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Evaluation and Bulked Segregant Analysis of Major Yield QTL qtl12.1 Introgressed into Indigenous Elite Line for Low Water Availability under Water Stress

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Rice science 2013年第1期20卷 25-30页

作者： N.Manikanda BOOPATHI Gat SWAPNASHRI P.kavitha S.SATHISH R.NITHYA Wickneswari RATNAM Arvind KUMAR Department of Plant Molecular Biology and Bioinformatics CPMB&BTamil Nadu Agricultural UniversityCoimbatore-3India Universiti Kebangsaan Malaysia Bangi SelangorMalaysia Division of Plant Breeding Genetics and BiotechnologyInternational Rice Research InstituteMetro ManilaPhilippines

Near isogenic lines carrying large-effect QTL （qtl2.1）, which has a consistent influence on grain yield under upland drought stress conditions in a wide range of environments, were evaluated under water stress in the fields. The line which gave higher yield under drought was crossed with a local elite line, PMK3, and forwarded to F2：3 generation. Significant variation was found among the F2：3 lines for agronomic traits under water stress in the fields. Low to high broad sense heritability （H） for investigated traits was also found. Water stress indicators such as leaf rolling and leaf drying were negatively correlated with plant height, biomass and grain yield under stress. Bulked segregant analysis （BSA） was performed with the markers in the vicinity of qUl2.1, and RM27933 was found to be segregated perfectly well in individual components of drought resistant and drought susceptible bulks which were bulked based on yield under water stress among F2：3 lines. Hence, this simple and breeder friendly marker, RM27933, may be useful as a potentially valuable candidate marker for the transfer of the QTL qtl12.1 in the regional breeding program. Bioinformatic analysis of the DNA sequence of the qtl12.1 region was also done to identify and analyze positional candidate genes associated with this QTL and to ascertain the putative molecular basis of qUl2.1.

关键词： rice bulked segregant analysis water stress quantitative trait locus marker-assisted selection

Microbial Adhesion on Orthodontic Ligating Materials: An <i>in Vitro</i>Assessment

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Advances in Microbiology 2013年第1期3卷 108-114页

作者： Pandurangan Harikrishnan Thillai Saku Subha Varadharajan kavitha Arumugam Gnanamani Microbiology Division Central Leather Research Institute (Council of Scientific and Industrial Research) Adyar Chennai India Teeth’N’Jaws Center Chennai India

Orthodontic fixed appliance therapy is the commonest mode of treatment for most types of malocclusions (teeth irregularities). However, these materials are liable for microbial adhesion, which predisposes the wearer to increased microbial burden. The present study aims to evaluate, microbial adhesion and growth on commonly used orthodontic ligating materials (Teflon coated wire, stainless steel wire, elastic rings) under in vitro condition. Furthermore, the role of saliva on adhesion and microbial colonization on said materials was also assessed. Experiments were conducted with three different orthodontic ligating materials each in 6 numbers. Growth OD, metabolic activity and cell viability were the experimental variables in addition to SEM (Scanning Electron Microscopy) analysis performed. Results revealed irespective of the nature of the ligating materials, microbial adhesion and growth were observed in all the materials and suggested that the chosen materials promotes microbial adhesion. Nevertheless, stainless steel ligatures were less prone to adhesion compared to Teflon coated and elastic ligatures. Presence of saliva accelerates adhesion and growth.

关键词： Adhesion Growth Orthodontic Ligatures Growth OD CFU Metabolic Activity XTT

Hypoxia-inducible factor 2α is a negative regulator of osteoblastogenesis and bone mass accrual

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Bone Research 2019年第1期7卷 91-104页

作者： Christophe Merceron kavitha Ranganathan Elizabeth Wang Zachary Tata Shreya Makkapati Mohd Parvez Khan Laura Mangiavini Angela Qing Yao Laura Castellini Benjamin Levi Amato J.Giaccia Ernestina Schipani Department of Orthopaedic Surgery School of MedicineUniversity of MichiganAnn ArborMIUSA Division of Plastic and Reconstructive Surgery Department of SurgeryUniversity of MichiganAnn ArborMIUSA Department of Radiation Oncology Stanford University Medical SchoolStanfordCAUSA

Osteoblasts,which are the bone-forming cells,operate in a hypoxic *** transcription factors hypoxia-inducible factor-1α(HIF1)and HIF2 are key mediators of the cellular response to *** are expressed in ***1 is known to be a positive regulator of bone ***,the role of HIF2 in the control osteoblast biology is still poorly *** this study,we used mouse genetics to demonstrate that HIF2 is an inhibitor of osteoblastogenesis and bone mass ***,we provided evidence that HIF2 impairs osteoblast differentiation at least in part,by upregulating the transcription factor *** findings constitute a paradigm shift,as activation of the hypoxia-signaling pathway has traditionally been associated with increased bone formation through *** HIF2 could thus represent a therapeutic approach for the treatment of the low bone mass observed in chronic diseases,osteoporosis,or aging.

关键词： is cells has

纤维蛋白胶与无缝无胶自体球结膜瓣固定术治疗翼状胬肉的疗效比较（英文）

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国际眼科杂志 2019年第11期19卷 1819-1827页

作者： Manipur Raviraj Sahana Chikkanayakanahalli Venugopal kavitha Acharya Pavana Bomalapura Ramamurthy Lakshmi 哈桑眼科医学研究所

目的:比较两种大小纤维蛋白胶与无缝无胶自体球结膜瓣固定术在原发性翼状胬肉手术中的患者舒适度、移植物稳定性、移植物炎症、复发等术后并发症。方法:本研究对2014-12/2016-08共80例翼状胬肉患者(80眼)进行前瞻性介入对比研究。研究... 详细信息

目的:比较两种大小纤维蛋白胶与无缝无胶自体球结膜瓣固定术在原发性翼状胬肉手术中的患者舒适度、移植物稳定性、移植物炎症、复发等术后并发症。方法:本研究对2014-12/2016-08共80例翼状胬肉患者(80眼)进行前瞻性介入对比研究。研究组随机抽取并分为两组,组1接受纤维蛋白胶疗法,组2采用无缝合无胶结膜自体移植固定术。每组再将等量的受试者随机平均分为两组(组1:组A+组B,组2:组C+组D)。组A(自体移植物的大小与裸眼巩膜相同)和组B(比裸巩膜大1 mm)实施纤维蛋白胶疗法;组C(自体移植物的大小与裸眼巩膜相同)和组D(比裸巩膜大1 mm)采用无缝线无胶结膜自体移植固定术。每一位患者都接受翼状胬肉切除术,并根据组别使用不同大小的自体球结膜瓣。结果:组1平均年龄为43.525,组2平均年龄为42.2。男性20例,女性60例。37例患者右眼有翼状胬肉。四组间平均手术时长相似。在术后随访期间,除结膜下出血(纤维蛋白胶组在术后1wk内明显增多)外,4组间患者的舒适度、移植物回缩、移植物炎症和移植物水肿等术后参数均相似(P<0.0001)。组2仅3例患者出现4级移植物回缩/移位。术后1wk,组A和组D各出现1例移植囊肿患者。随访6mo后,组D中2例患者复发。结论:两种方法均安全有效,术后不适及并发症少。与纤维蛋白胶疗法相比,无缝无胶疗法更加经济且效果相当。由于该手术成本低,且具有纤维蛋白胶疗法的所有优点,无缝无胶法可被认为是治疗患者非常有效的方法。

关键词：原发性翼状胬肉自体结膜瓣移植纤维蛋白胶无胶缝合法

Reviewing the Effectiveness of Contribution of Microstrip Antenna in the Communication System

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Open Journal of Antennas and Propagation 2017年第2期5卷 47-62页

作者： R. J. kavitha H. S. Aravinda Research Scholar Visvesvaraya Technological University Belagavi India Proferssor & Head of the Department of Electronics & Communication Engineer JSSATE Bangalore India

The wireless communication serves the efficient information among two or more points wirelessly. Antenna is the main component in the communica-tion, which radiates and receives the radio waves or in broad way. The an-tenna also plays a role of impedance matching device, which performs the mat- ching of impedances like free-space & transmitter and receiver im-pedances at receiver end. The antennas can be categorized as Wire Antenna, Reflector Antenna, Multi-strip Antenna, Aperture Antenna, Lens Antenna, and Array Antenna. In this paper, the Multi-strip Antenna fundamentals are discussed with its categorization. In this paper various aspects of the Multi-strip antenna are discussed along with the existing researches in it. A research gap is formulated based on the research survey and presents a future scope of research. The existing research gap in Multi-strip Antenna is formulated along with the future line of research in order to overcome the existing research gap.

关键词： Antenna Feeding Technique MSA Wireless Communication

Synthetic Lethality Induced by Toxic Polyglutamine Tract II: A Survey in Drosophila

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Open Journal of Genetics 2015年第2期5卷 58-70页

作者： Ping Zhang Daniel Camacho Shashank Vodapally Shanado Williams kavitha Kannan Department of Molecular and Cell Biology University of Connecticut Storrs USA

Mutant proteins containing an expanded polyglutamine tract induce cell death and cause neurodegenerative diseases. These toxic proteins interfere with a variety of physiological pathways, but the key interactions between the toxins and cellular factors remain unclear. To model the diseases in Drosophila, the GMR-Gal4/UAS gene expression system has been used extensively, which operates in the eyes. By using the system, genome-wide studies have resulted in the isolation of functionally diverse groups of Drosophila genes that interact with the disease proteins. We previously reported that coexpressing the Drosophila Dikar gene and an expanded polyglutamine tract by GMR-Gal4/UAS induced a synthetic lethality. We carried out follow-up experiments to isolate additional synthetic lethal alleles. Our data provide evidence that synthetic lethality associated with expressing an expanded polyglutamine tract is more common than thought to be and could have escaped the conventional genetic screens. Our results also suggest that 1) the gene expression system is leaky, allowing expression outside of the primary target eye cell types;2) expressing an expanded polyglutamine tract is extremely toxic to cells;and 3) combining the leaky expression and the toxicity results in a lethal-prone condition. Thus, genetic modifications to the disease proteins’ acute toxicity could frequently lead to synthetic lethality. However, synthetic lethal alleles are excluded from most conventional screens, necessitating alternative approaches such as a two-step method used in this study to isolate the modifiers. Since synthetic lethality reflects essential genetic buffering networks, studying these alleles may hold the keys to identify the critical interactions in the disease development between the toxic proteins and the physiological pathways.

关键词： Polyglutamine Diseases Drosophila Genetic Screen GMR-Gal4/UAS System Synthetic Lethal Mutations

Micro RNAs potential utility in colon cancer: Early detection, prognosis, and chemosensitivity

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World Journal of Gastroenterology 2015年第27期21卷 8284-8292页

作者： Michael Hollis kavitha Nair Arpita Vyas Lakshmi Shankar Chaturvedi Sahil Gambhir Dinesh Vyas Department of Surgery College of Human Medicine Michigan State University Department of Medicine Emory University Pediatrics College of Human Medicine Michigan State University

Over the past decade, research has shown that aberrant expression of micro RNA(mi RNA) is involved in colorectal cancer development and progression. Micro RNAs are small sequences of non-coding RNA that regulate expression of genes involved in important cellular functions, such as cell differentiation, multiplication, and apoptosis. A specific mi RNA may display the effects of a tumor suppressor or oncogene. Altered mi RNA expression is found in colorectal cancer(CRC) and patterns of mi RNA expression correlate with CRC detection and outcome. Studies also have examined the use of circulating serum mi RNA and fecal mi RNA expression as non-invasive markers for early detection. Here, we review recent evidence demonstrating the potential role of mi RNA in CRC and the implications of its use in the diagnosis, prognosis, and management of CRC.

关键词： Colorectal cancer Microrna Expression Serum microRNA Fecal microRNA Diagnostic Prognostic Therapeutic

Gut Microbiota Dysbiosis and Their Impact on Biochemical and Inflammatory Profiles in Cafeteria Diet Fed Sprague Dawley Rats

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Advances in Microbiology 2019年第9期9卷 775-789页

作者： Reem Moath Alasmar kavitha Varadharajan Muralitharan Shanmugakonar Hamda A. Al-Naemi Laboratory Animal Research Centre Qatar University Doha Qatar Department of Biological and Environmental Sciences Qatar University Doha Qatar

Gut microbiota plays a major role in regulating the host metabolism and immune system. However, the structure of microbiome population is altered constantly by diverse factors including diet and environment. In particular, the gut microbiome dynamics is influenced by diet composition and their associated metabolites. Many studies in the recent past reported on diet induced dysbiosis in the gut microbiome, the modulating ratio between Firmicutes and Bacteroidetes plays a central role in maintaining the microbiome diversity in the gut and their abundance regulates obese conditions. Although there are several reports on gut microbial dysbiosis (Firmicutes/Bacteroidetes) at phylum level but only few of them highlight at the genera level. In the present study, we focused more on the impact of cafeteria diet (CAF) with respect to the gut microbiome richness at the genera level in SD rats. Three weeks old Sprague Dawley (SD) rats were fed with normal chow diet and cafeteria diet (CAF). After 10 weeks, serum, tissue samples (small intestine and cecum), cecum fecal and fecal pellet were collected. Biochemical analysis from serum, Gene expression analysis of pro-inflammatory markers from tissues and microbiome analysis from fecal samples were analysed. CAF diet fed rat in the present study developed obesity with increased body weight, few of them developed the resistance to weight gain (WGR) and these animal shows significantly increased abundance of Bacteriodetes-Prevotella compared to obese animals. This study suggests that detailed research needed to address the contribution of microbiota abundance at the genera level. We further explored the influence of diet induced microbiota changes on immune response;increase in Bacteroidetes leads to increased LPS and this in turn elicit immune reaction in the gut. Moreover, variation in gut microbiota also affects the gut barrier function (Tight junction proteins) and increase metabolic endotoxemia that leads to activation of innate

关键词： Gut Microbiota Cafeteria Diet Obesity Inflammatory Markers RT-PCR

Gut Microbiota Dysbiosis in Cafeteria Diet Fed Sprague Dawley Rats

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Advances in Microbiology 2018年第12期8卷 975-993页

作者： kavitha Varadharajan Muralitharan Shanmugakonar Sandra Concepcion Das Hamda A. Al-Naemi Laboratory Animal Research Centre (LARC) Qatar University Doha Qatar Department of Biological and Environmental Sciences Qatar University Doha Qatar

Diet plays a major role in the body physiology and metabolism. The quantity, nature and stability of the macronutrients present in the diet have a major impact on the composition of gut microbiota. Gut microbiota plays a major role in the body metabolism and leads to obese or lean phenotype. Bacteriodetes, Firmicutes, Proteobacteria and Actinobacteria are the major microbes that inhabit in the region of the gut. We made an attempt to study the effects of Cafeteria (CAF) diets and normal chow diets on diet consumption, weight gain, metabolism and composition of gut microbiota in fecal and cecum samples from three weeks old Sprague Dawley (SD) rats (n = 18/group) using 16S rDNA high throughput sequencing. Results revealed that distinctive diet based phenotypical changes were observed in some of the Cafeteria diet fed rats. Interestingly, some weight gain resistant (WGR) animals in Cafeteria diet fed groups show similar trend like that of control normal chow fed rats. Fecal microbiome analysis indicates that the ratio of Bacteriodetes is higher than the Firmicutes in cecum samples of Cafeteria diet fed rats whereas no significant difference is found in fecal samples of Cafeteria diet fed rats and as well as in control rats. Further analysis of other taxa at the level of family and genus of microbial abundance are also discussed. Our study suggests that contribution of gut microbiota towards obesity is not at the phylum level, and microbiome composition even at the level of species or strain may exert impact on the metabolism of the Cafeteria diet.

关键词： Gut Microbiota Obesity Cafeteria Diet Feces Weight Gain Resistant Next Generation Sequencing