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Alteration of somatostatin receptor subtype 2 gene expression in pancreatic tumor angiogenesis

World Journal of Gastroenterology 2004年第1期10卷 132-135页

作者： Manoj Kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

AIM: To explore the difference of somatostatin receptor subtype 2 (SST2R) gene expression in pancreatic cancerous tissue and its adjacent tissue, and the relationship between the change of SST2R gene expression and pancreatic tumor angiogenesis related genes. METHODS: The expressions of SST2R, DPC4, p53 and ras genes in cancer tissues of 40 patients with primary pancreatic cancer, and the expression of SST2R gene in its adjacent tissue were determined by immunohistochemiscal LSAB method and EnVisionTM method. Chi-square test was used to analyze the difference in expression of SST2R in pancreatic cancer tissue and its adjacent tissue, and the correlation of SST2R gene expression with the expression of p53, ras and DPC4 ***: Of the tissue specimens from 40 patients with primary pancreatic cancer, 35 (87.5%) cancer tissues showeda negative expression of SST2R gene, whereas 34 (85%) a positive expression of SST2R gene in its adjacent tissues. Five (12.5%) cancer tissues and its adjacent tissues simultaneously expressed SST2R. The expression of SST2R gene was markedly higher in pancreatic tissues adjacent to cancer than in pancreatic cancer tissues (P0.05). CONCLUSION: There was a significant difference of SST2R gene expression in pancreatic cancer tissues and its adjacent tissues, which might be one cause for the different therapeutic effects of somatostatin and its analogs on pancreatic cancer patients. There were abnormal expressions of SST2R, DPC4, p53 and ras genes in pancreatic carcinogenesis, and moreover, the loss or decrease of SST2R gene expression was significantly negatively correlated with the overexpression of tumor angiogenesis correlated p53 and ras genes, suggesting that SST2R gene togethe

关键词：胰腺癌肿瘤血管生成生长抑制素受体亚型2 免疫组织化学肿瘤病理学

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THAI experimental research on hydrogen risk and source term related safety systems

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Frontiers in Energy 2021年第4期15卷 887-915页

作者： Sanjeev gupta Martin FREITAG Gerhard POSS Becker Technologies GmbH Rahmannstrasse 11Eschborn 65760Germany

In the defense-in-depth concept employed for the safety of nuclear installations,maintaining integrity of containment as the last barrier is of high importance to limit the release of radioactivity to the environment in case of a severe *** active and passive safety systems implemented in containments of light water reactors(LWRs)are designed to limit the consequences of such *** the performance and reliability of such systems under accident conditions is critical to the safety of nuclear *** the aftermath of the Fukushima accident,there has been focus on re-examining the existing safety systems to demonstrate their capabilities for a broader range of boundary conditions comprising both the early as well as the late phases of an *** addition to the performance testing of safety systems,their interaction with containment atmosphere needs detailed investigations to evaluate the effects of operation of safety systems on H2 risk and fission product(FP)behavior in containment,which may ultimately have an impact on the source term to the *** this context,an extensive containment safety related experimental research has been conducted in a thermalhydraulics,hydrogen,aerosols,and iodine test facility(THAI,60 m3,single vessel)/(THAI+,80 m3,two interconnected vessels).Related to the subject of this paper,experimental investigations covered performance testing of various safety and mitigation systems,i.e.,containment spray,passive autocatalytic recombiner(PAR),pressure suppression pool(water pools),and effects of their operation on H2 risk and in-containment FP *** experimental results have provided a better phenomenological understanding and database for validation and further improvement of a safety analysis tool based on computation fluid dynamic(CFD)and lumped parameter(LP)modeling *** paper summarizes the main insights obtained from the aforesaid THAI experimental research covering safety systems

关键词： severe accident containment safety mitigation H2 risk source term

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Optimizing calcination of coal by-products for maximizing REE leaching recovery and minimizing Al,Ca,and Fe contamination

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Journal of Rare Earths 2024年第7期42卷 1354-1365,I0006页

作者： Tushar gupta Ahmad Nawab Rick Honaker MP Materials Mountain Pass Mine 67750 Bailey RoadMountain PassCA92366USA Department of Mining Engineering University of KentuckyLexingtonKY40506USA

High-temperature calcination is effective in improving the leaching characteristics of rare earth elements(REEs)from conventional REE-bearing minerals by transforming them into more leachable ***,the recovery of contaminants such as Al,Fe,and Ca also increases *** objective of the study was to maximize the REE extraction while minimizing the concentration of contaminant ions(Al,Ca,and Fe)in the leach *** density fractions of the coarse refuse from the Baker and Fire Clay seam coal refuse were pulverized to a top size of 180μm and used as a feedstock for the *** the samples generated from thermal treatment were leached at 1%(w/v)using 1.2 mol/L sulfuric acid at 75℃ for 2 *** results from a parametric program based on a Box-Behnken design were used for modeling and optimization of three operating parameters associated with the lab-scale calcination *** parameters included temperature(400-800℃),ramp rate(2-10℃/min)and holding time(0-120 min).It was determined that the calcination temperature was the most significant parameter influencing REE *** majority of the heavy rare earth elements(HREEs)were found to be present in an insoluble form in the calcination products and were marginally affected by thermal treatment.A strong correlation between light rare earth elements recovery(LREEs)and Al suggested a possible association with *** optimum operating conditions for high REE recovery with comparatively lower contaminant concentration for 1.6 specific gravity float and 2.2 sink fractions of Baker and Fire Clay seam material were determined to be at 776,800℃ and 407,800℃,calcining temperatures,respectively.A higher optimum temperature of 1.6 float fraction of Baker seam relative to Fire Clay seam material was due to elevated pyrite concentration in Baker seam *** treatment at 400℃ converted pyrite into a soluble intermedium iron oxide,resulting in a high Fe content in the ***

关键词： Calcination Optimization Rare earth elements Coal refuse

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Expression of TREM-1 mRNA in acute pancreatitis

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World Journal of Gastroenterology 2004年第18期10卷 2744-2746页

作者： Manoj Kumar gupta Department of Surgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030Hubei ProvinceChina

AIM: To explore the expression of triggering receptor expressed on myeloid cells (TREM-I) mRNA in acute pancreatitis (AP).METHODS: Using the reverse transcription polymerase chain reaction (RT-PCR), we examined the expression of TREM-1 mRNA in 10 cases of mild acute pancreatitis (MAP), 8 cases of severe acute pancreatitis (SAP), and 10 cases of healthy control subjects. And we also examined the expression of TREM-1 mRNA in 14 cases of AP (including 10 MAP and 4 SAP) before treatment, after successful therapy and clinically ***: The expression of TREM-1 mRNA in the groups of MAP, SAP patients and healthy control subjects was 0.771±0.274, 1.092±0.331 and 0.459±0.175, respectively;there was a significant difference among the three groups (P<0.05). And there was also a significant difference between the AP patients (0.914±0.341) and healthy control subjects (0.459+0.175) (P<0.05). Moreover, in the 14 cases of AP, before treatment, after successful therapy and clinically cured, the expression of TREM-1 mRNA was 0.905±0.226,0.739±0.169 and 0.633±0.140, respectively, and there was a significant difference among the three stages (P<0.05).CONCLUSION: The expression of TREM-1 mRNA in the patients with AP increases obviously, and correlates with the degree of AP. Furthermore, the expression of TREM-1 mRNA is distinctly different at the different stages of AP. It indicates TREM-1 may play an important role in the occurrence and development of AP.

关键词：基因表达 TREM-1 mRNA 急性胰腺炎消化系统

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Identification,development,and application of cross-species intron-spanning markers in lentil(Lens culinaris Medik.)

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The Crop Journal 2018年第3期6卷 299-305页

作者： Debjyoti Sen gupta Jitendra Kumara Sunanda gupta Sonali Dubey Priyanka gupta Narendra Pratap Singh Gaurav Sablok Division of Crop Improvement ICAR-Institute of Pulses ResearchKanpur 208024UPIndia Division of Plant Biotechnology ICAR-Institute of Pulses ResearchKanpur 208024UPIndia Department of Biodiversity and Molecular Ecology Research and Innovation CentreFondazione Edmund MachVia E.Mach 138010 San Michele all'AdigeTrentoItaly

Lentil(Lens culinaris Medik) is one of the most important food legumes in the world. The use in lentil of molecular marker-assisted breeding is limited, owing to the low availability of polymorphic markers. In the present study, we developed a set of polymorphic intron-spanning markers(ISMs) using a cross-species mapping approach. In this approach, putative unique transcripts(PUTs) of L. culinaris were mapped onto the Medicago truncatula genome, exploiting its closeness with the lentil genome. Spliced alignment of the PUTs resulted in a total of 25,717 alignments, allowing the development of 1703 ISMs. From these, a subset of 105 ISMs were synthesized and validated with a 51% amplification success rate in 32 lentil genotypes. Of these ISMs, 40(74%) were polymorphic and generated 2–11 alleles per locus in a genetically diverse panel of 32 lentil genotypes including wild *** set of polymorphic ISMs along with their functional annotation data will be useful in lentil breeding.

关键词： Allele diversity Cross-species Genotypes Introns Lentil Molecular markers

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Unraveling the intricacies of mammalian fertilization

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Asian Journal of Andrology 2014年第6期16卷 801-802页

作者： Satish K gupta Reproductive Cell Biology Lab National Institute ofImmunology New Delhi 110067 India.

It is imperative to understand the molecular basis of various steps involved during fertilization. In the manuscript by Bianchi et al.1 a novel protein, Juno on egg membrane （oolemma） has been characterized that binds to sperm specific protein, Izumo-1. Monoclonal antibodies against Juno inhibited in vitro fertilization. Juno knock-out female mice failed to deliver litters on mating. It is rapidly shed from oolemma after fertilization, suggesting its role in preventing polyspermy. Taken together these studies will help in our understanding of sperm-egg recognition mechanisms and also facilitate development of new fertility treatment regimens and novel contraceptives.

关键词： @@

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Understanding the influence of petrographic parameters on strength of differently sized shale specimens using XRD and SEM

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International Journal of Mining Science and Technology 2021年第5期31卷 953-961页

作者： Debashis Das Brijes Mishra Neel gupta RESPEC LexingtonKY 40508USA West Virginia University MorgantownWV 26506USA

Ground failure is a major contributor to fatalities in underground mines in the *** coal mines in the Northern Appalachian have weak roof rock composed of shale,which is prone to failure under high horizontal *** the relationship among strength,specimen size and rock petrographic parameters is essential for developing an effective ground control *** effect studies have found that rock strength varies with specimen *** paper attempts to understand this strength variation using three specimen sizes(254-mm,508-mm,and 762-mm).The specimen strength was measured and the major petrographic parameters affecting the strength,namely grain size,grain shape,quartz content,clay content,*** analyzed using X-ray diffraction(XRD)and scanning electron microscopy(SEM).The petrographic parameters were then correlated with the strength of the three differently sized *** results showed that 508-mm specimen had the lowest *** content of the 508-mm specimen was lower than that of 254-mm and 762-mm *** content and average grain size of the 508-mm specimen were higher than those of 254-mm and 762-mm *** results clearly show that grain size,quartz content and clay content contribute to strength variation observed in differently sized shale specimens.

关键词： Shale strength XRD(X-ray diffraction) SEM(scanning electron microscopy) Grain size Quartz content Grain shape

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Pathophysiology of alcoholic pancreatitis:An overview

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World Journal of Gastroenterology 2006年第46期12卷 7421-7427页

作者： Parimal Chowdhury Priya gupta Department of Physiology and Biophysics University of Arkansas for Medical sciences Little Rock Arkansas United States

Use of alcohol is a worldwide habit regardless of socio- economic background. Heavy alcohol consumption is a potential risk factor for induction of pancreatitis. The current review cites the updated literature on the alcohol metabolism, its effects on gastrointestinal and pancreatic function and in causing pancreatic injury, genetic predisposition of alcohol induced pancreatitis. Reports describing prospective mechanisms of action of alcohol activating the signal transduction pathways, induction of oxidative stress parameters through the development of animal models are being presented.

关键词： Alcohol Metabolism Pancreatic function Pancreatitis Mechanism of action

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Performance evaluation of cement-stabilized pond ash-rice husk ashclay mixture as a highway construction material

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Journal of Rock Mechanics and Geotechnical Engineering 2017年第1期9卷 159-169页

作者： Deepak gupta Arvind Kumar Department of Civil Engineering National Institute of Technology (NIT) Jalandhar India

This paper reports the results of an investigation carried out on clay soil stabilized with pond ash(PA),rice husk ash(RHA) and cement. Modified Proctor compaction tests were performed in order to investigate the compaction behavior of clay, and California bearing ratio(CBR) tests were performed to determine the strength characteristics of clay. For evaluation purpose, the specimens containing different amounts of admixtures were prepared. Clay was replaced with PA and RHA at a dosage of 30%e45% and5%e20%, respectively. The influence of stabilizer types and dosages on mechanical properties of clay was evaluated. In order to study the surface morphology and crystallization characteristics of the soil samples, scanning electron microscopy(SEM) and X-ray diffraction(XRD) analyses were carried out,respectively. The results obtained indicated a decrease in the maximum dry density(MDD) and a simultaneous increase in the optimum moisture content(OMC) with the addition of PA and *** linear regression analysis(MLRA) showed that the predicted values of CBR tests are in good agreement with the experimental values. Developed stabilized soil mixtures showed satisfactory strength and can be used for construction of embankments and stabilization of sub-grade soil. The use of locally available soils, PA, RHA, and cement in the production of stabilized soils for such applications can provide sustainability for the local construction industry.

关键词： California bearing ratio(CBR) Pond ash(PA) Rice husk ash(RHA) Optimum moisture content(OMC) Maximum dry density(MDD)

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Optimal design of hybrid renewable-energy microgrid system:a techno-economic-environment-social-reliability perspective

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Clean Energy 2024年第1期8卷 66-83页

作者： Manoj gupta Annapurna Bhargava Electrical Engineering Department Rajasthan Technical UniversityKotaRajasthan 324010India Electrical and Electronics Engineering Department IPS Academy Institute of Engineering and Science IndoreMadhya Pradesh 452012India

The main objective of this paper is to select the optimal model of a hybrid renewable-energy microgrid(MG)system for a village in *** MG comprises solar photovoltaic(PV)modules,a wind turbine generator,a biomass generator,a battery bank,a diesel generator and an electric *** optimal model selection is based on technical,economic,environmental,social and reliability parameters.A novel spoonbill swarm optimization algorithm is proposed to select the best hybrid MG *** optimization results are compared with particle swarm optimization,the genetic algorithm and the grasshopper optimization *** number or size of components of the optimized MG system is 215 PV modules,92 kW of wind turbine generation,25 kW of biomass generation,267 batteries,22 kW of electric vehicles and 30 kW of diesel *** optimized system was selected based on technical factors such as renewable dispersion(93.5%),the duty factor(5.85)and excess energy(15975 kWh/year)as well as eco-nomic considerations including the net present cost(Rs.34686622)and the cost of energy(9.3 Rs./kWh).Furthermore,environ-mental factors such as carbon emissions(396348 kg/year)and atmospheric particulate matter(22.686 kg/year);social factors such as the human progress index(0.68411),the employment generation factor(0.0389)and local employment generation(15.64643);and reliability parameters including loss of power supply probability(0.01%)and availability index(99.99%)were considered during the selection *** spoonbill swarm optimization algorithm has reduced the convergence time by 1.2 times and decreased the number of iterations by 0.83 times compared with other *** performance of the MG system is validated in the MATLAB®*** results show that the MG system is the optimal system considering technical,economic,environmental,social and reliability ***,the spoonbill swarm optimization algorithm is found to be more efficient than the other

关键词： cost of electricity microgrid reliability spoonbill techno-economic

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