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Impact of endoscopically minimal involvement on IL-8 mRNA expression in esophageal mucosa of patients with non-erosive reflux disease

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World Journal of Gastroenterology 2003年第12期9卷 2801-2804页

作者： YuseiKanazawa HajimeIsomoto Chun-YangWen Ai-PingWang VladimirASaenko AkiraOhtsuru FuminaoTakeshima katsuhisaomagari YoheiMizuta IkuoMurata ShunichiYamashita ShigeruKohno SecondDepartmentofInternalMedicine AtomicBombDiseaseInstituteNagasakiUniversitySchoolofMedicineNagasakiJapan DepartmentofMolecularPathology AtonaicBombDiseaseInstituteNagasakiUniversitySchoolofMedicineNagasakiJapan DepartmentofMolecularMedicine AtomicBombDiseaseInstitute~NagasakiUniversitySchoolofMedicineNagasakiJapan DepartmentofPharmacotherapeutids NagasakiUniversityGraduateSchoolofBiomedicalSciencesNagasakiJapan

AIM:Little has been known about the pathogenesis of non- erosive reflux disease(NERD).Recent studies have implicated interleukin 8(IL-8)in the development and progression of gastroesophgeal reflux disease(GERD).The purpose of this study was to determine IL-8 RNA expression levels in NERD patients with or without subtle mucosal changes. METHODS:We studied 26 patients with NERD and 13 asymptomatic *** sample was taken from the esophagus 3 cm above the gastroesophageal junction and snap frozen for measurement of IL-8 mRNA levels by real-time quantitative polymerase chain reaction(PCR).We also examined mRNA expression of IL-8 receptors,CXCR-1 and -2 by reverse transcriptase *** patients were endoscopically classified into grade M(mucosal color changes without visible mucosal break)and N(neither minimal involvement nor mucosal break)of the modified Los Angeles classification. RESULTS:The relative IL-8 mRNA expression levels were significantly higher in esophageal mucosa of NERD patients than those in esophageal mucosa of the *** was a significant difference in IL-8 mRNA levels between grades M and *** CXCR-1 and -2 mRNAs were constitutively expressed in esophageal ***: Our results suggest that high IL-8 levels in esophageal mucosa may be involved in the pathogenesis of NERD through interaction with its receptors. NERD seems to be composed of a heterogeneous population in terms of not only endoscopically minimal involvement but also immune and inflammatory processes.

关键词： Adult Aged Alcohol Drinking Base Sequence Comparative Study DNA Primers Endoscopy, Digestive System Female Gastroesophageal Reflux Gene Expression Regulation Helicobacter Infections Helicobacter pylori Hernia, Hiatal Humans Interleukin-8 Male Middle Aged RNA, Messenger Reverse Transcriptase Polymerase Chain Reaction Risk Factors Smoking

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