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Androgens exert sexually dimorphic effects on angiogenesis： novel insight into the relationship between androgens and cardiovascular disease

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Asian Journal of Andrology 2011年第4期13卷 626-627页

作者： katya b rubinow John K Amory Stephanie T Page Division of Metabolism Endocrinology and Nutrition University of Washington Seattle WA 98195 USA General internal Med c ne Un versity of Washington Seattle WA 98195 USA

The effects of androgen exposure on cardiovascular disease （CVD） risk in men remain poorly understood. Given the earlier incidence of CVD among men relative to women, androgens historically have been assumed to pote... 详细信息

关键词： Androgens sexually

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Androgen receptor deficiency in monocytes/ macrophages does not alter adiposity or glucose homeostasis in male mice

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Asian Journal of Andrology 2018年第3期20卷 276-283页

作者： katya b rubinow barbara Houston Shari Wang Leela Goodspeed Kayoko Ogimoto Gregory J Morton Christopher McCarty Robert E braun Stephanie T Page Division of Metabolism Endocrinology and Nutrition Department of Medicine University of Washington School of Medicine Seattle WA 98195 USA Jackson Laboratory Bar Harbor ME 04609 USA

Androgen deprivation in men leads to increased adiposity, but the mechanisms underlying androgen regulation of fat mass have not been fully defined. Androgen receptor （AR） is expressed in monocytes/macrophages, which are resident in key metabolic tissues and influence energy metabolism in surrounding cells. Male mice bearing a cell-specific knockout of the AR in monocytes/macrophages （M-ARKO） were generated to determine whether selective loss of androgen signaling in these cells would lead to altered body composition. Wild-type （WT） and M-ARKO mice （12-22 weeks of age, n = 12 per group） were maintained on a regular chow diet for 8 weeks and then switched to a high-fat diet for 8 additional weeks. At baseline and on both the regular chow and high-fat diets, no differences in lean mass or fat mass were observed between groups. Consistent with the absence of differential body weight or adiposity, no differences in food intake （3.0 ± 0.5 g per day for WT mice vs 2.8 ± 0.4 g per day for M-ARKO mice） or total energy expenditure （0.6 ± 0.1 Kcal h-1 for WT mice vs 0.5 ± 0.1 Kcal h-1 for M-ARKO mice） were evident between groups during high-fat feeding. Liver weight was greater in M-ARKO than that in WT mice （1.5 ± 0.1 g vs 1.3 ± 0.0 g, respectively, P = 0.02）. Finally, M-ARKO mice did not exhibit impairments in glucose tolerance or insulin sensitivity relative to WT mice at any study time point. In aggregate, these findings suggest that AR signaling specifically in monocytes/macrophages does not contribute to the regulation of systemic energy balance, adiposity, or insulin sensitivity in male mice.

关键词： androgen receptor knockout mice macrophages male hypogonadism metabolic syndrome

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Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice

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中国药理学与毒理学杂志 2013年第3期 463-464页

作者： LU Yi-hong SUN Jin-chun katya PETROVA YANG Xi James GREENHAW Laura K SCHNACKENbERG William SALMINEN Donna L MENDRICK Richard D bEGER Division of Systems biology National Center for Toxicological ResearchUS Food and Drug AdministrationJeffersonAR 72079USA Jiangsu Institute for Food and Drug Control PAREXEL International BostonMAUSA

Green tea has a considerable amount of polyphenolic catechins and has been promoted to have beneficial effects on health including protective effects against oxidative ***(APAP) is a widely used analgesic drug which is usually safe at recommended therapeutic doses but overdose can cause acute liver *** studies explored the effects of green tea extract(GTE) on APAP-induced hepatotoxicity using UPLC /MS-and NMR-based metabolomic *** b6C3F1 mice were orally administered GTE under three scenarios either prior to or after a single dose of *** /MS and NMR were employed for metabolomics analysis of the biochemical changes in mice livers with GTE pretreatment 3 h or 3 d prior to APAP exposure or GTE exposure 6 h after *** upon the data,GTE given prior to APAP ameliorated the APAP-induced hepatotoxicity in a dose dependent manner whereas GTE given after APAP potentiated the *** belonging to multiple classes including but not limited to acylcarnitines,energy metabolism,bile acids,and lysoPCs were identified and *** metabolites were significantly altered by APAP exposure alone compared to *** pretreatment generally resulted in these metabolite levels returning to control levels or being less *** given after APAP,however,caused more changes in the metabolites over what was induced by APAP alone indicating more severe *** with biochemistry and histopathology results,the changes in liver metabolites indicated perturbations of fatty acid metabolism,energy metabolism,bile acids metabolism and phospholipids metabolism induced by APAP with differing effects on these metabolites depending upon the time of GTE *** results indicate that the time at which GTE was given highly influenced the severity of APAPinduced *** studies clearly highlight the need to understand the interactions between herbs and other dietary supplements with commonly used ove

关键词： green tea extract acetaminophen hepatotoxicity metabolic profiling

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Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice

Metabolomics evaluation of the effects of green tea extract ...

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2013年（第三届）中国药物毒理学年会暨药物非临床安全性评价研究论坛

Green tea has a considerable amount of polyphenols catechins and has been promoted to have beneficial effects on health including protective effects against oxidative ***(APAP) is a widely used analgesic drug which is usually safe at recommended therapeutic doses but overdose can cause acute liver *** studies explored the effects of green tea extract(GTE) on APAP-induced hepatotoxicity using UPLC/MS- and NMR-based metabolomic *** b6C3F1 mice were orally administered GTE under three scenarios either prior to or after a single dose of ***/MS and NMR were employed for metabolomics analysis of the biochemical changes in mice livers with GTE pretreatment 3 h or 3 d prior to APAP exposure or GTE exposure 6 h after *** upon the data,GTE given prior to APAP ameliorated the APAP-induced hepatotoxicity in a dose dependent manner whereas GTE given after APAP potentiated the *** belonging to multiple classes including but not limited to acylcarnitines,energy metabolism,bile acids,and lysoPCs were identified and *** metabolites were significantly altered by APAP exposure alone compared to *** pretreatment generally resulted in these metabolite levels returning to control levels or being less *** given after APAP,however,caused more changes in the metabolites over what was induced by APAP alone indicating more severe *** with biochemistry and histopathology results, the changes in liver metabolites indicated perturbations of fatty acid metabolism,energy metabolism,bile acids metabolism and phospholipids metabolism induced by APAP with differing effects on these metabolites depending upon the time of GTE *** results indicate that the time at which GTE was given highly influenced the severity of APAP-induced *** studies clearly highlight the need to understand the interactions between herbs and other dietary supplements with commonly used ove

关键词： green tea extract acetaminophen hepatotoxicity metabolic profiling

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Metabolomics evaluation of the effects of green tea extract on acetaminophen-induced hepatotoxicity in mice

Metabolomics evaluation of the effects of green tea extract ...

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作者： LU Yi-hong SUN Jin-chun katya PETROVA YANG Xi James GREENHAW Laura K SCHNACKENbERG William SALMINEN Donna L MENDRICK Richard D bEGER PAREXEL Intemational Jiangsu Institute for Food and Drug Control Division of Systems biology National Center for Toxicological ResearchUS Food and Drug Administration

Green tea has a considerable amount of polyphenolic catechins and has been promoted to have beneficial effects on health including protective effects against oxidative ***(APAP) is a widely used analgesic drug which is usually safe at recommended therapeutic doses but overdose can cause acute liver *** studies explored the effects of green tea extract(GTE) on APAP-induced hepatotoxicity using UPLC/MS- and NMR-based metabolomic *** b6C3F1 mice were orally administered GTE under three scenarios either prior to or after a single dose of ***/MS and NMR were employed for metabolomics analysis of the biochemical changes in mice livers with GTE pretreatment 3 h or 3 d prior to APAP exposure or GTE exposure 6 h after *** upon the data,GTE given prior to APAP ameliorated the APAP-induced hepatotoxicity in a dose dependent manner whereas GTE given after APAP potentiated the *** belonging to multiple classes including but not limited to acylcamitines,energy metabolism,bile acids,and lysoPCs were identified and *** metabolites were significantly altered by APAP exposure alone compared to *** pretreatment generally resulted in these metabolite levels returning to control levels or being less *** given after APAP,however,caused more changes in the metabolites over what was induced by APAP alone indicating more severe *** with biochemistry and histopathology results, the changes in liver metabolites indicated perturbations of fatty acid metabolism,energy metabolism,bile acids metabolism and phospholipids metabolism induced by APAP with differing effects on these metabolites depending upon the time of GTE *** results indicate that the time at which GTE was given highly influenced the severity of APAPinduced *** studies clearly highlight the need to understand the interactions between herbs and other dietary supplements with commonly used over

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