburgTX 78539USA.

Background:Using native wildflowers for restoring marginal lands has gained considerable *** of wildflowers can be challenging due to several environmental *** the microbial community in degraded habitats can potentially result in the native plant performance and habitat *** study was conducted to investigate the impact of native soil microbes and seeding depth on germination of south Texas native *** wildflower species,Ratibida columnifera(Nutt.)(Mexican Hat)and Verbesina encelioides(Cav.)(cowpen daisy),were treated with microbial wash extracted from native soils,and germination rate was recorded for 14-day *** further analyzed the growth,biomass allocation,and root colonization by mycorrhizal fungi in these two plants growing them in a plant growth chamber for 6 *** determine the impact of seeding depth,we planted the seeds of the two plant species at 2-cm,6-cm,and 12-cm depth and monitored germination and plant ***:The two species responded differently to the seeding depth and microbial wash *** wash treatment resulted in higher germination rate in *** compared to control,while it did not have any impact on *** seed *** microbial treatment did not influence the total biomass,it had a significant impact on the biomass allocation in both the plant *** seeds germinated at both 2-cm and 6-cm depth and did not germinate at 12 cm,while the *** seeds germinated only at 2 cm and did not germinate at 6-cm or 12-cm seeding ***:While our results are species specific,our results indicate that native soil microbes can potentially improve the seed germination and growth of *** results also indicate the importance of specific seeding depth when sowing wildflower seeds for habitat restoration.

关键词： Habitat restoration Soil microbes Seeding depth Wildflowers Root endophytes

Gourds and Tendrils of Cucurbitaceae: How Their Shape Diversity, Molecular and Morphological Novelties Evolved via Whole-Genome Duplications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2020年第8期13卷 1108-1110页

作者： Josuébarrera-Redondo Rafael Lira-Saade Luis E.Eguiarte Departamento de Ecología Evolutiva Instituto de EcologíaUniversidad Nacional Autónoma de MéxicoCircuito Exterior s/n Anexo al Jardín BotánicoCiudad de México 04510Mexico UBIPRO Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoAvenido de los Barrios#1Col.Los Reyes IztacalaTlalnepantlaEstado de México 54090Mexico

Whole-genome duplications(WGDs)are regarded as important drivers of macroevolution in plants(Clark and Donoghue,2018).However,there are few studies that test a connection between WGDs and evolutionary *** proper study of evolutionary patterns related to WGDs needs a well-resolved phylogeny,accurate dates of the WGD events,and historical reconstructions of the evolutionary novelties(Clark and Donoghue,2018).The advent of exhaustive phylogenomic studies is becoming a promising way to solve these issues,as wholegenome data can help clarify obscure phylogenetic relationships,evaluate patterns associated with WGDs,and track down the evolution of life-history traits that shaped plant lineages(Bellot et al.,2020).

关键词： Whole phylogeny traits

A regularization scheme for explicit level-set XFEM topology optimization

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Mechanical Engineering 2019年第2期14卷 153-170页

作者： Markus J.GEISS Jorge L.barrera Narasimha BODDETI Kurt MAUTE Ann and H.J.Smead Department of Aerospace Engineering Sciences University of Colorado at BoulderBoulderCO 80309-0429USA Singapore University of Technology and Design SUTD Digital Manufacturing and Design CentreSingapore 487372Singapore

Regularization of the level-set(LS)field is a critical part of LS-based topology optimization(TO)*** this is achieved by advancing the LS field through the solution of a Hamilton-Jacobi equation combined with a reinitialization *** approach,however,may limit the maximum step size and introduces discontinuities in the design ***,energy functionals and intermediate LS value penalizations have been *** paper introduces a novel LS regularization approach based on a signed distance field(SDF)which is applicable to explicit LSbased *** SDF is obtained using the heat method(HM)and is reconstructed for every design in the optimization *** governing equations of the HM,as well as the ones describing the physical response of the system of interest,are discretized by the extended finite element method(XFEM).Numerical examples for pro?blems modeled by linear elasticity,nonlinear hyperelasticity and the incompressible Navier-Stokes equations in two and three dimensions are presented to show the applicability of the proposed scheme to a broad range of design optimization problems.

关键词： level-set regularization explicit level-sets XFEM CutFEM topology optimization heat method signed distance field nonlinear structural mechanics fluid mechanics

Influence of local and landscape environmental factors on alpha and beta diversity of macroinvertebrates in Andean rivers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Mountain Science 2023年第9期20卷 2487-2501页

作者： DIAZ-ROJAS Camila A PEDROZA-RAMOS Adriana X barrera-HERRERA July A ROA-FUENTES Camilo A Ecology Unit in Aquatic Systems Research Group Pedagogical and Technological University of ColombiaUPTCAvenida Central del Norte 39-115TunjaBoyacáColombia

Research on macroinvertebrate community structure in Andean rivers has been oriented towards describing patterns of alpha and gamma diversity by taking into account environmental predictors at local spatial scales(e.g.,micro-and mesohabitats).However,the patterns of beta diversity and the importance of landscape-scale variables have been evaluated to a lesser *** objective of this study was to describe the patterns of alpha and beta diversity of benthic macroinvertebrates in the Andean rivers of the Orinoco basin and their relationship with local and landscape environmental variation.A stratified random sampling of macroinvertebrates was carried out at 40 sites(comprising an altitudinal range of between 500 and 2900 m.a.s.l.),local and landscape variables were *** results showed that the variation of alpha diversity was influenced by local and landscape variables,which are directly and indirectly related to the contribution of sediments,substrate composition and flow velocity,providing a heterogeneity of *** beta diversity was explained by the combined effect of local and landscape *** the beta diversity phenomena,turnover was predominant while nestedness presented a minor contribution and both were explained in greater proportion by local descriptors and some landscape variables,specifically those of a geomorphological *** results concur with the view of an environmental and spatial hierarchy within the river habitat and highlight the influence of multiple scales on macroinvertebrate *** above suggests that both local and landscape scales must necessarily be considered for environmental management and the conservation of Andean lotic ecosystems.

关键词： Andean lotic systems Andean agroecosystems Instream habitat Landcover Turnover Nestedness

Abiotic stress-associated microRNAs in plants： discovery, expression analysis, and evolution

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Frontiers in Biology 2013年第2期8卷 189-197页

作者： Blanca E. barrera-FIGUEROA Zhigang WU Renyi LIU Departamento de Biotecnologia Universidad del Papaloapan Tuxtepec Oaxaca 68301 Mexico Department of Botany and Plant Sciences University of California Riverside CA 92521 USA

Abiotic stresses such as drought, cold, and high salinity are among the most adverse factors that affect plant growth and yield in the field. MicroRNAs are small RNA molecules that regulate gene expression in a sequence-specific manner and play an important role in plant stress response. Identifying abiotic stress-associated microRNAs and understanding their function will help develop new strategies for improvement of plant stress tolerance. Here we highlight recent advances in our understanding of abiotic stress-associated miRNAs in various plants, with focus on their discovery, expression analysis, and evolution.

关键词： microRNA abiotic stress epigenetics gene expression evolution

A narrative review of the success of intramuscular gluteal injections and its impact in psychiatry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2018年第3期1卷 161-170页

作者： Erfan Soliman Sarujan Ranjan Tianyou Xu Carol Gee Aidan Harker Alvaro barrera John Geddes Department of Engineering Sciences Institute of BiomedicalEngineering Old Road Campus Research BuildingUniversity of Oxford Oxford OX3 7DQ UK Warneford Hospital Oxford Health NHS Foundation Trust Warneford Ln Oxford OX3 7JX UK Department of Psychiatry University of Oxford Warneford Hospital Warneford Ln Oxford OX3 7JX UK

There are 12 billion injections given worldwide every year. For many injections, the intramuscular route is favoured over the subcutaneous route due to the increased vascularity of muscle tissue and the corresponding increase in the bioavailability of drugs when administered intramuscularly. This paper is a review of the variables that affect the success of intramuscular injections and the implications that these success rates have in psychiatry and general medicine. Studies have shown that the success rates of intended intramuscular injections vary between 32 and 52%, with the rest potentially resulting in inadvertent subcutaneous drug deposition. These rates are found to be even lower for certain at-risk populations, such as obese patients and those on antipsychotic medications. The variables associated with an increased risk of injection failure include female sex, obesity, site of injection, and subcutaneous fat depth. New guidelines and methods are needed in order to address this challenge and ensure that patients receive optimum care. Looking forward, the best way to improve the delivery of intramuscular injections worldwide is to develop uniform algorithms or innovative medical devices to confirm or guarantee successful delivery at the bedside.

关键词： Intramuscular injection Gluteal Subcutaneous Ultrasound Computed tomography Antipsychotic