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Open Journal of Immunology 2011年第3期1卷 74-79页

作者： Will Christenson Rachel Horton kayla campbell Kelly Meacham Amber Schroeder Gene M. Scalarone Department of Biological Sciences Idaho State University

This present study was designed to evaluate B. dermatitidis antigens, prepared from two isolates (B5896, 597), when the yeast cells were allowed to lyse in distilled water for one day or seven days. The indirect enzyme-linked immunosorbent assay (ELISA) was used to determine the ability of the lysate reagents to detect antibodies in 30 rabbit and 30 dog serum specimens. Mean absorbance values with B5896 lysate antigen ranged from 1.637 (day 1) to 1.461 (day 7) and absorbance values with 597 antigen ranged from 1.579(day 1) to 1.396 (day 7) with the serum specimens from immunized rabbits. Serum specimens from infected dogs yielded absorbance values ranging from 1.672 (day 1) to 1.763 (day 7) with the B5896 and values ranging from 1.909 (day 1) to 1.224 (day 7) with the 597. Optimal reactivity was obtained with the day 1 lysate using both lysate antigens against the rabbit sera and with the 597 antigen against the dog sera. Slightly greater reactivity was evidenced with the day 7 B5896 antigen when the dog sera was tested. Comparative studies are continuing in order to produce an optimal anti-genic preparation for antibody detection in blastomycosis.

关键词： ELISA Blastomycesdermatitidis Antibody Detection Lysate Antigens

Comparison of antibody detection with Blastomyces dermatitidis yeast lysate antigens in serum specimens from immunized rabbits and infected dogs

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Emergency department management of acute agitation in the reproductive age female and pregnancy

Open Journal of Immunology 2011年第3期

作者： Will Christenson Rachel Horton kayla campbell Kelly Meacham Amber Schroeder Gene M. Scalarone

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World Journal of Emergency Medicine 2024年第2期15卷 83-90页

作者： Ariella Gartenberg kayla Levine Alexander Petrie Department of Emergency Medicine Jacobi Medical Center and Montefiore Medical CenterNY 10461USA Department of Psychiatry and Behavioral Sciences Albert Einstein College of Medicine and Montefiore Medical CenterNY 10461USA Department of Emergency Medicine Jacobi Medical Center and North Central Bronx HospitalNY 10461USA

BACKGROUND:Agitation is a common presentation within emergent departments(EDs).Agitation during pregnancy should be treated as an obstetric emergency,as the distress may jeopardize both the patient and *** safety of psychotropic medications in the reproductive age female has not been well *** review aimed to explore a summary of general agitation recommendations with an emphasis on ED management of agitation during ***:A literature review was conducted to explore the pathophysiology of acute agitation and devise a preferred treatment plan for ED management of acute agitation in the reproductive age or pregnant ***:While nonpharmacological management is preferred,ED visits for agitation often require medical *** should be selected based on the etiology of agitation and the clinical setting to avoid major adverse *** effects are common in pregnant *** mild to moderate agitation in pregnancy,diphenhydramine is an effective sedating agent with minimal adverse *** moderate to severe agitation,high-potency typical psychotropics are preferred due to their neutral effects on *** has become the most frequently utilized psychotropic for agitation during *** generation psychotropics are often utilized as second-line therapy,including *** and ketamine have demonstrated adverse fetal ***:While randomized control studies cannot be ethically conducted on pregnant patients requiring sedation,animal models and epidemiologic studies have demonstrated the effects of psychotropic medication exposure in *** the fetal risk associated with multiple doses of psychotropic medications remains unknown,weighing the risks and benefits of each agent,while utilizing the lowest effective dose remains critical in the treatment of acute agitation within the EDs.

关键词： Agitation Pregnancy Haloperidol Ketamine Benzodiazepines

Targeted therapy for leptomeningeal metastases in non-small cell lung cancer-Changing treatment paradigms

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Chinese Journal of Cancer Research 2017年第6期29卷 535-542页

作者： Binay Kumar Shah Isaac Pak Nibash Budhathoki kayla Buker Binaytara Foundation BellinghamWA 98226USA Cancer Center PeaceHealth United General HospitalSedro WoolleyWA 98284USA pacific Northwest University School of Medicine YakimaWA 98901USA Department of Internal Medicine Interfaith Medical CenterBrooklynNY 11213USA Creighton University School of Medicine OmahaNebraska 68178USA

Leptomeningeal metastasis is an uncommon but serious complication in patients with advanced cancers. Leptomeningeal metastasis is diagnosed in approximately 5% of the patients, most commonly among patients with cancers of breast and lung, melanoma, and gastrointestinal malignancies. Treatment goal is to improve survival and quality of the patients. Use of targeted therapies and immunotherapy has led to improved survival of patients with non-small cell lung cancer （NSCLC）. In this article, we review emerging data on use of mutation-specific agents and immunotherapy in the treatment of leptomeningeal metastasis among patients with NSCLC.

关键词： Non-small cell hmg cancer leptomeningeal metastases immunotherapy

GIGANTEA Integrates Photoperiodic and Temperature Signals to Time when Growth Occurs

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Molecular Plant 2020年第3期13卷 357-359页

作者： James Ronald kayla McCarthy Seth Jon Davis University of York Department of BiologyHeslingtonYork YO105DDUK Key Laboratory of Plant Stress Biology School of Life SciencesHenan UniversityKaifeng 475004China

Circadian clocks synchronize internal physiological responses to occur at the most optimal time of the *** plants,hormone signaling is under the control of this *** has been previously shown that the circadian clock moderates the plant’s sensitivity to gibberellin(GA)by regulating the expression of GA ***,two papers by Nohales and Kay(2019)and Park et al.(2020)revealed that post-translational regulation of DELLA proteins by the circadian clock also contributes to timing when the plant is most sensitive to GA.

关键词： Photoperiod clock translational

Climate drives differences in the germination niche of a globally distributed invasive grass

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Journal of Plant Ecology 2020年第2期13卷 195-203页

作者： Rebecca A.Fletcher kayla M.Varnon Jacob N.Barney Virginia Tech School of Plant and Environmental Sciences675 Old Glade RdBlacksburgVA 24061USA

Aims Exotic invasive species are often exposed to strong selection pressures in their new ranges that can often lead to substantial intraspecific *** differentiation in the timing of life history events in response to climate gradients is thought to be an important mechanism facilitating the range expansion of many invasive *** seed producing plants,the timing of seed germination determines the first environmental conditions experienced by newly emerged germinates,and can have important implications for the successful colonization,establishment and spread of invasive plants—though the role of germination in the success of invasive plants remains poorly *** We assessed the variation in seed germination dynamics among 10 populations of the invasive plant Johnsongrass(Sorghum halepense)across its North American distribution,capturing both a temperature and precipitation gradient,and whether that variation is associated with home *** were exposed to a wide range of temperatures(11–48℃)and two water availability *** Findings We found that Johnsongrass seeds germinated across a wide range of temperatures,but there was substantial variation among populations in the proportion of seeds that germinated in response to both temperature and water *** indicates that as Johnsongrass expanded its range from warmer climates into cooler climates,there was a concurrent shift in the germination temperature niche to cooler *** results suggest that the germination of Johnsongrass seeds has adapted to home climate allowing this invader to maximize germination throughout its range,and that this may be an important contributing factor to its invasion into new environments.

关键词： adaptation among-population variation Johnsongrass Sorghum halepense temperature water availability

Challenges in the microbiological food safety of fresh produce:Limitations of post-harvest washing and the need for alternative interventions

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Food Quality and Safety 2017年第4期1卷 289-301页

作者： kayla Murray Fan Wu John Shi Sophia Jun Xue Keith Warriner Department of Food Science University of Guelph Guelph Food Research Center Agriculture and Agri-food CanadaGuelphOntorioCanada

Fresh produce(processed fruit and vegetables)continues to be the main source of foodborne illness outbreaks implicating pathogens such as Escherichia coli O157:H7,Salmonella,Listeria monocytogenes and human parasites(*** A,Cyclospora).Previously,outbreaks were primarily limited to leafy greens,tomatoes,and cantaloupes,but more recently there has been a trend of more diverse produce types(*** and papayas)being *** on-farm good agriculture practices(GAP)contribute to preventing pathogens entering the fresh produce chain,it cannot be relied upon completely due to the open nature of *** a consequence,there is an identified need for interventions that can remove field-acquired contamination,especially given fresh produce is eaten *** the following review,an overview of foodborne illness outbreaks linked to contaminated fresh produce will be described along with potential sources of ***-harvest washing that was once considered decontamination is now viewed as a high-risk cross-contamination *** challenges in monitoring the post-harvest wash process will be discussed along with processing factors that need to be considered.A range of alternative,or supplemental,non-aqueous interventions will be described including irradiation,ultraviolet light,high hydrostatic pressure,gas phase(ozone and chlorine dioxide),and hydroxyl radicals generated through advanced oxidative process or gas *** have been proved to be effective at pathogen control on the laboratory scale and are poised to enter commercial *** current status of these alternative interventions along with challenges of integrating into commercial practice will be described.

关键词： Fresh produce Escherichia coli O157:H7 Salmonella Listeria Iirradiation Ozone Chlorine dioxide Advanced oxidative process Post-harvest Washing Leafy greens Fruit Vegetable

Synthesis of a-SnWO_4 thin-film electrodes by hydrothermal conversion from crystalline WO_3

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Chinese Chemical Letters 2015年第4期26卷 474-478页

作者： kayla J.Pyper Taylor C.Evans Bart M.Bartlett Department of Chemistry University of Michigan

Thin film electrodes of the orthorhombic form of tin tungstate （α-SnWO4） were prepared using a hydrothermal method to convert thin films of WO3 in aqueous SnCI2. The pH dependence of the growth mechanism was identified by scanning electron microscopy （SEM） and X-ray diffraction （XRD）. The XRD patterns show complete conversion of WO3（s） to SnWO4（s） at pH 1, 4, and 7. SEM images reveal a morphology change from sponge-like platelets to sharp nanowires as the pH increases from 1 to 7. The α-SnWO4 thin films were reddish brown in color, and display an indirect band gap of 1.9 eV by diffuse reflectance UV-vis spectroscopy. α-SnWO4 is therefore solar-responsive, and a chopped light linear sweep voltammogram recorded under 100 mW/cm2 AM1.5 simulated solar illumination in a pH 5 0.1 mol/L KPi buffer show a visible light response for photoelectrochemical water oxidation, producing 32 μA/cm2 at 1.23 V vs. RHE.

关键词： Alpha tin tungstateHydrothermal conversionMicrostructureHydrothermal method

Cremaster muscle thickening: the anatomic difference in men with testicular retraction due to hyperactive cremaster muscle reflex

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Asian Journal of Andrology 2023年第4期25卷 484-486页

作者： Parviz K Kavoussi Hayden T Henderson kayla Hudson Romtin Mehrabani-Farsi Graham Luke Machen Austin Fertility and Reproductive Medicine/Westlake IVF AustinTX 78746USA

The objective was to assess whether men suffering from testicular retraction secondary to hyperactive cremaster muscle reflex havean anatomic difference in the thickness of the cremaster muscle in comparison to men who do not have retraction. From March2021 to December 2021, 21 men underwent microsurgical subinguinal cremaster muscle release (MSCMR) on 33 spermatic cordunits, as 12 of them had bilateral surgery, at Surgicare of South Austin Ambulatory Surgery Center in Austin, TX, USA. Duringthat same time frame, 36 men underwent subinguinal microsurgical varicocele repair on 41 spermatic cord units, as 5 werebilateral for infertility. The thickness of cremaster muscles was measured by the operating surgeon in men undergoing MSCMRand varicocele repair. Comparison was made between the cremaster muscle thickness in men with testicular retraction due toa hyperactive cremaster muscle reflex undergoing MSCMR and the cremaster muscle thickness in men undergoing varicocelerepair for infertility with no history of testicular retraction, which served as an anatomic control. The mean cremaster musclethickness in men who underwent MSCMR was significantly greater than those undergoing varicocele repair for infertility, witha mean cremaster muscle thickness of 3.9 (standard deviation [s.d.]: 1.2) mm vs 1.0 (s.d.: 0.4) mm, respectively. Men withtesticular retraction secondary to a hyperactive cremaster muscle reflex demonstrate thicker cremaster muscles than controls,those undergoing varicocele repair. An anatomic difference may be a beginning to understanding the pathology in men whostruggle with testicular retraction.

关键词： cremaster muscle orchialgia testicular retraction

Interactions between maternal parity and feed additives drive the composition of pig gut microbiomes in the post‑weaning period

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Journal of Animal Science and Biotechnology 2024年第3期15卷 1241-1257页

作者： kayla Law Eduardo Rosa Medina Garcia Chad Hastad Deborah Murray Pedro E.Urriola Andres Gomez Department of Animal Science University of Minnesota1364 Eckles AvenueSaint PaulMN 55108USA New Fashion Pork 164 Industrial ParkwayJacksonMN 56143USA

Background Nursery pigs undergo stressors in the post-weaning period that result in production and welfare *** challenges disproportionately impact the offspring of primiparous sows compared to those of mul-tiparous *** is known regarding potential interactions between parity and feed additives in the post-weaning period and their effects on nursery pig ***,the objective of this study was to investigate the effects of maternal parity on sow and offspring microbiomes and the influence of sow parity on pig fecal microbi-ome and performance in response to a prebiotic *** weaning,piglets were allotted into three treat-ment groups:a standard nursery diet including pharmacological doses of Zn and Cu(Con),a group fed a commercial prebiotic only(Preb)based on an Aspergillus oryzae fermentation extract,and a group fed the same prebiotic plus Zn and Cu(Preb+ZnCu).Results Although there were no differences in vaginal microbiome composition between primiparous and mul-tiparous sows,fecal microbiome composition was different(R^(2)=0.02,P=0.03).The fecal microbiomes of primiparous offspring displayed significantly higher bacterial diversity compared to multiparous offspring at d 0 and d 21 post-weaning(P<0.01),with differences in community composition observed at d 21(R^(2)=0.03,P=0.04).When analyzing the effects of maternal parity within each treatment,only the Preb diet triggered significant microbiome distinc-tions between primiparous and multiparous offspring(d 21:R^(2)=0.13,P=0.01;d 42:R^(2)=0.19,P=0.001).Composi-tional differences in pig fecal microbiomes between treatments were observed only at d 21(R^(2)=0.12,P=0.001).Pigs in the Con group gained significantly more weight throughout the nursery period when compared to those in the Preb+ZnCu *** Nursery pig gut microbiome composition was influenced by supplementation with an Aspergillus oryzae fermentation extract,with varying effects on performance

关键词： Aspergillus prebiotic Copper Feed additives Maternal Nursery pig microbiome Parity Swine microbiome Trace minerals Zinc