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Novel risk markers for gastric cancer screening: Present status and future prospects

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World Journal of Gastrointestinal Endoscopy 2010年第12期2卷 381-387页

作者： Shotaro Enomoto Takao Maekita Hiroshi Ohata Kimihiko Yanaoka Masashi Oka Masao ichinose Second Department of Internal Medicine Wakayama Medical University

Initial identification of populations at high risk of gastric cancer (GC) is important for endoscopic screening of GC. As serum pepsinogen (PG) test-positive subjects with progression of chronic atrophic gastritis (CAG) show a high likelihood of future cancer development, this population warrants careful follow-up observation as a high-risk GC group. By combining the PG test with Helicobacter pylori (HP) antibody titers, the HP-related chronic gastritis stage can be classified, thus identifying not only a GC high-risk group but also a low-risk group. Among PG test-negative patients without CAG, those with high serum PG Ⅱ levels and HP antibody titers are thought to have severe gastric mucosal inflammation and the risk of diffuse-type GC is also high. Meanwhile, in gastric mucosae obtained by endoscopic biopsy, HP infection induces aberrant DNA methylation in CpG islands in multiple gene regions and the extent of methylation clearly correlates with GC risk. By quantifying aberrant DNA methylation in suitable gene markers, we can determine the extent of the epigenetic field for cancerization. These novel concepts and risk markers will have many clinical applications in gastrointestinal endoscopy, including more efficient endoscopic GC screening and a strategic approach to metachronous multiple GCs after endoscopic treatment.

关键词： Gastric cancer Screening Risk Pepsinogen Helicobacter pylori DNA methylation

A minimally invasive multiple percutaneous drainage technique for acute necrotizing pancreatitis

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World Journal of Emergency Medicine 2014年第4期5卷 310-312页

作者： Takero Terayama Toru Hifumi Nobuaki Kiriu Hiroshi Kato Yuichi Koido Yoshiaki ichinose Kohei Morimoto Kuroda Yasuhiro Division of Critical Care Medicine and Trauma National Hospital Organization Disaster Medical Center Emergency Medical Center Kagawa University Hospital Division of Radiology National Hospital Organization Disaster Medical Center

BACKGROUND: In approximately 20% of patients, necrotizing pancreatitis is complicated with severe acute pancreatitis, with high morbidity and mortality rates. Minimally invasive step-up approach is both safe and effective, but sometimes requires multiple access ***: A 62-year-old woman was admitted with diabetic ketoacidosis, and initial computed tomography(CT) revealed no evidence of acute pancreatitis. She was clinically improved with insulin therapy, fl uid administration, and electrolyte replacement. However, on the 14 th day of admission, she developed a high-grade fever, and CT demonstrated evidence of acute necrotizing pancreatitis with a large collection of peripancreatic fl uid. Percutaneous transgastric drainage was performed and a 14 French gauge(Fr) pigtail catheter was placed 1 week later, which drained copious pus. Because of persistent high-grade fever and poor clinical improvement, multiple 8 and 10 Fr pigtail catheters were placed via the initial drainage route, allowing the safe and effective drainage of the extensive necrotic tissue that was occupying the bilateral anterior pararenal ***: After drainage, the patient recovered well and the last catheter was removed on day 123 of ***: Multiple percutaneous drainage requires both careful judgment and specialist skills. The perforation of the colon and small bowel as well as the injury of the kidney and major vessels can occur. The current technique appears to be safe and minimally invasive compared with other drainage methods in patients with extended, infected necrotic pancreatic pseudocysts.

关键词： Percutaneous drainage Acute necrotizing pancreatitis Minimally invasive technique

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基于夜间灯光数据的环渤海地区城市化过程

地理学报 2005年第3期60卷 409-417页

作者：何春阳李景刚陈晋史培军潘耀忠李京卓莉一之瀬俊明北京师范大学环境演变与自然灾害教育部重点实验室北京师范大学资源学院北京100875 日本国立环境研究所

利用1992年、1996年和1998年的三期DMSP/OLS夜间灯光数据,提取了区域尺度的环渤海地区20世纪90年代的城市群空间信息,建立了城市群地区面状、线状和点状城市化空间模式,分析了环渤海城市群地区20世纪90年代的城市化过程。基本结论如下:... 详细信息

利用1992年、1996年和1998年的三期DMSP/OLS夜间灯光数据,提取了区域尺度的环渤海地区20世纪90年代的城市群空间信息,建立了城市群地区面状、线状和点状城市化空间模式,分析了环渤海城市群地区20世纪90年代的城市化过程。基本结论如下:①20世纪90年代环渤海城市群地区城市斑块数量增长较快,城市化过程明显,但小斑块所占比重较大,城市斑块破碎度增加。同时,区域内城市重心基本维持在经度117.93o和纬度38.49o附近,整体上表现出向西北方向移动的趋势。②20世纪90年代环渤海城市群地区城市化过程基本上可以从空间上概括为在中心城市和大城市周围的面状城市化过程、沿交通干线周围的线状城市化过程和广大区域内以新兴小城市或小城镇出现为特征的点状城市化过程三种基本过程。其中,面状城市化过程一直居于优势地位,但面状城市化过程的基本有效范围主要局限在面状城市斑块周围3￣4km范围。线状城市化过程和点状城市过程所占的比例相对较小,但表现出明显的增强趋势,在区域内的影响范围正逐渐扩大。

关键词：城市化过程环渤海地区 20世纪90年代数据灯光夜间 1992年 1998年 1996年城市群 DMSP 空间信息区域尺度空间模式中心城市基本过程交通干线有效范围影响范围斑块 OLS 线状破碎度小城镇小城市大区域趋势

基于DMSP/OLS灯光数据的快速城市化过程的生态效应评价研究——以环渤海城市群地区为例

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遥感学报 2007年第1期11卷 115-126页

作者：李景刚何春阳史培军陈晋潘耀忠一之瀬俊明北京师范大学环境演变与自然灾害教育部重点实验室北京师范大学资源学院日本国立环境研究所

快速有效地评估城市化过程带来的生态环境后果,对于优化城市土地利用格局、降低和防范城市生态环境风险,非常必要。因此本文综合利用DMSP/OLS夜间灯光数据和SPOT/VGT时间序列数据等多源遥感信息,以NDVI与时间的积分值来表征一定时间段... 详细信息

快速有效地评估城市化过程带来的生态环境后果,对于优化城市土地利用格局、降低和防范城市生态环境风险,非常必要。因此本文综合利用DMSP/OLS夜间灯光数据和SPOT/VGT时间序列数据等多源遥感信息,以NDVI与时间的积分值来表征一定时间段内的植被初级生产力,探讨了环渤海城市群地区城市化过程对植被初级生产力的季节性变化影响。发现:(1)研究区全年总的平均初级生产力总体表现为城市地区低于非城市地区的特征。(2)研究区平均初级生产力一般是在8月份最高,而在1月份最低;同时,一个生长季内,平均初级生产力总体呈现为4—11月城市地区低于非城市地区,而12月到次年3月则是城市地区要高于非城市地区的趋势,但这种趋势在各土地覆盖类型间也存在很大的不同。(3)研究区全年总的平均初级生产力,城市地区NDVI为110.23d/km2,而非城市地区为123.94d/km2,两者相差13.71d/km2,即城市化过程已经在一定程度上减弱了研究区的植被初级生产力。

关键词：城市化初级生产力环渤海地区 DMSP/OLS 生态效应

Steakhouse syndrome causing large esophageal ulcer and stenosis

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World Journal of Gastrointestinal Endoscopy 2011年第5期3卷 101-104页

作者： Shotaro Enomoto Kazuyuki Nakazawa Kazuki Ueda Yoshiyuki Mori Yoshimasa Maeda Naoki Shingaki Takao Maekita Uki Ota Masashi Oka Masao ichinose Department of Gastroenterology School of MedicineWakayama Medical University811-1 KimiideraWakayama CityWakayama 641-0012Japan Department of Gastroenterology Nishimurakai Koyo Hospital40 TsuhadaWakayama CityWakayama 640-8315Japan Ota Medical Clinic 424-1 OtaWakayama City640-8323 WakayamaJapan

A 66-year-old man developed dysphagia during dinner and was evaluated 2d later in our hospital because of persistent *** gastrointestinal endoscopy showed no impacted food,but advanced esophageal cancer was suspected based on the presence in the upper esophagus of a large irregular ulcerative lesion with a thick white coating and *** imaging studies were performed to evaluate for metastases,revealing circumferential esophageal wall thickening and findings suggestive of lung and mediastinal lymph node ***,dysphagia symptoms and the esophageal ulcer improved after hospital admission,and histopathological examination of the esophageal mucosa revealed only nonspecific *** the timeof symptom onset,the patient had been eating stewed beef tendon(Gyusuji nikomi in Japanese) without chewing *** ulceration due to steakhouse syndrome was therefore *** lung lesion was a primary lung cancer that was surgically *** rare,steakhouse syndrome can cause large esophageal ulceration and stenosis,so care must be taken to distinguish this from esophageal cancer.

关键词： Esophageal stenosis Esophagus Ulcer Dysphagia Steakhouse syndrome

hepatocellular 癌的 Ultrasonogram 在 radiofrequency 脱离以后与结果被联系

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World Journal of Hepatology 2012年第12期4卷 374-381页

作者： Kosaku Moribata Hideyuki Tamai Naoki Shingaki Yoshiyuki Mori Tatsuya Shiraki Shotaro Enomoto Hisanobu Deguchi Kazuki Ueda Izumi Inoue Takao Maekita Mikitaka Iguchi Masao ichinose Second Department of Internal Medicine Wakayama Medical University

AIM:To investigate the association between B-mode ultrasound classification of small hepatocellular carcinoma(HCC) and outcome after radiofrequency ablation(RFA).METHODS:Ninety-seven cases of HCC treated using RFA between April 2001 and March 2006 were *** images were classified as follows:type 1,with halo(n=29);and type 2,without halo(n=68).Type 2 was further categorized into three subgroups:type 2a,homogenous hyperechoic(n=9);type 2b,hypoechoic with smooth margins(n=43);and type 2c(n=16),hypoechoic with irregular or unclear *** with type 2a HCC were excluded from analysis due to the small number of ***:Two year recurrence rates for type 2b,type 1 and type 2c were 26%,42% and 69%,respectively,with significant differences between type 2b and type 2c(P<0.01),and between type 1 and type 2c(P<0.05).Five year survival rates were 89%,43% and 65%,*** was significantly longer for type 2b than for other types(type 1 vs type 2b,P<0.01;type 2b vs type 2c,P<0.05).On univariate analysis,factors contributing to recurrence were number of tumors,tumor stage,serum level of lens culinaris agglutinin-reactive alpha-fetoprotein and ultrasound classification(P<0.05).Factors contributing to survival were tumor stage and ultrasound classification(P<0.05).Multivariate analysis identified ultrasound classification as the only factor independently associated with both recurrence and survival(P<0.05).CONCLUSION:B-mode ultrasound classification of small HCC is a predictive factor for outcome after RFA.

关键词： B-mode ultrasound Hepatocellular carcinoma Radiofrequency ablation Recurrence Prognosis

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Ni-P化学镀层相变过程研究

太原理工大学学报 2005年第5期36卷 567-570页

作者：卫英慧毕虎才侯利锋胡兰青许并社市野濑英喜2 太原理工大学材料科学与工程学院山西太原030024

针对镍磷化学镀镀层相变过程中存在的问题,通过X射线衍射、差热分析和透射电镜等手段对含磷原子数分数12.15%的镍磷镀层的镀态组织和晶化过程进行了初步研究。结果表明,这种中磷含量的镍磷镀层镀态下组织为非晶态,晶化起始温度321℃;退... 详细信息

针对镍磷化学镀镀层相变过程中存在的问题,通过X射线衍射、差热分析和透射电镜等手段对含磷原子数分数12.15%的镍磷镀层的镀态组织和晶化过程进行了初步研究。结果表明,这种中磷含量的镍磷镀层镀态下组织为非晶态,晶化起始温度321℃;退火过程中,非晶组织中先形成镍纳米晶,然后纳米晶镍伴随晶化过程进行迅速长大,并在镍基体上析出亚稳过渡相Ni12P5和稳定的Ni3P相,400℃退火90min后的组织为晶粒尺寸为微米级的镍基体上分布着弥散的Ni3P相和少量的Ni12P5相。

关键词：化学镀镍磷相变