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China's Success in My Eyes

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China News Release 2022年第12期 46-49页

作者： katsumi Tanigaki 不详

When I was on the left side of 30s,I worked as an international scientist in Tsukuba,Japan,a science city newly built by the Japanese government.A 45-minute drive from Tokyo,Tsukuba is home to 31 national scientific research *** to the internationalized research environment there,I was able to interact with numerous foreign scholars.

关键词： institutions Tokyo Japanese

Land use patterns and tree species diversity in the Volta Geological Unit, Togo

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Journal of Mountain Science 2019年第8期16卷 1869-1882页

作者： FOLEGA Fousseni ATAKPAMA Wouyo WALA Kperkouma MUKETE Beckline SHOZO shibata AKIRA Osawa ZHAO Xiu-hai AKPAGANA Koffi Geomatic and Ecosystems Modeling/Laboratory of botany and Plant Ecology Faculty of SciencesUniversity of LomeLome01BP1515Togo Key Laboratory for Forest Resources&Ecosystem Processes Beijing Forestry UniversityBeijing 100083China Graduate School of Global Environmental Studies Kyoto UniversityKyoto 606-8501Japan Department of Forest Management Beijing Forestry UniversityBeijing 100083China

The application of remote sensing in understanding tree species structural diversity and land use patterns relationship is imperative for reforestation and biodiversity conservation efforts. This study assesses land use patterns and tree species structural diversity in previously reforested hilly sandstone regions of northern Togo. The physical height, and diameter at breast height(DBH) more than 5 cm of all tree species in each given plot were measured in summer 2017. A total of 75 plots of 900 m^2 installed along the toposequence were recorded. In addition, a semi-supervised classification of Landsat 8 images in January of 2018, was also used to classify the land use patterns. 36 tree species and 19 families were recorded for the entire study area. Meanwhile, 19 tree species and 15 families were recorded for the previously afforested zones. The most abundant species included the Sterculiaceae, Zygophyllaceae, Meliaceae, and Mimosaceae. The trees stand structure represented 8.61 ± 0.57 m, 11.28 ± 1.76 cm, and 0.018 ± 0.009 m^2 per hectare for height, diameter and basal area respectively. Major land use patterns were tree and shrub savannahs, parklands and croplands which represented over 60% of the landscape. It is necessary to examine the regeneration and vegetative multiplication potentials of the most frequent and abundant tree species for any eventual future afforestation programs in these hilly sandstone regions of northern Togo.

关键词： Ecological diversity Land use Ecological restoration Forest degradation Togo

Gastric adenocarcinoma inducing portal hypertension:A rare presentation

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World Journal of Gastroenterology 2007年第6期13卷 960-963页

作者： Pradipta Ghosh katsumi Miyai Mario Chojkier Department of Medicine Division of Gastroenterology and Hepatology University of California San Diego San Diego California United States Department of Pathology University of California San Diego San Diego California United States Veterans Affairs Medical Center Cancer Center University of California San Diego California United States

Advanced gastric cancer usually presents with symptoms due to direct extension into adjacent viscera, distant metastases from lymphatic or hematogenic dissemination and peritoneal seeding. However, portal hypertension as a presentation of metastatic gastric cancer is rare and usually seen in association with other malignancies, e.g. hepatocellular and pancreatic carcinoma. We report a case of signet ring adenocarcinoma of the stomach that presented with esophageal and duodenal varices and bleeding due to portal hypertensive gastropathy. Pagetoid spread of cancer cells likely caused early metastasis and the unusual presentation. We also discussed the pathophysiology of development of portal hypertension in association with malignancies.

关键词： Advanced Gastric adenocarcinoma Signet ring Portal hypertension

A chemo-mechanical switchable valve on microfluidic chip based on a thermally responsive block copolymer

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Chinese Chemical Letters 2022年第6期33卷 3083-3086页

作者： Sifeng Mao Xiaohong Hu Yumi Tanaka Lin Zhou Chenhan Peng Nahoko Kasai Hizuru Nakajima Shungo Kato katsumi Uchiyama Department of Applied Chemistry Graduate School of Urban Environmental SciencesTokyo Metropolitan UniversityHachioji-shiTokyo 192-0397Japan University Education Center Tokyo Metropolitan UniversityHachioji-shiTokyo 192-0397Japan

Microfluidic devices have become a powerful tool for chemical and biologic *** control different functional parts on the microchip,valve plays a key role in the *** conventional methods,physio-mechanical valves are usually used on microfluidic ***,we reported a chemo-mechanical switchable valve on microfluidic chip by using a thermally responsive block *** wettability changes of capillary with copolymer modification on inner surface were investigated to verify the function as a *** with modification of poly-(N-isopropylacrylamide-co-hexafluoroisopropyl acrylate)(P(NIPAAm-co-HFIPA))with a 20%HFIPA was demonstrated capable of control aqueous solution stop or go *** short capillaries with copolymer modification were integrated in microchannels as *** the temperature changing around lower critical solution temperature(LCST),the integrated chemo-mechanical switchable valve exhibited excellent“OPEN–CLOSE”behavior for microflow *** optimization of the block copolymer sequences and molar ratio,a switching time as low as 20 s was *** developed micro valve was demonstrated effective for flow control on microchip.

关键词： Microchip Valve Flow control NIPPAm Chemo-mechanical switch Thermo-responsive polymer

Hepatitis A complicated with acute renal failure and high hepatocyte growth factor: A case report

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World Journal of Gastroenterology 2015年第32期21卷 9671-9674页

作者： Shinji Oe Michihiko shibata Koichiro Miyagawa Yuichi Honma Masaaki Hiura Shintaro Abe Masaru Harada Department of Internal Medicine School of Medicine University of Occupational and Environmental Health

A 58-year-old man was admitted to our hospital. Laboratory data showed severe liver injury and that the patient was positive for immunoglobulin M anti-hepatitis A virus(HAV) antibodies. He was also complicated with severe renal dysfunction and had an extremely high level of serum hepatocyte growth factor(HGF). Therefore, he was diagnosed with severe acute liver failure with acute renal failure(ARF) caused by HAV infection. Prognosis was expected to be poor because of complications by ARF and high serum HGF. However, liver and renal functions both improved rapidly without intensive treatment, and he was subsequently discharged from our hospital on the 21 st hospital day. Although complication with ARF and high levels of serum HGF are both important factors predicting poor prognosis in acute liver failure patients, the present case achieved a favorable outcome. Endogenous HGF might play an important role as a regenerative effector in injured livers and kidneys.

关键词： Acute hepatitis Acute renal failure Hepatitis A vi

Investigating drivers of active nitrification in organic horizons of tropical forest soils

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Soil Ecology Letters 2023年第3期5卷 89-99页

作者： Shinichi Watanabe Makoto shibata Yoshiko Kosugi Lion Marryanna Keitaro Fukushima Arief Hartono Shinya Funakawa Graduate School of Global Environmental Studies Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto606-8502Japan Graduate School of Agriculture Kyoto UniversityKitashirakawa Oiwake-choSakyo-kuKyoto606-8502Japan Forest Research Institute Malaysia 52109 KepongSelangorMalaysia Center for Ecological Research Kyoto University509-3Hirano 2-chomeOtsu-shiShiga520-2113Japan Faculty of Agriculture Bogor Agricultural UniversityJalan MerantiKampus IPB Darmaga 16680BogorIndonesia

High nitrate leaching has been observed from the O horizons of some tropical forests;however,the drivers of high nitrate production(active nitrification)in these O horizons have not yet been *** study investigated the drivers of active nitrification in the O horizon of tropical forest soils by focusing on two of the most widely recognized controlling factors of nitrification,total N,and *** collected mineral and O horizons from eight tropical forests in Cameroon,Indonesia,and Malaysia and measured gross nitrification *** O horizons showed significantly higher gross nitrification rates than mineral horizons,indicating that these O horizons have a high potential for *** nitrification rates in the O horizons were positively correlated with both total N and pH,and the chemical properties(e.g.,total content of N,P,and base cations)were *** correlations suggested that the underlying driver of nitrification in the O horizon was nutrient richness in the *** also indicated a threshold of gross nitrification rates around pH values of 5.5–*** elucidate that active nitrification and subsequent high nitrate leaching from the O horizon could be driven by nutrient-rich litter,possibly derived from soil fertility and tree species.

关键词： nitrogen dynamics gross nitrification rate organic horizon forest floor acidic soil leguminous trees

Chrono-exercise: Time-of-day-dependent physiological responses to exercise

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Sports Medicine and Health Science 2023年第1期5卷 50-58页

作者： Hyeon-Ki Kim Zsolt Radak Masaki Takahashi Takayuki Inami Shigenobu shibata Research Center for Molecular Exercise Science University of Physical EducationBudapestHungary Institute of Physical Education Keio UniversityYokohamaJapan Chrono-nutrition Research Center Waseda UniversityTokyoJapan Institute for Liberal Arts Tokyo Institute of TechnologyTokyoJapan Faculty of Science and Engineering Waseda UniversityJapan

Exercise is an effective strategy to prevent and improve obesity and related metabolic *** increases the metabolic demand in the *** many of the metabolic health benefits of exercise depend on skeletal muscle adaptations,exercise exerts many of its metabolic effects through the liver,adipose tissue,and ***,exercise is the physiological state in which inter-organ signaling is most *** contrast,circadian rhythms in mammals are associated with the regulation of several physiological and biological functions,including body temperature,sleep-wake cycle,physical activity,hormone secretion,and metabolism,which are controlled by clock *** and lipid tolerance reportedly exhibit diurnal variations,being lower in the evening than in the ***,the effects of exercise on substrate metabolism at different times of the day may *** this review,the importance of exercise timing considerations will be outlined,incorporating a chrono-exercise perspective.

关键词： Chrono-exercise Exercise timing Inter-organ communication Circadian rhythm Energy metabolism

Single-cell analysis for identification of T-cell clonotypes associated with IgG4 production of autoimmune pancreatitis

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Gastroenterology Report 2023年第1期11卷 590-592页

作者： Kensuke shibata Nao Fujimori Takamasa Oono Daisuke Motooka Daisuke Okuzaki Koh-Hei Sonoda Yoshihiro Ogawa Sho Yamasaki Department of Microbiology and Immunology Graduate School of MedicineYamaguchi UniversityUbeJapan Department of Ophthalmology Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Department of Molecular Immunology Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuokaJapan Single Cell Genomics Human ImmunologyWorld Premier International Research Center Initiative Immunology Frontier Research CenterOsaka UniversitySuitaJapan Genome Information Research Center Research Institute for Microbial DiseasesOsaka UniversitySuitaJapan Laboratory of Molecular Immunology Immunology Frontier Research CenterOsaka UniversitySuitaJapan Division of Molecular Immunology Medical Mycology Research CenterChiba UniversityChibaJapan

Introduction Autoimmune pancreatitis(AIP)is one of the recently established immunoglobulin G4-related diseases(IgG4-RD)[1].The detailed pathogenic mechanisms have been an intensive research area for prophylactic and therapeutic purposes because aberrant immune activation and tissue fibrosis in AIP are the major factors that worsen the disease outcomes in these patients.

关键词： IgG4 pancreatitis diseases

Mutations of pre-core and basal core promoter before and after hepatitis B e antigen seroconversion

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World Journal of Gastroenterology 2015年第2期21卷 541-548页

作者： Nozomi Kamijo Akihiro Matsumoto Takeji Umemura Soichiro shibata Yuki Ichikawa Takefumi Kimura Michiharu Komatsu Eiji Tanaka Department of Medicine Shinshu University School of MedicineMatsumoto 390-8621Japan

AIM: To investigate the role of pre-core and basal core promoter(BCP) mutations before and after hepatitis Be antigen(HBe Ag) ***: The proportion of pre-core(G1896A) and basal core promoter(A1762T and G1764A) mutant viruses and serum levels of hepatitis B virus(HBV) DNA, hepatitis B surface antigen(HBs Ag), and HB core-related antigen were analyzed in chronic hepatitis B patients before and after HBe Ag seroconversion(n = 25), in those who were persistently HBe Ag positive(n = 18), and in those who were persistently anti-HBe positive(n = 43). All patients were infected with HBV genotype C and were followed for a median of 9 ***: Although the pre-core mutant became predominant(24% to 65%, P = 0.022) in the HBe Ag seroconversion group during follow-up, the proportion of the basal core promoter mutation did not change. Median HBV viral markers were significantly higher in patients without the mutations in an HBe Ag positive status(HBV DNA: P = 0.003; HBs Ag: P < 0.001; HB core-related antigen: P = 0.001). In contrast, HBV DNA(P = 0.012) and HBs Ag(P = 0.041) levels were significantly higher in patients with the pre-core mutation in an anti-HBe positive ***: There is an opposite association of the pre-core mutation with viral load before and after HBe Ag seroconversion in patients with HBV infection.

关键词： Seroconversion Hepatitis B core-related antigen Pr