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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： Mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta katsushi nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

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Simulation Evaluation of Filtering Method for Improving Pedestrian Positioning Accuracy Using Signal Strengths

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Wireless Sensor Network 2019年第6期11卷 81-94页

作者： Yuya nishimaki Hisato Iwai Kenya Sato Computer and Information Science Graduate School of Science and Engineering Doshisha University Kyoto Japan Electrical and Electronic Engineering Graduate School of Science and Engineering Doshisha University Kyoto Japan

In recent years, we have been able to use various services using the position information of smartphones and tablets. In addition, research on intelligent transport systems (ITS) has been actively conducted. To consider reducing traffic accidents by exchanging position information between pedestrians and vehicles by vehicle-to-pedestrian communication, we require accurate position information for pedestrians and vehicles. The GPS (global positioning system) is the most widely used method for acquiring position information. However, in urban areas, the GPS signal is affected by the surrounding buildings, which increases the positioning error. In this study, a method to improve the positioning accuracy of pedestrians using the signal strengths from vehicles and beacons was proposed. First, a Kalman filter was applied to the signal strength. Then, the path loss index was dynamically calculated using vehicle-to-vehicle communication. Finally, the position of a pedestrian was obtained using weighted centroid localization (WCL) after filtering the nodes. The positioning accuracy was evaluated using a simulator and demonstrated the superiority of the proposed method.

关键词： Outdoor Positioning Vehicle-to-Pedestrian Communication Vehicle-to-Vehicle Communication Signal Strength Path Loss Index WCL

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Successful treatment for esophageal carcinoma with lung metastasis by induction chemotherapy followed by salvage esophagectomy: Report of a case

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World Journal of Gastroenterology 2006年第25期12卷 4101-4103页

作者： Shin Ichi Kosugi Tatsuo Kanda Tadashi nishimaki Satoru Nakagawa Kazuhito Yajima Manabu Ohashi Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata University Graduate School of Medical and Dental Sciences Niigata CityJapan First department of Surgery Faculty of Medicine University of the RyukyusOkinawaJapan

We here report a case of a 51-year-old man with lung metastasis from esophageal carcinoma that was initially treated by combination chemotherapy consisting of fluorouracil and nedaplatin. Because metastatic disease disappeared, salvage esophagectomy was performed. Although chest wall recurrence developed at the thoracotomy wound, prolonged survival of 48 months was achieved by local tumor resection and additional chemotherapy. This combination chemotherapy is regarded as a promising and considerable treatment for metastatic esophageal carcinoma.

关键词： Esophageal carcinoma Lung metastasis Induction chemotherapy Fluorouracil Nedaplatin Salvage esophagectomy

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Mild Decrease in Skin Temperature Reduces the Heart Rate during Moderate Exercise

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Journal of Sports Science 2017年第6期5卷 305-312页

作者： Masayuki Konishi Hiroki Tabata Karina Ando Hyeon-Ki Kim Mio nishimaki Mi Xiang Shizuo Sakamoto Faculty of Sport Sciences Waseda University Tokorozawa Saitama 359-1192 Japan Graduate School of Sport Sciences Waseda University Tokorozawa Saitama 359-1192 Japan Research Fellow of the Japan Society for the Promotion of Science Chiyoda-ku Tokyo 102-0083 Japan Japan Institute of Sports Sciences Kita-ku Tokyo 115-0056 Japan

The purpose of this study was to investigate the effects of a mild decrease in skin temperature on the heart rate, substrate oxidation, and hormonal responses during exercise. Ten young men performed treadmill exercises approximately 65% of their maximal oxygen uptake for 60 min under two trials：（1） mild body cooling trial, and （2） control trial. Rectal and skin temperatures were recorded during and after exercise. Heart rate and oxygen uptake were monitored during exercise. Blood samples for catecholamine, cortisol, free fatty acid, insulin, and glucose concentrations were collected before, immediately after, and 1 h after exercise. In the mild body cooling trial, mean skin temperature decreased by 1.7 ＋ 0.7~C in the last minutes of exercise, compared with before exercise. No differences in rectal temperature were seen between the two trials. Although oxygen uptake during exercise and blood parameters did not differ between the trials, heart rate and subjective fatigue during exercise was lower in the mild body cooling trial than in the control trial. This study suggests that mild body cooling reduces the heart rate and subjective fatigue during moderate exercise, but does not affect substrate oxidation or hormonal responses to exercise.

关键词： Mild body cooling climatic terrain therapy cold exposure

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Accuracy and Utility of Vessel Analysis Using Non-Contrast CT for Planning Endovascular Aortic Repair

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Open Journal of Medical Imaging 2024年第3期14卷 96-105页

作者： Midori Komita-Moriya Yukihisa Ogawa Akiyuki Kotoku Shintaro Nawata Kenji Kuramochi Yasuyoshi Ogawa Kiyoshi Chiba Hiroshi nishimaki Hidefumi Mimura Department of Radiology St. Marianna University School of Medicine Kanagawa Japan Department of Radiology Tokai University School of Medicine Hachioji Hospital Tokyo Japan Radiological Technology St. Marianna University School of Medicine Kanagawa Japan Department of Cardiovascular Surgery St. Marianna University School of Medicine Kanagawa Japan

Objectives: This study aimed to determine whether errors in vascular measurements would affect device selection in endovascular aortic repair (EVAR) by comparing measurements obtained using non-contrast computed tomography (NCT) with those obtained using contrast-enhanced CT (CECT). Materials and Methods: This single-center, retrospective study included 25 patients who underwent EVAR for abdominal aortic aneurysm at our institution. A 1-mm horizontal cross-sectional slice of NCT and CECT from each patient was retrospectively reviewed. The area from the abdominal aorta to the common iliac artery was divided into four zones. A centerline was created using the NCT by manually plotting the center points. Subsequently, the centerlines were automatically extracted and manually corrected during the arterial phase of CECT. The diameter and length of each zone were measured for each modality. The mean diameters and lengths of the target vessels were compared between NCT and CECT. Results: The measurements obtained using both methods were reproducible and demonstrated good agreement. The mean differences in vessel length and diameter measurements for each segment between NCT and CECT were not statistically significant, indicating good consistency. Conclusion: NCT may be useful for preoperative EVAR evaluation in patients with renal dysfunction or allergies to contrast agents.

关键词： Non-Contrast CT Vessel Analysis EVAR Contrast-Enhanced CT Abdominal Aortic Aneurysm

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脐血中白细胞介素-6、白细胞介素-8和可溶性肿瘤坏死因子受体-1可预测早产儿慢性肺病

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世界核心医学期刊文摘（妇产科学分册） 2005年第4期1卷 14-15页

作者： An H. nishimaki S. Ohyama M. 高雪莲 Department of Pediatrics Dept. of Obstetrics and Gynecology Yokohama City Univ. Sch. Med. Y. Kanagawa Japan

Objectives In order to predict the latedevelopment of chronic lung disease of prematurity (CLD), cytokines in the cord blood were assessed in this study. Study design Eighteen premature infants with CLD were enrolled. Cord blood plasma levels of cytokines of these infants and 12 control infants without CLD were measured including interleukin (IL)-1β, IL-2, IL-4, IL-6, IL-8, IL-10, interferon (IFN)-γ, tumor necrosis factor (TNF)-α, soluble TNF receptor-I, and soluble IL-6 receptor using a cytometric bead array and an enzyme-linked immunosorbent assay. Results The cord blood IL-6, IL-8, and sTNFR-I levels were significantly elevated in CLD infants compared with those in control (P <.05). IL-1β, IL-2, IL-4, IL-10, and IFN-γwere undetectable in both groups. CLD infants with maternal chorioamnionitis had higher IL-6 than those without chorioamnionitis (P <.01). In CLD infants, IL-6 was higher in the infants who required prolonged oxygen therapy (P<.05). Conclusion Elevated inflammatory cytokines in the cord blood are associated with the progression to CLD.

关键词：白细胞介素慢性肺病脐血慢性肺疾病肿瘤坏死因子绒毛膜炎炎性细胞因子细胞因子浓度酶联免疫吸附法定量技术

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