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Oxygen uptake during the last bouts of exercise incorporated into high-intensity intermittent cross-exercise exceeds the V_ O2max of the same exercise mode

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Sports Medicine and Health Science 2024年第1期6卷 63-69页

作者： Yuzhong Xu Xin Liu katsunori Tsuji Takafumi Hamaoka Izumi Tabata Faculty of Sport and Health Science Ritsumeikan UniversityKusatsuShigaJapan

Oxygen uptake(V O_(2))was measured during a non-exhaustive high-intensity intermittent cross-exercise(HIICE)protocol consisting of four alternating bouts of 20 s running(R)and three bouts of bicycle exercise(BE)at~160%and~170%maximal oxygen uptake(V O_(2)max),respectively,with 10 s between-bout rests(sequence R-BE-R-BER-BE-R).The V O_(2) during the last BE([52.2±5.0]mL⋅kg^(-1)⋅min^(-1))was significantly higher than the V O_(2)max of the BE([48.0±5.4]mL⋅kg^(-1)⋅min^(-1),n=30)and similar to that of *** clarifying the underlying mechanisms,a corresponding HIICE-protocol with BE and arm cranking ergometer exercise(AC)was used(sequence AC-AC-BE-AC-BE-AC-AC-BE).In some experiments,thigh blood flow was occluded by a cuff around the upper *** occlusion,the V O_(2) during the AC([39.2±7.1]mL⋅kg^(-1)⋅min^(-1)[6th bout])was significantly higher than the V O_(2)max of AC([30.2±4.4]mL⋅kg^(-1)⋅min^(-1),n=7).With occlusion,the corresponding V O_(2)([29.8±3.9]mL⋅kg^(-1)⋅min^(-1))was reduced to that of the V O_(2)max of AC and significantly less than the V O_(2) without *** findings suggest that during the last bouts of HIICE may exceed the of the specific exercise,probably because it is a summation of the V O_(2) for the ongoing exercise plus excess post-oxygen consumption(EPOC)produced by the previous exercise with a higher V O_(2)max.

关键词： Maximal oxygen uptake Running Bicycle ergometer exercise Arm cranking ergometer exercise Cross-exercise Excess post-exercise oxygen consumption (EPOC) Tabata training

Positive Effect of Transcranial Direct Current Stimulation on Visual Verbal Working Memory in Patients with Attention-Deficit/Hyperactivity Disorder

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Open Journal of Psychiatry 2024年第4期14卷 334-346页

作者： Tomoko Uchida Daisuke Matsuzawa Tadashi Shiohama katsunori Fujii Akihiro Shiina Masamitsu Naka Katsuo Sugita Eiji Shimizu Naoki Shimojo Hiromichi Hamada Department of Pediatrics Graduate School of Medicine Chiba University Chiba Japan Research Center for Child Mental Development Chiba University Chiba Japan Division of Medical Care and Treatment Center for Forensic Mental Health Chiba University Chiba Japan Department of Cognitive Behavioral Physiology Graduate School of Medicine Chiba University Chiba Japan

Background: Working memory is an executive function that plays an important role in many aspects of daily life, and its impairment in patients with attention-deficit/hyperactivity disorder (ADHD) affects quality of life. The dorsolateral prefrontal cortex (DLPFC) has been a good target site for transcranial direct current stimulation (tDCS) due to its intense involvement in working memory. In our 2018 study, tDCS improved visual-verbal working memory in healthy subjects. Objective: This study examines the effects of tDCS on ADHD patients, particularly on verbal working memory. Methods: We conducted an experiment involving verbal working memory of two modalities, visual and auditory, and a sustained attention task that could affect working memory in 9 ADHD patients. Active or sham tDCS was applied to the left DLPFC in a single-blind crossover design. Results: tDCS significantly improved the accuracy of visual-verbal working memory. In contrast, tDCS did not affect auditory-verbal working memory and sustained attention. Conclusion: tDCS to the left DLPFC improved visual-verbal working memory in ADHD patients, with important implications for potential ADHD treatments.

关键词： Working Memory Attention-Deficit/Hyperactivity Disorder Dorsolateral Prefrontal Cortex Transcranial Direct Current Stimulation

Can early precut reduce post-endoscopic retrograde cholangiopancreatography pancreatitis in patients with difficult bile duct cannulation?

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World Journal of Gastrointestinal Endoscopy 2024年第9期16卷 519-525页

作者： Tomohiro Tanikawa Keisuke Miyake Mayuko Kawada katsunori Ishii Takashi Fushimi Noriyo Urata Nozomu Wada Ken Nishino Mitsuhiko Suehiro Miwa Kawanaka Hidenori Shiraha Ken Haruma Hirofumi Kawamoto Department of General Internal Medicine 2 Kawasaki Medical SchoolOkayama 7008505Japan

BACKGROUND Endoscopic retrograde cholangiopancreatography(ERCP)is associated with a variety of adverse events(AEs).One of the most important AEs is post-ERCP pancreatitis(PEP),which is most common in cases of difficult biliary *** the precut technique has been reported as a PEP risk factor,recent studies indicate that early precut could reduce PEP,and that precut itself is not a risk *** To evaluate the safety of the precut technique,especially in terms of *** We conducted a retrospective study,spanning the period from November 2011 through December *** included 1556 patients,aged≥20 years,who underwent their initial ERCP attempt for biliary disease with a naïve papilla at the Kawasaki University General Medical *** compared the PEP risk between the early precut and the delayed precut *** The PEP incidence rate did not significantly differ between the precut and nonprecut ***,the PEP incidence was significantly lower in the early precut group than the delayed precut group(3.5%vs 10.5%;P=0.02).The PEP incidence in the delayed precut group without pancreatic stent insertion(17.3%)was significantly higher compared to other cases(P<0.01).CONCLUSION Our findings indicate that early precut may reduce PEP *** the precut decision is delayed,a pancreatic stent should be inserted to prevent PEP.

关键词： Endoscopic retrograde cholangiopancreatography Post-endoscopic retrograde cholangiopancreatography pancreatitis Precut Needle-knife precut papillotomy

Effects of water saturation and loading rate on direct shear tests of andesite

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 653-662页

作者： Tianshu Bao Kimihiro Hashiba katsunori Fukui Department of Systems Innovation The University of TokyoTokyo113-8656Japan

For estimating the long-term stability of underground framework,it is vital to learn the mechanical and rheological characteristics of rock in multiple water saturation ***,the majority of previous studies explored the rheological properties of rock in air-dried and water saturated conditions,as well as the water effects on compressive and tensile *** this study,andesite was subjected to direct shear tests under five water saturation conditions,which were controlled by varying the wetting and drying *** tests were conducted at alternating displacement rates under three vertical *** results reveal that the shear strength decreases exponentially as water saturation increases,and that the increase in shear strength with a tenfold increase in displacement rate is nearly constant for each of the vertical *** on the findings of the shear tests in this study and the compression and tension tests in previous studies,the influences of both water saturation and loading rate on the Hoek-Brown failure criterion for the andesite was *** results indicate that the brittleness index of the andesite,which is defined as the ratio of uniaxial compressive strength to tensile strength,is independent of both water saturation and loading rate and that the influences of the water saturation dependence and the loading rate dependence of the failure criterion can be converted between each other.

关键词： Direct shear test Water saturation Loading rate dependence Failure criterion

LESS-INVASIVE LASER THERAPY AND DIAGNOSIS USING A TABLETOP MID-INFRARED TUNABLE LASER

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Journal of Innovative Optical Health Sciences 2010年第4期3卷 285-292页

作者： HISANAO HAZAMA katsunori ISHII KUNIO AWAZU Graduate School of Engineering Osaka University 2-1 YamadaokaSuitaOsaka 565-0871Japan Research Institute of Nuclear Engineering University of Fukui 3-9-1 BunkyoFukuiFukui 910-8507Japan Institute for Chemical Research Kyoto University GokashoUjiKyoto 611-0011Japan

Since numerous characteristic absorption lines caused by molecular vibration exist in the midinfrared(MIR)wavelength region,selective excitation or selective dissociation of molecules is possible by tuning the laser wavelength to the characteristic absorption lines of target *** applying this feature to the medical fields,less-invasive treatment and non-destructive diagnosis with absorption spectroscopy are possible using tunable MIR lasers.A high-energy nanosecond pulsed MIR tunable laser was obtained with difference-frequency generation(DFG)between a Nd:YAG and a tunable Cr:forsterite *** MIR-DFG laser was tunable in a wavelength range of 5.5–10μm and generated laser pulses with energy of up to 1.4mJ,a pulse width of 5 ns,and a pulse repetition rate of 10 *** removal of atherosclerotic lesion was successfully demonstrated with the MIR-DFG laser tuned at a wavelength of 5.75μm,which corresponds to the characteristic absorption of the ester bond in cholesterol esters in the atherosclerotic *** have developed a non-destructive diagnostic probe with an attenuated total reflection(ATR)prism and two hollow optical *** absorption spectrum of cholesterol was measured with the ATR probe by scanning the wavelength of the MIR-DFG laser,and the spectrum was in good agreement with that measured with a commercial Fourier transform infrared spectrometer.

关键词： Mid-infrared tunable laser difference-frequency generation selective treatment attenuated total reflection spectroscopy hollow optical fiber

Electron transmission and quantum current distribution of C_(70) molecule

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Science China(Physics,Mechanics & Astronomy) 2008年第2期51卷 126-132页

作者： katsunori Tagami3 MASARU Tsukada Nano Technology Research Centre 120-5 Waseda University

The characteristics of electron transmission through C70 molecule bridge in which two atomic chain leads are connected to long-axis carbon atoms are investigated theoretically by using tight-binding approach based on the Green's function with only one π orbital electron per carbon atom. Electron transmission through C70 molecule from the input to the output terminal is obtained. From the spectrum, the switching feature of the electron transmission through C70 is found, and the oscil-lation property based on the quantized level is explained. The quantum current distributions inside C70 molecule bridge are calculated and simulated by the quan-tum current density theory based on Fisher-Lee formula at the energy point E = -0.2 eV, where the transmission spectrum shows a peak. The maximum and the mini-mum bond quantum currents are presented, and the reason why the currents are distributed nonuniformly is explained by the phase difference of the atomic orbits. The result shows that the currents at each atomic site agree with Kirchhoff quan-tum current conservation law.

关键词： C70 molecule electron transmission quantum current distribution

Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology

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Science China Chemistry 2012年第1期55卷 19-30页

作者： TANAKA katsunori KATSUMURA Shigeo FUKASE Koichi Department of Chemistry Graduate School of ScienceOsaka University1-1 Machikaneyama Department of Chemistry and Open Research Center on Organic Tool Molecules School of Science and TechnologyKwansei Gakuin University

While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine *** electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent *** chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural ***,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-*** labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging.

关键词： 6π-azaelectrocyclization enzyme inhibition lysine natural product synthesis synthetic biology labeling chemical engineering living cells N-glycan in vivo imaging tumor targeting

Gastric carditis:Is it a histological response to high concentrations of luminal nitric oxide?

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World Journal of Gastroenterology 2006年第36期12卷 5767-5771页

作者： katsunori Iijima Tooru Shimosegawa Division of Gastroenter-ology Tohoku University Graduate School of Medicine Sendai Miyagi Japan

During the last decade, inflammation (carditis) and in- testinal metaplasia localized to immediately below the human gastro-oesophageal junction have received much attention in relation to the rising incidence of cancer at this site. Since these histological findings are frequently observed even among those who are H pylori-negative, the causative factors for such histologic events at the human gastro-oesophageal junction remain obscure. A series of recent studies have demonstrated that a high level of salivary nitrite is sustained over several hours after the ingestion of a high nitrate meal, and that the nitrite in swallowed saliva is rapidly converted to nitric oxide by an acid catalyzed chemical reaction at the gastro-oesophageal junction. Eventually, a substantial amount of nitric oxide diffuses from the lumen into the adjacent tissue. Therefore, the human gastro-oesopha- geal junction is likely to be a region of high nitrosative stress. Considering the life-time exposure of the gastro- oesophageal junction to cytotoxic levels of nitric oxide, this may account for the high prevalence of inflamma- tion, intestinal metaplasia, and subsequent development of neoplasia at this site. Although gastric acid, pepsin, and bile acid have been intensively investigated as a cause of adenocarcinoma at the gastro-oesophageal junction and the distal esophagus, nitric oxide and the related nitrosative stress should also be examined.

关键词： Nitric oxide Gastro-oesophageal junction Dietary nitrate Carditis Intestinal metaplasia at gastro-oesophageal junction

Physicochemical characterization of forest and sugarcane leaf combustion’s particulate matters using electron microscopy,EDS,XRD and TGA

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Journal of Environmental Sciences 2021年第1期33卷 296-310页

作者： Hay Mon Oo Preechar Karin Nuwong Chollacoop katsunori Hanamura Faculty of Engineering King Mongkut's Institute of Technology LadkrabangBangkok 10520Thailand National Metal and Materials Technology Center National Science and Technology Development AgencyPathum Thani 12120Thailand School of Engineering Tokyo Institute of TechnologyTokyo 152-8552Japan

Physical characteristics and quantitative elemental composition of PM and residual ash produced from sugarcane leaves(SCL)combustion were investigated using TEM-EDS compared with forest leaves(FRL).SEM-EDS was used to analyze the microstructure and chemical composition of biomass raw leaves and *** analysis was also performed to investigate the characterization of the crystalline nanostructure,structure of PM,and residual ash compared to the TEM image processing *** oxidation kinetics of biomass raw materials,PM,and residual ash were investigated by *** morphology of fine and ultrafine agglomerate structure of SCL soot and residual ash are not significantly different from the FRL soot and residual *** average diameter sizes of single primary nanoparticles of SCL and FRL soot are approximately 37 nm and 35 nm,while the sizes of residual ash are about 18 nm and 22 nm,*** single primary nanoparticles of soot are mainly composed of curve line crystallites of carbon fringes,while residual ash is composed of straightline lattice *** average fringe lengths of SCL and FRL soot are about 1.25 nm and 1.04 nm from the outer shell and 0.89 nm and 0.74 nm from the inner *** interlayer spacing of curve line carbon fringes of SCL and FRL soot is approximately 0.359 nm and 0.362 nm by the TEM image analysis and it was matched with XRD *** biomass PMs are mainly composed of soot,Si,Ca,and K compounds:SiO_(2),CaCO3,and KCl.

关键词： Biomass combustion Particulate matter Soot Ashes TEM XRD TGA