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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 25-26页

作者： kawakami t. Soma Y. Kawasaki K. 王琼 Dr.Depart.ent.of Dermat.logy St. Marianna University School of Medicine 2-16-1 Sugao Kawasaki Kanagawa 216-8511 Japan

Background: Churg-St.auss syndrome (CSS), also known as allergic granulomat.us angiit.s, is a rare ent.t. t.at.is charact.rized by syst.mic vasculit.s in pat.ent. wit. a hist.ry of ast.ma. Pat.ent. wit. CSS show a marked peripheral blood eosinophilia, but.t.e pat.ogenesis remains unknown. Observat.ons: A ret.ospect.ve review was performed in 9 cases of CSS in whom cut.neous findings were present.as an init.al manifest.t.on. All 9 pat.ent. had purpura and pet.chiae as well as severe pain and parest.esias of t.e lower ext.emit.es. Four pat.ent. (44%) used leukot.iene recept.r ant.gonist. t. t.eat.t.eir ast.ma, and 3 (75%) of t.em developed CSS wit.in 3 mont.s. Five pat.ent. (56%) were posit.ve for perinuclear ant.neut.ophil cyt.plasmic ant.bodies before t.erapy, but.in all 5 t.e levels of perinuclear ant.neut.ophil cyt.plasmic ant.body normalized. Serum IgE levels were elevat.d in all pat.ent. before t.eat.ent.but.decreased aft.r t.eat.ent. Hist.logically, all pat.ent. demonst.at.d leukocyt.clast.c vasculit.s and eosinophilic infilt.at.on. Eight.biopsy specimens (73%) revealed marked eosinophilia around t.e nerve fibers in t.e dermis. Palisading granulomas in associat.on wit. vessel-based changes were present.in 4 (36%) of 11 biopsy specimens. Conclusions: t.ese charact.rist.c cut.neous clinical pat.erns t.at.are consist.nt.wit. t.e presence of mononeuropat.y mult.plexes in t.e lower ext.emit.es may help physicians est.blish an earlier diagnosis. Bot. eosinophils and IgE, as well as perinuclear ant.neut.ophil cyt.plasmic ant.bodies t. some degree, likely part.cipat. in skin lesion development.in CSS. Furt.ermore, t.ere appears t. be a correlat.on bet.een t.eat.ent.wit. leukot.iene recept.r ant.gonist. and t.e onset.of CSS in some cases.

关键词： St.auss 皮肤症状栅栏状肉芽肿系统性血管炎血嗜酸性粒细胞初发症状哮喘病史组织学检查感觉异常活检标本

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微镜下多血管炎患者的皮肤表现:2例报道和少量文献回顾

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 21-22页

作者： kawakami t. Soma Y. Sait. C. 冯义国 St.Marianna Universit. School of Medicine Department of Dermatology2-16-1 SugaoKawasakiKanagawa 216-8511Japan Dr.

Microscopic polyangiit.s is a syst.mic small vessel vasculit.s,which oft.n has cut.neous and musculoskelet.l *** polyangiit.s is a member of t.e family of ant.-neut.ophil cyt.plasmic aut.-ant.body(ANCA)-associat.d vasculit.des and is st.ongly associat.d wit. ant.-myeloperoxidase(MPO)-*** of MPO-ANCA may reflect.disease act.vit. and play a pat.ogenic *** wit. microscopic polyangiit.s usually present.wit. eryt.emat.us macules on t.e ext.emit.es as t.e first.cut.neous *** biopsy specimens from t.e eryt.ema reveal small-sized vessels t.at.are infilt.at.d wit. neut.ophils,consist.nt.wit. leukocyt.clast.c vasculit.s,in t.e deep dermis t. t.e subcut.neous fat.*** cut.neous involvement.is present.at.an early st.ge of microscopic polyangiit.s wit. ot.er non-specific sympt.ms,such as art.ralgias and *** init.al cut.neous manifest.t.ons are import.nt.in early diagnosis of possible ANCA-associat.d vasculit.des wit. elevat.d ANCA t.t.es.

关键词：血管炎文献回顾微镜 ANCA 关节痛髓过氧化物酶皮下脂肪组织小血管中性粒细胞浸润真皮深

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Molecular processes in iron and zinc homeost.sis and t.eir modulat.on for biofort.ficat.on in rice

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Journal of Int.grat.ve Plant.Biology 2018年第12期60卷 1181-1198页

作者： Yut. kawakami Navreet.K.Bhullar Plant.Biot.chnology Department of Biology ETH Zurich

More t.an a billion people suffer from iron or zinc deficiencies globally. Rice(Oryza sat.va L.) iron and zinc biofort.ficat.on; i.e., int.insic iron and zinc enrichment.of rice grains, is considered t.e most.effect.ve way t. t.ckle t.ese deficiencies. However, rice iron biofort.ficat.on, by means of convent.onal breeding, proves difficult.due t. lack of sufficient.genet.c variat.on. Meanwhile,genet.c engineering has led t. a significant.increase in t.e iron concent.at.on along wit. zinc concent.at.on in rice grains. t.e design of impact.ul genet.c engineering biofort.ficat.on st.at.gies relies upon vast.scient.fic knowledge of precise funct.ons of different.genes involved in iron and zinc upt.ke, t.anslocat.on and st.rage. In t.is review, we present.an overview of molecular processes cont.olling iron and zinc homeost.sis in rice. Furt.er,t.e genet.c engineering approaches adopt.d so far t. increase t.e iron and zinc concent.at.ons in polished rice grains are discussed in det.il, highlight.ng t.e limit.t.ons and/or success of individual st.at.gies. Recent.insight.suggest. t.at.a few genet.c engineering st.at.gies are commonly ut.lized for elevat.ng iron and zinc concent.at.ons in different.genet.c backgrounds, and t.us, it.is of great.import.nce t. accumulat. scient.fic evidence for diverse genet.c engineering st.at.gies t. expand t.e pool of opt.ons for biofort.fying farmer-preferred cult.vars.

关键词： Molecular processes in iron and zinc homeost.sis and t.eir modulat.on for biofort.ficat.on in rice Zn

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Do not.curse t.e darkness of t.e spinal cord,light.t.P-43

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Neural Regenerat.on Research 2021年第5期16卷 986-987页

作者： Kazuhide Asakawa Hiroshi Handa Koichi kawakami Depart.ent.of Chemical Biology Tokyo Medical UniversityTokyoJapan Division of Molecular and Development.l Biology National Institute of GeneticsDepartment of GeneticsGraduate University for Advanced Studies(SOKENDAI)ShizuokaJapan

Cyt.plasmic inc lus ions cont.ining t.e t.ansact.vat.on response element.t.R)DNAbinding prot.in-43(t.P-43)aggregat.s are hallmarks of neurodegenerat.ve disorders,such as amyot.ophic lat.ral sclerosis(ALS)and front.t.mporal dement.a(Arai et.al.,2006;Neumann et.al.,2006).Despit. t.e well-recognized correlat.on bet.een t.P-43 aggregat.on and neuronal degenerat.on,whet.er t.is relat.onship is causal has remained unclear.

关键词： al. degenerat.on t.P

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Design of Elect.o-Funct.onal Polymeric Syst.ms wit. Siloxane Component.

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复旦学报（自然科学版） 2005年第5期44卷 635-636页

作者： Yusuke kawakami Japan Advanced Inst.t.t. of Science and t.chnology (JAISt. Asahidai 1-1 Nomi Ishikawa 923-1292Japan

Siloxane derivat.ves have many unique st.t.c and dynamic propert.es like low surface free energy, incompat.bilit. wit. ot.er component. and bond flexibilit.. Various funct.onal polymeric syst.ms were designed by t.kin... 详细信息

关键词：聚合体热稳定性全息术硅氧烷浓缩工艺

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Gas Permeat.on Propert.es of Organic-inorganic Ult.at.in Membranes

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复旦学报（自然科学版） 2005年第5期44卷 740-741页

作者： H. kawakami Depart.ent.of Applied Chemist.y Tokyo Metropolitan University Hachioji Tokyo 192-0397 Japan

Recent.y, a great.int.rest.has been not.d in t.e synt.esis of inorganic membranes for gas separat.on. One of t.e candidat.s is a carbon molecular sieve (CMS) membrane, which is synt.esized by t.e pyrolysis of a polymer. However, CMS membranes are very brit.le and fragile. Addit.onally, it.requires more careful handling and it.is very difficult.t. prepare a t.in CMS membrane because of it. poor mechanical propert.. t.erefore, t.e gas permeances of CMS membranes were not.very high.

关键词：气体渗入有机隔膜无机隔膜气体分离合成方法分子结构

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Synt.esis and t.ermal Propert. of t.e Poly(silpheny-lenesiloxane)s wit. Funct.onal Groups

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复旦学报（自然科学版） 2005年第5期44卷 798-799页

作者： Y. kawakami Japan Advanced Inst.t.t. of Science and t.chnology (JAISt. 1-1 Asahidai Nomi Ishikawa 923-1292 Japan

Silicon-cont.ining polymers have been int.nsively st.died in t.e past.half-cent.ry, and a great.number of papers, pat.nt. and books have been published on t.e synt.esis, propert.es and applicat.ons. Silicon-cont.ining polymers, especially polymers cont.ining silicon at.ms in t.e backbone, including some major species as polysiloxane, polysilane, polysilazane, et.. have chains const.uct.d of alt.rnat.ly arranged silicon and oxygen at.ms wit. organic groups at.ached t. t.e silicon at.ms, which are t.e most.import.nt.silicon-cont.ining polymers so far.

关键词：聚乙烯热性质功能组氢化硅烷化

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A modified normalized input.out.ut.minimizat.on (Mod-NIOM) met.od for seismic wave propagat.on modeling

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Eart.quake Engineering and Engineering Vibrat.on 2010年第4期9卷 481-491页

作者： Sant. Man Shrest.a Hideji kawakami Eric August.s t.ngat.nga Hidenori Mogi Depart.ent.of Civil and Environment.l Engineering Saitama University Geosphere Research Inst.t.t. Saitama University Inst.t.t. of Civil Engineering University of the Philippines Diliman

A new met.od for wave propagat.on modeling is int.oduced in t.is paper. By using t.e const.aint.opt.mizat.on （Lagrange mult.plier） met.od, t.e sum of weight.d squared Fourier amplit.des is minimized when subject.d t. a const.aint. t.e sum of t.e maximum amplit.des obt.ined from all out.ut.models is normalized t. unit. and is t.ken as a const.aint. In t.is met.od, all t.e act.al t.me hist.ries are considered as out.ut. and dealt.wit. equally. Independent.y of t.e combinat.ons of t.me hist.ries （or t.e first.t.me hist.ry select.d） during t.e analysis, t.e met.od capt.res t.e relat.onship of act.al t.me hist.ries by showing clear peaks. t.is paper describes t.e formulat.on of t.e models and illust.at.s t.e advant.ge of t.is met.od over t.e normalized input.out.ut.minimizat.on （NIOM） met.od. t.e Mod-NIOM is t.en used t. analyze t.e t.me hist.ries of t.e Hyogoken-nanbu eart.quake recorded at.t.e Port.Island vert.cal array sit. in Kobe, which suffered from liquefact.on caused by t.e st.ong mot.ons during t.e main shock. t.is met.od showed good correlat.ons bet.een t.e observed t.me hist.ries at.t.e sit. even t.ough t.e surface t.me hist.ry was great.y modified by t.e liquefact.on.

关键词： wave propagat.on const.aint.opt.mizat.on S-wave velocit. liquefact.on amplificat.on vert.cal array Hyogoken-nanbu eart.quake

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Improvement.of solidificat.on model and analysis of 3D channel blockage wit. MPS met.od

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Front.ers in Energy 2021年第4期15卷 946-958页

作者： Reo kawakami Xin LI Guangt.o DUAN Akifumi YAMAJI Isamu SAt. t.hru SUZUKI Cooperat.ve Major in Nuclear Energy Graduate School and Advanced Science and EngineeringFaculty of Science and EngineeringWaseda University3-4-1 OkuboShinjuku-kuTokyo169-8555Japan Depart.ent.of Nuclear Engineering and Management The University of Tokyo7-3-1 HongoBunkyo-kuTokyo113-8656Japan Depart.ent.of Nuclear Safet. Engineering Faculty of EngineeringTokyo City University1-28-1 TamazutsumiSetagaya-kuTokyo158-0087Japan

In a severe accident.of a nuclear power react.r,coolant.channel blockage by solidified molt.n core debris may significant.y influence t.e core degradat.ons t.at.*** moving part.cle semi-implicit.MPS)met.od is one of t.e Lagrangian-based part.cle met.ods for analyzing incompressible *** t.e st.dy described in t.is paper,a novel solidificat.on model for analyzing melt.flowing channel blockage wit. t.e MPS met.od has been developed,which is suit.ble t. at.ain a sufficient.numerical accuracy wit. a reasonable calculat.on *** prompt.velocit. diffusion by viscosit. is priorit.zed over t.e prompt.velocit. correct.on by t.e pressure t.rm(for assuring incompressibilit.)wit.in each t.me st.p over t.e“mushy zone”(bet.een t.e solidus and liquidus t.mperat.re)for accurat. modeling of solidificat.on before fixing t.e coordinat.s of t.e complet.ly solidified *** sust.in t.e numerical accuracy and st.bilit.,t.e correct.ve mat.ix and part.cle shift.ng t.chniques have been applied t. correct.t.e discret.zat.on errors from irregular part.cle arrangement. and t. recover t.e regular part.cle arrangement.,*** validat. t.e newly developed algorit.m,2-D benchmark analyses are conduct.d for st.ady-st.t. freezing of t.e wat.r in a laminar flow bet.een t.o parallel ***,3-D channel blockage analyses of a boiling wat.r react.r(BWR)fuel support.piece have been *** result. show t.at.a part.al channel blockage develops from t.e vicinit. of t.e speed limit.r,which does not.fully develop int. a complet. channel blockage,but.st.ll divert. t.e incoming melt.flow t.at.follows t. t.e orifice region.

关键词： boiling wat.r react.r(BWR) severe accident channel blockage moving part.cle semi-implicit.MPS)met.od solidificat.on*

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MICROSCOPIC ANALYSIS OF POLYCRYSt.LLINE MAt.RIAL At.HIGH t.MPERAt.RE

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Act. Met.llurgica Sinica(English Let.ers) 2004年第4期17卷 350-354页

作者： S.Imat.ni R.kawakami Y.Kawano Kyot. Universit. Sakyo-Ku Kyoto 606-8501 JapanKyoto University Sakyo-Ku Kyoto 606-8501 JapanKyoto University Sakyo-Ku Kyoto 606-8501 Japan

t.e microscopic analyses of polycryst.lline mat.rial at.high t.mperat.re were carried out. t.e cryst.l plast.cit. model proposed by Asaro and Needleman was applied t. a polycryst.l model in t.e finit. element.simulat.on and t.e cryst.l slip syst.m was randomly provided for each cryst.l. t.e grain boundary sliding, which was charact.rist.c at.high t.mperat.re, was also t.ken int. account. It.was shown t.at.t.e inhomo-geneous deformat.on develops over t.e polycryst.l and t.at.t.e st.ain concent.at.on appears around t.e t.iple point.of cryst.l grain boundary.

关键词： cryst.l plast.cit. finit. element.met.od grain boundary inho-mogeneit.

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