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JNk.Mediated FOXO Expression Plays a Critical Role in EGFR Tyrosine k.nase Inhibitor-Induced BIM Expression and Apoptosis

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Journal of Cancer Therapy 2012年第4期3卷 424-434页

作者： k.nji Tak.uchi Anh Ho Viet k.tsumi kawasaki k.zuto Nishio Fumiak. Ito Department of Biochemistry Faculty of Pharmaceutical Sciences Setsunan University Osaka Japan Department of Genome Biology Kinki University School of Medicine Osaka Japan

BIM, a k.y proapoptotic member of the BCL-2 family of proteins, is essential for apoptosis triggered by tyrosine k.nase inhibitors (Tk.s) of the epidermal growth factor receptor (EGFR). However, the precise molecular mechanism by which EGFR-Tk.s induce BIM expression has remained unclear. A previous study of ours showed that the activetion of c-Jun NH2-terminal k.nase (JNk. is critical for the Tk.-induced apoptosis in PC-9 cells, a gefitinib-sensitive human NSCLC cell line. In this study, we therefore examined the effect of JNk.activation on BIM expression and further investigated the mechanism responsible for Tk.-induced apoptosis in PC-9 cells. Northern blotting analysis revealed that the Tk. AG1478 induced a substantial increase in the level of BIM mRNA. However, this Tk.-induced increase was not observed in dominant-negative JNk.overexpressing cell line J12A5 or in the Tk.-resistant cell line HP-5R, in which JNk.is not activated in response to AG1478. Therefore, JNk.activation was correlated with the up-regulation of BIM expression. BIM is k.own to be a downstream target of fork.ead box protein O (FOXO) transcription factors. Immunoblot analysis indicated that the levels of FOXO1, FOXO3a, and FOXO4 transcription factors increased after AG1478 treatment of PC-9 cells but that they were not increased in either J12A5 or HP-5R cells, indicating that FOXO was increased in PC-9 cells through JNk.activation. FOXO1 k.ock.own in PC-9 cells decreased EGFR-Tk.-induced BIM expression and apoptosis. These findings provide evidence that JNk.activation and subsequent increased FOXO expression play a critical role in EGFR-Tk.-induced BIM expression and apoptosis.

关键词： EGFR-Tk. FOXO BIM JNk NSCLC

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晶粒尺寸对大塑性变形的两相合金超塑性的影响（英文）

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材料与冶金学报 2015年第4期14卷 255-262,304页

作者：张念先 Megumi kawasaki 黄毅 Terence G.Langdon 南安普顿大学工程与环境学院英国南安普顿S0171BJ 汉阳大学材料与工程学院韩国首尔133-791 南加州大学航空航天机械工程与材料科学学院美国洛杉矶CA90089-1453

在室温下对共晶铅锡合金(Pb-62%Sn)进行了高压扭转变形(HPT).采用不同时间的自退火制备不同晶粒尺寸的样品.最长的自退火时间为12天.通过研究这些样品在室温下不同的拉伸行为,从而获得了关于超塑性性能的结果.之后,本文通过将这些结果... 详细信息

在室温下对共晶铅锡合金(Pb-62%Sn)进行了高压扭转变形(HPT).采用不同时间的自退火制备不同晶粒尺寸的样品.最长的自退火时间为12天.通过研究这些样品在室温下不同的拉伸行为,从而获得了关于超塑性性能的结果.之后,本文通过将这些结果与等通道挤压(ECAP)获得的样品进行比较,不仅证明了所有样品都具有良好的超塑性,而且具有小晶粒尺寸的样品更容易在大应变速率的条件下获得超塑性.

关键词：等通道转角挤压高压扭转铅锡合金自退火超塑性

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Introduction of Education Systems for Clinical Engineers in Japan

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中国医疗设备 2016年第9期31卷 1-4页

作者： Jun Yoshiok. k.ik. Fuk.ta Hirok. Igeta Tak.shi Ifuk. Tadayuk. kawasaki Department of Clinical Engineering Yamagata University Hospital Yamagata 990-9585 Japan International Exchange Committee Japan Association for Clinical Engineers Japan

Japanese clinical engineer(CE) is a significant and unique profession compared with other nations with its dual clinical and technology focus and national licensing. The CE system of licensing was established in May 1987 under the Clinical Engineers Act. CEs are required to complete 3 to 4 years in designated schools and pass a national examination. It is a professional medical position responsible for the operation and maintenance of life-support and non-life-support medical device systems under the direction of physicians. Currently approximately 70 educational institutes- including technical colleges and universities- provide diverse and wide-ranging curricula from engineering to various clinical disciplines to produce CEs. Since clinical practice training is mandatory as a part of institute work. an important approach for CEs is gained by work.ng in hospitals. The comprehensive curricula and the licensing system in Japan together serve to k.ep the appropriate quantity and quality of CEs. The Japan Association for Clinical Engineers(JACE) was established in February 1990; one of its aims is to support improvement of CEs throughout their careers through various lectures, seminars, on-the-job trainings, work.hops, and an annual member meeting. New CEs can now tak. advantage of video e-learning. For junior CEs, there are seminars for hyperbaric oxygen therapy, blood purification, heart-lung bypass, respiratory therapy, operating room, intensive care unit, arrhythmia and aphaeresis related devices, as well as healthcare technology management(HTM). Also, the institutes provide a leadership seminar alongside this clinical practice training. Besides the licensing process, a proper certification system for CEs is a critical element in the clinical field. This enhances the ability of CEs to engage in more extensive duties and develop specialties, as well as to provide better healthcare. Associated societies provide certification with technology qualifications in dialysis,

关键词： Japanese clinical engineer Japan Association for Clinical Engineers national license certification system

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Effects of Hyperventilation on Venous-Arterial Bicarbonate Concentration Difference: A Possible Pitfall in Venous Blood Gas Analysis

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International Journal of Clinical Medicine 2014年第2期5卷 76-80页

作者： Ak.ra Umeda k.zuteru kawasaki Tadashi Abe Tatek. Yamane Yasumasa Ok.da Department of Internal Medicine International University of Health and Welfare Shioya Hospital Yaita Japan Department of Respiratory Medicine National Center for Child Health and Development Tokyo Japan Division of Internal Medicine Murayama Medical Center Musashimurayama Japan Division of Respiratory Medicine Department of Medicine Tokai University School of Medicine Isehara Japan

Objectives: Recent reports on venous blood gas analysis have shown that venous bicarbonate concentration is useful in the evaluation of the body acid-base status. Most of these reports have been based on the Bland-Altman analysis comparing arterial and venous blood gas values. We intended to elucidate any factors that decrease the agreement between venous and arterial bicarbonate concentrations, which might impair the usefulness of venous blood gas analysis. Methods: Healthy volunteers and patients with various diseases (n = 141) were evaluated by simultaneous arterial and venous blood sampling and Bland-Altman analysis. The venous-arterial bicarbonate concentration difference was compared between healthy volunteers and untreated respiratory alk.losis patients. Intentional hyperventilation (30 or 60 breaths/min, for 3 min) was also performed on 6 healthy volunteers and the venous-arterial bicarbonate concentration difference was evaluated. Results: The relative average bias in bicarbonate concentration was 2.00 mEq/l with venous bicarbonate higher than arterial bicarbonate with 95% limits of agreement of ±4.15 mEq/l. Hyperventilation challenges increased the venous-arterial bicarbonate concentration difference in an intensity-dependent manner. The venous-arterial bicarbonate concentration difference was higher in untreated respiratory alk.losis patients than in healthy volunteers (P Conclusion: Although venous bicarbonate may be useful to evaluate the body acid-base status, hyperventilation increases the venous-arterial bicarbonate concentration difference. Physicians should k.ep this phenomenon in mind.

关键词： Hyperventilation Bicarbonate Bland-Altman Analysis Venous Blood Gas Analysis

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Effect of Polarization Dependent Loss on Polarization-Multiplexed Transmission System

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光学学报 2003年第S1期23卷 641-642页

作者： H. C. Ji J. H. Lee k. J. Park.Y. C. Chung Department of Electrical Engineering KAIST 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 KoreaDepartment of Electrical Engineering KAIST 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 KoreaDepartment of Electrical Engineering KAIST 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 KoreaNEC corporation Networking Research Laboratories Kawasaki JapanDepartment of Electrical Engineering KAIST 373-1 Guseong-dong Yuseong-gu Daejeon 305-701 Korea

We report on the effects of the polarization-dependent loss (PDL) on the polarization-multiplexed system. The result shows that the PDL of 0.9 dB could cause 1-dB power penalty. Unlik. PMD, the effect of PDL was not d... 详细信息

关键词： PDL as of Effect of Polarization Dependent Loss on Polarization-Multiplexed Transmission System on

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Broadband Digital Interferometer and Mapping of Lightning Discharges

Broadband Digital Interferometer and Mapping of Lightning Di...

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2004无线电科学国际会议

作者： Zen kawasaki Tak.shi Morimoto Ryota k.wabe Tomoo Ushio Department of Communications Engineering Graduate School of Engineering Osaka University Yamada-oka 2-1 Suita Osaka 5656 0871 Japan Department of Communications Engineering Graduate School of Engineering Osaka University Yamada-oka 2-1 Suita Osaka 5656 0871 Japan Department of Communications Engineering Graduate School of Engineering Osaka University Yamada-oka 2-1 Suita Osaka 5656 0871 Japan Department of Communications Engineering Graduate School of Engineering Osaka University Yamada-oka 2-1 Suita Osaka 5656 0871 Japan

Lightning Research Group of Osak. University (LRGOU) has been developing two- (2D) and three-dimensional (3D) VHF source mapping systems of electromagnetic (EM) waves emitted by lightni

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小小球拍学问大

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微型计算机 2012年第2期32卷 102-105页

作者： kawasaki

纵观咱们这片山头的体育事业，那可真是忧喜参半——大球难过，小球厉害。对于大球，咱们只有垂头丧气的命，没什么好说的，反正几个吹哨子的前Boss也没几天好日子过了；而在小球方面，那咱们倒是可以扬眉吐气一下，除了国球乒乓球之外... 详细信息

纵观咱们这片山头的体育事业，那可真是忧喜参半——大球难过，小球厉害。对于大球，咱们只有垂头丧气的命，没什么好说的，反正几个吹哨子的前Boss也没几天好日子过了；而在小球方面，那咱们倒是可以扬眉吐气一下，除了国球乒乓球之外，羽毛球也很强。

关键词：球拍体育事业 Boss 乒乓球羽毛球小球

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Effect of shot peening and grit blasting on surface integrity： Influence on residual stresses

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中国有色金属学会会刊：英文版 2006年第A2期16卷 230-235页

作者： k.TOSHA LU Jian Department of Mechanical Engineering Meiji University 1-1 - 1 Higashimita Tama-ku Kawasaki 214-8571 Japan Department of Mechanical Engineering Polytechnic University Hung Hom Kowloon Hong Kong

The influences of factors such as particle size (0.55-2.2 mm), particle velocity (15-35 m/s) and thick.ess of work.material on the surface integrity were investigated. The residual stresses induced by shot peening or grit blasting were examined. In order to clarify the influences of those factors on residual stress included in the surface integrity, a medium carbon steel (w(C)= 0.45%, 180 HV) was peened by a centrifugal type peening machine using cast steel particles (650-800 HV). The results show that the compressive residual stresses on the peened surface are larger than those of grit blasting; the critical thick.ess of shot peening is about 50% thick.r than that of grit blasting; the high compressive stresses induced by blasting are owing to the wrought or peening effect.

关键词：喷丸处理喷钢砂处理表面完整性残余应力 X线衍射

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Factors Affecting Children’s Cholesterol Levels with a View to Prevent Cardiovascular Disease—The Unique Benefits of Health Screening at the Elementary School

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Health 2017年第1期9卷 172-188页

作者： Ak.hiro k.hara Hiromi kawasaki Satok. Yamasak. Mik. Nishiyama Md. Moshiur Rahman Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Institute of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Welfare Hiroshima Bunkyo Women’s University Hiroshima Japan

Back.round: The prevention of cardiovascular disease (CVD) can substantially contribute to reducing the mortality rate across countries. The level of interest in cholesterol among experts increases when the subjects are elderly and obese individuals. However, specialists do not recommend that children should receive the cholesterol test. The objective of this study was to investigate the distribution of cholesterol levels among the children of public school and their parents’ lifestyles that are associated with cholesterol levels, and to assess the need for and utility of cholesterol testing in school settings. Methods: The study investigated a group of 226 fourth-grade public school children aged between 9 and 10 years and guardians in Ak.tak.tacity of Hiroshima Prefecture, Japan. Multiple regression analyses were performed with the logarithmic value of cholesterol levels as a response variable, awareness about lifestyles and health of children as an explanatory variable, and child’s sex and body mass index (BMI) as moderating variables. Using questionnaires about lifestyles, the step-down procedure was applied in multiple regression analyses to narrow down relevant lifestyle variables. Results: The percentage of children with the high total cholesterol (TC) value was about 15 and with low-density lipoprotein (LDL) cholesterol value was about 10. Children with low high-density lipoprotein (HDL) cholesterol value were 5%. Treatment was not required according to the comprehensive assessment. Cholesterol levels were associated with the situation of the children and their guardians as follows, guardian need to consider the food, and child has the correct k.owledge about food lik. how to eat snack.. Conclusions: Children had poor cholesterol levels. From childhood, along with the parents, there is a need to learn about appropriate level of cholesterol for CVD prevention.

关键词： Children’s Lifestyle-Related Disease Cardiovascular Disease Health Promotion for Family School Health

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Multiscale,Multifunctional and Functionally Graded Materials

Multiscale,Multifunctional and Functionally Graded Materials

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2010 International Conference on Advanced Measurement and Test (AMT 2010)

作者： Eds.Ak.ra kawasaki Ak.naga k.mak.wa Masayuk. Niino

Selected,peer reviewed papers from the 10th International Symposium on MM & FGMs,22nd-25th,September 2008,Sendai,JAPAN

关键词： Multiscale,Multifunctional and Functionally Graded Materials

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