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Fahr’s Syndrome Discovered at Adulthood Revealing the Pseudohypoparathyroidism

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Open Journal of Rheumatology and Autoimmune Diseases 2019年第4期9卷 129-133页

作者： kawtar nassar Saadia Janani Department of Rheumatology Ibn Rochd University Hospital Center Medicine and Pharmacy University of Casablanca Casablanca Morocco

Fahr’s syndrome is a rare clinicopathological entity, defined by the presence of intracerebral calcifications not arteriosclerotic, bilateral and symmetric at the level of the basal ganglia, whose main etiology is dysparathyroidism, rarely pseudohypoparathyroidism. Hypocalcemia and hyperphosphatemia despite normal or high levels of parathyroid hormone are the result of resistance to the action of parathyroid hormone. The clinical profile is not specific but dominated by neuropsychiatric symptoms. We report the case of a 30-year-old patient with type pseudohypoparathyroidism revealed one year ago by Fahr’s syndrom. The diagnosis made by convulsion history since the age of 5 years resistant to treatment, the disturbance of metabolism disorders, and the presence of intracerebral calcifications. The vitamin D and calcium supplementation have contributed to the stabilization of the disease.

关键词： Fahr’s Syndrome Pseudohypoparathyroidism Convulsion Intracerebral Calcification Hypocalcemia

Review Venous Thromboembolism Risk with Anti-Osteoporosis Drugs

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Open Journal of Rheumatology and Autoimmune Diseases 2018年第4期8卷 111-119页

作者： kawtar nassar Wafae Rachidi Saadia Janani Ouafa Mkinsi Department of Rheumatology Ibn Rochd University Hospital Center Medicine and Pharmacy University of Casablanca Casablanca Morocco

Osteoporosis is the most common skeletal diseases, predisposing the patient to an increased risk of fractures. It is an important health issue linked to increased morbidity and mortality. Prevention and treatment strategies are now well defined and are always updating. Indeed, the therapeutic decision is based on the individual risk of fracture, efficiency and degree of therapeutic tolerance. However, some side effects, although rare can be attributed to drugs used. The benefit and risks of prescription drugs can be optimized by choosing the right time and the right treatment. The purpose of this article is the study of thromboembolic risk of various drugs recommended in osteoporosis. Furthermore we discuss preventive measures, and the different approaches after the first event.

关键词： Osteoporosis Venous Thrombosis Drugs Estrogens Progestins

Type IV Aggressive and Symptomatic Vertebral Hemangioma

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Open Journal of Rheumatology and Autoimmune Diseases 2015年第3期5卷 87-91页

作者： kawtar nassar Wafae Rachidi Saadia Janani Ouafa Mkinsi Rheumatology Department Ibn Rochd University Hospital Casablanca Morocco

Vertebral hemangiomas (VHs) are benign tumours with rich vasculature. They are the most common tumours of the spine with an estimated incidence of 10% - 12% of the population. Despite its high incidence, they are often asymptomatic and only 0.9% - 1.2% are symptomatic. They may also be aggressive and are characterised by bone expansion, extra osseous extension of the tumour, disturbance of local blood flow and, in rare cases, compression fractures. We report a 59-year-old woman, presented with back pain after falling from standing height. Magnetic resonance imaging revealed lumbar spine vertebral fractures and T12 osteolytic lesion with spinal canal extension, concurring to VH type IV, according to Tomita’s surgical classification of spinal. Embolization, posterior decompression and fixation were performed followed by postoperative radiotherapy. Her symptoms were resolved immediately without recurrence after 6 mouths.

关键词： Vertebral Haemangioma Extension Radiotherapy Ethanol Embolization Surgery

AA Amyloidosis Secondary to Primary Sjögren Syndrome: Can It Be Developed without Chronic Inflammation?

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Open Journal of Rheumatology and Autoimmune Diseases 2021年第2期11卷 29-35页

作者： Soukaina Zaher kawtar nassar Ibtissam Razzouki Meriem Regragui Mehdi Karkouri Saadia Janani Department of Rheumatology University Hospital Center of Ibn Rochd Hassan II-Casablanca University Casablanca Morocco Department of Pathology University Hospital Center of Ibn Rochd Hassan II-Casablanca University Casablanca Morocco

Background: The association of primary Sjögren syndrome (PSS) and AA amyloidosis is a rare occurrence. Objective: To describe the phenotype of patients with this association through our two cases and a literature review. Materials and methods: A report of two cases of AA amyloidosis complicating primary Sjögren syndrome with a literature review. Results: Eight patients of Primary Sjögren’s Syndrome complicated by AA amyloidosis were studies. Six cases were reported in the literature by consulting several databases. 50% of patients had a positive immunological assessment, three cases with kidney damage, and three cases lung damage. Conclusion: The immunological activity in the Primary Sjogren’s Syndrome requires the search not only a lymphoma but also AA amyloidosis apart from any clinical or biological chronic inflammation.

关键词： AA Amyloidosis Amyloid Primary Sjögren Syndrome