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无损检测 1995年第1期17卷 28-30页

作者： R.kawase H.Haraguchi T.Hamamoto 孙国平

本研究旨在建立热喷涂陶瓷涂层超声无损评价的方法。热喷涂二氧化二铝涂层中的超声速度由所试制的实验装置测得,并对超声速度与喷涂涂层特性的关系作了探讨。

关键词：超声检验覆层陶瓷热喷涂

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Recent advances in the surgical treatment of hepatocellular carcinoma

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World Journal of Gastroenterology 2014年第39期20卷 14381-14392页

作者： Zenichi Morise Norihiko Kawabe Hirokazu Tomishige Hidetoshi Nagata Jin kawase Satoshi Arakawa Rie Yoshida Masashi Isetani Department of Surgery Fujita Health University School of Medicine Banbuntane Houtokukai Hospital Nagoya 454-8509 Japan

Hepatocellular carcinoma(HCC) is the most common primary liver malignancy. The treatment of HCC is complex and complicated by the severity of associated chronic liver disease, the stage of HCC, and the clinical condition of the patient. Liver resection(LR) is one of the most efficient treatments for patients with HCC, with an expected 5-year survival of 38%-61% depending on the stage of the disease. Improved liver function assessment, increased understanding of segmental liver anatomy from advanced imaging studies, and surgical technical progress are important factors that have led to reduced mortality in patients with HCC. The indication for LR may be expanded due to emerging evidences from laparoscopic hepatectomies and combined treatments with newly developed chemotherapies. Liver transplantation(LT) is considered as an ideal treatment for removal of existing tumors and the injured/preneoplastic underlying liver tissue with impaired liver function and the risk of multicentric carcinogenesis that results from chronically injured liver. However, LT is restricted to patients with minimal risk of tumor recurrence under immunosuppression. The expansion of criteria for LT in HCC patients is still under trial and discussion. Limited availability of grafts, as well as the risk and the cost of transplantation have led to considerable interest in expansion of the donor pool, living donor-related transplantation, and combined treatment involving LR and LT. This highlight presents evidence concerning recent studies evaluating LR and LT in HCC patients. In addition, alternative therapies for the treatment of early stage tumors and the management of patients on transplant waiting lists are discussed.

关键词： Hepatocellular carcinoma Surgical treat-ment Hepat

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从家蚕分离的一种新细小病毒的DNA

中国蚕业 1982年第3期 35-38+47页

作者： Masao Nakagaki Shigemi kawase 何家禄

从家蚕中分离的称作为“Ina-FV”(伊那——软化病病毒)的细小病毒,是DNA病毒。纯化的Ina—FV直径为22±0.5mm,沉降系数为102S。用氯化铯(CsCl)密度梯度分离,该病毒颗粒出现在密度为1.40—1.45克/毫升处。Ina—FV的DNA含量是28±2％。低... 详细信息

从家蚕中分离的称作为“Ina-FV”(伊那——软化病病毒)的细小病毒,是DNA病毒。纯化的Ina—FV直径为22±0.5mm,沉降系数为102S。用氯化铯(CsCl)密度梯度分离,该病毒颗粒出现在密度为1.40—1.45克/毫升处。Ina—FV的DNA含量是28±2％。低盐缓冲液中的DNA具典型单链分子(ss)的性质。用高盐和升温条件提取,可得到双链DNA(ds DNA)。

关键词： DNA FV 双链单链细小病毒细小脱氧核糖核酸病毒病毒颗粒缓冲液家蚕桑蚕

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飞行时间太赫兹断层成像

生命科学仪器 2010年第6期8卷 7-9页

作者： Kodo kawase Koji SUIZU Takayuki SHIBUYA Nagoya University

介绍了利用超短激光脉冲的高分辨飞行时间太赫兹断层成像的发展。其基本原理是,首先非线性光学晶体获得的宽带太赫兹脉冲进入到样品,随后检测每一层反射回来的回波脉冲。利用高斯窗口的去卷积过程我们可以获得清晰、高分辨的断层成像谱... 详细信息

介绍了利用超短激光脉冲的高分辨飞行时间太赫兹断层成像的发展。其基本原理是,首先非线性光学晶体获得的宽带太赫兹脉冲进入到样品,随后检测每一层反射回来的回波脉冲。利用高斯窗口的去卷积过程我们可以获得清晰、高分辨的断层成像谱图。与聚四氟乙烯薄膜机械厚度测量的结果比较,如果一个样品的折射率为n,则轴向分辨率低于10/nμm。

关键词：太赫兹脉冲断层成像飞行时间非线性光学晶体聚四氟乙烯薄膜超短激光脉冲轴向分辨率回波脉冲

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蔗糖酯及其在制糖过程中的应用

甘蔗糖业 1982年第3期 40-43页

作者： N.kawase 张巧巧

众所周知,在所有自然形成的多元醇产物中,蔗糖具有最高的纯度。因而,在全世界蔗糖消费量很大。又由于它具有化学活性,自从十八世纪中期以来,人们就致力于把蔗糖的八个羟基转化成酯或醚。然而,只是到了最近,对这种化合物的研究才有所进展... 详细信息

众所周知,在所有自然形成的多元醇产物中,蔗糖具有最高的纯度。因而,在全世界蔗糖消费量很大。又由于它具有化学活性,自从十八世纪中期以来,人们就致力于把蔗糖的八个羟基转化成酯或醚。然而,只是到了最近,对这种化合物的研究才有所进展,但在八个羟基中也只有一个或两个能被转化。通常,蔗糖酯由具有八到二十二个碳原子的长链脂肪酸和蔗糖构成,它的蔗糖部分是亲水基而长链脂肪酸部分为憎水基。蔗糖酯具有这样一些表面活性作用:诸如乳化、分散、渗

关键词：大日本制糖公司分蜜制糖粘度降糖厂水泥外加剂表面活性剂煮炼二糖蔗糖方程方程式精炼糖制糖过程

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阳离子表面活性剂溶剂连续萃取比色测定法

环境工程学报 1980年第9期 76-80页

作者： Jiro kawase Makoto Yawanaka 薛艾

用自动分析仪测定阳离子表面活性剂的快速、自动比色法已经发展起来。此法是根据阳离子表面活性剂与二号橙试剂反应时形成离子对络合物进行连续溶剂萃取的原理而建立起来的。在二号橙中放入甲醇,可以使七种不同类型的表面活性剂得到好... 详细信息

用自动分析仪测定阳离子表面活性剂的快速、自动比色法已经发展起来。此法是根据阳离子表面活性剂与二号橙试剂反应时形成离子对络合物进行连续溶剂萃取的原理而建立起来的。在二号橙中放入甲醇,可以使七种不同类型的表面活性剂得到好的显色和具有相同的克分子响应值。用改变水相的pH值来测定胺和季胺表面活性剂混合物中的脂肪胺,此法已应用数种商品阳离子表面活性剂的测定。结果与二相滴定法所得结果一致。检测极限为1.5μM,容量为每小时10—20个样品,相对准确度好于1.5％。除熟知的头发漂洗、织物软化、洗净剂外,近来阳离子表面活性剂的新品种商品已

关键词：阳离子表面活性剂商品试剂二号橙

Cell Proliferation Ability of Mouse Fibroblast-Like Cells and Osteoblast-Like Cells on a Ti-6Al-4V Alloy Film Produced by Selective Laser Melting

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Materials Sciences and Applications 2014年第7期5卷 475-483页

作者： Mayu kawase Tatsuhide Hayashi Masaki Asakura Akimichi Mieki Hironari Fuyamada Masahiro Sassa Shizuka Nakano Masashi Hagiwara Toru Shimizu Tatsushi Kawai Advanced Laser and Process Technology Research Association (ALPROT) Tokyo Japan Laser Sintering Department ASPECT Inc. Tokyo Japan Advanced Laser and Process Technology Research Association (ALPROT) Tokyo Japan Low-Formability-Materials Processing Group Advanced Manufacturing Research Institute National Institute of Advanced Industrial Science and Technology Tsukuba Japan Department of Dental Materials Science Aichi Gakuin University School of Dentistry Nagoya Japan Department of Dental Materials Science Aichi Gakuin University School of Dentistry Nagoya Japan Advanced Laser and Process Technology Research Association (ALPROT) Tokyo Japan Department of Gerodontology Aichi Gakuin University School of Dentistry Nagoya Japan

Successful regeneration of tissues and organs relies on the application of suitable substrates or scaffolds in scaffold-based regenerative medicine. In this study, Ti-6Al-4V alloy films (Ti alloy film) were produced using a three-dimensional printing technique called Selective Laser Melting (SLM), which is one of the metal additive manufacturing techniques. The thickness of produced Ti alloy film was approximately 250 μm. The laser-irradiated surface of Ti alloy film had a relatively smooth yet porous surface. The non-irradiated surface was also porous but also retained a lot of partially melted Ti-6Al-4V powder. Cell proliferation ability of mouse fibroblast-like cells (L929 cells) and mouse osteoblast-like cells (MC3T3-E1 cells) on both the surfaces of Ti alloy film was examined using WST assay. Both L929 and MC3T3-E1 cells underwent cell proliferation during the culture period. These results indicate that selective laser melting is suitable for producing a cell-compatible Ti-6Al-4V alloy film for biomaterials applications.

关键词： Selective Laser Melting (SLM) Ti-6Al-4V Film Mouse Fibroblast-Like Cell Mouse Osteoblast-Like Cell Cell Compatibility

Identification of the Stress Which Causes Optineurin Aggregation

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Neuroscience & Medicine 2019年第2期10卷 150-161页

作者： Satoshi Inagaki Michinori Funato Junko Seki Chizuru kawase Kazuki Ohuchi Shiori Ando Shinsuke Nakamura Masamitsu Shimazawa Hideo Kaneko Hideaki Hara Molecular Pharmacology Department of Biofunctional Evaluation Gifu Pharmaceutical University Gifu Japan Department of Clinical Research National Hospital Organization Nagara Medical Center Gifu Japan

Glaucoma is a common neurodegenerative disease that can cause blindness and occurs worldwide. Currently, lowering intraocular pressure is the only therapy available to protect retinal ganglion cells (RGCs). However, this therapy does not prevent RGC death in all patients. Therefore, new therapeutic approaches for glaucoma are urgently required, and neuroprotection of RGCs is a focus for many researchers. Optineurin (OPTN) is one of the normal tension glaucoma (NTG) relative genes, while mutant OPTN can form a characteristic aggregation, causing RGC death. Hence, elucidation of the mechanism of OPTN aggregation might provide a clue to help understand RGC death. To examine whether non-mutant OPTN could also aggregate, we pharmacologically induced some glaucoma-related stresses, such as endoplasmic reticulum (ER) stress, glutamate toxicity, activation of TNF-α signaling, mitochondrial dysfunction, and autophagic flux impairment. Our results showed that ER stress, TNF-α signaling, and autophagic flux are involved in OPTN aggregation. Furthermore, our data indicated that increased ER stress, activation of TNF-α signaling, and impaired autophagic flux induce OPTN aggregation, suggesting that OPTN aggregation might be an important therapeutic target not only for familial NTG with mutated OPTN but also for patients with glaucoma more generally.

关键词： Glaucoma Induced Pluripotent Stem Cells Retinal Ganglion Cells Optineurin Protein Aggregation

从软化病病毒感染的家蚕中分离出的浓核症病毒的结构蛋白

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中国蚕业 1982年第4期 27-30页

作者： M.Nakagaki S.kawase 何家禄

高度纯化的家蚕浓核症病毒粒子,经十二烷基磺酸钠一聚丙烯酰胺凝胶电泳(SDSPAGE)的分析,发现有四个结构蛋白。从相对迁移率和阻滞系数测定出分子量。主要病毒蛋白(VP1)约占病毒蛋白总量的65%,分子量约为50,000,其余三个次要的蛋白VP2,VP... 详细信息

高度纯化的家蚕浓核症病毒粒子,经十二烷基磺酸钠一聚丙烯酰胺凝胶电泳(SDSPAGE)的分析,发现有四个结构蛋白。从相对迁移率和阻滞系数测定出分子量。主要病毒蛋白(VP1)约占病毒蛋白总量的65%,分子量约为50,000,其余三个次要的蛋白VP2,VP3,VP4,分子量分别约为57,000,70,000和77,000。每一个家蚕浓核症病毒

关键词：标志蛋白家蚕桑蚕病毒粒子病毒体软化病 DNV 蛋白分子蜡螟病毒蛋白 VPI 光密度摄影密度

家蚕浓核病毒(山梨株)DNA的电子显微镜研究

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Virologica Sinica 1987年第3期 94-103页

作者：胡远扬 H.SEKI S. kawase 武汉大学病毒系日本山梨县蚕业试验场日本名古屋大学农学部武汉

最近所分离的家蚕浓核病毒(DNV)山梨株(Y-DNV)与最初在家蚕中发现的DNV伊那株在各种理化性质方面有所不同。从Y-DNV中提取的病毒DNA在琼脂糖凝胶电泳中出现二条带(DNA Ⅰ和Ⅱ)。用限制性内切酶处理这些DNA,其结果也明显不同。为了弄清... 详细信息

最近所分离的家蚕浓核病毒(DNV)山梨株(Y-DNV)与最初在家蚕中发现的DNV伊那株在各种理化性质方面有所不同。从Y-DNV中提取的病毒DNA在琼脂糖凝胶电泳中出现二条带(DNA Ⅰ和Ⅱ)。用限制性内切酶处理这些DNA,其结果也明显不同。为了弄清这些现象,用电子显微镜对这些DNA分子进行研究。通过琼脂糖凝胶电泳分离的DNA Ⅰ和DNA Ⅱ都是双链线状分子,但DNA Ⅰ分子的长度略长。在电子显微镜下,二种DNA的构象没有差异,因此可以肯定DNA Ⅰ和DNAⅡ有不同的碱基序列组成。这在DNV中是罕见的,因为到目前为止所知道的所有DNV都只有4种结构蛋白。基于这种情况,在前一篇论文我们曾推测这些蛋白质可能是来自两种DAV,它们各自具有其中3种或4种结构蛋白。应当指出的是,Y-DNV的衣壳本身是由一种还是由二种结构所组成的还需要进一步的研究给予证实。因为Y-DNV的病毒直径很小,它不可能包含二种DNA(分子量分别为2.1×10~6d,和1.7×10~6d.)所以家蚕Y-DNV很可能是由二种相似但是不相同的DNV所组成的混合物。

关键词： DNA 琼脂糖凝胶长度抽提色谱试剂山梨家蚕浓核病毒 DNV 病毒体病毒粒子电镜电子显微镜