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Prognostic Impact of Surgical Margin Width in Hepatectomy for Colorectal Liver Metastasis

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Journal of Clinical and Translational Hepatology 2023年第3期11卷 705-717页

作者： katsunori sakamoto Toru Beppu Kohei Ogawa Kei Tamura Masahiko Honjo Naotake Funamizu Yasutsugu Takada Department of Hepato-Biliary-Pancreatic and Breast Surgery Ehime University Graduate School of MedicineToon EhimeJapan Department of Surgery Yamaga City Medical CenterKumamotoJapan

As for resection for colorectal liver metastasis (CRLM), secur-ing an adequate surgical margin is important for achieving a better prognosis. However, it is often difficult to achieve ade-quate margins for the resection of CRLM. So the current sur-vival impact of sub-centi/millimeter surgical margins in he-patectomy for CRLM should be evaluated. In the current era of multidisciplinary treatment options, this review focused on the prognostic impact of a sub-centi/millimeter surgical margin width in hepatectomy for CRLM. We systematically reviewed retrospective studies that clearly described the sur-gical margin width for hepatectomy for CRLM. We selected studies conducted since 2000 that involved patients diag-nosed as having CRLM. We focused on studies that investi-gated not only surgical margins, but also microscopic surgical curability such as R0 (microscopically complete resection) or R1 (microscopically incomplete resection), which clearly de-scribe their definitions. Based on our literature review, 1, 2, or 5 mm was considered the minimum surgical margin width for hepatectomy for CRLM. Although a surgical margin width of 1 mm is acceptable for hepatectomy for CRLM, submil-limeter margins, which are defined as R1 in many reports, are only acceptable for limited patients such as those who have undergone preoperative chemotherapy. Zero-mm mar-gins are also acceptable in limited patients such as those who show a good response to preoperative chemotherapy. New chemotherapy agents have been reported to reduce the prognostic impact of a narrow surgical margin width. The incidence of margin recurrence, which is a major concern regarding R1 resection of CRLM, is about 20-30% according to the majority of earlier reports. As evaluations of the actual prognostic impact of the surgical margin remain difficult, fur-ther study is warranted.

关键词： Surgical margin Colorectal liver metastasis Chemotherapy.

An estimate of the conversion rates of SO_2 to SO_4^(2-)- and NO_2 to HNO_(3+) NO_3^- for the evaluation air pollution in Beijing

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Journal of Environmental Sciences 1990年第1期2卷 41-48页

作者： Kazuhiko sakamoto katsunori Kimijima Tadao Suzuki Masahiro Uchiyama Yoshikazu Hashimoto Hisao ohta Yasuaki maeda Nobutoshi Horiuchi Shin Suzuki Saitama University Japan.Saitama University Japan.Automobile Research Institute Japan.The National Institute Environmental Sciences Japan.Keio University Japan.Chiba Environmental Protection Association Japan.Osaka Prefectural University Japan.Chiba University Japan.Chiba University Japan.

The conversion rates of SO2 to SO42- and NO2 to HNO3+NO3- are estimated from the field-data obtained in Beijing in summer, 1988. The results show that the conversion rate of NO2 is about four times as much as that of SO2; The conversion rates have a diurnal variation in a day. On the average, the rate of SO2 is estimated to be 4.7% h-1 during the daytime and 3.4% h-1 during the nighttime. Similarly, the rate of NO2 is estimated to be 17.2% h-1 and 12% h-1 respectively.

关键词： sulphur dioxide nitrogen oxide computer modeling conversion rate oxidation.

Improvement of Plasma Performance Using Carbon Pellet Injection in Large Helical Device

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Plasma Science and Technology 2011年第3期13卷 290-296页

作者： Shigeru MORITA Motoshi GOTO Kenichi NAGAOKA Chunfeng DONG Hangyu ZHOU Zhengying CUI Yunbo DONC Xiang GAO TKatsumi IDA katsunori IKED Osamu KANEKO Shiyao LIN Haruhisa NAKANO Masaki OSAKABE Ryuichi sakamoto Yasuhiko TAKEIRI Ang TI Katsuyoshi TSUMORI Mikiro YOSHINUMA LHD experiment group National Institute for Fusion Science Toki 509-5292 Gifu Japan Graduate University for Advanced Studies Toki 509-5292 Gifu Japan Southwestern Institute of Physics Chengdu 610041 China Institute of Plasma Physics Chinese Academy of Sciences Hefei 230031 China

A cylindrical carbon pellet with a size of 1.2L x 1.2φ mm to 1.8L x 1.8φ mm and a velocity of 100 m/s to 300 m/s was injected into large helical device （LHD） for an efficient fueling based on its deeper deposition instead of hydrogen gas puffing and ice pellet injection. Electron density increment of Ane = 10^14 cm^-3 is successfully obtained by single carbon pellet injection without plasma collapse. Typical density and temperature of the ablation plasma of the carbon pellet, e.g., 6.5× 10^16 cm^-3 and 2.5 eV for CII, are examined respectively by spectroscopic method. A confinement improvement up to 50% compared to ISS-95 stellarator scaling is clearly observed in a relatively low-density regime of ne = 2 × 10^13 cm^-3 to 4×10^13 cm^-3, and high ion temperature Ti（0） of about 6 keV is also observed with an internal transport barrier at ne = 1.2 × 10^13 cm^-3. In particular, the improvement in the ion temperature largely exceeds that observed in hydrogen gas-puffed discharges, which typically ranges below 3 keV.

关键词： carbon pellet injection confinement improvement high ion temperature

NAT2＊6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis

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World Journal of Gastroenterology 2007年第45期13卷 6003-6008页

作者： Norihide Higuchi Naoko Tahara katsunori Yanagihara Kiyoyasu Fukushima Naofumi Suyama Yuichi Inoue Yoshitsugu Miyazaki Tsutomu Kobayashi Koh-ichiro Yoshiura Norio Niikawa, Chun-Yang Wen, Hajime Isomoto,Saburou Shikuwa, Katsuhisa Omagari, Yohei Mizuta, Shigeru Kohno, Kazuhiro Tsukamoto Norio Niikawa Chun-Yang Wen Hajime Isomoto Saburou Shikuwa Katsuhisa Omagari Yohei Mizuta Shigeru Kohno Kazuhiro Tsukamoto Department of Pharmacotherapeutics Nagasaki University Graduate School of Biomedical Sciences 1-14 Bunkyo-machi Nagasaki 852-8521 Japan Department of Internal Medicine Nagasaki University Graduate School of Biomedical Sciences Sakamoto 1-7-1 Nagasaki 852-8501 Japan Division of Internal Medicine Japanese Red Cross Nagasaki Genbaku Isahaya Hospital Isahaya 859-0497 Japan Department of Internal Medicine Nagasaki Municipal Medical Center Nagasaki 852-8012 Japan Y Department of Internal Medicine Isahaya Health Insurance General Hospital Isahaya 854-8501 Japan Department of Human Genetics Nagasaki University Graduate School of Biomedical Sciences Sakamoto 1-12-4 Nagasaki 852-8523 Japan SORST JST Kawaguchi Japan Department of Digestive Disease Center Beihua University Jilin 132013 Jilin Province China

AIM: To investigate an association between N -acetyltransferase 2 (NAT2 )-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single nucleotide polymorphisms, haplotypes, and diplotypes of NAT2 were determined by the PCR-restriction fragment length polymorphism method, and the results were compared between TB patients with and without adverse effect, using multivariate logistic regression ***: Statistical analysis revealed that the frequency of a variant haplotype, NAT2*6A , was signifi cantly increased in TB patients with hepatotoxicity, compared with those without hepatotoxicity [P = 0.001, odds ratio (OR) = 3.535]. By contrast, the frequency of a wild-type (major) haplotype, "NAT2*4", was signif icantly lower in TB patients with hepatotoxicity than those without hepatotoxicity (P < 0.001, OR = 0.265). There was no association between NAT2-haplotypes and skin rash or eosinophilia. CONCLUSION: The present study shows that NAT2 is one of the determinants of anti-TB drug-induced hepatotoxicity. Moreover, the haplotypes, NAT2*4 and NAT2*6A, are useful new biomarkers for predicting anti- TB drug-induced hepatotoxicity.

关键词： Tuberculosis Anti-tuberculosis drugs Drug-induced hepatotoxicity NAT2-haplotype DNA-baseddiagnosis