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World Journal of Gastroenterology 2012年第34期18卷 4798-4800页

作者： Akihiko Kida Koichiro Matsuda Satoshi Hirai Akiyoshi Shimatani Yousuke Horita katsushi hiramatsu Mitsuru Matsuda Hidero Ogino Shin Ishizawa Yatsugi Noda Department of Internal Medicine Toyama Prefectural Central Hospital Department of Clinical Pathology Toyama Prefectural Central Hospital

We report a rare case of a small-bowel lymphangioma causing massive gastrointestinal (GI) bleeding that we successfully diagnosed and treated using double-balloon enteroscopy (DBE). An 81-year-old woman suffering from repeated GI bleeding of unknown origin underwent a capsule endoscopy at a previous hospital. She was suspected of having bleeding from the jejunum, and was referred to our department for diagnosis and treatment. An oral DBE revealed a 20 mm × 10 mm, regularly surfaced, white to yellowish, elongated, pedunculated jejunal polyp with small erosions at 10 cm distal to the ligament of Treiz. Since no other source of bleeding was identified by endoscopy in the deep jejunum, anendoscopic polypectomy (EP) was performed for this lesion. A subsequent histopathological examination of the resected polyp showed clusters of lymphatic vessels with marked cystic dilatation in the submucosa and the deep layer of the lamina propria mucosae. These characteristics are consistent with the typical features of small-bowel lymphangioma with erosions. Although clip-ping hemostasis was performed during EP, re-bleeding occurred. Finally, a complete hemostasis was achieved by performing an additional argon plasma coagulation.

关键词： Small-bowel lymphangioma Gastrointesti-nal bleeding Double-balloon enteroscopy

The marriage of coherent Raman scattering imaging and advanced computational tools

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Light(Science & Applications) 2023年第6期12卷 943-945页

作者： Walker Peterson Kotaro hiramatsu Keisuke Goda Department of Chemistry The University of TokyoTokyo 113-0033Japan Research Center for Spectrochemistry The University of TokyoTokyo 113-0033Japan Department of Bioengineering University of CaliforniaLos AngelesCA 90095USA Institute of Technological Sciences Wuhan UniversityWuhanHubei 430072China LucasLand Inc.Tokyo 101-0052Japan

Coherent Raman scattering microscopy can provide high-contrast tissue and single-cell images based on the inherent molecular vibrations of the ***,conventional techniques face a three-way trade-off between Raman spectral bandwidth,imaging speed,and image *** currently challenging to address via optical design,this trade-off can be overcome via emerging computational tools such as compressive sensing and machine learning.

关键词： coherent overcome hough

A rare presentation of appendiceal diverticulitis associated with pelvic pseudocyst

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World Journal of Gastroenterology 2008年第8期14卷 1293-1295页

作者： Hirotaka Niwa Takeyuki hiramatsu Department of Surgery Yaizu City Hospital Yaizu-City Shizuoka Japan

We report a case of a 32-year-old woman with episodic right lower quadrant abdominal pain. With the diagnosis of either acute appendicitis or tubo-ovarian abscess, she was treated with antibiotics, which successfully relieved the pain and the inflammatory findings. She repeated the clinical condition a few times and antibiotics worked each time. In a year, her subjective symptoms became milder, however, a giant pelvic cyst appeared. She had an exploratory laparotomy to confirm this diagnosis. Histopathological studies revealed herniated appendiceal mucosa through the muscular layer associated with chronic inflammation and marked fibrosis. Gynecological disorders such as endometriosis or lutein cyst rupture was denied. These findings represent appendiceal diverticulitis. We discuss the clinical features of the disease and its relation with the pelvic pseudocyst.

关键词： Appendiceal diverticulitis Perforation Pelvic pseudocyst

Senescence accelerated mice(SAM):A model of aging and effects of antioxidants,Toki-shakuyakusan

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生物物理学报 2009年第S1期25卷 99-100页

作者： Midori hiramatsu Tohoku University of Community and Science Sakata-city Yamagata 998-8580 Japan

Senescence accelerated mice (SAMP8) have a shorter lifespan with deficits in learning and memory, compared with control SAMR1 mice (Takeda, Elsevier Science BV, 1994).

关键词： A model of aging and effects of antioxidants,Toki-shakuyakusan SAM

Pneumococcal infection transmission between family members with congenital asplenia: A case report

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World Journal of Clinical Cases 2019年第24期7卷 4277-4284页

作者： Jumpei Shibata Kazuhiro hiramatsu Tuneaki Kenzaka Takehito Kato Department of General Surgery Toyohashi Municipal Hospital50 Aza Hachiken NishiAotake-ChoAichi 4418570ToyohashiJapan Division of Community Medicine and Career Development Kobe University Graduate School of MedicineHyogo 6520032KobeJapan

BACKGROUND Asplenia,the lack of a spleen,can be congenital and increases susceptibility to severe infections caused by encapsulated bacteria,such as Streptococcus pneumoniae(***).We report two cases of severe pneumococcal infection in two asplenic family members living in the same *** SUMMARY Patient 1,a 38-year-old man with a history of congenital hepatitis B infection and hypospadias,was brought to our emergency department with complaints of cyanosis,cough,and edema of his *** was clinically diagnosed as hyposplenic with overwhelming pneumococcal *** was admitted to the intensive care unit and was administered antibiotics and catecholaminergic therapy but died 2 h after *** 2,a 63-year-old woman with a history of type 2 diabetes,was brought to our emergency department one month after admission of Patient *** was diagnosed as asplenic with overwhelming pneumococcal ***-taking revealed that she was the mother of Patient 1 and the two had lived in the same *** was admitted to the intensive care unit and was rapidly provided antibiotics and catecholaminergic intervention but died one day after *** Pneumococcal bacteremia caused by virulent *** may be transmitted within *** residents of households where individuals with pneumococcal bacteremia are living should be educated about the risk of *** members of patients with congenital asplenia/hyposplenia,all family members should be examined to assess their splenic function.

关键词： Streptococcus pneumoniae Pneumococcal infection Asplenia Hyposplenia Isolated congenital asplenia Septic shock Case report

ENVIRONMENTAL FRIENDLY ANODIZING ON AZ91D MAGNESIUM ALLOYS AND COATING CHARACTERISTICS

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 411-415页

作者： A. Saijo M. Hino M. hiramatsu T. Kanadani Hori Metal Finishing Industry Co. Ltd. Abe Ochiai-cho Takahashi-shi Okayama 716-0061 Japan Industrial Technology Research Institute of Okayama Prefecture Haga Okayama-sh i Okayama 701-1296 Japan Industrial Technology Research Institute of Okayama Prefecture Haga Okayama-sh i Okayama 701-1296 Japan Graduate School of Okayama University of Science Ridai-cho Okayama-shi Okayam a 700-0005 Japan

An environmental friendly anodizing treatment (Anomag) from a phosphate-based so lution without heavy metals on AZ91D magnesium alloy was studied. The characteri stics of the coatings, such as structure, composition and corrosion resistance w ere investigated. The effects of this anodizing treatment on the mechanical prop erties were examined. X-ray diffraction (XRD) analysis revealed that the structu re of the coatings is amorphous or glassy. In salt spray tests coatings with an average thickness of 10μm had an anticorrosive performance of over 1000 hours. Fatigue tests revealed that anodizing onto AZ91D magnesium alloy does not affect the fatigue strength. These results demonstrate the utility of this anodizing t reatment on magnesium alloy for application as a structural material, such as in the automotive field.

关键词： magnesium alloy anodizing environmental friendliness

ELECTROPLATED Zn-Ni-SiO_(2) COMPOSITE COATINGS TREATED WITH A SILANE COUPLING AGENT TO REPLACE CHROMATING

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 416-422页

作者： M.Hino M.hiramatsu K.Murakami A.Saijo T.Kanadani Industrial Technology Research Institute of Okayama Prefecture HagaOkayama-sh iOkayama 701-1296Japan Hori Metal Finishing Industry Co. Ltd.AbeOchiai-choTakahashi-shiOkayama 716-0061Japan Graduate School of Okayama University of Science Ridai-choOkayama-shiOkayam a 700-0005Japan

The fixing of a silane coupling agent to Zn-Ni-silica(SiO_(2))composite coatings was studied for the purpose of developing a coating process as an alternative to *** corrosion resistance of Zn-Ni-silica composite coatings was rem arkably improved by the silica nanoparticles in the composite,which were disper sed in the surface of this *** silane coupling agent formed chemical bonds with the inorganic silica particles during the silane coupling treatment on the se composite *** treatment suppressed the formation of white corrosion products to the same extent as chromating,as measured in salt spray *** is concluded that treating Zn-Ni-silica composite coatings with silane coupling agents is a viable alternative technique to chromating.

关键词： electrodeposition Zn-Ni-SiO_(2)composite coating silane coupling reatment chrome-free environmental friendlines

Maintenance for healed erosive esophagitis:PhaseⅢcomparison of vonoprazan with lansoprazole

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World Journal of Gastroenterology 2018年第14期24卷 1550-1561页

作者： Kiyoshi Ashida Katsuhiko Iwakiri Naoki hiramatsu Yuuichi Sakurai Tetsuharu Hori Kentarou Kudou Akira Nishimura Eiji Umegaki Department of Gastroenterology Rakuwakai Otowa HospitalKyoto 607-8062Japan Department of Gastroenterology Nippon Medical School Graduate School of MedicineTokyo 113-8603Japan Department of Gastroenterology and Hepatology Osaka Rosai HospitalSakaiOsaka 591-8025Japan Takeda Pharmaceutical Company Limited Osaka 540-8645Japan Department of Gastroenterology Kobe University Graduate School of MedicineKobeHyogo 650-0017Japan

AIM To compare vonoprazan 10 and 20 mg vs lansoprazole 15 mg as maintenance therapy in healed erosive esophagitis(EE).METHODS A total of 607 patients aged ≥ 20 years, with endoscopically-confirmed healed EE following 8 wk of treatment with vonoprazan 20 mg once daily, were randomized 1:1:1 to receive lansoprazole 15 mg(n = 201), vonoprazan 10 mg(n = 202), or vonoprazan 20 mg(n = 204), once daily. The primary endpoint of the study was the rate of endoscopically-confirmed EE recurrence during a 24-wk maintenance period. The secondary endpoint was the EE recurrence rate at Week 12 during maintenance treatment. Additional efficacy endpoints included the incidence of heartburn and acid reflux, and the EE healing rate 4 wk after the initiation of maintenance treatment. Safety endpoints comprised adverse events(AEs), vital signs, electrocardiogram findings, clinical laboratory results, serum gastrin and pepsinogen Ⅰ/Ⅱ levels, and gastric mucosa histopathology *** Rates of EE recurrence during the 24-wk maintenance period were 16.8%, 5.1%, and 2.0% with lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg, respectively. Vonoprazan was shown to be non-inferior to lansoprazole 15 mg(P < 0.0001 for both doses). In a post-hoc analysis, EE recurrence at Week 24 was significantly reduced with vonoprazan at both the 10 mg and the 20 mg dose vs lansoprazole 15 mg(5.1% vs 16.8%, P = 0.0002, and 2.0% vs 16.8%, P < 0.0001, respectively); by contrast, the EE recurrence rate did not differ significantly between the two doses of vonoprazan(P = 0.1090). The safety profiles of vonoprazan 10 and 20 mg were similar to that of lansoprazole 15 mg in patients with healed EE. Treatment-related AEs were reported in 11.4%, 10.4%, and 10.3% of patients in the lansoprazole 15 mg, vonoprazan 10 mg, and vonoprazan 20 mg arms, *** Our findings confirm the non-inferiority of vonoprazan 10 and 20 mg to lansoprazole 15 mg as maintenance therapy for patients with heale

关键词： Gastroesophageal reflux disease Erosive esophagitis Lansoprazole Potassium-competitive acid blockers Vonoprazan Maintenance therapy

Fabrication of Binary Diffractive Lenses and the Application to LED Lighting for Controlling Luminosity Distribution

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Optics and Photonics Journal 2013年第1期3卷 67-73页

作者： Atsushi Motogaito Kazumasa hiramatsu Division of Electrical and Electronic Engineering Graduate School of Engineering Mie University Tsu Japan

We designed and fabricated two types of binary diffractive lenses using Electron beam lithography (EBL) on optical films film for controlling LED light. In the case of the binary diffractive convex lens with 2-mm focal length, it is possible to control the luminous intensity distribution. To improve the diffraction efficiency and realize a thin LED light source, the binary diffractive lenses with 100-μm-order focal length are effective. Furthermore we fabricated and characterized the binary diffractive concave lenses for application in LED lighting. It is found that white-light LEDs are strongly diffused by using the binary diffractive concave lenses.

关键词： Light Emitting Diode (LED) Luminosity Distribution Binary Diffractive Lens Electron Beam Lithography (EBL) Optical Film

Clinical features and prognosis of patients with extrahepatic metastases from hepatocellular carcinoma

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World Journal of Gastroenterology 2007年第3期13卷 414-420页

作者： Kiminori Uka Hiroshi Aikata Shintaro Takaki Hiroo Shirakawa Soo Cheol Jeong Keitaro Yamashina Akira hiramatsu Hideaki Kodama Shoichi Takahashi Kazuaki Chayama Department of Medicine and Molecular Science Division of Frontier Medical Science Programs for Biomedical Research Graduate School of Biomedical Sciences Hiroshima University Hiroshima Japan

AIM: To assess the clinical features and prognosis of 151 patients with extrahepatic metastases from primary hepatocellular carcinoma (HCC), and describe the treatment strategy for such patients. METHODS: After the diagnosis of HCC, all 995 consecutive HCC patients were followed up at regular intervals and 151 (15.2%) patients were found to have extrahepatic metastases at the initial diagnosis of primary HCC or developed such tumors during the follow-up period. We assessed their clinical features, prognosis, and treatment strategies. RESULTS: The most frequent site of extrahepatic metastases was the lungs (47%), followed by lymph nodes (45%), bones (37%), and adrenal glands (12%). The cumulative survival rates after the initial diagnosis of extrahepatic metastases at 6, 12, 24, and 36 mo were 44.1%, 21.7%, 14.2%, 7.1%, respectively. The median survival time was 4.9 mo (range, 0-37 mo). Fourteen patients (11%) died of extrahepatic HCC, others died of primary HCC or liver failure. CONCLUSION: The prognosis of HCC patients with extrahepatic metastases is poor. With regard to the cause of death, many patients would die of intrahepatic HCC and few of extrahepatic metastases. Although most of HCC patients with extrahepatic metastases should undergo treatment for the primary HCC mainly, treatment of extrahepatic metastases in selected HCC patients who have good hepatic reserve, intrahepatictumor stage (T0-T2), and are free of portal venous invasion may improve survival.

关键词： Hepatocellular carcinoma Extrahepatic metastases Prognosis Causes of death