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What will happen in patients with advanced nonalcoholic fatty liver disease?

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Hepatobiliary Surgery and Nutrition 2019年第3期8卷 283-285页

作者： Takefumi Kimura Naoki tanaka Eiji tanaka Molecular Signaling Section Laboratory of Bioorganic ChemistryNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institutes of HealthBethesdaMDUSA Department of Internal Medicine Division of GastroenterologyShinshu University School of MedicineMatsumotoJapan Department of Metabolic Regulation Shinshu University School of MedicineMatsumotoJapan International Research Center for Agricultural Food Industry Shinshu UniversityMatsumotoJapan

Non-alcoholic fatty liver disease(NAFLD)and advanced form non-alcoholic steatohepatitis(NASH)have been become globally major chronic liver diseases(1,2).NAFLD is one of the leading causes of liver cirrhosis,hepatic failure,and hepatocellular carcinoma(HCC)(3).A large number of retrospective studies reported the importance of hepatic fibrosis with NAFLD patients as the strongest factor of liver-related mortality(4,5).On the other hand,NAFLD patients with advanced hepatic fibrosis are thought to have higer risk of developing vascular events and extrahepatic cancers because of the high prevalence of coexisting cardiometabolic risk factors,such as hypertension,diabetes mellitus,dyslipidemia,and obesity(6).However,since former literatures included only few NAFLD patients with advanced hepatic fibrosis,it is hard to estimate the accurate risk on the whole spectrum of these complications.

关键词： patients hepatic NAFLD

A solution to Tingley's problem for isometries between the unit spheres of compact C~*-algebras and JB~*-triples

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Science China Mathematics 2019年第3期62卷 553-568页

作者： Antonio M.Peralta Ryotaro tanaka Departamento de Ana'lisis Matem'atico Facultad de Ciencias Universidad de Granada Faculty of Mathematics Kyushu University

Let f : S(E) → S(B) be a surjective isometry between the unit spheres of two weakly compact JB*-triples not containing direct summands of rank less than or equal to 3. Suppose E has rank greater than or equal to 5. Applying techniques developed in JB*-triple theory, we prove that f admits an extension to a surjective real linear isometry T : E → B. Among the consequences, we show that every surjective isometry between the unit spheres of two compact C*-algebras A and B, without assuming any restriction on the rank of their direct summands(and in particular when A = K(H) and B = K(H′)), extends to a surjective real linear isometry from A into B. These results provide new examples of infinite-dimensional Banach spaces where Tingley's problem admits a positive answer.

关键词： Tingley’s problem extension of isometries JB*-triples compact operators

First-principles screening of structural properties of intermetallic compounds on martensitic transformation

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npj Computational Materials 2017年第1期3卷 23-36页

作者： Joohwi Lee Yuji Ikeda Isao tanaka Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Elements Strategy Initiative for Structure Materials(ESISM) Kyoto UniversityKyoto 606-8501Japan Center for Materials Research by Information Integration National Institute for Materials Science(NIMS)Tsukuba 305-0047 IbarakiJapan Nanostructures Research Laboratory Japan Fine Ceramics CenterNagoya 456-8587 AichiJapan Toyota Central R&D Laboratories Inc.Nagakute 480-1192 AichiJapan

Martensitic transformation with good structural compatibility between parent and martensitic phases are required for shape memory alloys(SMAs)in terms of functional *** this study,first-principles-based materials screening is systematically performed to investigate the intermetallic compounds with the martensitic phases by focusing on energetic and dynamical stabilities as well as structural compatibility with the parent *** B2,D0_(3),and L2_(1) crystal structures are considered as the parent phases,and the 2H and 6M structures are considered as the martensitic *** total,3384 binary and 3243 ternary alloys with stoichiometric composition ratios are *** is found that 187 alloys survive after the *** of the surviving alloys are constituted by the chemical elements already widely used in SMAs,but other various metallic elements are also found in the surviving *** energetic stability of the surviving alloys is further analyzed by comparison with the data in Materials Project Database(MPD)to examine the alloys whose martensitic structures may cause further phase separation or transition to the other structures.

关键词： martensitic intermetallic alloys

Theoretical study of current-voltage characteristics of carbon nanotube wire functionalized with hydrogen atoms

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Science China Chemistry 2012年第5期55卷 796-801页

作者： FUENO Hiroyuki KOBAYASHI Yoshikazu tanaka Kazuyoshi Department of Molecular Engineering Graduate School of Engineering Kyoto University Nishikyo-ku Kyoto 615-8510 Japan

A functionalized single-walled carbon nanotube (SWCNT) of a finite length with a ring-like hydrogenation around its surface is designed toward fabrication of a molecular field-effect transistor (FET) device. The molecular wire thus designed is equipped with a quantum dot inside, which is confirmed by theoretical analysis for electronic transport. In particular, the current-voltage (I-V) characteristics under influence of the gate voltage are discussed in detail.

关键词： single-walled carbon nanotube molecular field-effect transistor molecular wire electron transport

INFLUENCE OF THREAD PITCH ON LOAD DISTRIBUTION ON THREADED END OF PRESSURE CYLINDER

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Chinese Journal of Mechanical Engineering 1998年第4期11卷 36-41页

作者： Kobayashi, Mitsuo Hongo, Kaoru tanaka, Michihiko Kogakuin Univ Tokyo Japan

One of the design methods for closing the end of a pressure cylinder is to screw down a screw plug on the threaded end of the cylinder. In this case, there is the problem of stress concentration in the threaded end of the pressure cylinder. To solve the problem, it is necessary to know accurately the load distribution on the threaded end of the cylinder. To find the load distribution on the threaded end of the pressure cylinder engaged with the screw plug, the following experiments are carried out. Applying the tensile load between the screw plug and the pressure cylinder and regarding the situation above as equivalent to the situation in which the internal pressure is applied, the load distribution is measured with the strain gauge. The influence of thread pitch on the load distribution on the threaded end of the cylinder is presented and an optimum pitch for design is discussed.

关键词： Pressure cylinder Screw plug Threaded end Load distribution Experiment analysis

Positive Luminescent Sensor for Aerobic Conditions Based on Polyhedral Oligomeric Silsesquioxane Networks

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Chemical Research in Chinese Universities 2021年第1期37卷 162-165页

作者： Kazumasa SUENAGA Kazuo tanaka Yoshiki CHUJO Department of Polymer Chemistry Graduate School of EngineeringKyoto UniversityKatsuraNishikyo-kuKyoto615-8510Japan

There are numerous numbers of hypoxia-selective luminescent probes based on oxygen quenching of *** show a unique design for luminescent probes to detect hyperoxia utilizing hybrid networks consisting of aggregation-induced emission(AIE)-active dyes and disulfide *** the initial state,emission from the AIE-active dyes is inducible by suppressing energy-consumable intramolecular motions in the hybrid matrices,while the decrease in intensity was detected by releasing molecular motions corresponded to bond scission at the disulfide ***,it was shown that this process selectively proceeds in *** a result,positive luminescent signals were obtained in hyperoxia.

关键词： Polyhedral oligomeric silsesquioxane(POSS) Network polymer Hypoxia Luminescent probe

Characterizing mouse male germ cell-specific actin capping protein α3 （CPα3）： dynamic patterns of expression in testicular and epididymal sperm

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Asian Journal of Andrology 2008年第5期10卷 711-718页

作者： Keizo Tokuhiro Yasushi Miyagawaq Hiromitsu tanaka tanaka Project Center for Advanced Science and Innovation Osaka University 3-1 Yamadaoka Osaka 565-0871 Japan Department of Urology Osaka University Graduate School of Medicine Osaka 565-0871 Japan Department of Science for Laboratory Animal Experimentation Research Institute for Microbial Disease Osaka University 3-1 Yamadaoka Suita Osaka 565-0871 Japan Faculty of Pharmaceutical Sciences Nagasaki International University Sasebo Nagasaki 859-3298 Japan

Aim： To characterize mouse capping protein α3 （CPα3） during spermatogenesis and sperm maturation. Methods： We produced rat anti-CPα3 antiserum and examined the expression of CPα3 in various mouse tissues using Western blot analysis and the localization of CPα3 in testicular and epididymal sperm using immunohistochemical analyses. We also examined how the localization of CPα3 and β-actin （ACTB） in sperm changed after the acrosomal reaction by performing immunohistochemical analyses using anti-CPα3 antiserum and anti-actin antibody. Results： Western blot analysis using specific antiserum revealed that CPα3 was expressed specifically in testes. Interestingly, the molecular weight of CPα3 changed during sperm maturation in the epididymis. Furthermore, the subcellular localization of CPα3 in sperm changed dynamically from the flagellum to the post-acrosomal region of the head during epididymal maturation. The distribution of ACTB was in the post-acrosomal region of the head and the flagellum. After inducing the acrosomal reaction, the CPα3 and ACTB localization was virtually identical to the localization before the acrosomal reaction. Conclusion： CPα3 might play an important role in sperm morphogenesis and/or sperm function.

关键词： acrosome male germ cell-specific spermatogenesis testis

Discovery and application of 6π-azaelectrocyclization to natural product synthesis and synthetic biology

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Science China Chemistry 2012年第1期55卷 19-30页

作者： tanaka Katsunori KATSUMURA Shigeo FUKASE Koichi Department of Chemistry Graduate School of ScienceOsaka University1-1 Machikaneyama Department of Chemistry and Open Research Center on Organic Tool Molecules School of Science and TechnologyKwansei Gakuin University

While elucidating the inhibitory mechanism of a hydrolytic enzyme by aldehyde-containing natural product,we discovered a reaction involving a rapid 6π-azaelectrocyclization of azatrienes generated from aldehyde with lysine *** electrocyclic reaction of the 1-azatriene system,a cyclization precursor,exhibited a significant substituent *** chiral piperidine synthesis and a one-pot library synthesis of pyridines on solid-supports were applied to synthesize pyridine/indole alkaloid-type natural ***,we developed lysine-based labeling and engineering of biomolecules and living cells based on the rapid 6π-*** labels and oligosaccharide structures were introduced efficiently and selectively into surface lysines under the mild conditions;notable effects of N-glycans on proteins and living cells were visualized for the first time by PET and noninvasive fluorescence imaging.

关键词： 6π-azaelectrocyclization enzyme inhibition lysine natural product synthesis synthetic biology labeling chemical engineering living cells N-glycan in vivo imaging tumor targeting

Primary site resection is superior for incurable metastatic colorectal cancer

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World Journal of Gastroenterology 2010年第28期16卷 3561-3566页

作者： Yusuke Tanoue Nobutaka tanaka Yukihiro Nomura Department of General Surgery Asahi General HospitalI-1326 Asahi289-2511 ChibaJapan

AIM:To investigate survival in patients treated with FOLFOX followed by primary site resection or palliative surgery for incurable metastatic colorectal cancer. METHODS:Between 2001 and 2009,a total of 98 patients with colorectal adenocarcinoma and non-resectable metastases were diagnosed and treated with the new systemic agent chemotherapy regimen FOLFOX. Primary site resection was carried out in 38 patients, creation of a colostomy or bypass without resection was carried out in 36 patients,and 23 were not operated on because of advanced *** survival times of patients in different groups were analyzed. RESULTS:There were no differences between the patients regarding their general condition,concurrent disease,or tumor stage according to AJCC *** median survivals of the three groups were 30.6,20.8,and 12.7 mo(log-rank P value<0.05),*** postoperative complication rate was higher in the primary site resection group than in the palliative surgery group. CONCLUSION:The results indicate that there are benefits from primary site resection for incurable metastatic colorectal cancer with systemic chemotherapy.

关键词： Colorectal cancer Chemotherapy Primary resection Palliative surgery FOLFOX FOLFIRI